PKk>LǠrefs.MYD||7.Lavernia, C. D'Apuzzo, M. Rossi, M. D. Lee, D.2008IAccuracy of knee range of motion assessment after total k `nee arthroplasty85-91J Arthroplasty23 6 Suppl 1 2008/09/09Analysis of Variance *Arthroplasty, Replacement, Knee Female Humans Knee Joint/*radiography Male Observer Variation *Range of Motion, ArticularSepMeasurement of knee joint range of motion (ROM) is important to assess after total knee arthroplasty. Our objective was to determine level of agreement and accuracy between observers with different knowledge on total ROM after total knee arthroplasty. Forty-one patients underwent x-ray of active and passive knee ROM (gold standard). Five different raters evaluated observed and measured ROM: orthopedic surgeon, clinical fellow, physician assistant, research fellow, and a physical therapist. A 1-way analysis of variance was used to determine differences in ROM between raters over both conditions. Limit of agreement for each rater for both active and passive total ROM under both conditions was calculated. Analysis of variance indicated a difference between raters for all conditions (range, P = .004 to P < or =.0001). The trend for all raters was to overestimate ROM at higher ranges. Assessment of ROM through direct observation without a goniometer provides inaccurate findings.+http://www.ncbi.nlm.nih.gov/pubmed/18722308Lavernia, Carlos D'Apuzzo, Michele Rossi, Mark D Lee, David Research Support, Non-U.S. Gov't United States The Journal of arthroplasty J Arthroplasty. 2008 Sep;23(6 Suppl 1):85-91.*1532-8406 (Electronic) 0883-5403 (Linking)18722308COrthopaedic Institute at Mercy Hospital, Miami, Florida 33133, USA.6S0883-5403(08)00491-9 [pii] 10.1016/j.arth.2008.05.019engn||7Hoppenfeld, S.19793Physical examination of the knee joint by complaint3-20Orthop Clin North Am101 1979/01/01Diagnosis, Differential Dislocations/*diagnosis Humans Joint Diseases/*diagnosis Knee Injuries/*diagnosis *Knee Joint Ligaments, Articular/*injuries Osteoarthritis/diagnosis Osteochondritis/diagnosis Palpation/methods Physical Examination/*methodsJan)http://www.ncbi.nlm.nih.gov/pubmed/450402{Hoppenfeld, S Case Reports United states The Orthopedic clinics of North America Orthop Clin North Am. 1979 Jan;10(1):3-20.%0030-5898 (Print) 0030-5898 (Linking)450402eng w||7:Grishina, A. Haramati, L. B. Hoppenfeld, B. Freeman, L. M.2002WUtilization of CT-PA in an emergency department with readily available V/Q scintigraphy75-8 Emerg Radiol92 2004/08/04Jul PURPOSE: To describe the role of computed tomographic pulmonary angiography (CT-PA) in the emergency department of an institution which utilizes ventilation-perfusion (V/Q) scintigraphy as its primary imaging modality for the diagnosis of pulmonary embolism. METHODS AND MATERIALS: We retrospectively identified and reviewed the records of 24 consecutive patients evaluated in the emergency department from October 1998 to September 2000 who were suspected of having pulmonary embolism. The inclusion criterion was that the images from the emergency department and work-up included CT-PA, which was the initial imaging test after chest radiograph. There were 10 men and 14 women with a mean age of 63. Results of CT-PA were categorized as positive, negative, limited negative (no main or lobar pulmonary emboli but not all segmental arteries visualized), or nondiagnostic. Each chart was reviewed with reference to clinical presentation, relevant history, results of Doppler ultrasonography of the legs, V/Q scan and pulmonary angiography, and discharge diagnosis. During the same study period, approximately 400 V/Q scans were performed from the emergency department. RESULTS: Each patient had a clinical presentation consistent with pulmonary embolism. CT-PA diagnosed pulmonary emboli in 21% (5/24), was negative in 33% (8/24), was limited negative in 38% (9/24), and was nondiagnostic in 8% (2/24). Chest radiographs were abnormal in 71% (17/24). V/Q scans were performed in 17% (4/24; 1 near normal, 2 low probability, 1 intermediate probability). None of these four patients was discharged with a diagnosis of pulmonary embolism. Doppler ultrasound leg exam was performed in 38% (9/24). Among the 5 patients diagnosed with pulmonary embolism, 1/3 examined had Doppler evidence of deep vein thrombosis (DVT). Among the 19 patients not diagnosed with pulmonary embolism, 3/6 examined had Doppler evidence of DVT. No patient with a negative or limited negative CT-PA was discharged with a diagnosis of pulmonary embolism. CT-PA provided alternative diagnoses explaining the patient's symptoms in 68% (13/19) of those not diagnosed with pulmonary embolism. During the most recent 12 months of the study period, 210 V/Q scans were performed from the emergency department, with results available in 194 cases as follows: normal/near normal 32% ( n=62), low probability 47% ( n=92), intermediate probability 14% ( n=28), high probability 6% ( n=12). CONCLUSION: V/Q scintigraphy is the primary imaging modality for suspected pulmonary embolism in our emergency department. However, when utilized, CT-PA played an important role in patient management by confirming or excluding pulmonary embolism or providing an alternative diagnosis in the majority of patients suspected of having pulmonary embolism.+http://www.ncbi.nlm.nih.gov/pubmed/15290581Grishina, Alla Haramati, Linda B Hoppenfeld, Brad Freeman, Leonard M United States Emergency radiology Emerg Radiol. 2002 Jul;9(2):75-8. Epub 2002 May 7.%1070-3004 (Print) 1070-3004 (Linking)15290581Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA.10.1007/s10140-002-0197-8eng ||7+Hoppenfeld, S. Lonner, B. Murthy, V. Gu, Y.2004TThe rib epiphysis and other growth centers as indicators of the end of spinal growth47-50Spine (Phila Pa 1976)291 2003/12/31DAdolescent Adult Age Determination by Skeleton Body Height Braces Cohort Studies Epiphyses/*growth & development/radiography Female Humans Ilium/growth & development/radiography Male Ribs/*growth & development/radiography Scoliosis/*radiography/therapy Sex Factors Spine/*growth & development/radiography Statistics as TopicJan 1{STUDY DESIGN: The association of capping and fusion of the iliac apophysis, and closure of the proximal humerus and rib epiphyseal growth plates to the end of spinal growth, was evaluated in a cohort of patients with juvenile and adolescent idiopathic scoliosis. OBJECTIVES: To determine the association of closure of the proximal rib epiphysis growth plate, the proximal humeral epiphyseal growth plate, and capping (Risser 4), and fusion (Risser 5) of the iliac apophysis to growth cessation in patients with idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Accurate evaluation of remaining spinal growth is the basis of decision-making in skeletally immature patients with scoliosis. The ossification of the iliac apophysis (Risser sign) has been the main indicator used for making this determination. The accuracy of this sign has been called into question and may be supplemented with data from other growth centers. METHODS: A total of 101 patients with juvenile or adolescent idiopathic scoliosis undergoing brace treatment were followed for a minimum of 2 years following termination of bracing. Serial height measurements and evaluation of iliac apophysis ossification, proximal humerus, and rib epiphysis growth center closure were performed for each patient. RESULTS: The iliac apophysis capped (Risser 4) at a mean age of 14.9 years for girls and 16.0 years in boys. Seventy-six of the 101 patients (75.2%) had further growth after Risser 4 status. The mean growth was 1.75 cm in the girls and 2.46 cm in the boys. No growth occurred after iliac apophysis fusion (Risser 5) or closure of either the rib epiphysis or proximal humerus growth plates. CONCLUSIONS: Capping of the iliac apophysis is not the final indicator for the end of spinal growth. Other growth centers should be evaluated in conjunction with serial height measurements when making decisions on the management of the scoliosis patient.+http://www.ncbi.nlm.nih.gov/pubmed/14699275}Hoppenfeld, Stanley Lonner, Baron Murthy, Vasantha Gu, Yun United States Spine Spine (Phila Pa 1976). 2004 Jan 1;29(1):47-50.*1528-1159 (Electronic) 0362-2436 (Linking)14699275WDepartment of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, NY, USA."10.1097/01.BRS.0000103941.50129.66eng ||7ZCynamon, J. Atar, E. Steiner, A. Hoppenfeld, B. M. Jagust, M. B. Rosado, M. Sprayregen, S.2003TCatheter-induced vasospasm in the treatment of acute lower gastrointestinal bleeding211-6J Vasc Interv Radiol142 Pt 1 2003/02/13Aged *Catheterization *Embolization, Therapeutic Female Gastrointestinal Hemorrhage/radiography/*therapy Hemostatic Techniques Humans Male Mesenteric Artery, Inferior Mesenteric Artery, Superior Retrospective Studies *VasoconstrictionFeb`PURPOSE: To demonstrate results in managing lower gastrointestinal (GI) bleeding with the use of superselective catheterization and intentional induction of vasospasm of the bleeding vessel without the use of embolic agents or vasospasm-inducing medications. MATERIALS AND METHODS: A retrospective review of 15 episodes of lower GI bleeding treated in the past 6 years by intentional catheter-induced vasospasm (CIV) to achieve thrombosis of a bleeding source was conducted. Nine patients had angiographically proven inferior mesenteric artery bleeding and six had angiographically proven superior mesenteric artery bleeding. RESULTS: Bleeding was stopped initially in all patients after effective treatment of the feeding artery. Only one patient experienced a repeat episode of bleeding 2 days later, which required hemicolectomy. Two other patients who underwent adequate embolization underwent surgery at the discretion of the surgeon involved. The remainder were clinically observed and discharged after return of stable vital signs and hematocrit levels. None of the patients treated had clinically evident intestinal ischemia or infarction. There was one significant repeat incidence of bleeding 2 months after CIV that may have represented recurrent bleeding from the original site. CONCLUSION: CIV may be a safe and effective first-line method of embolizing known lower GI bleeding. Whether CIV is used as primary therapy or as the result of spasm incurred during superselective catheterization, the patient may be regarded as successfully treated and followed accordingly, thereby possibly avoiding acute surgical therapy.+http://www.ncbi.nlm.nih.gov/pubmed/12582189Cynamon, Jacob Atar, Eli Steiner, Ari Hoppenfeld, Brad M Jagust, Marcy B Rosado, Madeline Sprayregen, Seymour United States Journal of vascular and interventional radiology : JVIR J Vasc Interv Radiol. 2003 Feb;14(2 Pt 1):211-6.%1051-0443 (Print) 1051-0443 (Linking)12582189Department of Radiology, Division of Vascular Radiology, Montefiore Medical Center, University Hospital for the Albert Einstein College of Medicine, 111 East 210th Street, Bronx, New York 10467-2490, USA. jcmdir@aol.comeng||7Hoppenfeld, B. M. Cynamon, J.2001>Basic arterial techniques for peripheral arterial thrombolysis84-91Tech Vasc Interv Radiol42 2002/05/01Adult Aged Arterial Occlusive Diseases/*complications/*drug therapy Dose-Response Relationship, Drug Equipment Design Equipment Safety Female Femoral Artery/*pathology Fibrinolytic Agents/*therapeutic use Heparin/*therapeutic use Humans Male Middle Aged Peripheral Vascular Diseases/*complications/*drug therapy Popliteal Artery/*pathology Thrombolytic Therapy/instrumentation/*methods Treatment Outcome Urokinase-Type Plasminogen Activator/*therapeutic useJunThis article is an overview of the techniques of percutaneous intervention for recanalizing acute or subacute occluded arteries. The indications and results for specific thrombolytics and interventions are discussed in subsequent articles.+http://www.ncbi.nlm.nih.gov/pubmed/11981793Hoppenfeld, B M Cynamon, J Case Reports Review United States Techniques in vascular and interventional radiology Tech Vasc Interv Radiol. 2001 Jun;4(2):84-91.%1089-2516 (Print) 1557-9808 (Linking)11981793Department of Radiology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E. 210th Street, Bronx, NY 10467-2401, USA.S1089-2516(01)90001-0 [pii]eng f||73Anand, N. Idio, F. G., Jr. Remer, S. Hoppenfeld, S.1998yThe effects of perioperative blood salvage and autologous blood donation on transfusion requirements in scoliosis surgery532-4J Spinal Disord116 1999/01/12Adolescent Blood Loss, Surgical Blood Transfusion, Autologous/*utilization Female Humans Male Prospective Studies Scoliosis/*surgeryDecfFifty consecutive cases of surgical instrumentation and fusion for adolescent idiopathic scoliosis were prospectively studied to test the hypothesis that the use of predonated autologous blood combined with judicious perioperative blood salvage could decrease the amount of homologous blood needed. All cases had posterior instrumentation and fusion. Nineteen patients had their rib prominence resected with an average of 4.8 ribs per patient. Our protocol called for perioperative blood salvage with the cell saver and reinfusion of postoperative drained blood if more than 300 ml were drained in 4 hours. Two units of predonated autologous blood was made available. Hypotensive anesthesia and meticulous hemostasis kept the blood loss to a minimum. The average total blood loss was 1,055 ml. Blood loss per segment was 91 ml with an average of 11 segments fused per patient. Patients with rib resection had a blood loss of 1,105 ml, while those without had a blood loss of 955 ml. The cell saver blood returned per case was 391 ml with the hematocrit of the product averaging 46%. Twelve patients were reinfused an average of 300 ml of the postoperative drained blood. The predonated autologous blood was used as part of the intraoperative fluid management. In no patient was homologous blood needed. The average starting hematocrit was 35.6%, with the hematocrit at discharge (seventh day) being 32.4%. There were no complications or blood transfusion reactions. Our results suggest that judicious perioperative blood management may decrease the need for homologous blood transfusion in selected posterior idiopathic scoliosis surgery.*http://www.ncbi.nlm.nih.gov/pubmed/9884300Anand, N Idio, F G Jr Remer, S Hoppenfeld, S Review United states Journal of spinal disorders J Spinal Disord. 1998 Dec;11(6):532-4.%0895-0385 (Print) 0895-0385 (Linking)9884300Department of Orthopedics, Albert Einstein College of Medicine Orthopedic Program at The Bronx-Lebanon Hospital Center, Bronx, NY 10457, USA.engi||7 /Hoppenfeld, S. Gross, A. Andrews, C. Lonner, B.1997hThe ankle clonus test for assessment of the integrity of the spinal cord during operations for scoliosis208-12J Bone Joint Surg Am792 1997/02/01Adolescent Adult Ankle Joint/*physiology Female Humans Intraoperative Complications/*diagnosis Male Middle Aged Monitoring, Intraoperative/*methods *Reflex Scoliosis/*surgery Sensitivity and Specificity Spinal Cord Injuries/*diagnosis *Spinal FusionFeb$The ankle clonus test, a method for evaluating the integrity of the spinal cord during operations for scoliosis, is predicated on the finding that patients recovering from general anesthesia normally have temporary ankle clonus bilaterally. An absence of transient ankle clonus has been shown to indicate neurological compromise. The test was performed for 1006 patients who were being managed with spinal arthrodesis and instrumentation and 115 control patients who had an operation under general anesthesia because of a condition that was unrelated to the spine. The six patients in whom a neurological deficit developed all had had a so-called positive result on the ankle clonus test (that is, an absence of transient ankle clonus). There were no false-negative results and three false-positive results; the test therefore had a sensitivity of 100 per cent and a specificity of 99.7 per cent. The ankle clonus test was found to be more accurate than the wake-up test and monitoring of somatosensory evoked potentials for predicting neurological compromise.*http://www.ncbi.nlm.nih.gov/pubmed/9052541Hoppenfeld, S Gross, A Andrews, C Lonner, B United states The Journal of bone and joint surgery. American volume J Bone Joint Surg Am. 1997 Feb;79(2):208-12.%0021-9355 (Print) 0021-9355 (Linking)9052541SJack D. Weiler Hospital, Albert Einstein College of Medicine, Bronx, New York, USA.eng||7 &Hoppenfeld, S. Lopez, R. A. Molnar, G.19916Plantar weight-bearing pattern in idiopathic scoliosis757-60Spine (Phila Pa 1976)167 1991/07/01Adolescent Braces Foot/*physiology Humans Internal Fixators Kyphosis/physiopathology/therapy Posture Scheuermann Disease/physiopathology/therapy Scoliosis/*physiopathology/therapy Spinal Fusion Weight-Bearing/physiologyJulEighty-four patients were objectively evaluated with a weight-bearing pattern analyzer to determine whether spine deformity has an effect on the amount of weight borne on the right versus left foot and on the fore versus the hind foot. Patients with idiopathic scoliosis treated with bracing and surgery and patients with Scheuermann's kyphosis treated with bracing were compared with control subjects. Patients with right thoracic and thoracolumbar curves did not bear more weight on the right foot, as was previously thought. Patients with relatively unaffected lumbar spines exhibited normal sagittal plane weight-bearing patterns, whereas patients with double major and lumbar curves did show abnormalities in the weight-bearing pattern. Bracing of curves less than 40 degrees did not alter the plantar weight-bearing pattern, but it did significantly alter the pattern in curves greater than 40 degrees. Surgically treated patients were found to have increased hindfoot weight-bearing irrespective of the curve type or surgery.*http://www.ncbi.nlm.nih.gov/pubmed/1925750dHoppenfeld, S Lopez, R A Molnar, G United states Spine Spine (Phila Pa 1976). 1991 Jul;16(7):757-60.%0362-2436 (Print) 0362-2436 (Linking)19257505Albert Einstein College of Medicine, Bronx, New York.engo||7 &Hoppenfeld, S. Gross, M. Giangarra, C.19908Nonoperative treatment of neuropathic spinal arthropathy54-6Spine (Phila Pa 1976)151 1990/01/01Adult Arthropathy, Neurogenic/radiography/*therapy Humans Immobilization Male Orthotic Devices Physical Therapy Modalities SupinationJan*http://www.ncbi.nlm.nih.gov/pubmed/2326701pHoppenfeld, S Gross, M Giangarra, C Case Reports United states Spine Spine (Phila Pa 1976). 1990 Jan;15(1):54-6.%0362-2436 (Print) 0362-2436 (Linking)2326701[Department of Orthopaedic Surgery, Albert Einstein College of Medicine, New York, New York.eng}|7 Hoppenfeld, S.1989XPercutaneous removal of herniated lumbar discs. 50 cases with ten-year follow-up periods92-7Clin Orthop Relat Res238 1989/01/01Adult Female Follow-Up Studies Humans Intervertebral Disk/*surgery Intervertebral Disk Displacement/complications/*surgery Lumbar Vertebrae Male Middle Aged Sciatica/etiologyJanL4-L5 herniated discs documented by myelogram were removed percutaneously from 50 patients, under local anesthesia and X-ray control, and the patients were followed for ten years. Forty-three patients (86%) had relief of sciatica and sensory deficit. However, only one out of eight patients who had had motor neurological deficit had return of normal power and relief of sciatica from this procedure. The best clinical results were in those patients who felt improvement and relief of pain in the leg at the time of the removal of the disc material. The best clinical results were in patients with a major bulge of the disc and decompression of the nerve root. Patients with sequestration of the disc do not uniformly respond well to this procedure. There were no significant complications. Percutaneous excision of herniated L4-L5 lumbar discs, under local anesthesia, is a safe and valid procedure to reduce patient morbidity and hospital stay, and it does not prejudice the outcome of a formal laminectomy if it should fail.*http://www.ncbi.nlm.nih.gov/pubmed/2910623rHoppenfeld, S United states Clinical orthopaedics and related research Clin Orthop Relat Res. 1989 Jan;(238):92-7.%0009-921X (Print) 0009-921X (Linking)29106235Albert Einstein College of Medicine, Bronx, NY 10461.eng*||7 +Shore, N. A. Schaefer, M. G. Hoppenfeld, S.1979@Iatrogenic TMJ difficulty: cervical traction may be the etiology541-2J Prosthet Dent415 1979/05/01Cervical Vertebrae Humans Iatrogenic Disease Spinal Diseases/therapy Splints Temporomandibular Joint Dysfunction Syndrome/*etiology/prevention & control Traction/*adverse effectsMayPatients in cervical traction for the treatment of cervical spine syndromes frequently complain that the traction makes them worse. It is possible that such patients may be suffering from TMJ symptoms. The physician treating a patient with cervical traction should consider prescribing an occlusal splint for patients without posterior teeth. The splint should be designed to distribute the stresses through the mandible to the maxillae via the teeth, splint, and TMJ.)http://www.ncbi.nlm.nih.gov/pubmed/286045Shore, N A Schaefer, M G Hoppenfeld, S United states The Journal of prosthetic dentistry J Prosthet Dent. 1979 May;41(5):541-2.%0022-3913 (Print) 0022-3913 (Linking)286045engn||7Hoppenfeld, S.19793Physical examination of the knee joint by complaint3-20Orthop Clin North Am101 1979/01/01Diagnosis, Differential Dislocations/*diagnosis Humans Joint Diseases/*diagnosis Knee Injuries/*diagnosis *Knee Joint Ligaments, Articular/*injuries Osteoarthritis/diagnosis Osteochondritis/diagnosis Palpation/methods Physical Examination/*methodsJan)http://www.ncbi.nlm.nih.gov/pubmed/450402{Hoppenfeld, S Case Reports United states The Orthopedic clinics of North America Orthop Clin North Am. 1979 Jan;10(1):3-20.%0030-5898 (Print) 0030-5898 (Linking)450402eng||7Hoppenfeld, S.1977 Back pain881-7Pediatr Clin North Am244 1977/11/01XAccidents, Traffic Back Pain/*etiology/radiography Bone Neoplasms/complications Child Humans Intervertebral Disk Displacement/complications Lumbar Vertebrae Osteoma, Osteoid/complications Scheuermann Disease/complications Spinal Diseases/complications Spine/abnormalities Spondylolisthesis/complications Sprains and Strains/complications X-RaysNov)http://www.ncbi.nlm.nih.gov/pubmed/144893kHoppenfeld, S United states Pediatric clinics of North America Pediatr Clin North Am. 1977 Nov;24(4):881-7.%0031-3955 (Print) 0031-3955 (Linking)144893eng||7Cressman, M. R. Hoppenfeld, S.1969OTreatment of an unusual case of tuberculosis of the cervical spine. Case report65-8 J Neurosurg301 1969/01/01*Cervical Vertebrae/radiography/surgery Child Female Humans *Kyphosis/etiology Pyrazinamide/therapeutic use Spinal Fusion Streptomycin/therapeutic use Thoracic Vertebrae/radiography Traction *Tuberculosis, Spinal/complications/drug therapy/surgeryJan*http://www.ncbi.nlm.nih.gov/pubmed/5766618pCressman, M R Hoppenfeld, S Case Reports United states Journal of neurosurgery J Neurosurg. 1969 Jan;30(1):65-8.%0022-3085 (Print) 0022-3085 (Linking)576661810.3171/jns.1969.30.1.0065eng!||7Hoppenfeld, S.1967'Congenital kyphosis in myelomeningocele276-80J Bone Joint Surg Br492 1967/05/01Child Child, Preschool Female Humans Infant Infant, Newborn Kyphosis/*complications/*congenital/*pathology/*radiography Male Spinal Dysraphism/*complications/*pathology/*radiographyMay*http://www.ncbi.nlm.nih.gov/pubmed/5338247xHoppenfeld, S England The Journal of bone and joint surgery. British volume J Bone Joint Surg Br. 1967 May;49(2):276-80.%0301-620X (Print) 0021-9355 (Linking)5338247eng~|7MRisser, J. C. Norquist, D. M. Cockrell, B. R., Jr. Tateiwa, M. Hoppenfeld, S.19669The effect of posterior spine fusion on the growing spine127-39Clin Orthop Relat Res46 1966/05/01Child Child, Preschool Female Follow-Up Studies Humans Lordosis Male Scoliosis/surgery *Spinal Fusion Spine/*growth & development/radiography Tuberculosis, Spinal/surgeryMay-Jun*http://www.ncbi.nlm.nih.gov/pubmed/5915107Risser, J C Norquist, D M Cockrell, B R Jr Tateiwa, M Hoppenfeld, S United states Clinical orthopaedics and related research Clin Orthop Relat Res. 1966 May-Jun;46:127-39.%0009-921X (Print) 0009-921X (Linking)5915107eng~|7*Shore, N. A. Frankel, V. H. Hoppenfeld, S.1964ICervical Traction and Temporomandibular Joint Dysfunction: Report of Case4-6J Am Dent Assoc68 1964/01/01Y*Cervical Vertebrae *Joint Diseases *Temporomandibular Joint *Traction *Whiplash InjuriesJan+http://www.ncbi.nlm.nih.gov/pubmed/14076334Shore, n a Frankel, v h Hoppenfeld, s United states Journal of the American Dental Association (1939) J Am Dent Assoc. 1964 Jan;68:4-6.%0002-8177 (Print) 0002-8177 (Linking)14076334engk~|7*Frankel, V. H. Shore, N. A. Hoppenfeld, S.1964lStress distribution in cervical traction: prevention of temporomandibular joint pain syndrome: a case report114-6Clin Orthop Relat Res32 1964/01/01Adult Brachial Plexus Neuritis/*therapy Female Humans Methods Temporomandibular Joint Dysfunction Syndrome/*prevention & control *TractionJan-Feb*http://www.ncbi.nlm.nih.gov/pubmed/5889048Frankel, V H Shore, N A Hoppenfeld, S United states Clinical orthopaedics and related research Clin Orthop Relat Res. 1964 Jan-Feb;32:114-6.%0009-921X (Print) 0009-921X (Linking)5889048eng||7#Pineda, V. Salvador, R. Soriano, J.2003;Bilateral breast cancer associated with diffuse scleroderma217-9Breast123 2003/12/09|Breast Neoplasms/*etiology Carcinoma, Ductal, Breast/*etiology Female Humans Middle Aged Scleroderma, Diffuse/*complicationsJun<There is a strong evidence to suggest the association between breast cancer and diffuse scleroderma, though it is an infrequent occurrence. We describe the clinical and radiological findings in a patient who, over a period of 2 years, was diagnosed initially of diffuse scleroderma, next with right breast cancer and finally with left breast cancer. A review of the literature evidencing the relation between these two pathologies is provided. We suggest that special vigilance for tumoral pathology of the breast should be performed in patients with systemic scleroderma.+http://www.ncbi.nlm.nih.gov/pubmed/14659331qPineda, V Salvador, R Soriano, J Case Reports Scotland Breast (Edinburgh, Scotland) Breast. 2003 Jun;12(3):217-9.%0960-9776 (Print) 0960-9776 (Linking)14659331~Radiology Department, Vall d'Hebron General Hospital, Autonomous University of Barcelona, Barcelona, Spain. vpineda@wanadoo.esS0960977603000079 [pii]eng|t7JGallego, J. Tunon, T. Soriano, G. Delgado, G. Lacruz, F. Villanueva, J. A.1995\Bilateral pallidostriatal necrosis caused by a wasp sting: a clinical and pathological study474-6J Neurol Neurosurg Psychiatry584 1995/04/01Aged Animals Brain Diseases/etiology/pathology/radiography Corpus Striatum/*pathology/radiography Globus Pallidus/*pathology/radiography Humans Insect Bites and Stings/*complications Male Necrosis/etiology/pathology/radiography Tomography, X-Ray Computed *WaspsApr$A previously healthy man developed an acute encephalopathy with coma after a single wasp sting on his chin. Brain CT showed bilateral pallidostriatal radio-lucencies. He died 72 hours after the sting with no evidence of primary cardiorespiratory failure or allergic reaction. Pathological findings were bilateral pallidostriatal necrosis and diffuse neuronal damage in the frontal, temporal, and parietal cortex. The neurotoxic effect of the poison, together with a hypersensitivity are the most likely explanations for this unusual encephalopathy.*http://www.ncbi.nlm.nih.gov/pubmed/7738559Gallego, J Tunon, T Soriano, G Delgado, G Lacruz, F Villanueva, J A Case Reports England Journal of neurology, neurosurgery, and psychiatry J Neurol Neurosurg Psychiatry. 1995 Apr;58(4):474-6.%0022-3050 (Print) 0022-3050 (Linking)10734387738559=Servicio de Neurologia, Hospital de Navarra, Pamplona, Spain.eng||7Soriano, J. M. Funk, J.1991P[Spontaneous bilateral lens resorption in a case of Hallermann-Streiff syndrome]195-8Klin Monbl Augenheilkd1993 1991/09/01Aphakia/*diagnosis/*genetics/pathology Cataract/*diagnosis/*genetics/pathology Child, Preschool Female Hallermann's Syndrome/*diagnosis/*genetics/pathology Humans Lens Capsule, Crystalline/pathologySepThe Hallermann-Streiff-syndrome was first described in 1948 by Hallermann and in 1950 by Streiff. The most common features are dyscephalia, cataract, microphthalmia, dental anomalies, hypotrichosis, cutaneous atrophy, and nanism. Anomalies of the eye include cataract, microphthalmia, nystagm, strabism, blue sclera, fundus anomalies and combined anomalies of all segments of the eye. The frequency of cataract is about 90%. Spontaneous resorption of the lens is described in about 8%. We present a five year old girl showing the typical dyscephalia of the Hallermann-Streiff-syndrome (bird face). Her lenses were replaced by opaque membranes. These membranes presumably were remnants of the posterior lens capsule.*http://www.ncbi.nlm.nih.gov/pubmed/1753673Soriano, J M Funk, J Case Reports English Abstract Germany Klinische Monatsblatter fur Augenheilkunde Klin Monbl Augenheilkd. 1991 Sep;199(3):195-8.%0023-2165 (Print) 0023-2165 (Linking)1753673TSpontane beidseitige Linsenresorption bei einem Fall von Hallermann-Streiff-Syndrom."Universitats-Augenklinik Freiburg.10.1055/s-2008-1046071ger||7OBagilet, D. Soriano, F. Goiburu, J. Fein, L. Guercetti, R. Valtorta, E. Dip, O.1988G[Bilateral empyema as a complication of central venous catheterization]502-3 Rev Clin Esp1839 1988/12/01\Catheterization, Central Venous/*adverse effects Empyema/*etiology Female Humans Middle AgedDec*http://www.ncbi.nlm.nih.gov/pubmed/3238106Bagilet, D Soriano, F Goiburu, J Fein, L Guercetti, R Valtorta, E Dip, O Case Reports Letter Spain Revista clinica espanola Rev Clin Esp. 1988 Dec;183(9):502-3.%0014-2565 (Print) 0014-2565 (Linking)3238106HEmpiema bilateral como complicacion de la cateterizacion venosa central.spaY||7Soriano, R. M. Weisz, I.1988M[Spondyloepiphyseal dysplasia tarda: bilateral total arthroplasty of the hip]778-81%Rev Chir Orthop Reparatrice Appar Mot748 1988/01/01}Adult Female *Hip Prosthesis Humans Male Osteoarthritis, Hip/etiology/*surgery Osteochondrodysplasias/complications/*genetics9A brother and sister with spondylo-epiphyseal dysplasia tarda developed severe premature osteoarthritis of the hips and were treated with bilateral hip replacement in young adult life. The clinical results are good and the radiographic evaluation showed no evidence of loosening at a mean follow-up of five years.*http://www.ncbi.nlm.nih.gov/pubmed/3253849Soriano, R M Weisz, I Case Reports English Abstract France Revue de chirurgie orthopedique et reparatrice de l'appareil moteur Rev Chir Orthop Reparatrice Appar Mot. 1988;74(8):778-81.%0035-1040 (Print) 0035-1040 (Linking)3253849RDysplasie spondylo-epiphysaire tardive: arthroplastie totale bilaterale de hanche.aNuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Headington, Oxford, U.K.fre<7<Ji, X. B. Kadara, R. O. Krussma, J. Chen, Q. Y. Banks, C. E.2010aUnderstanding the Physicoelectrochemical Properties of Carbon Nanotubes: Current State of the Art7-19Electroanalysis221Ynanoelectrochemistry electrocatalysis carbon nanotubes edge plane pyrolytic graphite electrodes electrochemical reactivity nanotubes catalysis plane pyrolytic-graphite electron-transfer kinetics iron-oxide impurities glassy-carbon electrochemical reactivity copper nanoparticles hydrogen-peroxide metal impurities paste electrodes nadh detectionJanCarbon nanotubes receive considerable attention in the area of electrochemistry not only due to their reported structural, mechanical or electronic properties but because they represent the world's smallest electrodes allowing electrochemistry to be performed where other electrode materials cannot penetrate. In this review, we overview recent developments in this area summarizing the fundamental advances in understanding the various factors and parameters that can significantly affect the electrochemical reactivity of carbon nanotubes, which is essential for their continual use and successful implementation in a plethora of areas and applications.://000273726100001.545IQ Times Cited:2 Cited References Count:105 1040-0397 ElectroanalISI:000273726100001Banks, CE Manchester Metropolitan Univ, Div Chem & Mat, Fac Sci & Engn, Sch Biol Chem & Hlth Sci, Chester St, Manchester M1 5GD, Lancs, England Manchester Metropolitan Univ, Div Chem & Mat, Fac Sci & Engn, Sch Biol Chem & Hlth Sci, Chester St, Manchester M1 5GD, Lancs, England Manchester Metropolitan Univ, Div Chem & Mat, Fac Sci & Engn, Sch Biol Chem & Hlth Sci, Manchester M1 5GD, Lancs, England Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China Univ Tartu, Inst Phys Chem, EE-51014 Tartu, EstoniaDOI 10.1002/elan.200900493English <7Avison, D. Banks, P.2008_Cross-cultural (mis)communication in IS offshoring: understanding through conversation analysis249-268!Journal of Information Technology234<information systems offshoring culture conversation analysisDecThe offshoring of information systems (IS) work has seen phenomenal growth in the past 5 or more years. This has resulted in IS professionals, interacting with workers from vastly different cultural backgrounds, in order to deliver IS project and support services. This cultural 'barrier' has been highlighted in the IS literature as a key challenge for offshoring; however, the attention given to research in the field has in the main been restricted to surveys or interviews, often reliant on reductionist national culture models. Within the fields of linguistics and anthropology, the ethnographic research technique of conversation analysis (CA) has been successfully applied to cross-cultural communications. However, there have been no concerted research efforts to apply CA to IS research in general and to IS offshoring in particular. Our research aims to address that gap by analysing naturally occurring recordings of telephone conferences between offshore vendor staff in India and UK/US employees of a major pharmaceutical company. The research has identified and analysed two important phenomena observed within these communications. Firstly, evidence of asymmetries of participation across cultural divides has been documented, and analysed for underlying causes, such as different attitudes to hierarchy and a lack of shared understanding of expected responses. Secondly, differences in the rhetorical organisation of conversation by participants have also been observed and clearly documented within transcribed specimens of these conversations. These phenomena led to seven findings that are aimed to stimulate further research. Finally, and perhaps most importantly, this paper demonstrates how the methodological approach of CA can be applied to IS offshoring research, producing key insights into culturally loaded conversations with clear applications for practice. We hope that this evidence of the potential of CA in IS research will inspire IS researchers to use the approach in other domains as well as in further work in offshoring situations.://000262106400004-389PG Times Cited:0 Cited References Count:53 0268-3962 J Inf TechnolISI:000262106400004 Avison, D ESSEC Business Sch, Dept Informat Syst, F-95021 Paris, France ESSEC Business Sch, Dept Informat Syst, F-95021 Paris, France ESSEC Business Sch, Dept Informat Syst, F-95021 Paris, France Brunel Univ, Sch Informat Syst & Comp, Uxbridge UB8 3PH, Middx, EnglandDoi 10.1057/Jit.2008.16English <7Craven, R. A. Banks, R. E.2008gUnderstanding and managing renal cell carcinoma: Can proteomic studies contribute to clinical practice?88-1068Proteomics in Nephrology - Towards Clinical Applications160laser-desorption/ionization-time flight-mass-spectrometry 2-dimensional gel-electrophoresis lindau tumor-suppressor kidney cancer shotgun proteomics therapeutic target protein expression urinary proteins interferon-alpha Renal cell carcinoma (RCC) is associated with a poor prognosis and there is a need for biomarkers to assist at all stages of disease management including diagnosis, prognosis, monitoring for relapse and predicting response to therapy. Additionally, identification of new therapeutic targets is a priority. Increased understanding of disease pathogenesis and the molecular changes underlying tumour formation is essential to assist in the rational design of such molecules. As the technologies underlying proteomics-based research have developed, they have been applied extensively to the analysis of cancers including RCC, with tissues, cell lines and biological fluids being used for analysis. A number of approaches have been adopted including two-dimensional polyacrylamide gel electrophoresis and mass spectrometry profiling of intact proteins, shotgun mass spectrometry-based profiling at the peptide level, antibody arrays and strategies analysing the immune response to tumours with a view to identifying tumour-associated antigens. Although these studies are still at a relatively early stage, promising results have been reported with some being taken forward to preliminary validation. The challenge now is to build on these initial efforts, focusing particularly on interrogating the less readily accessible, lower abundance proteome and implementing large-scale validation studies to develop potential markers, antigens and targets and facilitate translation of suitable findings into the clinic. Copyright (c) 2008 S. Karger AG, Basel.://000257140500008IBhx13 Times Cited:2 Cited References Count:75 Contributions to Nephrology 0302-5144Contrib NephrolISI:000257140500008 Banks, RE St James Univ Hosp, Canc Res UK Clin Ctr, Beckett St, Leeds LS9 7TF, W Yorkshire, England St James Univ Hosp, Canc Res UK Clin Ctr, Beckett St, Leeds LS9 7TF, W Yorkshire, England St James Univ Hosp, Canc Res UK Clin Ctr, Leeds LS9 7TF, W Yorkshire, EnglandEnglish<7Banks, G. T. Fisher, E. M. C.2008BCytoplasmic dynein could be key to understanding neurodegeneration-Genome Biology93amyotrophic-lateral-sclerosis motor-neuron degeneration axonal-transport superoxide-dismutase sod1 mutants complex mice mutation protein defectsA new mouse mutation, Sprawling, highlights an essential role for the dynein heavy chain in sensory neuron function, but it lacks the ability of other known heavy-chain mutations to ameliorate neurodegeneration due to defective superoxide dismutase.://000254659500005-283TN Times Cited:5 Cited References Count:21 1474-760X Genome BiolISI:000254659500005Banks, GT Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London WC1N 3BG, England Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London WC1N 3BG, England Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3BG, England$Artn 214 Doi 10.1186/Gb-2008-9-3-214Englishw<7 Banks, G.20086Understanding 'resource' conflicts in Papua New Guinea23-34Asia Pacific Viewpoint491Bconflict mining natural resources resolution ok tedi mine politicsAprPapua New Guinea, with its heavy dependence on natural resources, limited economic development in the past two decades, poor record of governance and high-profile separatist conflicts such as the Bougainville civil war, appears to be an exemplar of the 'Resource Curse' theory - the notion that natural resources actively undermine economic development. Using a number of examples from a range of scales, this paper argues that what appear to be 'resource' conflicts in Papua New Guinea are actually better conceived as conflicts around identity and social relationships. The very different conceptualisation of natural resources in most Melanesian societies - as elements of the social world as much as any external environmental sphere - means that resources become a conduit for local social and political agendas and tensions to be expressed. The nature of traditional conflict in Melanesian societies is discussed as a guide to the better management and resolution of what appear to be 'resource' conflicts in Papua New Guinea.://000254095300003-275TU Times Cited:3 Cited References Count:41 1360-7456Asia Pac ViewpISI:000254095300003Banks, G Massey Univ, Sch People Environm & Planning, Palmerston North, New Zealand Massey Univ, Sch People Environm & Planning, Palmerston North, New Zealand Massey Univ, Sch People Environm & Planning, Palmerston North, New Zealand$DOI 10.1111/j.1467-8373.2008.00358.xEnglish<7Banks, J. Oldfield, Z.2007SUnderstanding pensions: Cognitive function, numerical ability and retirement saving143-170Fiscal Studies282decision-makingJunIn a world of declining state pension provision, it is becoming increasingly important that individuals are able to understand the financial choices they face and can choose savings products, portfolios and contribution rates accordingly. In this paper, we look at numerical ability and other dimensions of cognitive function in a sample of older adults in England and examine the extent to which these abilities are correlated with various measures of wealth and retirement saving outcomes. As well as finding that relatively large fractions of the older population can be seen to have low levels of numeracy, we show that numeracy levels are strongly correlated with measures of retirement saving and investment portfolios, even when controlling for other dimensions of cognitive ability as well as educational attainment. Numeracy is also related to knowledge and understanding of pension arrangements, and with perceived financial security. In the short run, there may be a role for targeting simple retirement planning information at low-numeracy, low-education groups; a longer-run goal for retirement saving policy might be to improve numeracy levels more generally.://000246920700001-174DF Times Cited:4 Cited References Count:23 0143-5671 Fisc StudISI:000246920700001Banks, J UCL, Inst Fiscal Studies, London WC1E 6BT, England UCL, Inst Fiscal Studies, London WC1E 6BT, England UCL, Inst Fiscal Studies, London WC1E 6BT, EnglandEnglish<7 2Banks, C. E. Ji, X. B. Crossley, A. Compton, R. G.2006Understanding the electrochemical reactivity of bamboo multiwalled carbon nanotubes: the presence of oxygenated species at tube ends may not increase electron transfer kinetics 2137-2140Electroanalysis1821electrochemical reactivity multiwalled carbon nanotubes oxygenated species electron transfer kinetics plane pyrolytic-graphite nadh detection biosensorsOct-The result of acid washing multiwalled carbon bamboo nanotubes is explored with voltammetry and X-ray Photoelectron Spectroscopy; it is found that the presence of oxygenated species formed as a result at the ends of the nanotubes does not measurably change, the heterogeneous charge transfer kinetics.://000242025200014.105JC Times Cited:22 Cited References Count:21 1040-0397 ElectroanalISI:000242025200014 Compton, RG Univ Oxford, Phys & Theoret Chem Lab, S Parks Rd, Oxford OX1 3QZ, England Univ Oxford, Phys & Theoret Chem Lab, S Parks Rd, Oxford OX1 3QZ, England Univ Oxford, Phys & Theoret Chem Lab, Oxford OX1 3QZ, England Univ Oxford, Dept Mat, Oxford OX1 3PH, EnglandDOI 10.1002/elan.200603633English <7!8Deterding, L. J. Banks, G. C. Tomer, K. B. Archer, T. K.2004RUnderstanding global changes in histone H1 phosphorylation using mass spectrometry53-58Methods331histone h1 h1 isoforrns post-translational modifications transcription phosphorylation electrospray ionization mass spectrometry dexamethasone chromatin mmtv gene-expression in-vivo transcription proteomicsMay0Histone post-translational modifications have been implicated in a variety of biological processes such as gene expression, DNA replication, and chromatin assembly. The modifications include methylation, acetylation, phosphorylation, ubiquitination, glycosylation, and ADP-ribosylation. For several years, we have been investigating the role of historic HI phosphorylation in transcription using the hormone inducible mouse mammary tumor virus (MMTV) promoter. When mouse cells were exposed to prolonged treatment with dexamethasone, a significant decrease in the level of histone H1 phosphorylation was observed. Traditionally, Western analyses with anti-histone H1 and phospho-specific H1 antibodies were performed to observe changes in phosphorylation levels of the bulk H1 histories. More recently, we have applied electrospray ionization mass spectrometry to the analysis of histone H1 isoforms. Utilizing this approach, we have investigated the phosphorylation state of the specific H1 isoforms before and after prolonged treatment with dexamethasone. Specifically, we could determine that the relative phosphorylation levels of the histone H1.3, H1.4 and H1.5 isoforms decrease after prolonged hormone exposure. Recent advancements in mass spectrometry have proven invaluable toward the analysis of post-translational modifications on proteins. The continued developments in the area of mass spectrometry should provide new insights into not only the function of proteins but also into the basic regulatory mechanisms that control cellular functions. Published by Elsevier Inc.://000220556700008-808GD Times Cited:6 Cited References Count:22 1046-2023MethodsISI:000220556700008!Archer, TK NIEHS, Mol Carcinogenesis Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA NIEHS, Mol Carcinogenesis Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA NIEHS, Mol Carcinogenesis Lab, NIH, Res Triangle Pk, NC 27709 USA NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USADOI 10.1016/j.ymeth.2003.10.020English`<7"Tichon, J. Banks, J.2003VThe application of virtual reality to the understanding and treatment of Schizophrenia 1064-1068RKnowledge-Based Intelligent Information and Engineering Systems, Pt 1, Proceedings2773cognitive-behavioral therapyVirtual Reality (VR) techniques are increasingly being used in education about and in the treatment of certain types of mental illness. Research indicates VR is delivering on it's promised potential to provide enhanced training and treatment outcomes through incorporation of this high-end technology. Schizophrenia is a mental disorder affecting 1-2% of the population. A significant research project being undertaken at the University of Queensland has constructed virtual environments that reproduce the phenomena experienced by patients who have psychosis. The VR environment will allow behavioral exposure therapies to be conducted with exactly controlled exposure stimuli and an expected reduction in risk of harm. This paper reports on the work of the project, previous stages of software development and current and future educational and clinical applications of the Virtual Environments.://000186518000142VBx81t Times Cited:2 Cited References Count:10 Lecture Notes in Artificial Intelligence 0302-9743Lect Notes Artif IntISI:000186518000142Tichon, J Univ Queensland, Ctr Online Hlth, St Lucia, Qld 4067, Australia Univ Queensland, Ctr Online Hlth, St Lucia, Qld 4067, Australia Univ Queensland, Ctr Online Hlth, St Lucia, Qld 4067, Australia Univ Queensland, Adv Computat Modelling Ctr, St Lucia, Qld 4067, AustraliaEnglish<7#$Renting, H. Marsden, T. K. Banks, J.2003lUnderstanding alternative food networks: exploring the role of short food supply chains in rural development393-411Environment and Planning A353&quality globalization products marketsMarIn this paper we explore the development and incidence of alternative food networks within a European-wide context. By developing a consistent definition of short food supply chains, we address both the morphology and the dynamics of these, and then examine empirical evidence concerning their incidence and rural development impact across seven EU member states. These developments need to be seen as one significant contribution to the current transitions in rural Europe concerning the crisis of conventional intensive and productivist agriculture and the public consumer pressure for a larger variety of distinctive 'quality' food products.://000182249000003.667TM Times Cited:88 Cited References Count:52 0308-518XEnviron Plann AISI:000182249000003Renting, H Univ Wageningen & Res Ctr, Rural Social Grp, Dept Social Sci, 1 Hollandseweg, NL-6706 KN Wageningen, Netherlands Univ Wageningen & Res Ctr, Rural Social Grp, Dept Social Sci, 1 Hollandseweg, NL-6706 KN Wageningen, Netherlands Univ Wageningen & Res Ctr, Rural Social Grp, Dept Social Sci, NL-6706 KN Wageningen, Netherlands Univ Wales Coll Cardiff, Dept City & Reg Planning, Cardiff CF10 3WA, S Glam, WalesDoi 10.1068/A3510English<7$#Banks, J. Blundell, R. Smith, J. P.2003cUnderstanding differences in household financial wealth between the United States and Great Britain241-279Journal of Human Resources382consumption growthSproIn this paper, we describe the household wealth distribution in the United States and United Kingdom over the past two decades, and compare both wealth inequality and the form in which wealth is held. Unconditionally, there are large differences in financial wealth between the two countries at the top fifth of the wealth distribution. Even after controlling for age and income differences between the two countries, we show that the median U.S. household accumulates more financial wealth than their United Kingdom counterpart does. We explore a number of alternative reasons for these differences and reject some explanations as implausible. Some of the observed differences are due to what we refer to as "initial conditions," in particular previously high rates of corporate equity ownership in the U.S. and housing ownership among young British households. This only provides a partial explanation, however. Among other explanations are differences in the annuitization of retirement incomes and in the amount of wealth held in the form of housing equity. In the first case, forced and voluntary annuitization in the United Kingdom mean older households face considerably less longevity risk. In the second, higher house price volatility in the United Kingdom can create an incentive, as shown Banks, Blundell, and Smith (2002), used from stock market equity earlier in the life cycle.://000182088600002-664WZ Times Cited:9 Cited References Count:27 0022-166X J Hum ResourISI:000182088600002Banks, J Inst Fiscal Studies, London, England Inst Fiscal Studies, London, England Inst Fiscal Studies, London, England UCL, London WC1E 6BT, England RAND Corp, Santa Monica, CA 90406 USAEnglisho<7%Banks, W. A. Morley, J. E.2003^Memories are made of this: Recent advances in understanding cognitive impairments and dementia314-321IJournals of Gerontology Series a-Biological Sciences and Medical Sciences584amyloid-beta-protein nursing-home residents older mexican-americans blood-brain-barrier senescence-accelerated mouse randomized controlled trial limbic system structures age-related-changes long-term-care alzheimers-diseaseApr://000182011800004/663NN Times Cited:29 Cited References Count:166 1079-5006J Gerontol a-BiolISI:000182011800004Banks, WA St Louis VA Med Ctr, Geriatr Res Educ & Clin Ctr, St Louis, MO USA St Louis VA Med Ctr, Geriatr Res Educ & Clin Ctr, St Louis, MO USA St Louis VA Med Ctr, Geriatr Res Educ & Clin Ctr, St Louis, MO USA St Louis Univ, Div Geriatr Med, St Louis, MO USAEnglish<7&!Marsden, T. Banks, J. Bristow, G.2002UThe social management of rural nature: understanding agrarian-based rural development809-825Environment and Planning A345agriculture policyMayThere is a growing realisation that agriculture is a central mechanism for delivering sustainable rural development in Europe. However, agro-industrial and postproductivist logics and dynamics have largely tended to marginalise its significance. In this paper we explore some of the conceptual parameters needed to develop the rural development dynamic. This is one which recentralises agriculture and farm-based activities and provides a basis for countering the growing crisis in rural and agricultural policymaking. In order to further embed the rural development dynamic, however, new alliances need to be attached to the struggles that are currently underway in rural areas. This will involve the state and social scientists playing a greater constructive role in developing the social infrastructure around which current exemplars of agrarian-based rural development can become more mainstream.://000175681700004.553NE Times Cited:37 Cited References Count:25 0308-518XEnviron Plann AISI:000175681700004Marsden, T Univ Wales Coll Cardiff, Dept City & Regional Planning, Cardiff CF10 3WA, S Glam, Wales Univ Wales Coll Cardiff, Dept City & Regional Planning, Cardiff CF10 3WA, S Glam, Wales Univ Wales Coll Cardiff, Dept City & Regional Planning, Cardiff CF10 3WA, S Glam, WalesDoi 10.1068/A3427English <7'#Balasis, G. Banks, R. J. Whaler, K.19974Understanding telluric distortion matrices - Comment472-473!Geophysical Journal International1292May://A1997XA22900021,Xa229 Times Cited:1 Cited References Count:4 0956-540X Geophys J IntISI:A1997XA22900021Balasis, G Univ Edinburgh,Grant Inst Geol,Dept Geol & Geophys,W Mains Rd,Edinburgh Eh9 3jw,Midlothian,Scotland Univ Edinburgh,Grant Inst Geol,Dept Geol & Geophys,W Mains Rd,Edinburgh Eh9 3jw,Midlothian,ScotlandEnglish<7( Banks, M. E.1996VAfrican American single mothers: Understanding their lives and families - Dickerson,BJ609-612Psychology of Women Quarterly204Dec://A1996VW86800010,Vw868 Times Cited:0 Cited References Count:1 0361-6843Psychol Women QuartISI:A1996VW86800010uBanks, ME Abackans Diversified Comp Proc Inc,Uniontown,Oh 44685 Abackans Diversified Comp Proc Inc,Uniontown,Oh 44685English<7) Banks, M. E.1996NUnderstanding Latino families: Scholarship, policy, and practice - Zambrana,RE609-612Psychology of Women Quarterly204Dec://A1996VW86800012,Vw868 Times Cited:0 Cited References Count:1 0361-6843Psychol Women QuartISI:A1996VW86800012uBanks, ME Abackans Diversified Comp Proc Inc,Uniontown,Oh 44685 Abackans Diversified Comp Proc Inc,Uniontown,Oh 44685English<7* Banks, S. P.1994EUnderstanding Everyday Racism - an Interdisciplinary Theory - Essed,P141-1480International Journal of Intercultural Relations181Win://A1994MY69800008,My698 Times Cited:0 Cited References Count:1 0147-1767Int J Intercult RelISI:A1994MY69800008?Banks, Sp Univ Idaho,Moscow,Id 83843 Univ Idaho,Moscow,Id 83843English<7+#Teba, L. Banks, D. E. Balaan, M. R.1992NUnderstanding Circulatory Shock - Is It Hypovolemic, Cardiogenic, or Vasogenic121-129Postgraduate Medicine917;septic shock bicarbonate therapy resuscitation hemodynamicsMay 15Circulatory shock comprises a group of complex circulatory syndromes that result from a variety of conditions. It alters the function of most organ systems and has very high mortality. Identification of the type of shock (hypovolemic, cardiogenic, vasogenic, or a combination) and optimal treatment are aided by hemodynamic monitoring, including determination of preload, cardiac output, and systemic vascular resistance. Experimental studies and isolation of bioactive substances have improved understanding of the mechanisms involved in shock. Restoration of intravascular volume, cardiac contractility, and vascular tone and control of the underlying septic process when applicable are the basis of current therapy. Close monitoring and support of the affected organ systems in an intensive care environment facilitate recovery. Encouraging results with new treatments indicate improved chances for a satisfactory outcome in patients with circulatory shock.://A1992HY27000015-Hy270 Times Cited:0 Cited References Count:20 0032-5481 Postgrad MedISI:A1992HY27000015Teba, L W Virginia Univ,Med Ctr,Sch Med,Dept Med,Pul & Crit Care Med Sect,Rm G280 Hss,Morgantown,Wv 26506 W Virginia Univ,Med Ctr,Sch Med,Dept Med,Pul & Crit Care Med Sect,Rm G280 Hss,Morgantown,Wv 26506English<7, Banks, M. H.1985DTowards an Understanding of the Social-Context of Youth UnemploymentA54-A54-Bulletin of the British Psychological Society38May://A1985AJD6200032,Ajd62 Times Cited:0 Cited References Count:0 0007-1692B Brit Psychol SocISI:A1985AJD6200032XUniv Sheffield,Mrc,Esrc,Social & Appl Psychol Unit,Sheffield S10 2tn,S Yorkshire,EnglandEnglishb<7-<Jordan, K. Dziedzic, K. Mullis, R. Dawes, P. T. Jones, P. W.2001^The development of three-dimensional range of motion measurement systems for clinical practice 1081-1084 Rheumatology4010uelectromagnetic tracking device lumbar spine 3-dimensional measurement cervical-spine reliability kinematics movementOct://000171764600001-485PY Times Cited:3 Cited References Count:27 1462-0324 RheumatologyISI:000171764600001Jordan, K Univ Keele, Primary Care Sci Res Ctr, Hornbeam Bldg, Keele ST5 5BG, Staffs, England Univ Keele, Primary Care Sci Res Ctr, Hornbeam Bldg, Keele ST5 5BG, Staffs, England Univ Keele, Primary Care Sci Res Ctr, Keele ST5 5BG, Staffs, England Haywood Hosp, Staffordshire Rheumatol Ctr, Stoke On Trent ST6 7AG, Staffs, England Univ Keele, Dept Math, Keele ST5 5BG, Staffs, EnglandEnglish$<7.$Unver, B. Karatosun, V. Bakirhan, S.2009Reliability of Goniometric Measurements of Flexion in Total Knee Arthroplasty Patients: with Special Reference to the Body Position257-262#Journal of Physical Therapy Science213total knee arthroplasty goniometry reliability continuous passive motion intertester reliability universal goniometers follow-up range rehabilitation validity replacement trial hipAug[Purpose] To compare the reliability of goniometric measurements of knee flexion obtained in three different body positions of patients with total knee arthroplasty (TKA). [Subjects] The knees ( 15 1) of 92 TKA patients were the subjects of this study. [Methods] The range of flexion was measured at three instances: preoperatively, postoperative fifth day and at the time of discharge by universal goniometer measurement with the patient positioned in the supine, prone and sitting positions. [Results] There were no significant differences between the range of motion measurements in the three testing positions at the three instances. Also, the results from the three different testing positions were highly correlated (r>0.80). [Conclusion] The results of this study indicate that the position of the patient during the evaluation of range of knee flexion does not affect the results and that the three different body positions can be used interchangeably.://000269631600008-492CJ Times Cited:0 Cited References Count:37 0915-5287J Phys Ther SciISI:000269631600008Unver, B Dokuz Eylul Univ, Sch Physiotherapy, Cam Apt 7-3, TR-35330 Izmir, Turkey Dokuz Eylul Univ, Sch Physiotherapy, Cam Apt 7-3, TR-35330 Izmir, Turkey Dokuz Eylul Univ, Sch Physiotherapy, TR-35330 Izmir, Turkey Dokuz Eylul Univ, Dept Orthopaed & Traumatol, TR-35330 Izmir, TurkeyEnglish <7/UGardner, T. W. Larsen, M. Girach, A. Zhi, X. Prot Kinase C Diabetic Retinopathy 2009XDiabetic macular oedema and visual loss: relationship to location, severity and duration709-713Acta Ophthalmologica877bdiabetic macular oedema diabetic retinopathy ruboxistaurin visual acuity retinopathy ruboxistaurinNovPurpose: To assess the relationship between visual acuity (VA) and diabetic macular oedema (DMO) in relation to the location of retinal thickening and the severity and duration of central macular thickening. Methods: Data from 584 eyes in 340 placebo-treated patients in the 3-years-long Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) trial were used to investigate the relationship between VA and DMO. Eligible eyes had moderately severe to very severe non-proliferative diabetic retinopathy and VA of at least 45 letters on Early Treatment Diabetic Retinopathy Study (ETDRS) charts (Snellen equivalent = 20/125). Diabetic retinopathy and DMO status were assessed using stereo photographs. Results: Nearly one third of study eyes had foveal centre-involving DMO at the start of the trial. Sustained moderate visual loss was found in 36 eyes, most commonly associated with DMO at the centre of the fovea in 73% of eyes. There was a strong relationship (p < 0.001) between foveal centre involvement with DMO and mean VA. Mean VA decreased with increasing retinal thickness at the centre (p < 0.001) and increasing duration of centre-involving DMO (p < 0.001). Conclusion: This study documents the relationship between duration of DMO and progressive vision loss, and the key role of central foveal involvement in patients with diabetic retinopathy. These data will help to develop future strategies to prevent vision loss.://000270999300003,509FF Times Cited:0 Cited References Count:9 1755-375XActa OphthalmolISI:000270999300003Gardner, TW Penn State Coll Med, Dept Ophthalmol, 500 Univ Dr,HU19, Hershey, PA 17033 USA Penn State Coll Med, Dept Ophthalmol, 500 Univ Dr,HU19, Hershey, PA 17033 USA Penn State Coll Med, Dept Ophthalmol, Hershey, PA 17033 USA Penn State Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA Univ Copenhagen, Natl Eye Clin, Kennedy Ctr, DK-1168 Copenhagen, Denmark Glostrup Cty Hosp, Dept Ophthalmol, Glostrup, Denmark Merck & Co Inc, West Point, PA 19486 USA Sanofi Aventis Great Valley, Malvern, PA USA$DOI 10.1111/j.1755-3768.2009.01545.xEnglish <70De Siervi, A. De Luca, P. Moiola, C. Gueron, G. Tongbai, R. Chandramouli, G. V. R. Haggerty, C. Dzekunova, I. Petersen, D. Kawasaki, E. Kil, W. J. Camphausen, K. Longo, D. Gardner, K.2009\Identification of new Rel/NF kappa B regulatory networks by focused genome location analysis 2093-2100 Cell Cycle813atm chip/chip ets nf kappa b t-cells double-strand breaks gene-expression c-rel transcription factors DNA-repair atm activation cells cancer lifeJul 1NF kappa B is an inducible transcription factor that controls kinetically complex patterns of gene expression. Several studies reveal multiple pathways linking NF kappa B to the promotion and progression of various cancers. Despite extensive interest and characterization, many NF kappa B controlled genes still remain to be identified. We used chromatin immunoprecipitation combined with microarray technology (ChIP/chip) to investigate the dynamic interaction of NF kappa B with the promoter regions of 100 genes known to be expressed in mitogen-induced T-cells. Six previously unrecognized NF kappa B controlled genes (ATM, EP300, TGF beta, Selectin, MMP-1 and SFN) were identified. Each gene is induced in mitogen-stimulated T-cells, repressed by pharmacological NF kappa B blockade, reduced in cells deficient in the p50 NF kappa B subunit and dramatically repressed by RNAi specifically designed against cRel. A coregulatory role for Ets transcription factors in the expression of the NF kappa B controlled genes was predicted by comparative promoter analysis and confirmed by ChIP and by functional disruption of Ets. NF kappa B deficiency produces a deficit in ATM function and DNA repair indicating an active role for NF kappa B in maintaining DNA integrity. These results define new potential targets and transcriptional networks governed by NF kappa B and provide novel functional insights for the role of NF kappa B in genomic stability, cell cycle control, cell-matrix and cell-cell interactions during tumor progression.://000267603900027-465RG Times Cited:1 Cited References Count:43 1538-4101 Cell CycleISI:000267603900027;De Siervi, A Univ Buenos Aires, Dept Biol Chem, Sch Sci, CONICET,FCEyN,UBA, Intendente Guiraldes 2160,Ciudad Univ,Pab II,2nd, Buenos Aires, Argentina Univ Buenos Aires, Dept Biol Chem, Sch Sci, CONICET,FCEyN,UBA, Intendente Guiraldes 2160,Ciudad Univ,Pab II,2nd, Buenos Aires, Argentina Univ Buenos Aires, Dept Biol Chem, Sch Sci, CONICET,FCEyN,UBA, Buenos Aires, Argentina NCI, Lab Receptor Biol & Gene Express, Bethesda, MD 20892 USA NCI, Microarray Facil, Bethesda, MD 20892 USA NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA NIA, Immunol Lab, Bethesda, MD 20892 USAEnglishT<71NArnoczky, S. P. Swenson, C. Egerbacher, M. Gardner, K. Caballero, O. Burns, M.2007^The location in cartilage of infectious retrovirus in cats infected with feline leukemia virus 2030-20361Journal of Bone and Joint Surgery-American Volume89A9~human-immunodeficiency-virus tendon allografts transmission bone transplantation sterilization inactivation type-1 donor cellsSep Background: Previous studies have suggested that articular cartilage allografts were not likely to transmit infectious retrovirus since viral DNA could not be isolated from chondrocytes of infected individuals. However, the ability of the extracellular matrix of articular cartilage to harbor and transmit a retrovirus has not been examined. We hypothesized that articular cartilage fragments, but not isolated chondrocytes, from cats systemically infected with feline leukemia virus (FeLV) are capable of transmitting infectious retrovirus. Methods: Fresh cartilage segments and chondrocytes isolated from cats systemically infected with feline leukemia virus were used in this study. Feline embryonic fibroblast cells were cocultured with segments of cartilage, isolated chondrocytes, or fragments of cortical bone from each infected cat. The FeLV p27 antigen was measured in the coculture media by enzyme-linked immunosorbent assay. In addition, FeW proviral nucleic acids were quantified by real-time quantitative polymerase chain reaction with use of DNA extracted from feline embryonic fibroblast cell cocultures as well as isolated chondrocytes. Immunohistochemistry was used to assess for FeLV p27 antigen in both intact cartilage fragments and isolated chondrocytes. Results: Feline embryonic fibroblast cells cocultured with cartilage fragments from each of the five FeLV-infected cats all demonstrated high levels of proviral DNA, indicating transmission of infective virus. In addition, media from all cocultures of feline embryonic fibroblast cells and chondral fragments became positive for p27 antigen, indicating active viral replication. In contrast, cocultures of feline embryonic fibroblast cells and isolated chondrocytes from all FeLV-infected cats were negative for proviral DNA and p27 antigen. Likewise, no proviral nucleic acids could be detected in isolated chondrocytes from any infected cats. Cocultures of feline embryonic fibroblast cells with cortical bone fragments were positive for proviral DNA and p27 antigen. Immunohistochemical staining of cartilage fragments from FeLV-infected cats demonstrated the presence of p27 antigen throughout the extracellular matrix, but the p27 antigen was not detected in isolated chondrocytes. Conclusions: Articular cartilage fragments can readily transmit infectious retrovirus, but isolated chondrocytes were likely not the source of the infectious virus because they did not harbor proviral DNA or p27 antigen. Clinical Relevance: Because donor-cell viability improves the long-term function of chondral allografts (precluding the use of secondary sterilization procedures employed for tendon and bone allografts), these results underscore the importance of rigorous donor screening when the use of articular cartilage allografts is being considered.://000249346800020-208VH Times Cited:0 Cited References Count:27 0021-9355J Bone Joint Surg AmISI:000249346800020Arnoczky, SP Michigan State Univ, Coll Vet Med, Lab Comparat Orthopaed Res, Diagnost Ctr Populat & Anim Hlth, G-387, E Lansing, MI 48824 USA Michigan State Univ, Coll Vet Med, Lab Comparat Orthopaed Res, Diagnost Ctr Populat & Anim Hlth, G-387, E Lansing, MI 48824 USA Michigan State Univ, Coll Vet Med, Lab Comparat Orthopaed Res, Diagnost Ctr Populat & Anim Hlth, E Lansing, MI 48824 USA Michigan State Univ, Coll Vet Med, Dept Pathobiol & Diagnost Invest, Diagnost Ctr Populat & Anim Hlth, E Lansing, MI 48824 USADoi 10.2106/Jbjs.G.00054English i<72DStrickland, M. J. Siffel, C. Gardner, B. R. Berzen, A. K. Correa, A.20074Quantifying geocode location error using GIS methods-Environmental Health6Wbirth-defects positional accuracy air-quality associations prevention addresses programApr 4Background: The Metropolitan Atlanta Congenital Defects Program (MACDP) collects maternal address information at the time of delivery for infants and fetuses with birth defects. These addresses have been geocoded by two independent agencies: (1) the Georgia Division of Public Health Office of Health Information and Policy (OHIP) and (2) a commercial vendor. Geographic information system (GIS) methods were used to quantify uncertainty in the two sets of geocodes using orthoimagery and tax parcel datasets. Methods: We sampled 599 infants and fetuses with birth defects delivered during 1994-2002 with maternal residence in either Fulton or Gwinnett County. Tax parcel datasets were obtained from the tax assessor's offices of Fulton and Gwinnett County. High-resolution orthoimagery for these counties was acquired from the U. S. Geological Survey. For each of the 599 addresses we attempted to locate the tax parcel corresponding to the maternal address. If the tax parcel was identified the distance and the angle between the geocode and the residence were calculated. We used simulated data to characterize the impact of geocode location error. In each county 5,000 geocodes were generated and assigned their corresponding Census 2000 tract. Each geocode was then displaced at a random angle by a random distance drawn from the distribution of observed geocode location errors. The census tract of the displaced geocode was determined. We repeated this process 5,000 times and report the percentage of geocodes that resolved into incorrect census tracts. Results: Median location error was less than 100 meters for both OHIP and commercial vendor geocodes; the distribution of angles appeared uniform. Median location error was approximately 35% larger in Gwinnett (a suburban county) relative to Fulton (a county with urban and suburban areas). Location error occasionally caused the simulated geocodes to be displaced into incorrect census tracts; the median percentage of geocodes resolving into incorrect census tracts ranged between 4.5% and 5.3%, depending upon the county and geocoding agency. Conclusion: Geocode location uncertainty can be estimated using tax parcel databases in a GIS. This approach is a viable alternative to global positioning system field validation of geocodes.://000247333700001-180BB Times Cited:8 Cited References Count:21 1476-069XEnviron Health-UkISI:000247333700001Strickland, MJ Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA Battelle Ctr Publ Hlth Res & Evaluat, Atlanta, GA USA Comp Sci Corp, Atlanta, GA USA Ctr Dis Control & Prevent, Agcy Toxic Subst & Dis Registry, Atlanta, GA USA"Artn 10 Doi 10.1186/1476-069x-6-10English<734Gardner, M. E. Hymowitz, T. Xu, S. J. Hartman, G. L.20015Physical map location of the Rps1-k allele in soybean 1435-1438 Crop Science415tgenetic-linkage primary trisomics phytophthora rot molecular map glycine-max resistance markers integration rps2 rj2Sep-OctSeveral genetic maps of soybean [Glycine max (L.) Merr.] have been developed during the past decade. Different markers have been used to construct these maps including restriction fragment length polymorphism (RFLP), amplified fragment length polymorphism (AFLP), random amplified polymorphic DNA (RAPD), simple sequence repeat (SSR), and classical markers. However, virtually none of the maps and linkage groups developed has been associated with specific soybean chromosomes. For example, there are 13 single dominant resistance genes at 7 different loci that control Phytophthora sojae. These resistance genes (Rps genes) have not been located on any chromosomes, but several have been associated on classical and molecular maps. For example, the Rps1 locus is associated with molecular linkage group N. The objective of this study was to locate the Rps1 locus on a specific soybean chromosome using primary trisomic analysis. Crosses were made between 10 soybean trisomic lines and cv. Resnik (containing Rps1-k). The F2 populations from trisomic parents were inoculated with race 3 of P. sojae to determine the ratio of resistant to susceptible plants. Nine of the F2 populations tested segregated in a normal 3:1 ratio. The F2 population of triplo 3 segregated in a 2:1 ratio, the expected segregation ratio for a single dominant gene if the gene is located on the extra chromosome, suggesting that the Rps1 locus is on chromosome 3. Thus, chromosome 3 corresponds to molecular linkage group N of the integrated genetic linkage map.://000176236800010-563CK Times Cited:5 Cited References Count:31 0011-183XCrop SciISI:000176236800010Hartman, GL Univ Illinois, USDA ARS, 1101 W Peabody, Urbana, IL 61801 USA Univ Illinois, USDA ARS, 1101 W Peabody, Urbana, IL 61801 USA Univ Illinois, USDA ARS, Urbana, IL 61801 USA Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USAEnglish<74,Bell, J. L. Gardner, L. I. Landsittel, D. P.2000ySlip and fall-related injuries in relation to environmental cold and work location in above-ground coal mining operations40-48'American Journal of Industrial Medicine381slips falls environmental cold occupational injuries mine safety and health administration data proportionate mortality ratio hip fracture risk weather farmers iceJulFBackground The association between slip and fall-related injuries and environmental temperature was examined for mostly enclosed (inside vehicles, machinery, or buildings), outdoor (outside, not enclosed), and enclosed/outdoor jobs in the coal mining industry to see if differences existed among the three work locations that had varying exposure to cold temperatures. Methods Temperature data from the National Climatic Data Center and injury data from the Mine Safety and Health Administration were evaluated from 1985-1990 fur seven states. Proportionate methods were used to examine the relationship between slips and falls and temperature. Results Proportionate injury ratios of slips and fall-related injuries increased as temperature declined for all three work locations. Proportion of slips and fall-related injuries that occurred while running/walking increased with declining temperature, with the ground outside as the most common source of these injuries. Conclusions Outside movement becomes a greater hazard at freezing temperatures for workers in all locations, not just outdoor workers. Any intervention methods geared toward reducing injury incidents facilitated by cold weather must also be directed toward workers who spend time in more enclosed locations. Am. J, Ind, Med, 38:40-48, 2000. Published 2000 Wiley-Liss. Inc.(dagger).://000087449200005-321HC Times Cited:4 Cited References Count:37 0271-3586 Am J Ind MedISI:000087449200005|Bell, JL NIOSH, Ctr Dis Control & Prevent, Div Safety Res, Anal & Field Evaluat Branch, 1095 Willowdale Rd,M-S P1133, Morgantown, WV 26505 USA NIOSH, Ctr Dis Control & Prevent, Div Safety Res, Anal & Field Evaluat Branch, 1095 Willowdale Rd,M-S P1133, Morgantown, WV 26505 USA NIOSH, Ctr Dis Control & Prevent, Div Safety Res, Anal & Field Evaluat Branch, Morgantown, WV 26505 USAEnglish<75SWozniak, M. A. Kittner, S. J. Price, T. R. Hebel, J. R. Sloan, M. A. Gardner, J. F.1999QStroke location is not associated with return to work after first ischemic stroke 2568-2573Stroke3012cerebral infarction employment stroke, ischemic stroke outcome follow-up myocardial-infarction young-adults depression recovery prognosisDecBackground and Purpose-In prior studies, age, race, job category, disability, and cortical functions such as praxis, language, and memory have been associated with vocational outcome, but the influence of stroke location on return to work has never been critically examined. Methods-We examined the influence of stroke location on vocational outcome in patients with clinically confirmed acute ischemic stroke from the National Institute of Neurological Disorders and Stroke Stroke Data Bank. Results-Of 143 patients working full time at the time of first ischemic stroke, 23 patients were dead and 120 were alive at 1 year. Employment status was known in 109 (mean age, 55 years; 51 [47%] were white, and 82 [75%] were male), Fifty-eight (53%) had returned to work; most (85%) worked full time. Younger age was positively associated with return to work (P<0.05). In an age-adjusted analysis, stroke severity as measured by the Barthel Index 7 to 10 days after stroke was negatively associated with return to work (P<0.001), Higher household income and absence of cortical neurological dysfunction 7 to 10 days after stroke were positively but less strongly associated with return to work (P<0.08), Stroke location, sex, and depression at time of stroke were not associated with vocational outcome. Conclusions-Our data suggest that stroke location may be less important than other more easily measured factors in predicting vocational outcome.://000083890700010.259JL Times Cited:23 Cited References Count:26 0039-2499StrokeISI:000083890700010=Wozniak, MA Univ Maryland, Ctr Med, Dept Neurol, Sch Med, 22 S Greene St, Baltimore, MD 21201 USA Univ Maryland, Ctr Med, Dept Neurol, Sch Med, 22 S Greene St, Baltimore, MD 21201 USA Univ Maryland, Ctr Med, Dept Neurol, Sch Med, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Epidemiol, Baltimore, MD 21201 USAEnglish <767Hamaide, A. Arnoczky, S. P. Ciarelli, M. J. Gardner, K.1998uEffects of age and location on the biomechanical and biochemical properties of canine tracheal ring cartilage in dogs18-22'American Journal of Veterinary Research591\articular-cartilage mechanical-properties tensile properties human knee proteoglycans growthJanObjective-To evaluate effects of age (immature vs adult) and location along the trachea on the biomechanical properties (via a tensile stress relaxation rest) and biochemical properties (water content and total proteoglycan content) of canine tracheal ring cartilage. Sample population-Entire trachea from 8 immature and 8 adult dogs. Procedure-A section of each tracheal ring from 8 immature dogs (6 months old) and 8 adult dogs (2 to 3 years old) was tested biomechanically (maximal stress, equilibrium stress, equilibrium modulus, and percentage of relaxation) and processed for biochemical analysis (water content and total proteoglycan content). Two rings from each trachea were prepared for histologic analysis (H&E or safranin-O staining). Results-Biomechanical and biochemical parameters were not different between cervical and thoracic rings of either age group. Mean maximal stress, equilibrium stress, and equilibrium modulus were significantly higher for adult, compared with immature, dogs. However, percentage of relaxation for adult dogs was significantly lower. Tracheal rings of adult dogs had a significantly higher proteoglycan content and a significantly lower water content than did those of immature dogs. Water content and biomechanical parameters were significantly correlated, and proteoglycan content and biomechanical properties were significantly but weakly correlated. On histologic sectioning, a qualitative decrease in safranin-O staining in the rings of immature dogs also was observed. Conclusions and Clinical Relevance-Biomechanical and biochemical properties of the canine tracheal ring cartilage are altered with age. However, location of the ring along the trachea did not affect these properties for either age group. Results lend support to the theory that proteoglycan content has some effect on tensile properties of tracheal rings and may explain increased compliance observed in rings from dogs with collapsed trachea.://000071302100004-Yp669 Times Cited:7 Cited References Count:21 0002-9645 Am J Vet ResISI:000071302100004Hamaide, A Michigan State Univ, Coll Vet Med, Lab Comparat Orthopaed Res, E Lansing, MI 48824 USA Michigan State Univ, Coll Vet Med, Lab Comparat Orthopaed Res, E Lansing, MI 48824 USA Michigan State Univ, Coll Vet Med, Lab Comparat Orthopaed Res, E Lansing, MI 48824 USAEnglish <77Savard, P. Rouleau, J. L. Ferguson, J. Poitras, N. Morel, P. Davies, R. F. Stewart, D. J. Talajic, M. Gardner, M. Dupuis, R. Lauzon, C. Sussex, B. Potvin, L. Warnica, W.1997Risk stratification after myocardial infarction using signal-averaged electrocardiographic criteria adjusted for sex, age, and myocardial infarction location202-213 Circulation961tachycardia fibrillation arrhythmia risk factors electrocardiography late ventricular potentials serious arrhythmic events time domain analysis prognostic-significance radionuclide ventriculography sudden-death postinfarction patients programmed stimulation high-resolution cardiac deathJul 1Background The objectives were to investigate the factors influencing signal-averaged ECGs (SAECGs) recorded in patients after myocardial infarction (MI) and to develop criteria for predicting arrhythmic events (AEs) that account for these factors. Methods and Results SAECGs were recorded 5 to 15 days after MI in 2461 patients without bundle-branch block The duration (QRSd). terminal potential (VRMS), and terminal duration (LAS) of the filtered QRS were measured. During follow-up (17+/-8 months), AEs (arrhythmic death; ventricular tachycardia, VT; ventricular fibrillation, VF) occurred in 80 patients (3.3%). Receiver operating characteristic curves showed that QRSd discriminated patients with all types of AEs, but VRMS and LAS discriminated only VT patients; QRSd minus LAS also discriminated AE patients. Sea age, and MI location significantly affected the SAECG, survivors without VT or VF were divided into subgroups (2 sex x 4 age x 2 MI), and QRSd values exceeding the 70th percentile in each subgroup predicted AEs with a sensitivity of 65.4%. An unadjusted QRSd criterion showed the same overall sensitivity and specificity but with less uniform values for each subgroup. A Cox model was constructed by use of multiple prognostic indicators, and in rank order, QRSd, previous MI, and Killip class were predictive of AEs. Conclusions SAECG adjustments for sex, age, and MI location did not improve sensitivity and specificity but produced a more uniform predictive performance. The proposed criteria are based only on QRSd, because late potentials (VRMS and LAS) did not discriminate patients with sudden death. Duration of high-level activity during QRS (QRSd-LAS) can predict AEs, suggesting that the arrhythmogenic substrate involves a large mass of myocardium.://A1997XJ44200034.Xj442 Times Cited:48 Cited References Count:52 0009-7322 CirculationISI:A1997XJ44200034Savard, P Hop Sacre Coeur,Ctr Rech,5400 Gouin Ouest,Montreal,Pq H4j 1c5,Canada Hop Sacre Coeur,Ctr Rech,5400 Gouin Ouest,Montreal,Pq H4j 1c5,Canada Univ Montreal,Ecole Polytech,Inst Genie Biomed,Montreal,Pq,Canada Inst Cardiol,Dept Med,Montreal,Pq,Canada Memphis Tenn Vasc Fdn,Memphis,Tn Ottawa Ontario Heart Inst,Dept Med,Ottawa,on,Canada Royal Victoria Hosp,Dept Med,Montreal,Pq H3a 1a1,Canada Victoria Gen Hosp,Dept Med,Halifax,Ns,Canada Ctr Hosp Reg Amiante,Dept Med,Thetford Mines,Pq,Canada Hlth Sci Ctr,Dept Med,St Johns,Nf,Canada Univ Montreal,Dept Med Sociale & Prevent,Montreal,Pq H3c 3j7,Canada Foothills Prov Gen Hosp,Dept Med,Calgary,Ab T2n 2t9,CanadaEnglish i<788Gardner, R. G. Wells, J. E. Russell, J. B. Wilson, D. B.1995The Cellular Location of Prevotella-Ruminicola Beta-1,4-D-Endoglucanase and Its Occurrence in Other Strains of Ruminal Bacteria 3288-3292&Applied and Environmental Microbiology619Nbacteroides-ruminicola endoglucanase gene proteins cleavage sequence rumen DNASepPrevotella ruminicola B(1)4, TC1-1, TF1-3, and TS1-5 all produced immunologically cross-reacting 88- and 82-kDa carboxymethyl cellulases (CMCases), P. ruminicola 23, 118B, 20-63, and 20-78 had much lower CMCase activities, and Western blots (immunoblots) showed no cross-reaction with the B(1)4 CMCase antiserum, Fibrobacter succinogenes S85 and Selenomonas ruminantium HD4 and D produced CMCases, but these enzymes were smaller and did not cross-react with the B(1)4 CMCase antiserum. The B(1)4 CMCase antiserum inhibited the B(1)4 TC1-1, TF1-3, and TS1-5 CMCase activities and agglutinated these cells, but it had no effect on the other strains or species. On the basis of these results, the B(1)4 CMCase is a strain-specific enzyme that is located on the outside surface of the cells, P. ruminicola B(1)4 cultures, grown on sucrose, did not have significant CMCase activity, but these cells could bind purified 88- and 82-kDa CMCase but not 40.5-kDa CMCase, Because the 40.5-kDa CMCase is a fully active, truncated form of the CMCase, it appears that the N-terminal domain of the 88-kDa B(1)4 CMCase anchors the CMCase to the cells, Cells grown on cellobiose produced at least 10-fold more CMCase than the sucrose-grown cells, and the cellobiose-grown cells could only bind 15% as much CMCase as sucrose-grown cells. Virtually all of the CMCase activity of exponentially growing cultures was cell associated, but CMCase activity was eventually detected in the culture supernatant, On the basis of the observation that the 88-kDa CMCase was gradually converted to the 82-kDa CMCase when cultures reached the stationary phase without a change in specific activity, it appears that the 82-kDa protein is probably a proteolytic degradation product of the 88-kDa CMCase.://A1995RT79800016.Rt798 Times Cited:16 Cited References Count:17 0099-2240Appl Environ MicrobISI:A1995RT79800016Cornell Univ,Microbiol Sect,Ithaca,Ny 14853 Cornell Univ,Biochem Molec & Cellular Biol Sect,Ithaca,Ny 14853 Usda Ars,Ithaca,Ny 14853English<79Gardner, R. B. Govil, N. K.1994,On the Location of the Zeros of a Polynomial286-292Journal of Approximation Theory782AugThe classical Enestom-Kekeya Theorem states that a polynomial p(z) = SIGMA(v = 0)n a(v)z(v) satisfying 0 < a0 less-than-or-equal-to a1 less-than-or-equal-to ... less-than-or-equal-to a(n) has all its zeros in Absolute value of z less-than-or-equal-to 1. We extend this result to a larger class of polynomials by dropping the conditions that the coefficients be real and positive and weakening the hypothesis that coefficients be monotonic increasing. Our result generalizes and sharpens several known results. (C) 1994 Academic Press, Inc.://A1994PA23100009,Pa231 Times Cited:1 Cited References Count:5 0021-9045J Approx TheoryISI:A1994PA23100009Gardner, Rb E Tennessee State Univ,Dept Math,Johnson City,Tn 37614 E Tennessee State Univ,Dept Math,Johnson City,Tn 37614 Auburn Univ,Dept Math,Auburn,Al 36849English<7:Gardner, W. A. Spooner, C. M.1993rDetection and Source Location of Weak Cyclostationary Signals - Simplifications of the Maximum-Likelihood Receiver905-916#Ieee Transactions on Communications416 interceptionJun~The problem of dual-receiver interception of low-SNR signals, which includes detection of the presence of a particular signal type and location of its source, is considered. In particular, source-location based on time-difference-of-arrival (TDOA) measurements is considered, and the low-SNR maximum-likelihood receiver for joint detection and TDOA estimation is taken as a starting point. By explicitly revealing the way in which this receiver exploits the spectral correlation properties of the cyclostationary signal, several partial implementations with optimality properties of their own are proposed. These greatly simplified implementations, which require only a one-dimensional search over the TDOA parameter, are shown by simulation to perform competitively with the relatively complicated maximum-likelihood receiver, which requires a two- or three-dimensional search for PSK signals.://A1993LU57000015.Lu570 Times Cited:16 Cited References Count:13 0090-6778 Ieee T CommunISI:A1993LU57000015Gardner, Wa Univ Calif Davis,Dept Elect Engn & Comp Sci,Davis,Ca 95616 Univ Calif Davis,Dept Elect Engn & Comp Sci,Davis,Ca 95616English<7;Gardner, W. A. Chen, C. K.1992Signal-Selective Time-Difference-of-Arrival Estimation for Passive Location of Man-Made Signal Sources in Highly Corruptive Environments .1. Theory and Method 1168-1184&Ieee Transactions on Signal Processing405spectral correlationMayZFor the problem of estimating time difference of arrival (TDOA) of radio waves impinging on a pair of antennas for the purpose of passively locating the source of a communications or telemetry signal in the presence of interfering signals and noise, a new class of signal-selective algorithms that is highly tolerant to interference and noise is introduced. In part I of this two-part paper, the background theory of cyclostationary signals is presented and applied to the design of various new TDOA methods. In part II, algorithmic implementations are described and their performance capabilities are assessed by analysis and simulation. By virtue of the fact that the multiple-signal resolution problem is essentially eliminated in many applications by the signal selectivity of the algorithms, two performance advantages are gained: 1) the practicality of source location based on time-difference measurements with relatively closely spaced antennas is substantially enhanced, and 2) the problem of sorting through multiple TDOA estimates, resulting from multiple interferers, for the estimate corresponding to a particular signal of interest is eliminated. These new algorithms exhibit their signal selectivity regardless of the extent of temporal, spectral, or spatial overlap among received signals. It is only required that the signal of interest have a known (or measurable) analog carrier frequency or digital keying rate that is distinct from those of all interfering signals. Yet the computational complexity of these algorithms is comparable to that of conventional generalized cross-correlation algorithms.://A1992HR45700014.Hr457 Times Cited:40 Cited References Count:22 1053-587XIeee T Signal ProcesISI:A1992HR45700014Gardner, Wa Univ Calif Davis,Dept Elect Engn & Comp Sci,Davis,Ca 95616 Univ Calif Davis,Dept Elect Engn & Comp Sci,Davis,Ca 95616 Silicon Engines,Palo Alto,Ca 94303Englishc<7<Chen, C. K. Gardner, W. A.1992Signal-Selective Time-Difference-of-Arrival Estimation for Passive Location of Man-Made Signal Sources in Highly Corruptive Environments .2. Algorithms and Performance 1185-1197&Ieee Transactions on Signal Processing405May$For the problem of estimating time difference of arrival (TDOA) of radio waves impinging on a pair of antennas for the purpose of passively locating the source of a communications or telemetry signal in the presence of interfering signals and noise, a new class of signal-selective algorithms that are highly tolerant to interference and noise is introduced. In part I of this two-part paper, the background theory of cyclostationary signals is presented and applied to the design of various new TDOA methods. In this part II, algorithmic implementations are described and their performance capabilities are assessed by analysis and simulation. By virtue of the fact that the multiple-signal resolution problem is essentially eliminated by the signal selectivity of the algorithms, two performance advantages are gained: 1) the practicality of source location with relatively closely spaced antennas is substantially enhanced, and 2) the problem of sorting through multiple TDOA estimates, resulting from multiple interferers, for the estimate corresponding to a particular signal of interest is eliminated. These new algorithms exhibit their signal selectivity regardless of the extent of temporal, spectral, or spatial overlap among received signals. It is only required that the signal of interest have a known (or measurable) analog carrier frequency or digital keying rate that is distinct from those of all interfering signals. Yet the computational complexity of these algorithms is no more than that of conventional generalized cross-correlation algorithms.://A1992HR45700015-Hr457 Times Cited:28 Cited References Count:5 1053-587XIeee T Signal ProcesISI:A1992HR45700015Chen, Ck Silicon Engines,Palo Alto,Ca 94303 Silicon Engines,Palo Alto,Ca 94303 Univ Calif Davis,Dept Elect Engn & Comp Sci,Davis,Ca 95616Englishf<7=Gardner, W. W.1988>Tilting Pad Thrust Bearing Tests - Influence of Pivot Location609-613-Journal of Tribology-Transactions of the Asme1104Oct://A1988AE47900006,Ae479 Times Cited:8 Cited References Count:7 0742-4787J Tribol-T AsmeISI:A1988AE47900006(Waukesha Bearings Corp,Waukesha,Wi 53187EnglishX<7>+Gardner, R. Mcanulty, J. Feher, E. Lane, D.1985=Location of Rep and Inc Sequences in the F-Secondary Replicon145-148Plasmid132://A1985AFX9400008.Afx94 Times Cited:11 Cited References Count:12 0147-619XPlasmidISI:A1985AFX94000081Univ Auckland,Dept Cell Biol,Auckland,New ZealandEnglish <7?GRachkidi, R. Ghanem, I. Kalouche, I. El Hage, S. Dagher, F. Kharrat, K.2009^Is visual estimation of passive range of motion in the pediatric lower limb valid and reliable-Bmc Musculoskeletal Disorders10spastic cerebral-palsy concordance correlation-coefficient goniometric measurements reliability children joint ankle elbow reproducibilityOct 12kBackground: Visual estimation (VE) is an essential tool for evaluation of range of motion. Few papers discussed its validity in children orthopedics' practice. The purpose of our study was to assess validity and reliability of VE for passive range of motions (PROMs) of children's lower limbs. Methods: Fifty typically developing children (100 lower limbs) were examined. Visual estimations for PROMs of hip (flexion, adduction, abduction, internal and external rotations), knee (flexion and popliteal angle) and ankle (dorsiflexion and plantarflexion) were made by a pediatric orthopaedic surgeon (POS) and a 5(th) year resident in orthopaedics. A last year medical student did goniometric measurements. Three weeks later, same measurements were performed to assess reliability of visual estimation for each examiner. Results: Visual estimations of the POS were highly reliable for hip flexion, hip rotations and popliteal angle (rho(c) >= 0.8). Reliability was good for hip abduction, knee flexion, ankle dorsiflexion and plantarflexion (rho(c) >= 0.7) but poor for hip adduction (rho(c) = 0.5). Reproducibility for all PROMs was verified. Resident's VE showed high reliability (rho(c) >= 0.8) for hip flexion and popliteal angle. Good correlation was found for hip rotations and knee flexion (rho(c) >= 0.7). Poor results were obtained for ankle PROMs (rho(c) < 0.6) as well as hip adduction and abduction, the results of which not being reproducible. Influence of experience was clearly demonstrated for PROMs of hip rotations, adduction and abduction as well as ankle plantarflexion. Conclusion: Accuracy of VE of passive hip flexion and knee PROMs is high regardless of the examiner's experience. Same accuracy can be found for hip rotations and abduction whenever VE is performed by an experienced examiner. Goniometric evaluation is recommended for passive hip adduction and for ankle PROMs.://000271312200001-513HB Times Cited:0 Cited References Count:32 1471-2474Bmc Musculoskel DisISI:000271312200001Rachkidi, R St Joseph Univ, Dept Orthopaed Surg, Hotel Dieu, France Hosp, Beirut, Lebanon St Joseph Univ, Dept Orthopaed Surg, Hotel Dieu, France Hosp, Beirut, Lebanon St Joseph Univ, Dept Orthopaed Surg, Hotel Dieu, France Hosp, Beirut, Lebanon%Artn 126 Doi 10.1186/1471-2474-10-126English-<7@3Bennett, D. Hanratty, B. Thompson, N. Beverland, D.20096Measurement of knee joint motion using digital imaging 1627-1631International Orthopaedics336Xgoniometric measurements photography reliability surgery arthroplasty camera range elbowDecThe measurement of joint motion is common practice in many aspects of orthopaedic surgery. A number of techniques and instruments have been developed for this purpose. We describe a method of recording and measuring knee joint motion using digital imaging which demonstrated high inter-observer reliability (r > 0.948) and intra-observer repeatability (r > 0.906). This technique may offer some practical advantages over other methods of measuring joint motion.://000272174300026-524WE Times Cited:0 Cited References Count:22 0341-2695 Int OrthopISI:000272174300026Bennett, D Musgrave Pk Hosp, Orthopaed Outcomes Assessment Unit, Stockmans Lane, Belfast BT9 7JB, Antrim, North Ireland Musgrave Pk Hosp, Orthopaed Outcomes Assessment Unit, Stockmans Lane, Belfast BT9 7JB, Antrim, North Ireland Musgrave Pk Hosp, Orthopaed Outcomes Assessment Unit, Belfast BT9 7JB, Antrim, North Ireland Altnagelvin Hosp, Dept Trauma & Orthopaed, Altnagelvin BT47 6SB, Londonderry, North IrelandDOI 10.1007/s00264-008-0694-9English<7AWTrassinelli, M. Banas, D. Beyer, H. F. Jagodzinski, P. Kumar, A. Pajek, M. Stohlker, T.2007QHigh-accuracy crystal spectroscopy of the n=2 energy level of helium-like uranium441-451Canadian Journal of Physics855Uargon recoil ions x-ray optics lamb shift bragg spectrometer charged ions beams u-90+MayWe present a new experiment for the accurate study of the intrashell transition 1s2p (3)p(2)-> 1s2S S-3(1) in helium-like uranium near 4.5 keV using a Johann-type Bragg spectrometer with a spherically bent crystal. The focusing property of the bent crystal enhances the spectrometer's efficiency compared to flat crystal spectrometers and it will enable us, for the first time, to evaluate, accurately, the Lamb shift for n = 2 states in highly charged helium-like ions. The data will be acquired at the storage ring ESR of GSI using a fast H-like uranium beam colliding with a gas target. This measurement will provide the most sensitive test for the relativistic electron-electron interaction in a strong Coulomb field.://000248576200006-197SG Times Cited:2 Cited References Count:34 0008-4204 Can J PhysISI:000248576200006Trassinelli, M Gesell Schwerionenforsch mbH, Darmstadt, Germany Gesell Schwerionenforsch mbH, Darmstadt, Germany Gesell Schwerionenforsch mbH, Darmstadt, Germany Swietokrzyska Acad, Kielce, PolandDoi 10.1139/P07-028English <7BZJagodzinski, M. Kleemann, V. Angele, P. Schonhaar, V. Iselborn, K. W. Mall, G. Nerlich, M.2000]Experimental and clinical assessment of the accuracy of knee extension measurement techniques329-336,Knee Surgery Sports Traumatology Arthroscopy86knee extension rom goniometer anterior cruciate ligament in-situ forces strain behavior motion reconstruction flexion complications reliability range vivoNovThe purpose of this study was to analyze the accuracy of commonly used techniques for the measurement of knee extension and to compare them with a new measurement device. The bars of an external fixator were used to determine reference knee extension angles of 15 human cadavers. These angles were compared with measurements of knee extension on radiographs limited to the :knee joint. Extension was determined in various knee positions using a generic goniometer and it novel long arm goniometer. In a clinical study, two independent examiners categorized knee extension performance according to the IKDC. Sixteen knees with deficits in the range of motion were rated using a generic goniometer, a long arm goniometer and the novel extension measurement device. The radiological measurement of knee extension angles that were restricted to the shaft of femur and tibia had a systematic error of -5.2+/-1.9 degrees compared with the lines created by the centers of rotation. In the experimental setup, the mean absolute deviations were 3.92+/-1.41 degrees with a generic goniometer and 1.22+/-0.20 degrees with the extension measurement device. The variance of the measurements was significantly lower (2.64+/-0.28) than with the generic goniometer (23.72+/- 4.39; P<0.05). Correspondence in the IKDC rating was 63% using a standard goniometer, 50% with the long arm goniometer, and 96% using the novel device. Radiological measurements of knee extension limited to the area of the knee joint deviates systematically from measurements of the total axis of the bones. A precision goniometer that utilizes bony landmarks of the tibia and femur is superior in accuracy compared with standard and long arm goniometer techniques.://000165772100003-381PN Times Cited:6 Cited References Count:37 0942-2056Knee Surg Sport Tr AISI:000165772100003Jagodzinski, M Univ Regensburg, Med Ctr, Dept Trauma Surg, Franz Josef Str Allee 11, D-93042 Regensburg, Germany Univ Regensburg, Med Ctr, Dept Trauma Surg, Franz Josef Str Allee 11, D-93042 Regensburg, Germany Univ Regensburg, Med Ctr, Dept Trauma Surg, D-93042 Regensburg, Germany Tech Coll Mannheim, Dept Electro Engn, D-68161 Mannheim, Germany Univ Munich, Dept Forens Med, D-81280 Munich, GermanyEnglish<7CPEdwards, J. Z. Greene, K. A. Davis, R. S. Kovacik, M. W. Noe, D. A. Askew, M. J.2004/Measuring flexion in knee arthroplasty patients369-372Journal of Arthroplasty193oknee arthroplasty knee flexion goniometer goniometric measurements functional outcomes reliability motion rangeAprHFlexion following total knee arthroplasty can be visually estimated, measured with a goniometer placed against the patient's leg, or measured from a lateral radiograph of the flexed knee. Three examiners, in a blinded fashion, estimated the degree of maximal knee flexion and measured the flexion with a goniometer for 27 knees in 16 patients. A lateral knee radiograph then was taken and the flexion angle was measured from the radiograph by 2 different methods. Although interobserver and intraobserver correlation coefficients were high (0.79 and 0.92), 45% of the visual estimates and 22% of the goniometer measurements differed by 5degrees or greater from the radiographic measurements. These differences increased as the flexion angle increased. Body mass index did not affect the accuracy of the estimates or goniometer measurements.://000220917700018.813OZ Times Cited:13 Cited References Count:13 0883-5403J ArthroplastyISI:000220917700018Edwards, JZ Summa HLth Syst, Dept Orthopaed Surg, Walter A Hoyt Jr Musculoskeletal Res Lab, 444 N Main St, Akron, OH 44313 USA Summa HLth Syst, Dept Orthopaed Surg, Walter A Hoyt Jr Musculoskeletal Res Lab, 444 N Main St, Akron, OH 44313 USA Summa HLth Syst, Dept Orthopaed Surg, Walter A Hoyt Jr Musculoskeletal Res Lab, Akron, OH 44313 USA Orthopaed Surg Inc, Crystal Clin, Akron, OH USADOI 10.1016/j.arth.2003.12.001English <7DNSenavongse, W. Farahmand, F. Jones, J. Andersen, H. Bull, A. M. J. Amis, A. A.2003uQuantitative measurement of patellofemoral joint stability: force-displacement behavior of the human patella in vitro780-786Journal of Orthopaedic Research215patella dislocation instability laxity patellofemoral joint soft-tissue restraints lateral retinacular release extensor mechanism medial subluxation knee instability pressure surface contact planeSepUPatellofemoral joint instability is a common clinical problem. However, little quantitative data are available describing the stability characteristics of this joint. We measured the stability of the patella against both lateral and medial displacements across a range of knee flexion angles while the quadriceps were loaded physiologically. For eight fresh-frozen knee specimens a materials testing machine was used to displace the patella 10 mm laterally and 10 mm medially while measuring the required force, with 175 N quadriceps tension. The patella was connected via a ball-bearing patellar mounting 10 mm deep to the anterior surface to allow natural tilt and other rotations. Patellar force-displacement behavior was tested at flexion angles of 0degrees, 10degrees, 20degrees, 30degrees, 45degrees, 60degrees, and 90degrees. Significant differences were found between the lateral and medial restraining forces at 10 mm displacement. For lateral displacement, the restraining force was least at 20degrees of knee flexion (74 N at 10 mm displacement), rising to 125 N at 0degrees and 90degrees of knee flexion. The restraining force increased progressively, with knee flexion for medial patellar displacement, from 147 N at 0degrees to 238 N at 90degrees. With quadriceps tension, the patella was more resistant to medial than lateral displacement. Our finding that lateral patellar displacement occurred at the lowest restraining force when the knee was flexed 20degrees agrees with clinical experience of patellar instability. (C) 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.://000185080600004.717HC Times Cited:31 Cited References Count:28 0736-0266J Orthopaed ResISI:000185080600004Amis, AA Univ London Imperial Coll Sci Technol & Med, Biomech Sect, Dept Mech Engn, Exhibit Rd, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Biomech Sect, Dept Mech Engn, Exhibit Rd, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Biomech Sect, Dept Mech Engn, London SW7 2AZ, England Charing Cross Hosp, Imperial Coll, Musculoskeletal Surg Dept, London W6 8RF, England Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2AZ, England!Doi 10.1016/S0736-0266(03)00061-5English<7E+Bull, A. M. J. Berkshire, F. H. Amis, A. A.1998yAccuracy of an electromagnetic measurement device and application to the measurement and description of knee joint motion347-355`Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineering in Medicine212H5electromagnetic measurement device knee joint motion clinical rotations instrumented spatial linkages tracking device kinematics systemThe aims of this study were to analyse the accuracy and sensitivity to metals of an electromagnetic motion measurement device and to use it to provide a description of motion of the human knee joint. A calibrated grid and sine bar were used to measure translational and rotational accuracy, which were found to be +/-0.23 per cent of the step size (translation) and +/-2.0 per cent of the step size (rotation) within an optimal operational zone of minimal positional error for which the receiver to transmitter separation was between 271 and 723 mm. The presence of multiple receivers was found to have a significant effect on the accuracy only when positioned within 30 mm of one another. Mild steel was found to have a significant detrimental effect when within 150 mm of the transmitter or receiver. A stainless steel bone screw had no effect on the accuracy of the device. A mathematical description of knee joint motion is presented which describes the motion in terms of clinical rotations. The device is a useful tool for measuring joint motion in the operating theatre and laboratory, owing to its accuracy and insensitivity to surgical alloys.://000076290400004.126JP Times Cited:29 Cited References Count:23 0954-4119P I Mech Eng HISI:0000762904000042Bull, AMJ Univ London Imperial Coll Sci Technol & Med, Dept Mech Engn, Biomech Sect, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Dept Mech Engn, Biomech Sect, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Dept Mech Engn, Biomech Sect, London SW7 2AZ, EnglandEnglish<7FBull, A. M. J. Amis, A. A.1998.Knee joint motion: description and measurement357-372`Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineering in Medicine212H5knee kinematics measurement anterior cruciate ligament instrumented spatial linkages electromagnetic tracking device sagittal plane biomechanical analysis 3-dimensional kinematics coordinate system length patterns deficient knee cadaver knees5Knee joint motion has been described in various ways in the literature. These are explained and commented on. Two methods for describing knee joint motion with 6 degrees of freedom (DOF)-Euler angle and the helical axis of motion-are discussed. Techniques to measure joint motion which can either approximate the motion to less than 6 DOF or fully measure the spatial motion are identified. These include electrical linkage methods, radiographic and video techniques, fluoroscopic techniques and electromagnetic devices. In those cases where the full spatial motion is measured, the data are available to describe the motion in simpler terms (or with less DOF) than three rotations with three translations. This is necessary for clinical application and to facilitate communication between the clinician and the engineer.://000076290400005/126JP Times Cited:28 Cited References Count:122 0954-4119P I Mech Eng HISI:0000762904000052Bull, AMJ Univ London Imperial Coll Sci Technol & Med, Dept Mech Engn, Biomech Sect, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Dept Mech Engn, Biomech Sect, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Dept Mech Engn, Biomech Sect, London SW7 2AZ, EnglandEnglish<7G/Griffiths, G. I. G. Needs, R. J. Pickard, C. J.2009}Post-cotunnite phase of TeO2 obtained from first-principles density-functional theory methods with random-structure searching-Physical Review B8018density functional theory high-pressure effects solid-state phase transformations space groups tellurium compounds x-ray diffraction pressure gamma-teo2 crystalNovWe have used first-principles density-functional theory methods with a random-structure-searching technique to determine the structure of the previously unidentified post-cotunnite phase of TeO2. Our calculations indicate a transition from the cotunnite to post-cotunnite phase at 130 GPa. The predicted post-cotunnite structure has P2(1)/m space group symmetry and its calculated x-ray diffraction pattern is in reasonable agreement with the available experimental data. We find that the cotunnite phase reenters at about 260 GPa.://000272310900050-526RO Times Cited:1 Cited References Count:21 1098-0121 Phys Rev BISI:000272310900050eGriffiths, GIG Univ Cambridge, Cavendish Lab, Condensed Matter Theory Grp, JJ Thomson Ave, Cambridge CB3 0HE, England Univ Cambridge, Cavendish Lab, Condensed Matter Theory Grp, JJ Thomson Ave, Cambridge CB3 0HE, England Univ Cambridge, Cavendish Lab, Condensed Matter Theory Grp, Cambridge CB3 0HE, England UCL, Dept Phys & Astron, London WC1E 6BT, England*Artn 184115 Doi 10.1103/Physrevb.80.184115English <7HCarter, L. P. Griffiths, R. R.2009ePrinciples of laboratory assessment of drug abuse liability and implications for clinical developmentS14-S25Drug and Alcohol Dependence105Babuse liability clinical trial drug abuse drug development drug discrimination self-administration relative reinforcing efficacy schedule-controlled behavior multiple-choice procedure treated rhesus-monkeys discriminative stimulus gamma-hydroxybutyrate squirrel-monkeys tramadol hydrochloride risk-management united-statesDec 1Abuse liability testing plays an important role in informing drug development, regulatory processes, and clinical practice. This paper describes the current "gold standard" methodologies that are used for laboratory assessments of abuse liability in non-human and human subjects. Particular emphasis is given to procedures such as non-human drug discrimination, self-administration, and physical dependence testing, and human dose-effect abuse liability studies that are commonly used in regulatory submissions to governmental agencies. The potential benefits and risks associated with the inclusion of measures of abuse liability in industry-sponsored clinical trials is discussed. Lastly, it is noted that many factors contribute to patterns of drug abuse and dependence outside of the laboratory setting and positive or negative signals in abuse liability Studies do not always translate to high or low levels of actual abuse or dependence. Well-designed patient and physician education, pharmacovigilance, and postmarketing surveillance can reduce the diversion and misuse of drugs with abuse liability and can effectively foster the protection and promotion of public health. (C) 2009 Elsevier Ireland Ltd. All rights reserved.://0002716824000048Suppl. 1 518HS Times Cited:10 Cited References Count:104 0376-8716Drug Alcohol DepenISI:000271682400004 Griffiths, RR Johns Hopkins Univ, Dept Psychiat & Behav Sci, Johns Hopkins Sch Med, BPRU, 5510 Nathan Shock Dr, Baltimore, MD 21224 USA Johns Hopkins Univ, Dept Psychiat & Behav Sci, Johns Hopkins Sch Med, BPRU, 5510 Nathan Shock Dr, Baltimore, MD 21224 USA Johns Hopkins Univ, Dept Psychiat & Behav Sci, Johns Hopkins Sch Med, BPRU, Baltimore, MD 21224 USA Johns Hopkins Univ, Dept Neurosci, Johns Hopkins Sch Med, BPRU, Baltimore, MD 21224 USA Univ Arkansas Med Sci, Dept Psychiat, Inst Psychiat Res, Addict Res Ctr, Little Rock, AR 72205 USA$DOI 10.1016/j.drugalcdep.2009.04.003English<7IPavlic, M. Griffiths, M. W.2009bPrinciples, Applications, and Limitations of Automated Ribotyping as a Rapid Method in Food Safety 1047-1055Foodborne Pathogens and Disease69field gel-electrophoresis enterica serotype typhimurium campylobacter-jejuni strains listeria-monocytogenes escherichia-coli salmonella-enterica clostridium-perfringens differentiate strains comparative genomics processing-industryNov,Automated ribotyping (AR) is a genotyping method used for identification and characterization of foodborne pathogens to the strain level. The advantages of AR are full automation, rapidity, and high reproducibility and typeability. AR may be a suitable characterization method for some pathogens when the research purpose requires a genotyping method with a strong discriminatory power. AR is a sensitive subtyping method for pathogens such as Listeria monocytogenes and Salmonellae, while its discriminatory power may often not be sufficient for Campylobacter spp. and especially Escherichia coli. This review discusses the principles of manual and AR and provides examples of typical AR use in the subtyping of several major foodborne pathogens and a brief discussion of several other less prominent pathogens.://000271446900002-515DL Times Cited:0 Cited References Count:77 1535-3141Foodborne Pathog DisISI:0002714469000025Pavlic, M Beef Informat Ctr, 2000 Argentia Rd,Plaza 4,Suite 101, Mississauga, ON L5N 1W1, Canada Beef Informat Ctr, 2000 Argentia Rd,Plaza 4,Suite 101, Mississauga, ON L5N 1W1, Canada Univ Guelph, Dept Food Sci, Guelph, ON N1G 2W1, Canada Univ Guelph, Canadian Res Inst Food Safety, Guelph, ON N1G 2W1, CanadaDOI 10.1089/fpd.2009.0264English<7JCBerney, L. Kelly, M. Doyal, L. Feder, G. Griffiths, C. Jones, I. R.2005\Ethical principles and the rationing of health care: a qualitative study in general practice620-625#British Journal of General Practice55517mdecision making ethics focus groups healthcare rationing decision-making practitioners consultation vignettesAugBackground Researching sensitive topics, such as the rationing of treatments and denial of care, raises a number of ethical and methodological problems. Aim To describe the methods and findings from a number of focus group discussions that examined how GPs apply ethical principles when allocating scarce resources. Design of study A small-scale qualitative study involving purposive sampling, semi-structured interviews and focus groups. Setting Twenty-four GPs from two contrasting areas of London: one relatively affluent and one relatively deprived. Method Initial interviews asked GPs to identify key resource allocation issues. The interviews were transcribed and themes were identified. A number of case studies, each illustrative of an ethical issue related to rationing, were written up in the form of vignettes. In focus group discussions, GPs were given a number of these vignettes to debate. Results With respect to the ethical basis for decision making, the findings from this part of the study emphasised the role of social and psychological factors, the influence of the quality of the relationship between GPs and patients and confusion among GPs about their role in decision making. Conclusion The use of vignettes developed from prior interviews with GPs creates a non-threatening environment to discuss sensitive or controversial issues. The acceptance by GPs of general moral principles does not entail clarity of coherence of the application of these principles in practice.://000232519200009-973JR Times Cited:7 Cited References Count:23 0960-1643Brit J Gen PractISI:000232519200009Berney, L St George Hosp, Sch Med, Cranmer Terrace, London SW17 0RE, England St George Hosp, Sch Med, Cranmer Terrace, London SW17 0RE, England St George Hosp, Sch Med, London SW17 0RE, England Univ London, Queen Marys Sch Med & Dent, London WC1E 7HU, EnglandEnglish <7K+Griffiths, R. R. Bigelow, G. E. Ator, N. A.2003LPrinciples of initial experimental drug abuse liability assessment in humansS41-S54Drug and Alcohol Dependence703;drug abuse liability humans drug abusers drug development anxiolytics, hypnotics, drug liking multiple-choice procedure, arci, poms agonist-antagonist opioids multiple-choice procedure research-center inventory intravenous nicotine physical-dependence cigarette-smoking diazepam alprazolam hydromorphone postaddictsJun 5ZThis paper describes the rationale and procedures for conducting what is considered by many to be the current "gold standard" for initial abuse liability testing of a novel compound: the classic acute dose-effect comparison study in volunteers with histories of drug abuse. Such a trial is most appropriate for predicting the likelihood of abuse by drug abusers and, in turn, the extent of drug diversion and illicit street sales if the novel compound became available in the community. The dose-effect abuse liability trial typically involves a double-blind complete crossover design in 10 - 14 subjects with histories of polydrug abuse in a controlled clinical pharmacology laboratory setting. Drug conditions usually involve placebo, three doses of the novel compound and three doses of an appropriate reference compound of known abuse liability. In each session, the time-course of effects of a single drug dose are evaluated. Intervals between experimental sessions are typically I to several days. The importance of testing high supra-therapeutic doses of the novel drug for the validity of the trial is emphasized, and the use of a dose run-up pilot study for selecting maximal doses and matching doses between the novel and comparison compound is explained. The rationale and description of outcome measures is discussed, including measures that reflect likelihood of abuse (e.g. drug vs. money choice and subject ratings of liking, good effects, estimated monetary street value), secondary measures that should be considered in interpreting likelihood of abuse (e.g. drug identification, subject-rated side effects and mood changes), and additional concurrent measures to establish equivalence of the novel and comparison compound (e.g. behavioral performance, observer-rated assessments, physiological measures). (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.://0001836220000047Suppl. S 691TR Times Cited:44 Cited References Count:67 0376-8716Drug Alcohol DepenISI:000183622000004kGriffiths, RR Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 5510 Nathn Shock Dr, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 5510 Nathn Shock Dr, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21218 USA!Doi 10.1016/S0376-8716(03)00098-XEnglish <7LAtor, N. A. Griffiths, R. R.2003CPrinciples of drug abuse liability assessment in laboratory animalsS55-S72Drug and Alcohol Dependence703_abuse liability drug abuse drug development drug discrimination drug reinforcement drug withdrawal fda physical dependence self-administration progressive-ratio schedules discriminative stimulus properties daily dosing regimen rhesus-monkeys physical-dependence self-injection fixed-ratio behavioral pharmacology statistical-inference squirrel-monkeysJun 5This paper describes the rationale for use of preclinical assessments of abuse liability in laboratory animals, and then discusses, cross-cutting' methodological issues that apply to behavioral evaluations intended to contribute to an abuse liability evaluation package. Issues include use of. (1) positive and negative control conditions; (2) full dose-effect evaluations, (3) multiple dependent measures, (4) pharmacokinetic evaluations to guide choice of dose ranges, (5) a species for which good methodological and comparative data are available to aid interpretation of results, and (6) appropriate methods for the group or single-subject experimental design selected. The remainder of the paper describes basic methodology by which three core pieces of behavioral data required by the Food and Drug Administration for its use in the overall abuse liability analysis can be obtained preclinically. Reinforcing effects are assessed in study of drug self-administration; drug discrimination assesses degree of overlap of interoceptive stimulus effects with relevant comparison drugs; physical dependence potential is determined by assessing whether a withdrawal syndrome occurs after chronic drug administration. Background and methodological issues specific to each procedure are discussed. A key consideration for cross-cutting and specific methodological issues is that choices made enable confident interpretation of both positive and negative results. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.://0001836220000058Suppl. S 691TR Times Cited:60 Cited References Count:146 0376-8716Drug Alcohol DepenISI:000183622000005Ator, NA Johns Hopkins Sch Med, Behav Biol Res Ctr, Dept Psychiat & Behav Sci, 5510 Nathan Shock Dr,Ste 3000,Johns Hopkins Bayvi, Baltimore, MD 21224 USA Johns Hopkins Sch Med, Behav Biol Res Ctr, Dept Psychiat & Behav Sci, 5510 Nathan Shock Dr,Ste 3000,Johns Hopkins Bayvi, Baltimore, MD 21224 USA Johns Hopkins Sch Med, Behav Biol Res Ctr, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA Johns Hopkins Sch Med, Johns Hopkins Bayview Campus, Behav Biol Res Ctr, Dept Neurosci, Baltimore, MD 21224 USA!Doi 10.1016/S0376-8716(03)00099-1English<7M0Young-Min, S. A. Cawston, T. E. Griffiths, I. D.2001AMarkers of joint destruction: principles, problems, and potential545-548 Annals of the Rheumatic Diseases606early rheumatoid-arthritis pyridinium cross-links synovial-fluid biochemical markers bone metabolism keratan sulfate cartilage degradation controlled trial serum collagenJun://000168749300002.433FJ Times Cited:12 Cited References Count:28 0003-4967 Ann Rheum DisISI:000168749300002Young-Min, SA Med Sch Newcastle Upon Tyne, Sch Clin Med Sci, Dept Rheumatol, Floor 4 Catherine Cookson Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Med Sch Newcastle Upon Tyne, Sch Clin Med Sci, Dept Rheumatol, Floor 4 Catherine Cookson Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Med Sch Newcastle Upon Tyne, Sch Clin Med Sci, Dept Rheumatol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Freeman Rd Hosp, Musculoskeletal Unit, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, EnglandEnglish<7NGriffiths, P. J.1995In Quest of Certainty - Russell,Bertrand Search for Certainty in Religion and Mathematics up to the Principles of Mathematics - Andersson,S583-584Journal of Religion754Oct://A1995TD67100033,Td671 Times Cited:0 Cited References Count:1 0022-4189J ReligISI:A1995TD67100033IGriffiths, Pj Univ Chicago,Chicago,Il 60637 Univ Chicago,Chicago,Il 60637English<7OGriffiths, R. W.1990UPlastic-Surgery Outpatient Audit - Principles and Practice of Consultant Only Clinics735-741"British Journal of Plastic Surgery436Nov://A1990EK16800019-Ek168 Times Cited:7 Cited References Count:15 0007-1226Brit J Plast SurgISI:A1990EK16800019Griffiths, Rw No Gen Hosp,Herries Rd,Sheffield S5 7au,S Yorkshire,England No Gen Hosp,Herries Rd,Sheffield S5 7au,S Yorkshire,EnglandEnglishe<7P Griffiths, P.19885The Principles of Buddhist Psychology - Kalupahana,Dj628-629Journal of Religion684Oct://A1988Q617900051,Q6179 Times Cited:0 Cited References Count:1 0022-4189J ReligISI:A1988Q617900051TGriffiths, P Univ Notre Dame,Notre Dame,in 46556 Univ Notre Dame,Notre Dame,in 46556English<7Q/Haux, L. Cunin, P. Y. Griffiths, M. Come, G. M.1985DAutomatic Buildup of a Force Radical Reaction-Mechanism - Principles 1027-1031:Journal De Chimie Physique Et De Physico-Chimie Biologique8211-12Nov-Dec://A1985AZD8700002,Azd87 Times Cited:4 Cited References Count:1 0021-7689J Chim Phys PcbISI:A1985AZD8700002?Haux, L Intertech,Plaisir,France Intertech,Plaisir,France Fac Sci Dijon,F-21000 Dijon,France Commiss Communautes Europeennes,Bruxelles,Belgium Cnrs,Lish,F-13003 Marseille,France Ecole Natl Super Ind Chim,Inst Natl Polytech Lorraine,Cnrs,Ua 328,Dept Chim Phys React,F-54042 Nancy,France Univ Nancy 1,F-54000 Nancy,FranceFrench d|?R5Pivonka, Don E. Chalmers, John M. Griffiths, Peter R.2007SApplications of vibrational spectroscopy in pharmaceutical research and development xii, 372 p.!Chichester, England ; Hoboken, NJJ. WileyDrug development. Pharmaceutical chemistry. Infrared spectroscopy. Near infrared spectroscopy. Raman spectroscopy. Chemistry, Pharmaceutical methods. Spectroscopy, Near-Infrared methods. Spectrophotometry, Infrared methods. Spectrum Analysis, Raman methods.uhttp://www.loc.gov/catdir/toc/ecip075/2006038745.html http://www.loc.gov/catdir/enhancements/fy0739/2006038745-d.html|2006038745 GBA6A4088 101293059 013624269 editors, Don E. Pivonka, John M. Chalmers, Peter R. Griffiths. ill. (some col.) ; 25 cm. Includes bibliographical references and index. Introduction to vibrational spectroscopy / Peter R. Griffiths -- Sampling techniques and fiber-optic probes / John M. Chalmers and Peter R. Griffiths -- Vibrational spectroscopy in the discovery phase component of pharmaceutical research / Don E. Pivonka -- Applications of vibrational spectroscopy to combinatorial chemistry / Don E. Pivonka -- Vibrational spectroscopic analysis for the determination of structure : activity relationships (SAR) in molecular binding / Don E. Pivonka and Isao Noda -- Applications of vibrational optical activity in the pharmaceutical industry / Laurence A. Nafie and Rina K. Dukor -- Characterization and optimization of chemical synthesis using real-time vibrational spectroscopy / Fadi Homsi, Paul Barrett, Jian Wang and Roel Ferwerda -- Infrared and Raman spectroscopy for process development / George Zhou, Robert Guenard and Zhihong Ge -- The analysis of pharmaceutical substances and formulated products by vibrational spectroscopy / Don Clark and Alexander Pysik -- Raman analysis of pharmaceuticals / David E. Bugay, Jan-Olav Henck, Michael L. Longmire and Fiona C. Thorley -- Vibrational spectroscopy of solid-state forms : introduction, principles and overview / Terry L. Threlfall and John M. Chalmers -- Vibrational spectroscopy of solid-state forms : applications and examples / David H. Igo and Pingyun Chen -- Pharmaceutical applications of chemical mapping and imaging / Don Clark, Mark Henson, Fred LaPlant, Slobodan Šaši*c and Lin Zhang -- Terahertz spectroscopy for pharmaceutical applications / Mike Claybourn, Husheng Yang, Lubomir Gradinarksy, Jonas Johansson and Staffan Folestad -- History, trends and prognostications / Peter R. Griffiths, John M. Chalmers and Don E. Pivonka..:9780470870877 (hb. alk. paper) 0470870877 (hb. alk. paper)14643155?Jefferson or Adams Building Reading Rooms RS189.5.S65; A67 2007|?S6Everall, Neil J. Chalmers, John M. Griffiths, Peter R.2007>Vibrational spectroscopy of polymers : principles and practice xii, 574 p.!Chichester, England ; Hoboken, NJJohn Wiley & Sons Ltd.>Vibrational spectra. Polymers Spectra. Polymers Deterioration.vhttp://www.loc.gov/catdir/toc/ecip0711/2007006014.html http://www.loc.gov/catdir/enhancements/fy0739/2007006014-d.html2007006014 GBA6A0261 013612863 editors, Neil J. Everall, John M. Chalmers, Peter R. Griffiths. ill. ; 26 cm. Includes bibliographical references and index.<9780470016626 (hbk. alk. paper) 0470016620 (hbk. alk. paper)14729922=Jefferson or Adams Building Reading Rooms QC463.P5; V535 2007w|?T(Griffiths, Anthony J. F. McPherson, Joan1989100+ principles of genetics xii, 387 p.New York W.H. Freeman!Genetics Handbooks, manuals, etc.w88039075 Anthony J.F. Griffiths, Joan McPherson. ill. ; 24 cm. Includes index. One hundred plus principles of genetics. 07167201671022386:Jefferson or Adams Building Reading Rooms QH430; .A15 19898|?UGriffiths, Douglas1995.Principles and problems of electrical machines xiv, 400 p.New YorkPrentice Hall InternationalElectric machinery.994004676 Douglas Griffiths. ill. ; 24 cm. Includes index. 01324979803485482;Jefferson or Adams Building Reading Rooms TK2211; .G75 1995:~?VGriffiths, Hugh19225The general principles of chemical engineering design63 p. The chemical engineering libraryLondon,BennChemical engineering.B23010082 by Hugh Griffiths, with five illustrations. illus. 18 cm.101326575Jefferson or Adams Building Reading Rooms TP155; .G65v$|?WGriffiths, Iwan W.2006Angular Kinematics169-188.,Principles of biomechanics & motion analysis PhiladelphiaLippincott Williams & WilkinseKinesiology Handbooks, manuals, etc. Human mechanics Handbooks, manuals, etc. Biomechanics. Movement.http://www.loc.gov/catdir/enhancements/fy0712/2005051188-d.html http://www.loc.gov/catdir/enhancements/fy0811/2005051188-t.html2005051188 Ivan W. Griffiths. Principles of biomechanics and motion analysis ill. ; 29 cm. Incl)O~?X&Griffiths, Oswald Taylor, Ernest Miles1956The principles of company law589 p., Harpenden, Textbooks6thV57030623 ill., 23 cm. First ed., published in 1929, by E. Westby-Nunn and E.M. Taylor.15748503<Law Library Reading Room (Madison, LM201) KD2079; .W468 1956O~?Y:Griffiths, Oswald Taylor, Ernest Miles Westby-Nunn, Edward1949The principles of company law xxiii, 566 p.London, Textbooks5thCorporation law Great Britain.49028163 by O. Griffths and E. Miles Taylor. 23 cm. First ed. by E. Westby-Nunn and E. M. Taylor. "Corrigenda. Appendix xii" ([11] p.) inserted.9764072<Law Library Reading Room (Madison, LM201) KD2079; .W468 1949O~?ZGriffiths, Oswald1950The principles of company law564 p.London, Textbooks5th51025818 23 cm.6029512<Law Library Reading Room (Madison, LM201) KD2079; .W468 1950|?[Griffiths, Phillip Harris, Joe1978 Principles of algebraic geometry xii, 813 p.Pure and applied mathematicsNew YorkWileyGeometry, Algebraichttp://www.loc.gov/catdir/bios/wiley047/78006993.html http://www.loc.gov/catdir/description/wiley031/78006993.html http://www.loc.gov/catdir/toc/onix01/78006993.html78006993 Phillip Griffiths and Joseph Harris. ill. ; 24 cm. "A Wiley-Interscience publication." Includes bibliographical references and index. 04713279214154589Jefferson or Adams Building Reading Rooms QA564; .G64 1978 Jefferson or Adams Building Reading Rooms - STORED OFFSITE QA564; .G64 1978O|?\2Hill, R. Carter Griffiths, William E. Lim, Guay C.2008Principles of econometrics xxvii, 579 p. Hoboken, NJWiley3rd Econometrics.http://www.loc.gov/catdir/enhancements/fy0814/2008270112-d.html http://www.loc.gov/catdir/enhancements/fy0814/2008270112-t.html$2008270112 R. Carter Hill, William E. Griffiths, Guay C. Lim. ill. ; 27 cm. Rev. ed. of: Undergraduate econometrics / R. Carter Hill, William E. Griffiths, George G. Judge. 2nd. ed. A multi-media instructional package, including Web sites, is available to supplement the text. Includes index.9780471723608 (alk. paper)15130367;Jefferson or Adams Building Reading Rooms HB139; .H548 2008OO~?]:Westby-Nunn, Edward Taylor, Ernest Miles Griffiths, Oswald1937The principles of company law xxv, 475 p.London,Textbooks limited4th=Corporation law Great Britain. Stock companies Great Britain.38034308 23 cm.5968533MLaw Library Reading Room (Madison, LM201) - STORED OFFSITE KD2079; .W468 1937 etudes bibliographical references and index. 078175231014052815Jefferson or Adams Building Read~?^{$Williams, Marian Lissner, Herbert R.1962Useful Terms and Concepts12-13.Biomechanics of human motion PhiladelphiaSaunO|?_6Williams, Marian Lissner, Herbert R. LeVeau, Barney F.19771Williams and Lissner Biomechanics of human motion ix, 230 p. PhiladelphiaSaunders2d"Human locomotion. Human mechanics.75044605 Biomechanics of human motion Barney LeVeau. ill. ; 27 cm. Includes bibliographies and index. Biomechanics of human motion. 0721657737801567Jefferson or Adams Building Reading Rooms QP303; .W58 1977 Jefferson or Adams Building Reading Rooms - STORED OFFSITE QP303; .W58 1977 Yk$dersHuman locomotion.E62013591 [by] Marian Williams [and] Herbert R. Lissner. illus.F|7`,Gardner, T. W. Larsen, M. Girach, A. Zhi, X.2009XDiabetic macular oedema and visual loss: relationship to location, severity and durationActa Ophthalmologica 2009/10/13Oct 8Abstract. Purpose: To assess the relationship between visual acuity (VA) and diabetic macular oedema (DMO) in relation to the location of retinal thickening and the severity and duration of central macular thickening. Methods: Data from 584 eyes in 340 placebo-treated patients in the 3-years-long Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) trial were used to investigate the relationship between VA and DMO. Eligible eyes had moderately severe to very severe non-proliferative diabetic retinopathy and VA of at least 45 letters on Early Treatment Diabetic Retinopathy Study (ETDRS) charts (Snellen equivalent = 20/125). Diabetic retinopathy and DMO status were assessed using stereo photographs. Results: Nearly one third of study eyes had foveal centre-involving DMO at the start of the trial. Sustained moderate visual loss was found in 36 eyes, most commonly associated with DMO at the centre of the fovea in 73% of eyes. There was a strong relationship (p < 0.001) between foveal centre involvement with DMO and mean VA. Mean VA decreased with increasing retinal thickness at the centre (p < 0.001) and increasing duration of centre-involving DMO (p < 0.001). Conclusion: This study documents the relationship between duration of DMO and progressive vision loss, and the key role of central foveal involvement in patients with diabetic retinopathy. These data will help to develop future strategies to prevent vision loss.+http://www.ncbi.nlm.nih.gov/pubmed/19817721on behalf of the Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) Study Group* Journal article Acta ophthalmologica Acta Ophthalmol. 2009 Oct 8.1755-3768 (Electronic)19817721Departments of Ophthalmology and Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA..AOS1545 [pii] 10.1111/j.1755-3768.2009.01545.xEng |t7aDe Siervi, A. De Luca, P. Moiola, C. Gueron, G. Tongbai, R. Chandramouli, G. V. Haggerty, C. Dzekunova, I. Petersen, D. Kawasaki, E. Kil, W. J. Camphausen, K. Longo, D. Gardner, K.2009ZIdentification of new Rel/NFkappaB regulatory networks by focused genome location analysis2093-100 Cell Cycle813 2009/06/0914-3-3 Proteins/genetics/metabolism Cell Cycle Proteins/genetics/metabolism Cell Line Chromatin Immunoprecipitation DNA-Binding Proteins/genetics/metabolism E1A-Associated p300 Protein/genetics/metabolism Gene Expression Profiling *Gene Regulatory Networks Humans L-Selectin/genetics/metabolism Matrix Metalloproteinase 1/genetics/metabolism NF-kappa B/genetics/*metabolism Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic Protein-Serine-Threonine Kinases/genetics/metabolism Proto-Oncogene Proteins c-rel/genetics/*metabolism RNA Interference T-Lymphocytes/immunology/metabolism Transforming Growth Factor beta1/genetics/metabolism Tumor Suppressor Proteins/genetics/metabolismJul 1NFkappaB is an inducible transcription factor that controls kinetically complex patterns of gene expression. Several studies reveal multiple pathways linking NFkappaB to the promotion and progression of various cancers. Despite extensive interest and characterization, many NFkappaB controlled genes still remain to be identified. We used chromatin immunoprecipitation combined with microarray technology (ChIP/chip) to investigate the dynamic interaction of NFkappaB with the promoter regions of 100 genes known to be expressed in mitogen-induced T-cells. Six previously unrecognized NFkappaB controlled genes (ATM, EP300, TGFbeta, Selectin, MMP-1 and SFN) were identified. Each gene is induced in mitogen-stimulated T-cells, repressed by pharmacological NFkappaB blockade, reduced in cells deficient in the p50 NFkappaB subunit and dramatically repressed by RNAi specifically designed against cRel. A coregulatory role for Ets transcription factors in the expression of the NFkappaB controlled genes was predicted by comparative promoter analysis and confirmed by ChIP and by functional disruption of Ets. NFkappaB deficiency produces a deficit in ATM function and DNA repair indicating an active role for NFkappaB in maintaining DNA integrity. These results define new potential targets and transcriptional networks governed by NFkappaB and provide novel functional insights for the role of NFkappaB in genomic stability, cell cycle control, cell-matrix and cell-cell interactions during tumor progression.+http://www.ncbi.nlm.nih.gov/pubmed/19502793De Siervi, Adriana De Luca, Paola Moiola, Cristian Gueron, Geraldine Tongbai, Ron Chandramouli, G V R Haggerty, Cynthia Dzekunova, Inna Petersen, David Kawasaki, Ernest Kil, Whoon Jong Camphausen, Kevin Longo, Dan Gardner, Kevin ZIA BC010846-03/BC/NCI NIH HHS/United States Research Support, N.I.H., Intramural United States Cell cycle (Georgetown, Tex.) Cell Cycle. 2009 Jul 1;8(13):2093-100. Epub 2009 Jul 5.*1551-4005 (Electronic) 1551-4005 (Linking)280925019502793Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892, USA. adesiervi@qb.fcen.uba.ar 8926 [pii]eng||7bNArnoczky, S. P. Swenson, C. Egerbacher, M. Gardner, K. Caballero, O. Burns, M.2007^The location in cartilage of infectious retrovirus in cats infected with feline leukemia virus2030-6J Bone Joint Surg Am899 2007/09/05Animals Antigens, Viral/analysis Bone and Bones/virology Cartilage, Articular/*virology Cats Cells, Cultured Chondrocytes/virology Coculture Techniques DNA, Viral/analysis Extracellular Matrix/virology Fibroblasts/virology Gene Products, gag/analysis Immunohistochemistry Leukemia Virus, Feline/immunology/*isolation & purification Retroviridae Infections/transmission/virology Retroviridae Proteins/analysis Tumor Virus Infections/transmission/virology Virus ReplicationSep BACKGROUND: Previous studies have suggested that articular cartilage allografts were not likely to transmit infectious retrovirus since viral DNA could not be isolated from chondrocytes of infected individuals. However, the ability of the extracellular matrix of articular cartilage to harbor and transmit a retrovirus has not been examined. We hypothesized that articular cartilage fragments, but not isolated chondrocytes, from cats systemically infected with feline leukemia virus (FeLV) are capable of transmitting infectious retrovirus. METHODS: Fresh cartilage segments and chondrocytes isolated from cats systemically infected with feline leukemia virus were used in this study. Feline embryonic fibroblast cells were cocultured with segments of cartilage, isolated chondrocytes, or fragments of cortical bone from each infected cat. The FeLV p27 antigen was measured in the coculture media by enzyme-linked immunosorbent assay. In addition, FeLV proviral nucleic acids were quantified by real-time quantitative polymerase chain reaction with use of DNA extracted from feline embryonic fibroblast cell cocultures as well as isolated chondrocytes. Immunohistochemistry was used to assess for FeLV p27 antigen in both intact cartilage fragments and isolated chondrocytes. RESULTS: Feline embryonic fibroblast cells cocultured with cartilage fragments from each of the five FeLV-infected cats all demonstrated high levels of proviral DNA, indicating transmission of infective virus. In addition, media from all cocultures of feline embryonic fibroblast cells and chondral fragments became positive for p27 antigen, indicating active viral replication. In contrast, cocultures of feline embryonic fibroblast cells and isolated chondrocytes from all FeLV-infected cats were negative for proviral DNA and p27 antigen. Likewise, no proviral nucleic acids could be detected in isolated chondrocytes from any infected cats. Cocultures of feline embryonic fibroblast cells with cortical bone fragments were positive for proviral DNA and p27 antigen. Immunohistochemical staining of cartilage fragments from FeLV-infected cats demonstrated the presence of p27 antigen throughout the extracellular matrix, but the p27 antigen was not detected in isolated chondrocytes. CONCLUSIONS: Articular cartilage fragments can readily transmit infectious retrovirus, but isolated chondrocytes were likely not the source of the infectious virus because they did not harbor proviral DNA or p27 antigen.+http://www.ncbi.nlm.nih.gov/pubmed/17768202Arnoczky, Steven P Swenson, Cheryl Egerbacher, Monika Gardner, Keri Caballero, Oscar Burns, Meghan United States The Journal of bone and joint surgery. American volume J Bone Joint Surg Am. 2007 Sep;89(9):2030-6.%0021-9355 (Print) 0021-9355 (Linking)17768202Laboratory for Comparative Orthopaedic Research and Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA. arnoczky@cvm.msu.edu$89/9/2030 [pii] 10.2106/JBJS.G.00054eng 9~t7cDStrickland, M. J. Siffel, C. Gardner, B. R. Berzen, A. K. Correa, A.20074Quantifying geocode location error using GIS methods10Environ Health6 2007/04/06TCongenital Abnormalities/*epidemiology *Databases, Factual Female Geographic Information Systems/*standards/statistics & numerical data Georgia/epidemiology Humans Infant, Newborn Local Government Pregnancy Reproducibility of Results Residence Characteristics/*classification Taxes/statistics & numerical data Topography, Medical/*standardsBACKGROUND: The Metropolitan Atlanta Congenital Defects Program (MACDP) collects maternal address information at the time of delivery for infants and fetuses with birth defects. These addresses have been geocoded by two independent agencies: (1) the Georgia Division of Public Health Office of Health Information and Policy (OHIP) and (2) a commercial vendor. Geographic information system (GIS) methods were used to quantify uncertainty in the two sets of geocodes using orthoimagery and tax parcel datasets. METHODS: We sampled 599 infants and fetuses with birth defects delivered during 1994-2002 with maternal residence in either Fulton or Gwinnett County. Tax parcel datasets were obtained from the tax assessor's offices of Fulton and Gwinnett County. High-resolution orthoimagery for these counties was acquired from the U.S. Geological Survey. For each of the 599 addresses we attempted to locate the tax parcel corresponding to the maternal address. If the tax parcel was identified the distance and the angle between the geocode and the residence were calculated. We used simulated data to characterize the impact of geocode location error. In each county 5,000 geocodes were generated and assigned their corresponding Census 2000 tract. Each geocode was then displaced at a random angle by a random distance drawn from the distribution of observed geocode location errors. The census tract of the displaced geocode was determined. We repeated this process 5,000 times and report the percentage of geocodes that resolved into incorrect census tracts. RESULTS: Median location error was less than 100 meters for both OHIP and commercial vendor geocodes; the distribution of angles appeared uniform. Median location error was approximately 35% larger in Gwinnett (a suburban county) relative to Fulton (a county with urban and suburban areas). Location error occasionally caused the simulated geocodes to be displaced into incorrect census tracts; the median percentage of geocodes resolving into incorrect census tracts ranged between 4.5% and 5.3%, depending upon the county and geocoding agency. CONCLUSION: Geocode location uncertainty can be estimated using tax parcel databases in a GIS. This approach is a viable alternative to global positioning system field validation of geocodes.+http://www.ncbi.nlm.nih.gov/pubmed/17408484Strickland, Matthew J Siffel, Csaba Gardner, Bennett R Berzen, Alissa K Correa, Adolfo Evaluation Studies Research Support, U.S. Gov't, P.H.S. England Environmental health : a global access science source Environ Health. 2007 Apr 4;6:10.*1476-069X (Electronic) 1476-069X (Linking)185279817408484National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. MStrickland@cdc.gov+1476-069X-6-10 [pii] 10.1186/1476-069X-6-10eng [||7d,Bell, J. L. Gardner, L. I. Landsittel, D. P.2000ySlip and fall-related injuries in relation to environmental cold and work location in above-ground coal mining operations40-8'American Journal of Industrial Medicine381 2000/06/229Accidental Falls/*statistics & numerical data Accidents, Occupational/*statistics & numerical data Coal Mining/*statistics & numerical data *Cold Temperature Confidence Intervals Female Humans Incidence Injury Severity Score Male *Occupational Health Probability Registries Risk Factors United States/epidemiologyJulBACKGROUND: The association between slip and fall-related injuries and environmental temperature was examined for mostly enclosed (inside vehicles, machinery, or buildings), outdoor (outside, not enclosed), and enclosed/outdoor jobs in the coal mining industry to see if differences existed among the three work locations that had varying exposure to cold temperatures. METHODS: Temperature data from the National Climatic Data Center and injury data from the Mine Safety and Health Administration were evaluated from 1985-1990 for seven states. Proportionate methods were used to examine the relationship between slips and falls and temperature. RESULTS: Proportionate injury ratios of slips and fall-related injuries increased as temperature declined for all three work locations. Proportion of slips and fall-related injuries that occurred while running/walking increased with declining temperature, with the ground outside as the most common source of these injuries. CONCLUSIONS: Outside movement becomes a greater hazard at freezing temperatures for workers in all locations, not just outdoor workers. Any intervention methods geared toward reducing injury incidents facilitated by cold weather must also be directed toward workers who spend time in more enclosed locations.+http://www.ncbi.nlm.nih.gov/pubmed/10861765Bell, J L Gardner, L I Landsittel, D P Case Reports United states American journal of industrial medicine Am J Ind Med. 2000 Jul;38(1):40-8.%0271-3586 (Print) 0271-3586 (Linking)10861765Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, Morgantown, West Virginia 26505, USA. jbell@cdc.gov<10.1002/1097-0274(200007)38:1<40::AID-AJIM5>3.0.CO;2-F [pii]eng ||7eSWozniak, M. A. Kittner, S. J. Price, T. R. Hebel, J. R. Sloan, M. A. Gardner, J. F.1999QStroke location is not associated with return to work after first ischemic stroke2568-73Stroke3012 1999/12/03Age Factors Aged Analysis of Variance Aphasia/etiology Cerebral Cortex/pathology Cerebrovascular Circulation Employment/*statistics & numerical data Female Humans Infarction, Anterior Cerebral Artery/complications/pathology/physiopathology Infarction, Posterior Cerebral Artery/complications/pathology/physiopathology Male Middle Aged Prognosis Prospective Studies Severity of Illness Index Socioeconomic Factors Stroke/complications/*pathology/physiopathologyDecBACKGROUND AND PURPOSE: In prior studies, age, race, job category, disability, and cortical functions such as praxis, language, and memory have been associated with vocational outcome, but the influence of stroke location on return to work has never been critically examined. METHODS: We examined the influence of stroke location on vocational outcome in patients with clinically confirmed acute ischemic stroke from the National Institute of Neurological Disorders and Stroke Stroke Data Bank. RESULTS: Of 143 patients working full time at the time of first ischemic stroke, 23 patients were dead and 120 were alive at 1 year. Employment status was known in 109 (mean age, 55 years; 51 [47%] were white, and 82 [75%] were male). Fifty-eight (53%) had returned to work; most (85%) worked full time. Younger age was positively associated with return to work (P<0.05). In an age-adjusted analysis, stroke severity as measured by the Barthel Index 7 to 10 days after stroke was negatively associated with return to work (P<0.001). Higher household income and absence of cortical neurological dysfunction 7 to 10 days after stroke were positively but less strongly associated with return to work (P<0.08). Stroke location, sex, and depression at time of stroke were not associated with vocational outcome. CONCLUSIONS: Our data suggest that stroke location may be less important than other more easily measured factors in predicting vocational outcome.+http://www.ncbi.nlm.nih.gov/pubmed/10582979qWozniak, M A Kittner, S J Price, T R Hebel, J R Sloan, M A Gardner, J F K08NS01764/NS/NINDS NIH HHS/United States P01NS16332/NS/NINDS NIH HHS/United States R01DA/NS06625/POINS16332/DA/NIDA NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United states Stroke; a journal of cerebral circulation Stroke. 1999 Dec;30(12):2568-73.%0039-2499 (Print) 0039-2499 (Linking)10582979uDepartments of Neurology, University of Maryland School of Medicine, Baltimore 21201, USA. mwozniak@som.umaryland.edueng ||7f7Hamaide, A. Arnoczky, S. P. Ciarelli, M. J. Gardner, K.1998uEffects of age and location on the biomechanical and biochemical properties of canine tracheal ring cartilage in dogs18-22'American Journal of Veterinary Research591 1998/01/27Aging/*physiology Analysis of Variance Animals Cartilage/anatomy & histology/growth & development/*physiology Dogs Models, Biological Stress, Mechanical Tensile StrengthJanOBJECTIVE: To evaluate effects of age (immature vs adult) and location along the trachea on the biomechanical properties (via a tensile stress relaxation test) and biochemical properties (Water content and total proteoglycan content) of canine tracheal ring cartilage. SAMPLE POPULATION: Entire trachea from 8 immature and 8 adult dogs. PROCEDURE: A section of each tracheal ring from 8 immature dogs (6 months old) and 8 adult dogs (2 to 3 years old) was tested biomechanically (maximal stress, equilibrium stress, equilibrium modulus, and percentage of relaxation) and processed for biochemical analysis (water content and total proteoglycan content). Two rings from each trachea were prepared for histologic analysis (H&E or safranin-O staining). RESULTS: Biomechanical and biochemical parameters were not different between cervical and thoracic rings of either age group. Mean maximal stress, equilibrium stress, and equilibrium modulus were significantly higher for adult, compared with immature, dogs. However, percentage of relaxation for adult dogs was significantly lower. Tracheal rings of adult dogs had a significantly higher proteoglycan content and a significantly lower water content than did those of immature dogs. Water content and biomechanical parameters were significantly correlated, and proteoglycan content and biomechanical properties were significantly but weakly correlated. On histologic sectioning, a qualitative decrease in safranin-O staining in the rings of immature dogs also was observed. CONCLUSIONS AND CLINICAL RELEVANCE: Biomechanical and biochemical properties of the canine tracheal ring cartilage are altered with age. However, location of the ring along the trachea did not affect these properties for either age group. Results lend support to the theory that proteoglycan content has some effect on tensile properties of tracheal rings and may explain increased compliance observed in rings from dogs with collapsed trachea.*http://www.ncbi.nlm.nih.gov/pubmed/9442237Hamaide, A Arnoczky, S P Ciarelli, M J Gardner, K In Vitro Research Support, Non-U.S. Gov't United states American journal of veterinary research Am J Vet Res. 1998 Jan;59(1):18-22.%0002-9645 (Print) 0002-9645 (Linking)9442237Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA.eng r||7gSavard, P. Rouleau, J. L. Ferguson, J. Poitras, N. Morel, P. Davies, R. F. Stewart, D. J. Talajic, M. Gardner, M. Dupuis, R. Lauzon, C. Sussex, B. Potvin, L. Warnica, W.1997Risk stratification after myocardial infarction using signal-averaged electrocardiographic criteria adjusted for sex, age, and myocardial infarction location202-13 Circulation961 1997/07/01Age Factors Aged Arrhythmias, Cardiac/diagnosis/epidemiology Disease-Free Survival *Electrocardiography Female Follow-Up Studies Humans Male Middle Aged Multivariate Analysis Myocardial Infarction/*classification/mortality Risk Assessment Sex Factors Survival RateJul 1BACKGROUND: The objectives were to investigate the factors influencing signal-averaged ECGs (SAECGs) recorded in patients after myocardial infarction (MI) and to develop criteria for predicting arrhythmic events (AEs) that account for these factors. METHODS AND RESULTS: SAECGs were recorded 5 to 15 days after MI in 2461 patients without bundle-branch block. The duration (QRSd), terminal potential (VRMS), and terminal duration (LAS) of the filtered QRS were measured. During follow-up (17 +/- 8 months), AEs (arrhythmic death; ventricular tachycardia, VT; ventricular fibrillation, VF) occurred in 80 patients (3.3%). Receiver operating characteristic curves showed that QRSd discriminated patients with all types of AEs, but VRMS and LAS discriminated only VT patients; QRSd minus LAS also discriminated AE patients. Sex, age, and MI location significantly affected the SAECG; survivors without VT or VF were divided into subgroups (2 sex x 4 age x 2 MI), and QRSd values exceeding the 70th percentile in each subgroup predicted AEs with a sensitivity of 65.4%. An unadjusted QRSd criterion showed the same overall sensitivity and specificity but with less uniform values for each subgroup. A Cox model was constructed by use of multiple prognostic indicators, and in rank order, QRSd, previous MI, and Killip class were predictive of AEs. CONCLUSIONS: SAECG adjustments for sex, age, and MI location did not improve sensitivity and specificity but produced a more uniform predictive performance. The proposed criteria are based only on QRSd, because late potentials (VRMS and LAS) did not discriminate patients with sudden death. Duration of high-level activity during QRS (QRSd-LAS) can predict AEs, suggesting that the arrhythmogenic substate involves a large mass of myocardium.*http://www.ncbi.nlm.nih.gov/pubmed/9236435Savard, P Rouleau, J L Ferguson, J Poitras, N Morel, P Davies, R F Stewart, D J Talajic, M Gardner, M Dupuis, R Lauzon, C Sussex, B Potvin, L Warnica, W Research Support, Non-U.S. Gov't United states Circulation Circulation. 1997 Jul 1;96(1):202-13.%0009-7322 (Print) 0009-7322 (Linking)9236435sInstitut de genic biomedical, Ecole Polytechnique, Universite de Montreal, Quebec, Canada. savardp@igb.umontreal.caeng |t7h8Gardner, R. G. Wells, J. E. Russell, J. B. Wilson, D. B.1995The cellular location of Prevotella ruminicola beta-1,4-D-endoglucanase and its occurrence in other strains of ruminal bacteria3288-92Appl Environ Microbiol619 1995/09/01#Animals Cell Membrane/enzymology Cellulase/chemistry/immunology/*metabolism Enzyme Stability Glycoside Hydrolases/chemistry/immunology/*metabolism Gram-Negative Anaerobic Bacteria/enzymology Immunohistochemistry Molecular Weight Prevotella/*enzymology Rumen/*microbiology Species SpecificitySepPrevotella ruminicola B(1)4, TC1-1, TF1-3, and TS1-5 all produced immunologically cross-reacting 88- and 82-kDa carboxymethyl cellulases (CMCases). P. ruminicola 23, 118B, 20-63, and 20-78 had much lower CMCase activities, and Western blots (immunoblots) showed no cross-reaction with the B(1)4 CMCase antiserum. Fibrobacter succinogenes S85 and Selenomonas ruminantium HD4 and D produced CMCase, but these enzymes were smaller and did not cross-react with the B(1)4 CMCase antiserum. The B(1)4 CMCase antiserum inhibited the B(1)4, TC1-1, TF1-3, and TS1-5 CMCase activities and agglutinated these cells, but it had no effect on the other strains or species. On the basis of these results, the B(1)4 CMCase is a strain-specific enzyme that is located on the outside surface of the cells. P. ruminicola B(1)4 cultures, grown on sucrose, did not have significant CMCase activity, but these cells could bind purified 88- and 82-kDa CMCase but not 40.5-kDa CMCase. Because the 40.5-kDa CMCase is a fully active, truncated form of the CMCase, it appears that the N-terminal domain of the 88-kDa B(1)4 CMCase anchors the CMCase to the cells. Cells grown on cellobiose produced at least 10-fold more CMCase than the sucrose-grown cells, and the cellobiose-grown cells could only bind 15% as much CMCase as sucrose-grown cells. Virtually all of the CMCase activity of exponentially growing cultures was cell associated, but CMCase activity was eventually detected in the culture supernatant. On the basis of the observation that the 88-kDa CMCase was gradually converted to the 82-kDa CMCase when cultures reached the stationary phase without a change in specific activity, it appears that the 82-kDa protein is probably a proteolytic degradation product of the 88-kDa CMCase.*http://www.ncbi.nlm.nih.gov/pubmed/7574639Gardner, R G Wells, J E Russell, J B Wilson, D B Research Support, U.S. Gov't, Non-P.H.S. United states Applied and environmental microbiology Appl Environ Microbiol. 1995 Sep;61(9):3288-92.%0099-2240 (Print) 0099-2240 (Linking)1676097574639iSection of Biochemistry, Molecular and Cellular Biology, Cornell University, Ithaca, New York 14853, USA.engy||7i+Gardner, R. McAnulty, J. Feher, E. Lane, D.1985=Location of rep and inc sequences in the F secondary replicon145-8Plasmid132 1985/03/01*Chromosome Mapping DNA Restriction Enzymes DNA Transposable Elements Deoxyribonuclease EcoRI Escherichia coli/*genetics *F Factor Genes, Bacterial *Plasmids *RepliconMarMiniplasmids derived by deletion of DNA from the F plasmid secondary replicon have been tested for the ability to replicate and to express incompatibility with the IncFI plasmid, ColV3-K30. The results demonstrate that the minimal rep region of the secondary replicon lies within a 1.9-kb sequence (33.7F-35.6F kb), and that an inc region, presumably involved in replication control, is present in a 0.45-kb portion of the rep region (33.7F-34.15F kb). In addition, the secondary replicon was found not to require DNA polymerase I activity.*http://www.ncbi.nlm.nih.gov/pubmed/2987993}Gardner, R McAnulty, J Feher, E Lane, D Research Support, Non-U.S. Gov't United states Plasmid Plasmid. 1985 Mar;13(2):145-8.%0147-619X (Print) 0147-619X (Linking)29879930147-619X(85)90067-8 [pii]eng||7jGardner, M. B.1969<Image fusion, broadening, and displacement in sound location339-49J Acoust Soc Am462 1969/08/014*Auditory Perception Humans *Sound *Space PerceptionAug*http://www.ncbi.nlm.nih.gov/pubmed/5804103sGardner, M B United states The Journal of the Acoustical Society of America J Acoust Soc Am. 1969 Aug;46(2):339-49.%0001-4966 (Print) 0001-4966 (Linking)5804103eng||7k%Gardner, H. F. Clippinger, F. W., Jr.1969<A method for location of prosthetic and orthotic knee joints31-5 Artif Limbs132 1969/01/01]Amputation Humans Knee/radiography *Knee Joint Leg/surgery *Movement *Prostheses and ImplantsAutumn*http://www.ncbi.nlm.nih.gov/pubmed/5380875cGardner, H F Clippinger, F W Jr United states Artificial limbs Artif Limbs. 1969 Autumn;13(2):31-5.%0004-3729 (Print) 0004-3729 (Linking)5380875eng|?lGingrich, André Banks, Marcus2006LNeo-nationalism in Europe and beyond : perspectives from social anthropology vii, 303 p.New YorkBerghahn BooksPolitical anthropology Europe Congresses. Political culture Europe Congresses. Nationalism Europe Congresses. Europe Politics and government Congresses. Europe Social life and customs Congresses.6http://www.loc.gov/catdir/toc/ecip0616/2006019278.html2006019278 edited by Andre Gingrich and Marcus Banks. ill. ; 24 cm. Papers originally presented at a workshop in Brussels in 2001. Includes bibliographical references and index. Neo-nationalism in Europe and beyond / Marcus Banks and Andre Gingrich -- Nation, status and gender in trouble? : exploring some contexts and characteristics of neo-nationalism in Western Europe / Andre Gingrich -- Performing 'neo-nationalism' : some methodological notes / Marcus Banks -- Imagined kinship: the role of descent in the rearticulation of Norwegian ethno-nationalism / Marianne Gullestad -- The emergence of neo-nationalism in Denmark, 1992/2001 / Peter Hervik -- 'At your service!' : reflections on the rise of neo-nationalism in the Netherlands / Thijl Sunier and Rob van Ginkel -- Neo-nationalism and democracy in Belgium : on understanding the contexts of neo-communitarianism / Rik Pinxten -- 'Being the native's friend does not make you the foreigner's enemy!' : neo-nationalism, the Freedom Party and Jörg Haider in Austria / Thomas Fillitz -- Neo-nationalism or neo-localism? : integralist political engagements in Italy at the turn of the millennium / Jaro Stacul -- Regarding the Front National / Gerald Gaillard-Starzmann -- 'Healthy native soil' versus common agricultural policy : neo-nationalism and farmers in the EU, the example of Austria / Gertraud Seiser -- New nationalisms and the EU : occupying the available space / Maryon McDonald -- Neo-nationalism in India : a comparative counterpoint / Mukulika Banerjee -- Nationalism and neo-populism in Australia : Hansonism and the politics of the New Right in Australia / Bruce Kapferer and Barry Morris -- Afterthoughts / Ulf Hannerz.=1845451899 (hardback alk. paper) 1845451902 (pbk. alk. paper)14409790:Jefferson or Adams Building Reading Rooms GN575; .N46 2006~?mMorris, Leon Banks, Robert J.1974zReconciliation and hope : New Testament essays on atonement and eschatology presented to L. L. Morris on his 60th birthday317 p., plate.ExeterPaternoster PressEBible. Morris, Leon, 1914-2006. Morris, Leon, 1914-2006 Bibliography.g74189076 GB74-18026 edited by Robert Banks. port. ; 23 cm. "A select bibliography of the writings of L. L. Morris, compiled by David Williams": p. [15]-20. Includes bibliographical references and index. Hubbard, D. A. Leon Lamb Morris: an appreciation.--Reconciliation: Gerhardsson, B. Sacrificial service and atonement in the Gospel of Matthew.--Painter, J. Eschatological faith in the Gospel of John.--Bruce, F. F. The speeches in Acts-thirty years after.--Ellis, E. E. "Christ crucified."--Ridderbos, H. N. The earliest confession of the atonement in Paul.--Bornkamm, G. The revelation of Christ to Paul on the Damascus Road and Paul's doctrine of justification and reconciliation.--Martin, R. P. Reconciliation and forgiveness in Colossians.--Dunn, J. D. G. Paul's understanding of the death of Jesus.--Longenecker, R. N. The obedience of Christ in the theology of the early Church.--Marshall, I. H. The development of the concept of redemption in the New Testament.--Hope: Banks, R. The eschatological role of law in pre- and post-Christian Jewish thought.--Maddox, R. The function of the Son of Man in the Gospel thought.--Maddox, R. The function of the Son of Man in the Gospel of John.--Palmer, D. W. The resurrection of Jesus and the mission of the Church.--Cranfield, C. E. B. Some observations on Romans 8:19-21.--Robinson, D. W. B. The priesthood of Paul in the gospel of hope.--McCaughey, J. D. The death of death (I Cor.15:26).--Dalton, W. J. "So that your faith may also be your hope in God" (I Peter 1:21).--Beasley-Murray, G. R. How Christian is the Book of Revelation?--Ladd, G. E. Apocalyptic and New Testament theology.3157282:Jefferson or Adams Building Reading Rooms BS2395; .R4 1974I|?n Banks, Erik1994Complex derivatives : understanding and managing the risks of exotic options, complex swaps, warrants, and other synthetic derivatives vii, 229 p.ChicagoProbus Pub. Co./Derivative securities. Exotic options (Finance)9http://www.loc.gov/catdir/description/mh022/94143928.html^94143928 Erik Banks. ill. ; 24 cm. Includes bibliographical references (p. 215-222) and index. 1557385505659346Jefferson or Adams Building Reading Rooms HG6024.A3; B36 1994 Jefferson or Adams Building Reading Rooms - STORED OFFSITE HG6024.A3; B36 1994|?oBanks, Margaret A.1991^Understanding Canada's constitution : including summaries of some reports recommending changes vi, 93 p. London, Ont.Order from B.S.A.S.QConstitutional law Canada Popular works. Federal government Canada Popular works.[92195154 by Margaret A. Banks. ill. ; 23 cm. Includes bibliographical references and index. 09695632051569964=Law Library Reading Room (Madison, LM201) KE4219.2; .B36 1991O|?pBanks, Michael A.1990%Understanding FAX and electronic mail xxiii, 271 p.Sams understanding seriesCarmel, Ind., USA H.W. Sams1st0Facsimile transmission. Electronic mail systems.y89063713 Michael A. Banks. ill. ; 23 cm. Includes bibliographical references (p. 245) and index. FAX and electronic mail. 06722729704347076;Jefferson or Adams Building Reading Rooms TK6710; .B26 1990|?qBanks, Michael A.1982Understanding science fiction xi, 180 p.(Silver Burdett professional publicationsMorristown, N.J.Silver Burdett Co.~Science fiction, American Study and teaching. Science fiction, English Study and teaching. Science fiction Study and teaching.N80053720 Michael A. Banks. ill. ; 23 cm. Bibliography: p. 174. Includes index.0382290747 (pbk.)3718610;Jefferson or Adams Building Reading Rooms PS648.S3; B3 1982|?r)Barron, Terry Cavender, Jeff Banks, David1998Terry Barron's no nonsense guide to fly fishing Pyramid Lake : a quick, clear understanding of the nation's top lahontan cutthroat trout fisheryxii, 31, ix p. Sisters, Or.David CommunicationsCutthroat trout fishing Nevada Pyramid Lake Guidebooks. Fly fishing Nevada Pyramid Lake Guidebooks. Pyramid Lake (Nev.) Guidebooks.{http://www.loc.gov/catdir/enhancements/fy0715/99187485-d.html http://www.loc.gov/catdir/enhancements/fy0912/99187485-b.html99187485 edited and with a foreword by Jeff Cavender ; [editor, David Banks ; illustrations, Pet Chadwell]. Guide to fly fishing Pyramid Lake ill., maps ; 28 cm. 09637256371216000<Jefferson or Adams Building Reading Rooms SH687.4; .B37 1998|?sCompton, R. G. Banks, Craig E.2007Understanding voltammetry xii, 371 p.Singapore ; Hackensack, NJWorld ScientificVoltammetry Textbooks.4http://www.loc.gov/catdir/toc/fy0803/2008295931.html2008295931 GBA814159 014472135 Richard G. Compton, Craig E. Banks. ill. ; 24 cm. Includes bibliographical references and index.9812706259 978981270625615216183=Jefferson or Adams Building Reading Rooms QD116.V64; C65 2007k|?t:Graham, Gary Banks, David Yuskavitch, James Graham, Yvonne1999Gary Graham's no nonsense guide to fly fishing southern Baja : a quick, clear understanding of how & where to fly fish Baja's famous and remote saltwatersxvii, 48, x p."No nonsense fly fishing guidebooks Sister, Or.David Communications[Fly fishing Mexico Baja California Sur Guidebooks. Baja California Sur (Mexico) Guidebooks.{http://www.loc.gov/catdir/enhancements/fy0716/00501140-d.html http://www.loc.gov/catdir/enhancements/fy0913/00501140-b.html00501140 [author, Gary Graham ; editors, David Banks, Jim Yuskavitch, Yvonne Graham; maps & illustrations, Pete Chadwell]. ill., maps ; 28 cm. No nonsense guides. 189246900611938960Jefferson or Adams Building Reading Rooms SH573; .G73 1999 Jefferson or Adams Building Reading Rooms - STORED OFFSITE SH573; .G73 1999 O|?uJefferies, Jack P. Brown, Banks2010Understanding hospitality law xix, 600 p. Lansing, MI;Educational Institute, American Hotel & Lodging Association5thaHotels Law and legislation United States. Hospitality industry Law and legislation United States.2010483676 Jack P. Jefferies, Banks Brown. ill., forms ; 25 cm. + 1 instructor's guide. "391.5"--Spine. Includes bibliographical references and index. The common law basis for laws governing the hotelkeeper -- The hotelkeeper and the law of contracts -- The hotellkeeper and the laws of torts and negligence -- The hotel's duty to receive guests and its right to refuse guests -- Guest reservations -- Convention and group contracts with the hotel -- The guest's right to privacy -- The hotel's right to evict a guest, tenant, restaurant patron, of others -- Americans with disabilities act : public accommodations -- The hotel's duty to protect guests -- The hotel's liability regarding guests' property -- The hotel liability for loss of property of non-guests -- Safekeeping facilities -- Frauds committed against hotels and crimes of trespass -- Deceased guests -- General laws regarding food -- Other laws relating to food service -- State laws relating to alcoholic beverages -- Wage and hour laws applicable to hotel employees -- The family and medical leave act -- Laws against discrimination in employment -- Use of lie detector tests by hotel management -- National labor relations act -- Immigration reform and control act of 1986 -- Federal social security, unemployment insurance, and workers' compensation -- Federal income tax : withholding and reporting requirements -- Maintenance of guest registers -- Consumer proptection laws affecting hotels -- Public health and safety requirements -- Occupational safety and health act -- Licensing and regulation of hotels by cities, towns, and villages -- Telephone service and resale rights -- Copyright laws for music, television, video, and movies -- Fire safety laws -- Taxes -- Warranties and product liability -- Antitrust laws and hotels -- Understanding franchising -- Legal issues involving the internet -- The impact of terrorism on laws governing hotels.9780866123457 (pbk.)16445887=Law Library Reading Room (Madison, LM201) KF2042.H6; J43 2010O|?vJefferies, Jack P. Brown, Banks2001Understanding hospitality law xx, 544 p. Lansing, MI;Educational Institute, American Hotel & Lodging Association4thaHotels Law and legislation United States. Hospitality industry Law and legislation United States.v2003265355 Jack P. Jefferies, Banks Brown. ill., forms ; 25 cm. + 1 instructor's guide. "391T"--Spine. Includes index.0866122273 (pbk.)13050474=Law Library Reading Room (Madison, LM201) KF2042.H6; J43 2001|?w,Tinnin, Glenn Yuskavitch, James Banks, David2000yGlenn Tinnin's no nonsense guide to fly fishing in Arizona : a quick, clear understanding of where to fly fish in Arizonaxiv, 47, xii p."No nonsense fly fishing guidebooks Sisters, Or.David Communications3Fly fishing Arizona Guidebooks. Arizona Guidebooks.=http://www.loc.gov/catdir/enhancements/fy0716/00501375-d.html00501375 [author, Glenn Tinnin ; editors, Jim Yuskavitch & David Banks]. Guide to fly fishing in Arizona ill., maps ; 28 cm. Includes bibliographical references (p. iii). No nonsense guides. 189246902211938957Jefferson or Adams Building Reading Rooms SH469; .T56 2000 Jefferson or Adams Building Reading Rooms - STORED OFFSITE SH469; .T56 2000|?xUWibowo, Pungky Purnomo South-East Asian Central Banks. Research and Training Centre.,2008[Understanding and addressing the pro-cyclicality impact of Basel II in the SEACEN countries x, 198 p.Kuala Lumpur, Malaysia<South East Asian Central Banks, Research and Training Centrea2009318378 Pungky Purnomo Wibowo. ill. ; 24 cm. Includes bibliographical references (p. 174-175). 983947867215763746)Jefferson or Adams Building Reading Rooms|?y9Zeller, Bob Banks, David Yuskavitch, James Cavender, Jeff2000Bob Zeller's no nonsense business traveler's guide to fly fishing in the western states : a quick, clear & good-natured understanding of where to fly fish when you are traveling on business (or supposedly doing something else)xiii, 48, xiv p."No nonsense fly fishing guidebooks Sisters, Or.David Communications;Fly fishing West (U.S.) Guidebooks. West (U.S.) Guidebooks.{http://www.loc.gov/catdir/enhancements/fy0716/00501141-d.html http://www.loc.gov/catdir/enhancements/fy0913/00501141-b.html00501141 [author, Bob Zeller ; editors, David Banks, Jim Yuskavitch, & Jeff Cavender]. Guide to fly fishing in the western states ill., maps ; 28 cm. No nonsense guides. 189246901411939057Jefferson or Adams Building Reading Rooms SH464.W4; Z46 2000 Jefferson or Adams Building Reading Rooms - STORED OFFSITE SH464.W4; Z46 2000K|?z5McGlamry, E. Dalton Banks, Alan S. Downey, Michael S.1992&Comprehensive textbook of foot surgery2 BaltimoreWilliams & Wilkins2nd Foot Surgery.91030507 editors, E. Dalton McGlamry, Alan S. Banks, Michael S. Downey ; authors' editors, Rebekah McGlamry, Nancy Sinnott Vickers. ill. ; 29 cm. Includes bibliographical references and indexes. 06830585762961022~?{GAmerican Association of Blood Banks. Autologous Transfusion Committee.,1997BGuidelines for blood recovery and reinfusion in surgery and trauma28 p. Bethesda, Md.AABB'Blood Transfusion, Autologous. Surgery.98164367 American Association of Blood Banks, Autologous Transfusion Committee. 28 cm. Includes bibliographical references (p. 13-18).165974<Jefferson or Adams Building Reading Rooms RM172.7; .A46 1997O|?|Banks, Drew Daus, Kim2002?Customer.Community : unleashing the power of your customer base xxiii, 254 p.,The Jossey-Bass business & management series San Francisco Jossey-Bass1st=Customer relations. Market segmentation. Electronic commerce.http://www.loc.gov/catdir/bios/wiley044/2001008161.html http://www.loc.gov/catdir/description/wiley037/2001008161.html http://www.loc.gov/catdir/toc/wiley021/2001008161.html2001008161 Drew Banks, Kim Daus ; foreword by Scott Cook ; afterword by Michael Lowestein. ill. 24 cm. Includes bibliographical references (p. 235-243) and index. 078795621X12618011Jefferson or Adams Building Reading Rooms HF5415.5; .B363 2002 Jefferson or Adams Building Reading Rooms - STORED OFFSITE HF5415.5; .B363 20024O|?}Banks-Houston, Stacey2008DSeasons of wholiness : inspiration for the seasons in a woman's lifeKansas City, MOPassion Publishers1sti2008940810 Stacey Banks-Houston, Latora Grant Scott, Cynthia A. Saddler ; [edited by] Passion Publishers.9781604616750 (alk. paper)15506990~?~ Banks, J. A.1968Studies in British society220 p. New York,Crowell Great Britain Social conditions.68013376 (Joseph Ambrose), Edited by J. A. Banks. 21 cm. Tradition and change, by M. Stacey.--Coal and conflict, by W. H. Scott, and others.--Sects and society, by B. R. Wilson.--Power in co-operatives, by G. N. Ostergaard and A. H. Halsey.--Pentonville, by T. and P. Morris.--The home and the school, by J. W. B. Douglas.--Infant care in an urban community, by J. and E. Newsom. Includes bibliographical references.3120664|Jefferson or Adams Building Reading Rooms HN385; .B35 Jefferson or Adams Building Reading Rooms - STORED OFFSITE HN385; .B35||?Banks, Sara H. Cook, Scott1997A net to catch time1New York.A.A. Knopf : Distributed by Random House, Inc.kGullahs Juvenile fiction. Gullahs Fiction. Sea Islands Fiction. Georgia Fiction. African Americans Fiction.qDepicts a day in the life of a boy on one of Georgia's barrier islands as sequenced by the Gullah terms for time.>http://www.loc.gov/catdir/description/random0410/94048880.htmlN94048880 by Sara Harrell Banks ; illustrated by Scott Cook. col. ill. ; 29 cm.#0679866736 (trade) 0679966730 (GLB)3962888NJefferson or Adams Building Reading Rooms - STORED OFFSITE PZ7.B22635; Ne 1997M|?KBanks, Steven Gray, Scott Bloom, Michael McElfresh, Andy Klasky-Csupo Inc.,2001Double trouble95 p.#Nickelodian rocket power adventures#1New YorkSimon Spotlight/Nickelodeon1st>http://www.loc.gov/catdir/description/simon032/2001090076.html!2001090076 by Steven Banks based on the teleplays by Scott Gray, Michael Bloom, and Andy McElfresh. ill. ; 20 cm. "Based on the TV series Nickelodeon rocket power created by Klasky Csupo, Inc. ..."--P. facing t.p. "Ages 8-12"--P. [4] of cover. Nickelodeon rocket power (Television program) 068984555312382896OJefferson or Adams Building Reading Rooms - STORED OFFSITE PZ7.B22637; Dou 2001|?1Caruthers, Scott Banks, Marshall Hackerman, Debra1995gThe Strongput workout system : gain without pain : new technology breaks a century old exercise barrier xii, 79 p. Dubuque, IowaKendall/Hunt Pub.Exercise. Physical fitness.u94079894 Scott Caruthers, Marshall Banks, Debra Hackerman. ill. ; 26 cm. Includes bibliographical references (p. 78).0840397534 (pbk.)1600509:Jefferson or Adams Building Reading Rooms GV481; .C37 1995?~?sDewar, James Dewar, Helen Rose Banks Dickson, James Douglas Hamilton Ross, Hugh Munro Dickson, Ernest Charles Scott1927#Collected papers of Sir James Dewar2Cambridge Eng.The University PressScience. Chemistry. Physics.27016388 Edited by Lady Dewar, with the assistance of J. D. Hamilton Dickson...H. Munro Ross...and E. C. Scott Dickson...with two supplementary papers not heretofore published and an appendix and indexes. illus., diagrs. (1 fold.) 27 cm. Paged continuously.59290673Jefferson or Adams Building Reading Rooms Q113; .D4|?Redmond, Anthony D.2006ABC of conflict and disaster ix, 42 p.Malden, Mass. ; Oxford BMJ BooksiDisasters Health aspects. Health risk assessment. Disaster relief. Disasters. Emergency Medical Services.http://www.loc.gov/catdir/toc/ecip0517/2005022942.html http://www.loc.gov/catdir/enhancements/fy0802/2005022942-b.html http://www.loc.gov/catdir/enhancements/fy0802/2005022942-d.html2005022942 101254609 edited by Anthony D. Redmond ... [et al.]. col. ill. ; 30 cm. Includes bibliographical references and index. Humanitarian assistance : standards, skills, training, and experience / Marion Birch, Simon Miller -- Natural disasters / Anthony D. Redmond -- Needs assessment of humanitarian crises / Anthony D. Redmond -- Public health in the aftermath of disasters / Eric K. Noji -- Military approach to medical planning in humanitarian operations / Martin C.M. Bricknell, Tracey MacCormack -- Principles of war surgery / Steve J. Mannion, Eddie Chaloner -- The special needs of children and women / John Seaman, Sarah Maguire -- Displaced populations and long term humanitarian assistance / Maria Kett -- Psychological aspects of providing medical humanitarian aid / Ian Palmer -- Conflict recovery and intervening in hospitals / James M. Ryan, Peter F. Mahoney, Cara Macnab -- Approaches to conflict resolution / Ewan W. Anderson -- Weapons of mass destruction : threats and responses / Christine Gosden, Derek Gardener.0727917269 978072791726314069604<Jefferson or Adams Building Reading Rooms RA645.5; .A22 2006|?Grey, Joseph E. Harding, K. G.2006ABC of wound healingv, 50 p.Malden, Mass. ; OxfordBMJ/Blackwell Pub.Wound healing Handbooks, manuals, etc. Wounds and injuries Treatment Handbooks, manuals, etc. Wounds and Injuries therapy Handbooks. Ulcer therapy Handbooks. Wound Healing physiology Handbooks. Wounds and Injuries diagnosis Handbooks.http://www.loc.gov/catdir/toc/ecip0613/2006013655.html http://www.loc.gov/catdir/enhancements/fy0802/2006013655-b.html http://www.loc.gov/catdir/enhancements/fy0802/2006013655-d.html http://www.e-streams.com/es1002/es1002_4561.html2006013655 101274943 edited by Joseph E. Grey and Keith G. Harding. ill. (chiefly col.) ; 30 cm. Includes bibliographical references and index. Wound assessment / Joseph E. Grey, Stuart Enoch, Keith G. Harding -- Venous and arterial leg ulcers / Joseph E. Grey, Stuart Enoch, Keith G. Harding -- Diabetic foot ulcers / Michael E. Edmonds, A.V.M. Foster -- Pressure ulcers / Joseph E. Grey, Stuart Enoch, Keith G. Harding -- Traumatic and surgical wounds / David J. Leaper, Keith G. Harding -- Uncommon causes of ulceration / Girish K. Patel, Joseph E. Grey, Keith G. Harding -- Burns / Alex Benson, William A. Dickson, Dean E. Boyce -- Reconstructive surgery / Dean E. Boyce, Kayvan Shokrollahi -- Wound dressings / Vanessa Jones, Joseph E. Grey, Keith G. Harding -- Infections / Brendan Healy, Andrew Freedman -- Non-surgical and drug treatments / Stuart Enoch, Joseph E. Grey, Keith G. Harding -- Recent advances and emerging treatments / Stuart Enoch, Joseph E. Grey, Keith G. Harding.29780727916952 (alk. paper) 0727916955 (alk. paper)143540369Jefferson or Adams Building Reading Rooms RD94; .A23 20068|?$Goldman, Mitchel P. Weiss, Robert A.2006+Advanced techniques in dermatologic surgery xvi, 398 p.Basic and clinical dermatology35New YorkTaylor & FrancisSkin Surgery. Lasers in surgery. Skin Diseases surgery. Cosmetic Techniques. Laser Surgery methods. Reconstructive Surgical Procedures methods.?http://www.loc.gov/catdir/enhancements/fy0648/2005052954-d.html2005052954 101256419 edited by Mitchel P. Goldman, Robert A. Weiss ; associate editors, Neil S. Sadick, Alina A.M. Fratila. ill. (chiefly col.) ; 27 cm. + 1 CD-ROM (4 3/4 in.). Includes bibliographical references and index./0824754050 (Hardcover alk. paper) 978082475405114092472Machine Readable Collections - STORED OFFSITE RD520; .A38 2006 See Reference Staff. By Appt in Jefferson Main RR (MRC) RD520; .A38 2006|?"Fekrat, Sharon Weizer, Jennifer S.2006All about your eyes xvi, 199 p.DurhamDuke University PressEye Diseases. Ophthalmology.6http://www.loc.gov/catdir/toc/ecip0518/2005025674.html2005025674 GBA619492 013392053 Sharon Fekrat and Jennifer S. Weizer, editors. ; foreword by Paul Lee ; illustrations by Stanley M. Coffman. ill. ; 25 cm. Includes bibliographical references and index. 1 Anatomy of the eye and how it works -- 2 Preventive eye care -- 3 Common vision problems -- 4 Options for correcting vision -- 5 Eyelids and eyelashes -- 6 Conjunctiva and sclera -- 7 The cornea -- 8 The lens -- 9 Retina and choroid -- 10 Inflammation of the eyeball -- 11 The optic nerve -- 12 The eye muscles -- 13 The orbit -- 14 Eye injury -- 15 Systemic diseases that affect vision and the eye -- 16 Cosmetic eyelid surgery -- 17 Living with visual impairment.:082233660X (cloth alk. paper) 0822336995 (pbk. alk. paper)140955289Jefferson or Adams Building Reading Rooms RE46; .A44 2006O~?2006Arterial grafting for coronary bypass surgery : a textbook for cardiovascular surgeons, cardiologists, anethesiologists, and researchers New York, NYSpringer2nd"2005935948 [edited by] Guo-Wei HE.14144786O|?"Fowler, Murray E. Mikota, Susan K.2006+Biology, medicine, and surgery of elephants xv, 565 p. Ames, IowaBlackwell Pub.1stAsiatic elephant Diseases. African elephant Diseases. Captive wild animals Diseases Southeast Asia. Captive wild animals Diseases Africa. Veterinary medicine Southeast Asia. Veterinary medicine Africa. Veterinary surgery Southeast Asia. Veterinary surgery Africa.http://www.loc.gov/catdir/toc/ecip067/2006002167.html http://www.loc.gov/catdir/enhancements/fy0802/2006002167-d.html http://www.loc.gov/catdir/enhancements/fy0802/2006002167-b.html2006002167 GBA652876 013486085 [edited by] Murray E. Fowler, Susan K. Mikota. ill. ; 29 cm. Includes bibliographical references and index.20813806763 (alk. paper) 9780813806761 (alk. paper)14236545Jefferson or Adams Building Reading Rooms SF997.5.E4; B56 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE SF997.5.E4; B56 2006|?Ericsson, K. Anders2006:The Cambridge handbook of expertise and expert performance xv, 901 p.Cambridge ; New YorkCambridge University Press6Expertise. Ability. Performance Psychological aspects.http://www.loc.gov/catdir/toc/ecip067/2006002825.html http://www.loc.gov/catdir/enhancements/fy0633/2006002825-d.html http://www.loc.gov/catdir/enhancements/fy0733/2006002825-b.html2006002825 GBA625162 013408791 edited by K. Anders Ericsson ... [et al.]. ill. ; 27 cm. Includes bibliographical references and indexes. Introduction and perspective -- An introduction to Cambridge handbook of expertise and expert performance : its development, organization, and content / K. Anders Ericsson -- Two approaches to the study of experts' characteristics / Michelene T.H. Chi -- Expertise, talent, and social encouragement / Earl Hunt -- Overview of approaches to the study of expertise : brief historical accounts of theories and methods -- Studies of expertise from psychological perspectives / Paul J. Feltovich, Michael J. Prietula & K. Anders Ericsson -- Educators and expertise : a brief history of theories and models / Ray J. Amirault & Robert K. Branson -- Expert systems : a perspective from computer science / Bruce G. Buchanan, Randall Davis, & Edward A. Feigenbaum -- Professionalization, scientific expertise, and elitism : a sociological perspective / Julia Evetts, Harald A. Mieg, & Ulrike Felt -- Methods for studying the structure of expertise -- Observation of work practices in natural settings / William J. Clancey -- Methods for studying the structure of expertise : psychometric approaches / Philip I. Ackerman and Margaret E. Beier -- Laboratory methods for assessing experts' and novices' knowledge / Michelene T.H. Chi -- Task analysis / Jan Maarten Schraagen -- Eliciting and representing the knowledge of experts / Robert R. Hoffman and Gavan Lintern -- Protocol analysis and expert thought : concurrent verbalizations of thinking during experts' performance on representative tasks / K. Anders Ericsson -- Simulation for performance and training / Paul Ward, A. Mark Williams & Peter A. Hancock -- Methods for studying the acquisition and maintenance of expertise -- Laboratory studies of training, skill acquisition, and retention of performance / Robert W. Proctor & Kim-Phuon L. Vu -- Retrospective interviews in the study of expertise and expert performance / Lauren A. Sosniak -- Time budgets, diaries and analyses of concurrent practice activities / Janice M. Deakin, Jean Cote & Andrew S. Harvey -- Historiometric methods / Dean Keith Simonton -- Professional domains / Robert Hoffman -- Expertise in medicine and surgery / Geoff Norman ... [et al.] -- Expertise and transportation / Francis T. Durso & Andrew R. Dattel -- Expertise in software design / Sabine Sonnentag, Cornelia Niessen & Judith Volmer -- Professional writing expertise / Ronald T. Kellogg -- Professional judgments and "naturalistic decision making" / Karol G. Ross, Jennifer L. Shafer, & Gary Klein -- Decision making expertise / J. Frank Yates & Michael D. Tschirhart -- The making of a dream team : when expert teams do best / Eduardo Salas ... [et al.] -- Arts, sports & motor skills -- Music / Andreas C. Lehmann & Hans Gruber -- Expert performance in sport : a cognitive perspective / Nicola J. Hodges, Janet I. Starkes & Clare MacMahon -- Artistic performance : acting, ballet, and contemporary dance / Helga Noice & Tony Noice -- Perceptual-motor expertise / David A. Rosenbaum ... [et al.] -- Games and other types of expertise -- Expertise in chess / Fernand Gobet & Neil Charness -- Exceptional memory / John M. Wilding & Elizabeth R. Valentine -- Mathematical expertise / Brian Butterworth -- Expertise in history / Jim F. Voss & Jennifer Wiley -- Generalizable mechanisms mediating expertise and general issues -- A merging theory of expertise and intelligence / John Horn & Hiromi Masunaga -- Tacit knowledge, practical intelligence and expertise / Anna T. Cianciolo ... [et al.] -- Expertise and situation awareness / Mica R. Endsley -- Brain changes in the development of expertise : neuroanatomical and neurophysiological evidence about skill-based adaptations / Nicole M. Hill & Walter Schneider -- The influence of experience and deliberate practice on the development of superior expert performance / K. Anders Ericsson -- Development and adaptation of expertise : the role of self-regulatory processes and beliefs / Barry J. Zimmerman -- Aging and expertise / Ralf Th. Krampe & Neil Charness -- Social and sociological factors in the development of expertise / Harald A. Mieg -- Mode of expertise in creative thinking : evidence from case studies / Robert W. Weisberg.D052184097X (hardcover) 0521600812 (pbk.) 9780521840972 978052160081114246950=Jefferson or Adams Building Reading Rooms BF431; .C26835 2006O|?Scholefield, John H.2006Challenges in colorectal cancerp. Malden, Mass.Blackwell Pub.2ndXColon (Anatomy) Cancer. Rectum Cancer. Colorectal Neoplasms therapy. Colorectal Surgery.http://www.loc.gov/catdir/toc/ecip066/2006000979.html http://www.loc.gov/catdir/enhancements/fy0802/2006000979-b.html http://www.loc.gov/catdir/enhancements/fy0802/2006000979-d.html 2006000979 edited by John H. Scholefield ... [et al.]. cm. Includes index. Does lifestyle cause colorectal cancer? / Richard Nelson -- Screening for colorectal cancer: who, when and how? / Robert Steele -- What can the pathologist tell the multidisciplinary team about rectal cancer resection? / Phil Quirke -- Surgical hot topic: MRI-directed rectal cancer surgery / Brendan Moran, John H. Scholefield -- Minimally invasive surgery: where are we? Laparoscopic surgery for cancer of the colon and rectum / Pierre Guillou -- Minimally invasive surgery: where are we? Is there a role for TEM? / Theodore Saclarides -- What is the best strategy for the management of hereditary colorectal cancer? / Seung-Yong Jeong ... [et al.] -- Adjuvant radiotherapy and chemoradiotherapy in the treatment of rectal cancer / Rachel Cooper, David Sebag-Montefiore -- What is the right adjuvant therapy in colorectal cancer? / George Kim -- The role of the multidisciplinary team and the colorectal nurse specialist / Jill Dean -- The role of the multidisciplinary team in the management of colorectal cancer / Julia Jessop, Ian Daniels -- Follow-up after colorectal cancer resection: is it worthwhile? / John Northover, Chris Byrne -- Chemotherapy for advanced colorectal cancer / Axel Grothey -- Surgery for metastatic disease in colorectal cancer / Timothy G. John, Myrddin Rees -- Palliative care of the colorectal cancer patient / Ilora Finlay, Melanie Jefferson -- Future directions in the treatment of colorectal cancer / Heinz-Josef Lenz, Anthony El-Khoueiry.29781405127066 (alk. paper) 1405127066 (alk. paper)14233631|?Stockley, Robert A.2006%Chronic obstructive pulmonary diseasep. Malden, Mass.Blackwell Pub.DLungs Diseases, Obstructive. Pulmonary Disease, Chronic Obstructive.http://www.loc.gov/catdir/toc/ecip0511/2005012341.html http://www.loc.gov/catdir/enhancements/fy0802/2005012341-b.html http://www.loc.gov/catdir/enhancements/fy0802/2005012341-d.html2005012341 [edited by] Robert Stockley ... [et al.]. cm. Includes bibliographical references and index. Structure-function relationships: the pathology of airflow obstructions / Dennis Niewoehner -- The physiology of breathlessness / Donald Mahler -- The physiology of muscle / Ghislaine Gayan-Ramirez and Marc Decramer -- The physiology of exercise / Idelle Weisman -- Clinical assessment of control breathing / Joseph Milic-Emili and Antonia Koutsoukou -- The physiology of the vasculature / Norbert Voelkel -- Sleep in patients with COPD / Mark Elliott -- The phsyiology of cough / Bradley Undem and Mark Kollarick -- The physiology of gas exchange / Robert Rodriguez-Roisin -- The natural history of COPD / Jørgen Vestbo -- Cystic fibrosis / Mike Knowles and Marcus Kennedy -- Bronchiectasis and COPD / Robert Wilson -- Obliterative bronchiolitis / Marshall Hertz -- Asthma / Diana Grootendorst -- COPD: clinical presentation and evaluation / Bartolome Celli -- Monitoring and outcomes / Paul Jones -- Mucociliary clearance / Souheil El-Chemaly, Adam Wanner and Matthias Salathe -- Mucosal immunity, systemic immunity and its relationship to mucosal immunity / Yves Sibille -- COPD and pulmonary surfactant / C. Seifart and B. Muller -- The macrophage and its role in the pathogenesis of COPD / Jordan Metcalf -- Eosinophils and COPD / A. Wardlaw -- Airways epithelial defence, repair, and regeneration / Christelle Coraux ... [et al.] -- Neutrophil / Robert Stockley and Ian Woodhouse -- Lymphocytes / Marine Saetta -- Cytokines / Jack Elias and Robert Homer -- Echosinoides / Sven Eric Dahlen -- COPD and the vascular endothelium / Joe Garcia, David Marine and Stephanie Nonas -- Mesenchymal cells / Stephen Rennard -- Lung development / David Warburton, Cheng Chen, and Wei Shi -- Animal models / Piero Martorana ... [et al.] -- Proteinases and COPD / Anita Sullivan and Robert Stockley -- Oxidants / William MacNee -- Cigarette smoke / Stephen Rennard -- Pollution / Ken Donaldson -- Viruses in COPD / Sam Hibbitts and Colin Gelder -- Bacteria / Sanjay Sethi -- Genetic factors / Craig Hersh and Edwin Silverman -- Alpha 1-antitrypsin deficiency / Loutfi S. Aboussouan and James K. Stoller -- Body weight and systemic effects / Emile F.M. Wouters -- Lung connective tissue / Sarah Dunsmore and Geoffrey Laurent -- Aerosols and delivery systems / Stephen Newman -- Gastroesophageal reflux disease (GERD) / John DiBaise -- Upper airway diseases / Richard deShazo and Maria Rappai -- Acute pulmonary embolism / Victor Tapson -- Cancer / Stephen Spiro -- Infection management and airflow obstruction / Alan Fein, Jill Karpel, Antonio Anzueto -- Mechanical ventilation for exacerbation of COPD / Andrea Rossi -- Comorbidity / Robert Stockely -- Primary care / Daryl Freeman and David Price -- Pulmonary rehabilitation / Richard ZuWallack -- Social support / Robin Stevenson -- Long term invasive mechanical ventilation / Gerard Criner -- Smoking cessation / Phillip Tonnesen -- Oxygen therapy in COPD / Brian Tiep and Rick Carter -- Surgery (LVRS) / Fernando Martinez -- Anti-cholinergics / Ted Witek Jr. -- Beta2-agonists / Malcolm Johnson -- Corticosteroids / Olaf Selroos -- Phosphodiesterase 4 inhibitors in the treatment of COPD / Hermann Tenor ... [et al.] -- Antibiotic therapy in patients with COPD / Michael Niederman -- Antioxidants / Claudio Donner -- Mucolytics for COPD / Duncan Rogers and Bruce Rubin -- End-of-life and palliative care of patients with COPD / John Heffner -- Economic burden of COPD / David Au and Sean Sullivan -- Pharmacoepidemiology of COPD / Joan Soriano -- Behavioural aspects of COPD / Sue Hurd and Claude Lenrant -- Guidelines / Peter Calvery -- Protease inhibitors / Philip Davies, Malcolm MacCross, and Richard Mumford -- Retinoids / Steve Tudhope -- Chemokines in COPD / Peter Barnes.9781405122894 140512289713946376|?-Irving, Peter Rampton, David Shanahan, Fergus2006/Clinical dilemmas in inflammatory bowel diseasep. Malden, Mass.Blackwell Pub. LtdIInflammatory bowel diseases. Inflammatory bowel diseases Decision making.http://www.loc.gov/catdir/toc/ecip063/2005032519.html http://www.loc.gov/catdir/enhancements/fy0802/2005032519-d.html http://www.loc.gov/catdir/enhancements/fy0802/2005032519-b.html2005032519 edited by Peter Irving, David Rampton, Fergus Shanahan. cm. Includes bibliographical references and index. Capsule endoscopy: do we need it? / Joel Mawdsley & Mark Appleyard -- Pathology reports - pitfalls for the unwary / Wilfred Weinstein -- Non-invasive diagnosis and assessment / A J Di Mambro, A Terlevich, & C Probert -- What is the best way to image pelvic CD? / Vikram Sahni & Alison McLean -- Surveillance colonoscopy in Ulcerative Colitis: alternatives and ways to improve outcome / Mark Lust & William Connell -- Abnormal liver tests - what should we do? / A Suddle & Richard Marley -- Is monitoring necessary? / Rakesh Shah & Alastair Forbes -- Do they have a role in Crohn's disease? / Brian Feagan -- Is the use of steroids for Crohn's disease obsolete? / David Rampton -- Antibiotics: which, when and for how long? / A Kent & Jean-Frédéric Colombel -- Mycobacterium avium paratuberculosis (map) in Chrohn's disease: player or spectator? / Geoff Smith & Fergus Shanahan -- Tpmt testing: is it essential? / Azhar Ansari & Jeremy Sanderson -- 6-mercaptopurine or azathioprine / Dermot McGovern & Simon Travis -- Thiopurines: how long should we use them for / Alexandra Daley & Marc Lemann -- Ciclosporin: balancing risk and benefit? / Helena Deeney & Barney Hawthorne -- Contraindications - absolute or relative? / Rakesh Chaudhary & S Ghosh. How can we prevent TB? / Sasha Beresford & David Rampton -- Dealing with infusion reactions / Gert Van Assche & Paul Rutgeerts -- Use in UC / Sreedhar Subramanian & Jon Rhodes -- Infliximab and surgery - health or hazard? / David Rampton -- Nutritional therapy for Chron's disease: is it for adults / Donald Duerksen & Charles Bernstein -- Trials and tribulations - interpreting clinical trials in IBD / Elizabeth Carty & David Rampton -- Genetics - clinical therapeutic applications / Mark Tremelling & Miles Parkes -- Probiotics: separating science from snakeoil / John Keohane & Fergus Shanahan -- Worms / David Grunkemeier & R. Balfour Sartor -- Smoking and nicotine - poison for Crohn's, potion for colitis / Brian Bressler & A. Hilary Steinhart -- Heparin / Ailsa Hart & Stuart Bloom -- Leukocytapheresis / Peter Irving & David Rampton -- Appendicectomy for Ulcerative Colitis / Richard Makins & Graham Radford-Smith -- Biologic treatments in inflammatory bowel disease / Raymond D'Souza & James Lindsay -- Stem cells for inflammatory bowel disease / Paul Fortun & Chris Hawkey -- Complementary and alternative therapy - the way forward or a step back? / L Langmead & David Rampton -- Functional problems in inflammatory bowel disease / Eamon Quigley -- Psychological stress: something to worry about? / J Mawdsley & David Rampton -- Drugs to avoid / Paul Collins & Jonathan Rhodes -- Nsaids and cox-2 selective agents: cause or cure of pain in IBD? / David Scott & Ingvar Bjarnasson -- Iron replacement - is it safe and effective? / Stefanie Kulnigg & Christoph Gasche -- Hepatitis B and C viruses - how do they affect management of IBD? / Alick Nkhoma & Graham Foster -- Pregnancy: what can we use? / Thea Thomas & Elspeth Alstead -- How to prevent growth failure in children / Jutta Köglmeier & Nick Croft -- Predicting outcomes in severe UC, -- Simon travis. Ulcerative Colitis: CMV co-infection - does it matter? / Daan Hommes -- Treatment of oral Chrohn's disease / Carlo Nunes & Jeremy Sanderson -- Pathophysiologic approach to tratment of diarrhoea in Chrohn's disease / Henry Binder -- Short bowel / Jeremy Nightingale -- Management of internal fistulae / David Rampton -- What is indeterminate colitis? / Garret Cullen & Diarmuid O'Donoghue -- Pouches for indeterminate colitis?, -- Laura hancock & neil mortensen -- Colitis-associated cancer: what's the risk to your patients?, -- Jayne eaden -- What to do with dysplasia, DALMs and adenomas / Matt Rutter -- Pyoderma gangrenosum / Ana Paula Marinho Cunha & Fernando Veloso -- Arthritides - helping the joints without harming the gut / Horace Williams & Tim Orchard -- Sclerosing cholangitis - what to do? / SN Cullen & Roger Chapman -- Thromboembolic disease: an under-recognised complication? / Peter Irving & Fergus Shanahan -- Pulmonary manifestations: rare but real / Peter Irving -- Intestinal infections: mimics and precipitants of relapse / Sunil Samuel & Y Mahida -- Microscopic colitis / Debbie Nathan & Peter Gibson -- Diverticular colitis / Linmarie Ludeman & Neil Shepherd -- Out-patient services - do doctors still have a role? / Mark Kelly & Andrew Robinson -- Shared care: tactical team selection / RC Rakshit & John Mayberry -- Databases - are they worth the bother? / Stephen Grainger.9781405133777 140513377514167175 |? Stern, Yaakov2006+Cognitive reserve : theory and applicationsp.4Studies on neuropsychology, neurology, and cognitionNew YorkTaylor and FrancisCognition disorders Diagnosis. Neuropsychology. Aging physiology. Alzheimer Disease diagnosis. Brain physiology. Brain Injuries physiopathology. Cognition physiology. Neuropsychological Tests.2006016532 edited by Yaakov Stern. cm. Includes bibliographical references and index. The concept of cognitive reserve: a catalyst for research / Yaakov Stern -- Understanding cognitive reserve through genetics and genetic epidemiology / Joseph H. Lee -- Lifetime antecedents of cognitive reserve / Marcus Richards, Amanda Sacker, & Ian J. Deary -- Brain reserve capacity, cognitive reserve capacity, and age-based functional plasticity after congenital and acquired brain injury in children / Maureen Dennis ... [et al.] -- Traumatic brain injury and cognitive reserve / Erin D. Bigler -- Electroconvulsive therapy and coronary artery bypass grafting surgery: pseudoexperimental paradigms for studying cognitive reserve / Patricia A. Boyle, Susan A. Legendre Ropacki, Robert A. Stern -- The impact of cognitive reserve on neuropsychological measures in clinical trials / Linas A. Bieliauskas & Ami Antonucci -- Association between early life physical activity and late-life cognition: evidence for cognitive reserve / Miranda G. Dik ... [et al.] -- Assessment of lifetime participation in cognitively stimulating activities / Robert S. Wilson, Lisa L. Barnes, David A. Bennett -- Lifestyle activities and late-life changes in cognitive performance / Brent J. Small ... [et al.] -- Lifestyle patterns and cognitive reserve / Nikolaos Scarmeas -- Brain reserve: HIV morbidity and mortality / M.J Reinhard ... [et al.] -- Literacy and cognitive decline among ethnically diverse elders / Jennifer J. Manly ... [et al.] -- Brain reserve and risk of dementia: findings from the nun study / James A. Mortimer, David A. Snowdon, & William R. Markesbery -- Imaging cognitive reserve / Yaakov Stern -- Cognitive reserve in healthy aging and Alzheimer disease: evidence for compensatory reorganization of brain networks / Cheryl L. Grady -- A neurocognitive overview of aging phenomena based on the event-related brain potential (ERP) / David Friedman -- Adult neurogenesis and regeneration in the brain / Yevgenia Kozorovitskiy and Elizabeth Gould.F9781841694740 (hardcover alk. paper) 1841694746 (hardcover alk. paper)14393840|?Bain, Steve Gupta, Janesh Kumar2006HCore clinical cases in medicine and surgery : a problem-solving approach xvi, 336 p.Core clinical casesLondon New YorkAHodder Arnold ; Distributed in the USA by Oxford University PressClinical medicine Examinations Study guides. Clinical medicine Problems, exercises, etc. Surgery Examinations Study guides. Surgery Problems, exercises, etc.z2006280317 GBA500656 013074079 edited by Steve Bain, Janesh K. Gupta. Cases in medicine and surgery 25 cm. Includes index.&9780340816707 (pbk.) 0340816708 (pbk.)144867999Jefferson or Adams Building Reading Rooms RC46; .C67 2006G|?Goldman, Mitchel P.2006$Cutaneous and cosmetic laser surgery xii, 387 p. PhiladelphiaMosby ElsevieruSkin Surgery. Surgery, Plastic. Lasers in surgery. Laser Surgery methods. Reconstructive Surgical Procedures methods.2005056104 GBA603853 101260817 013354199 edited by Mitchel P. Goldman. col. ill. ; 29 cm. + 1 DVD-ROM (4 3/4 in.) Includes bibliographical references and index. System requirements for accompanying DVD-ROM: Windows and Macintosh.0323033121 978032303312114141855?Machine Readable Collections - STORED OFFSITE RD520; .C884 20068O|?#Clavien, Pierre-Alain Baillie, John2006DDiseases of the gallbladder and bile ducts : diagnosis and treatmentp. Malden, Mass.Blackwell Pub.2ndGallbladder Diseases. Bile ducts Diseases. Gallbladder Diseases diagnosis. Bile Duct Diseases diagnosis. Bile Duct Diseases therapy. Gallbladder Diseases therapy.http://www.loc.gov/catdir/toc/ecip066/2006000956.html http://www.loc.gov/catdir/enhancements/fy0802/2006000956-b.html http://www.loc.gov/catdir/enhancements/fy0802/2006000956-d.html2006000956 edited by Pierre-Alain Clavien, John Baillie ; associate editors, Michael A. Morse, Markus Selzner. cm. Includes bibliographical references and index. Anatomy and physiology of the biliary tree and gallbladder -- Pathology of the intra- and extrahepatic bile ducts and gallbladder -- Epidemiology of diseases of the bile ducts and the gallbladder -- Noninvasive imaging of the biliary system -- Endoscopic diagnosis and treatment of the bile ducts and the gallbladder -- Percutaneous diagnosis and treatment of disease of the biliary system -- Radiation therapy for disease of the biliary tree and gallbladder -- Surgery of the biliary system -- Laparoscopic treatment for diseases of the gallbladder and the biliary tree -- Laparoscopic bile duct injuries -- Medical and innovative therapies for biliary malignancies -- Natural history and pathogenesis of gallstones -- Acute and chronic cholecystitis -- Biliary fistula, gallstone ileus, and Mirizzi's syndrome -- Benign and malignant gallbladder tumors -- Acute cholangitis -- Cystic diseases of the biliary system -- Biliary complications of liver transplantation -- Primary sclerosing cholangitis -- Cholangiocarcinoma -- Primary biliary cirrhosis -- Intrahepatic cholestasis -- Biliary disease in infants and children.9781405127400 140512740614229274O|?2006&Eaes guidelines for endoscopic surgeryNew YorkSpringer1st82006923763 [edited by] Neugebauer, Sauerland, Fingerhut. 354032784314296803b|?Corbin, Terry P.2006eEmerging spine surgery technologies : current evidence and framework for evaluation of new technology xix, 611 p.St. Louis, Mo.Quality Medical Pub.Spine Surgery. Spine Surgery Technological innovations. Surgery Technological innovations. Spinal Diseases surgery. Spinal Fusion.6http://www.loc.gov/catdir/toc/ecip0516/2005020539.html{2005020539 edited by Terry P. Corbin ... [et al.]. ill. (some col.) ; 29 cm. Includes bibliographical references and index.1576261387 (hardcover)14047339:Jefferson or Adams Building Reading Rooms RD768; .E44 2006~?Medtech Insight LLC.,2006\European markets for minimally invasive cardiac surgery and intracoronary diagnostic devices1FNewport Beach, CA (23 Corporate Plaza, Suite 125, Newport Beach 92660)Medtech InsightrCardiovascular equipment industry Europe. Market surveys Europe. Heart Endoscopic surgery Economic aspects Europe.n2009285293 ill. ; 28 cm. Cover title. "October 2006." Loose-leaf. "A243." Includes bibliographical references.15609517@Jefferson or Adams Building Reading Rooms HD9995.C363; E853 2006 j|?Møller, Ann Pedersen, Tom2006-Evidence-based anaesthesia and intensive care xii, 399 p.Cambridge, UK ; New YorkCambridge University PressQAnesthesia. Critical care medicine. Evidence-based medicine. Anesthesia services.http://www.loc.gov/catdir/enhancements/fy0707/2007295043-d.html http://www.loc.gov/catdir/enhancements/fy0707/2007295043-t.html http://www.loc.gov/catdir/enhancements/fy0732/2007295043-b.html@2007295043 edited by Ann Møller and Tom Pedersen ; project co-ordinator, Jane Cracknell. Anaesthesia and intensive care ill. ; 25 cm. Also issued as an electronic book. Includes bibliographical references and index. Introducing evidence-based anaesthesia / Ann Møller and Tom Pedersen -- How to define the questions / Ann Møller -- Developing a search strategy, locating studies and electronic databases / Tom Pedersen -- Retrieving the data / John Carlisle -- Critical appraisal and presentation of study details / Helen Handoll -- Outcomes / Ann Møller -- The meta-analysis of a systematic review / Nathan Pace -- Bias in systematic reviews : considerations when updating your knowledge / Harald Herkner -- The Cochrane Collaboration and the Cochrane Anaesthesia Review Group / Tom Pedersen and Ann Møller -- Integrating clinical practice and evidence : how to learn and teach evidence-based medicine / Steven Knight and Andrew Smith -- Involving patients and consumers in health care and decision-making processes : nothing about us without us / Nete Villebro and Janet Wale -- Evidence-based medicine in the Third World / Ruth Hutchinson -- Preoperative anaesthesia evaluation / Maurizio Solca -- Regional anaesthesia versus general anaesthesia / Mina Nishimori and Jane Ballantyne -- Fluid therapy / Peter Choi and J. Mark Ansermino -- Antiemetics / John Carlisle -- Anaesthesia for day-case surgery / Kevin Walker and Andrew Smith -- Obstetrical anaesthesia / Stephen Halpern -- Anaesthesia for major abdominal and urological surgery / Paul Myles and Kate Leslie -- Anaesthesia for paediatric surgery / Neil S. Morton -- Anaesthesia for eye, ENT and dental surgery / Mathew Zacharias and Robyn Chirnside -- Anaesthesia for neurosurgery / Divya Chander and Adrian W. Gelb -- Cardiothoracic anaesthesia and critical care / R. Peter Alston -- Postoperative pain therapy / Timothy Canty and Jane Ballantyne -- Critical care medicine / Harald Herkner and Christof Havel -- Emergency medicine : cardiac arrest management, severe burns, near-drowning and multiple trauma / Stephen Priestley and Michael Ragg.0521690250 (pbk.) 978052169025614695674:Jefferson or Adams Building Reading Rooms RD81; .E857 2006 X|?4Cohen, Adam J. Brazzo, Brian G. Mercandetti, Michael20068The lacrimal system : diagnosis, management, and surgery xx, 281 p.New YorkSpringerLacrimal apparatus Surgery. Lacrimal apparatus Diseases Genetic aspects. Lacrimal apparatus Diseases Laser surgery. Lacrimal apparatus Laser surgery. Lacrimal Apparatus Diseases surgery Lacrimal Apparatus Diseases diagnosishttp://www.loc.gov/catdir/enhancements/fy0818/2005938668-d.html http://www.loc.gov/catdir/enhancements/fy0818/2005938668-t.html 2005938668 975908359 edited by Adam J. Cohen, Michael Mercandetti, Brian G. Brazzo. ill. ; 26 cm. Includes bibliographical references and index. Anatomy of the lacrimal system / Cat N. Burkat and Mark J. Lucarelli -- Gender and racial variations of the lacrimal system / Susan R. Carter and Roberta E. Gausas -- Nasal anatomy and evaluation / Joseph P. Mirante -- Congenital etiologies of lacrimal system obstructions / William R. Katowitz and James A. Katowitz -- Acquired etiologies of lacrimal system obstructions / Daniel P. Schaefer -- Evaluation of the tearing patient / Joshua Amato and Morris E. Hartstein -- Imaging and clinical evaluation of the lacrimal drainage system / Jonathan J. Dutton and Jeffrey J. White -- The tear-deficient patient / Michael A. Lemp -- Surgery of the punctum and canaliculus / Jennifer S. Landy, Charles B. Slonim, and Jay Justin Older -- Lacrimal trauma / Harry Marshak and Steven C. Dresner -- Primary external dacryocystorhinostomy / Richard H. Hart, Suzanne Powrie, and Geoffrey E. Rose -- Primary endonasal dacryocystorhinostomy / Francois Codere and David W. Rossman -- Transcanalicular dacryocystorhinostomy / Hans-Werner Meyer-Rüsenberg and Karl-Heinz Emmerich -- Conjunctivodacryocystorhinostomy / Jan Lei Iwata, Robert A. Weiss, and Michael Mercandetti -- Endoscopic conjunctivodacryocystorhinostomy / Geoffrey J. Gladstone and Brian G. Brazzo -- Pediatric balloon catheter dacryocystoplasty / Bruce B. Becker -- Balloon-assisted dacryoplasty in adults / John Pak and Mark T. Duffy -- Balloon-assisted lacrimal surgery / William L. White, Jerry K. Popham, and Robert G. Fante -- Nine-millimeter endoscopic balloon dacryocystorhinostomy: a new, less-invasive procedure for tearing in adults / David I. Silbert -- Radiofrequency dacryocystorhinostomy / Reynaldo M. Javate, Susan Irene E. Lapid-Lim, and Ferdinand G. Pamintuan -- Powered endoscopic dacryocystorhinostomy / Peter John Wormald and Angelo Tsirbas -- Laser dacryocystorhinostomy: part 1. laser-assisted endonasal endoscopic dacryocystorhinostomy / Michael Mercandetti -- Laser dacryocystorhinostomy: part 2. laser-assisted endonasal endoscopic dacryocystorhinostomy with the holmium:YAG laser / Ajay Tripathi and Niall P. O'Donnell -- Laser dacryocystorhinostomy: part 3. laser-assisted endonasal endoscopic dacryocystorhinostomy with the potassium titanyl phosphate laser / Showkat Mirza, Andrew K. Robson, and Marco Carvessacio -- Revision dacryocystorhinostomy / Adam J. Cohen, F. Campbell Waldrop, and David A. Weinberg -- The adjunctive use of mitomycin C in dacryocystorhinostomy / Jorge G. Camara, Mary Ann Yasay-Luis, and Irene D. Enriquez -- The Griffiths nasolacrimal catheter / John D. Griffiths -- The Sisler lacrimal canalicular trephine / Hampson A. Sisler.!0387253858 (hd.bd.) 978038725385514199685:Jefferson or Adams Building Reading Rooms RE201; .L43 2006O|?2006eLiver and biliary tract surgery : from embryolobical anatomy to 3D-imaging and transplant innovationsNew YorkSpringer1sthttp://www.loc.gov/catdir/enhancements/fy0814/2006937725-t.html http://www.loc.gov/catdir/enhancements/fy0825/2006937725-b.html http://www.loc.gov/catdir/enhancements/fy0825/2006937725-d.html=2006937725 [edited by] C. Karaliotas, Ch. Broelsch, N. Habib.!3211492755 (hardcover alk. paper)14617814 |?2006<Master skills : wrist & elbow arthroscopy and reconstruction Rosemont, IL(American Society for Surgery of the HandU2006930884 American Society for Surgery of the Hand ; [edited by] Thomas Trumble, MD.0974001821 (hardcover)14447590 ~|?Wyszynski, Diego F.2006.Neural tube defects : from origin to treatment xvii, 399 p.Oxford ; New York, NYOxford University Press/Neural tube Abnormalities. Neural Tube Defects.uhttp://www.loc.gov/catdir/toc/ecip055/2004029477.html http://www.loc.gov/catdir/enhancements/fy0637/2004029477-d.html 2004029477 edited by Diego F. Wyszynski. ill. ; 29 cm. Includes bibliographical references and index. Neural crest formation / Marianne Bronner-Fraser -- The embryonic basis of neural tube defects / Nicholas D.E. Greene, Andrew J. Copp -- The zebrafish as a model for analyzing neural tube defects / Hakryul Jo ... [et al.] -- Genetic regulation of early nervous system development / Ellen M. Carpenter -- Physical examination of the spine / Sergio A. Mendoza, Stuart L. Weinstein -- Classification of neural tube defects / Cynthia A. Moore -- Syndromes with neural tube defects / Laurie H. Seaver, Roger E. Stevenson -- The tethered cord syndrome / Cary R. Templin, John F. Sarwark -- Prenatal screening and diagnosis of neural tube defects / Glenn J. Gardener, Charles H. Rodeck -- Methodological issues in the study of neural tube defects / Russell S. Kirby -- Birth defects surveillance systems and neural tube defects / Lowell E. Sever -- An international perspective on anencephaly and spina bifida : prevalences by the turn of the century / Rolv T. Lie -- Studies on environmental factors in neural tube defects / Diego F. Wyszynski -- Non-syndromic neural tube defects : genetic basis and genetic investigations / Evadnie Rampersaud, Elizabeth C. Melvin, Marcy C. Speer -- Genetic risk factors for neural tube defects: variants in folate metabolism / Rima Rozen -- Genetics of syndromic neural tube defects / Sonja A. Rasmussen, Jaime L. Fras -- Mouse mutants as models of neural tube defects / Andrew J. Copp, Nicholas D. E. Greene, Jennifer N. Murdoch -- Fetal surgery for myelomeningocele / Kelly A. Bennett ... [et al.] -- Postnatal surgery for myelomeningocele / Jonathan P. Miller, Alan R. Cohen -- Neurosurgical management of adults with spina bifida / Harold L. Rekate -- Orthopedic surgery / Luciano Dias -- Urological needs of patients with neural tube defects / David B. Joseph -- Cognition, education, and learning disorders / Gregory S. Liptak -- Transition to adulthood / Gregory S. Liptak -- Transition, sex, and toilet training / David B. Shurtleff, William Walker, Carole Sobkowiak -- Psychological adjustment and family relationships in children and adolescents with spina bifida / Rachel Neff Greenley ... [et al.] -- When and how to communicate to people with spina bifida and their families / Sonya G. Oppenheimer -- Genetic counseling and interpretation of risk figures / Robert A. Saul -- Preventing all folic acid-preventable spina bifida / Godfrey P. Oakley Jr. -- The half-life of cost-of-illness estimates : the case of spina bifida / Norman J. Waitzman, Patrick S. Romano, Scott D. Grosse -- Insurance and coverage of care for individuals with spina bifida and other neural tube defects / Holly Grason, Jamie J. Perry -- Assessment of health-related quality of life in individuals with neural tube defects / Jim Stevenson, Ineke M. Pit-ten Cate -- Ethics at the forefront : moral decisions and responsibility when confronted with spina bifida / Mark J. Bliton.29780195166033 (alk. paper) 0195166035 (alk. paper)13814690>Jefferson or Adams Building Reading Rooms QM695.N45; N494 2006JO|?Evans, Randolph W.2006Neurology and trauma xix, 802 p.New YorkOxford University Press2ndNervous system Wounds and injuries. Central nervous system Wounds and injuries. Trauma, Nervous System complications. Trauma, Nervous System diagnosis. Trauma, Nervous System therapy. Iatrogenic Disease prevention & control.vhttp://www.loc.gov/catdir/toc/ecip0515/2005018932.html http://www.loc.gov/catdir/enhancements/fy0636/2005018932-d.html 2005018932 101251566 [edited by] Randolph W. Evans. ill. ; 26 cm. Includes bibliographical references and index. Epidemiology of brain injury / Jess F. Kraus and David L. McArthur -- The history of cerebral trauma / F. Clifford Rose -- Computerized tomography and magnetic resonance imaging in traumatic brain injury / Chi-Shing Zee ... [et al.] -- The neuropathology of trauma / David I. Graham ... [et al.] -- The postconcussion syndrome and the sequelae of mild head injury / Randolph W. Evans -- Posttraumatic cranial neuropathies / James R. Keane and Robert W. Baloh -- Posttraumatic epilepsy / L. James Willmore -- Traumatic intracranial hemorrhage / Joshua M. Ammerman, S. Taylor Jarrell, and Richard S. Polin -- Neurovascular trauma / Anil Nanda ... [et al.] -- Medical complications of head injury / Joseph Voelker and Alison M. Wilson -- Neurobehavioral outcome of head trauma / Daniel X. Capruso and Harvey S. Levin -- Neuropsychological testing alter traumatic brain injury / George P. Prigatano and Susan R. Borgaro -- Cognitive rehabilitation / James F. Malec and Keith D. Cicerone -- Spinal cord injury / David S. Baskin -- Complications of spinal cord injury / Oksana Volshteyn and John W. McDonald -- Low-back pain and sciatica: evaluation and treatment / James F. Howard, Jr. -- Zygapophysial joint trauma / Nikolai Bogduk -- Plexus injuries / Asa J. Wilbourn -- Occupational and use-related mononeuropathies / Timothy M. Miller and Michael J. Aminoff -- Electrodiagnostic studies in the evaluation of peripheral nerve injuries / Bashar Katirji -- Surgery of the injured peripheral nerve and brachial plexus / Shaden Marzouk, H. Bruce Hamilton, and David G. Kline -- Whiplash injuries / Randolph W. Evans -- Myofascial pain disorders / Charles E. Argoff and Anthony H. Wheeler -- Chronic regional pain syndrome I/II / Robert J. Schwartzman and Yakov Vorobeychik -- Epidemiology of sports injuries / Cory Toth -- Athletic head injury / Richard S. Polin and Nidhi Gupta -- Athletic spine injury / S. Taylor Jarrrell ... [et al.] -- High-altitude neurology / Ralf W. Baumgartner -- Neurological injury from undersea diving / E. Wayne Massey -- Lightning injuries / Michael Cherington -- Electrical injuries / Mary Capelli-Schellpfeffer -- Neurology of microgravity and space travel / Mavis D. Fujii -- Movement disorders: posttraumatic syndromes / Christopher G. Goetz and Ilia Itin -- Psychiatric aspects of the neurology of trauma / Harold Merskey -- Posttraumatic infections of the central nervous system / Allan R. Tunkel and Alan R. Turtz -- Functional symptoms and signs in neurology / Jon Stone and Michael Sharpe -- Physical trauma, psychological stress, and multiple sclerosis / Douglas S. Goodin -- The neurologist as expert witness / Michael I. Weintraub -- Complications of lumbar puncture / Randolph W. Evans -- Iatrogenic nerve injuries / Asa J. Wilbourn -- Complications of stereotactic brain surgery / Douglas Kondziolka and L. Dade Lunsford -- Iatrogenic complications of spine surgery / Anil Nanda, Satish Rudrappa, and Prasad Vannemreddy.%0195170326 (alk. paper) 978019517032014022688<Jefferson or Adams Building Reading Rooms RD593; .N4156 2006݄O|?Balwanz, Patti2006SNordie's at noon : the personal stories of four women "too young" for breast cancer xviii, 281 p. Cambridge, MADa Capo Lifelong1st Da Capo PressLBreast Cancer Patients Biography. Breast Cancer Anecdotes. Breast Neoplasms.http://www.loc.gov/catdir/toc/ecip0616/2006021043.html http://www.loc.gov/catdir/enhancements/fy0831/2006021043-b.html http://www.loc.gov/catdir/enhancements/fy0831/2006021043-d.html}2006021043 Patti Balwanz ... [et al.]. 22 cm. Includes bibliographical references (p. 265-271). Help, I have a lump! -- D-day (diagnosis day) -- Choices, choices, choices -- Surgery : and then there was one -- Chemotherapy : bald is beautiful -- A new sense of normal -- Can it happen to me-- again??? -- Relationships and intimacy -- Motherhood -- Two weeks -- Life is still good!F0738210862 (hardcover alk. paper) 9780738210865 (hardcover alk. paper)14429115<Jefferson or Adams Building Reading Rooms RC280.B8; N67 2006O|?#McLatchie, Greg R. Leaper, David J.2006Operative surgery xvi, 866 p.&Oxford specialist handbooks in surgeryOxford ; New YorkOxford University Press2nd+Surgery, Operative Handbooks, manuals, etc.http://www.loc.gov/catdir/enhancements/fy0628/2006297146-t.html http://www.loc.gov/catdir/enhancements/fy0724/2006297146-d.html2006297146 GBA560434 013255514 9780198510567 (pbk.) edited by Greg R. McLatchie and David J. Leaper. Oxford handbook of operative surgery ill. ; 19 cm. Previous ed.: 1996. Includes index.019851056X (pbk.)14585532Jefferson or Adams Building Reading Rooms RD32; .O94 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE RD32; .O94 2006M|?"Kaiser, Larry R. Jamieson, Glyn G.2006Operative thoracic surgery xi, 520 p.Operative surgery[ 7]London New YorkVHodder Arnold ; Distributed in the United States of America by Oxford University Press5th,Thoracic Surgical Procedures. Chest Surgery.?http://www.loc.gov/catdir/enhancements/fy0725/2007272832-d.htmlV2007272832 GBA3Z4653 101287143 006919485 edited by Larry R. Kaiser, Glyn G. Jamieson. ill. (chiefly col.) ; 29 cm. Rev. ed of: Thoracic surgery / edited byJohn W. Jackson and D.K.C. Cooper. London ; Boston : Butterworths, 1986. Includes bibliographical references and index. Thoracic surgery. Rob & Smith's operative surgery (5th ed.) ; v. 7.0340759739 978034075973814799263:Jefferson or Adams Building Reading Rooms RD536; .O64 2006)O|?Wyatt, Jonathan P.2006%Oxford handbook of emergency medicine xv, 743 p.Oxford medical publicationsOxford ; New YorkOxford University Press3rd~Emergency medicine Handbooks, manuals, etc. Emergencies Handbooks. Accidents Handbooks. Emergency Treatment methods Handbooks.6http://www.loc.gov/catdir/toc/ecip0620/2006028514.html(2006028514 Jonathan P. Wyatt ... [et al.]. ill. ; 19 cm. Rev. ed. of: Oxford handbook of accident and emergency medicine. 2nd ed. 2005. Includes bibliographical references and index. General approach -- Life-threatening emergencies -- Medicine -- Poisoning -- Infectious diseases -- Environmental emergencies -- Analgesia and anaesthesia -- Major trauma -- Wounds, fractures, orthopaedics -- Surgery -- Ophthalmology -- Ear, nose and throat -- Obstetrics and gynaecology -- Psychiatry -- Paediatrics. Oxford handbook of accident and emergency medicine.H9780199206070 (flexicover alk. paper) 0199206074 (flexicover alk. paper)14521993;Jefferson or Adams Building Reading Rooms RC86.8; .O94 2006O|?;Stringer, Mark D. Oldham, Keith T. Mouriquand, Pierre D. E.20062Pediatric surgery and urology : long-term outcomes xxiv, 1071 p. CambridgeCambridge University Press2ndChildren Surgery. Pediatric urology. Surgical Procedures, Operative. Child. Infant. Urologic Diseases surgery. Urologic Diseases.http://www.loc.gov/catdir/enhancements/fy0708/2007270775-d.html http://www.loc.gov/catdir/enhancements/fy0708/2007270775-t.html2007270775 GBA636127 013437012 9780521839020 edited by Mark Stringer, Keith T. Oldham, Pierre D.E. Mouriquand. ill., ports., ; 29 cm. Previous ed.: London: W.B. Saunders, 1998. Includes bibliographical references and index.0521839025 978052183902014734537;Jefferson or Adams Building Reading Rooms RD137; .P434 2006>|?)Giannoudis, Peter V. Pape, Hans-Christoph2006JPractical procedures in orthopaedic trauma surgery : a trainee's companion xii, 319 p.Cambridge New York ;Cambridge University PressrOrthopedic surgery. Fractures, Bone surgery Laboratory Manuals. Orthopedic Procedures methods. Laboratory Manuals.http://www.loc.gov/catdir/enhancements/fy0726/2007275602-d.html http://www.loc.gov/catdir/enhancements/fy0726/2007275602-t.html2007275602 GBA655689 101296095 013494754 edited by Peter V. Giannoudis and Hans-Christoph Pape. ill. (chiefly col.) 25 cm. Includes bibliographical references (p. [304]-314) and index.&9780521678599 (pbk.) 0521678595 (pbk.)14859767Jefferson or Adams Building Reading Rooms RD701; .P73 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE RD701; .P73 2006|?-Yehuda, Rachel New York Academy of Sciences.,2006EPsychobiology of posttraumatic stress disorder : a decade of progress xxiv, 549 p.+Annals of the New York Academy of Sciences,1071 Boston, Mass.BBlackwell Publishing on behalf of the New York Academy of SciencesPost-traumatic stress disorder Pathophysiology. Psychobiology. Biological psychiatry. Stress Disorders, Post-Traumatic physiopathology. Risk Factors. Stress Disorders, Post-Traumatic etiology.vhttp://www.loc.gov/catdir/toc/ecip0613/2006015217.html http://www.loc.gov/catdir/enhancements/fy0803/2006015217-d.html2006015217 101276109 edited by Rachel Yehuda. ill. ; 24 cm. Includes bibliographical references and index. Predictors of posttraumatic in police and other first responders / Charles Marmar ... [et al.] -- Longitudinal psychophysiological studies of heart rate : mediating effects and implications for treatment / Richard A. Bryant -- Predicting PTSD prospectively based on prior trauma history, trauma severity, and immediate biologic responses / Douglas L. Delahanty and Nicole R. Nugent -- Separation anxiety as a mediator between acute morphine administration and PTSD symptoms in injured children / Glenn Saxe ... [et al.] -- Efficacy of hydrocortisone in preventing posttraumatic stress disorder following critical illness and major surgery / Gustave Schelling ... [et al.] -- Memory performance in older trauma survivors : implications for the longitudinal course of PTSD / Julia Golier ... [et al.] -- Amygdala, medial prefrontal cortex, and hippocampal function / Lisa M. Shin, Scott L. Rauch, and Roger K. Pitman -- Relationship between cognitive and brain changes in posttraumatic stress disorder / J. Douglas Bremner -- Neuroimaging studies of emotional responses in PTSD / Israel Liberzon and Brian Martis -- Toward a psychobiology of posttraumatic self-dysregulation : reexperiencing, hyperarousal, dissociation, and emotional numbing / Paul A. Frewen and Ruth A. Lanius -- Electrophysiological responses to affective stimuli in American Indians experiencing trauma with and without PTSD / Cindy L . Ehlers ... [et al.] -- Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications / Rachel Yehuda -- Immune function in PTSD / Margaret Altemus ... [et al.] -- Alterations in stress reactivity after long-term treatment with Paroxetine in women with posttraumatic stress disorder / Eric Vermetten ... [et al.] -- Neuroendocrine regulation of sleep disturbance in PTSD / Thomas C. Neylan ... [et al.] -- Glucocorticoid-induced inhibition of memory retrieval : implications for posttraumatic stress disorder / Dominique J.-F de Quervain -- Social context and the psychobiology of posttraumatic stress / Sandra Galea ... [et al.] -- Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure / Roger K. Pitman ... [et al.] -- Developmental epidemiology of PTSD : neurocognitive self-regulation as a key mechanism / Karestan C. Koenen -- Applying biological data in the forensic and policy arenas / Richard J. McNally -- Clinical applications of neuroscience research in PTSD / Bessel A. van der Kolk -- Establishing an agenda for translational research on PTSD / Melinda M. Miller and Bruce S. McEwen -- Neurobiological consequences of early stress and childhood maltreatment : are results from animal and human studies comparable? / Martin Teicher, Akemi Tomoda, and Susan L. Andersen -- Toward an animal model of posttraumatic stress disorder / Anja Siegmund and Carsten T. Wotjak -- The contribution of an animal model toward uncovering biological risk factors for PTSD / Hagit Cohen ... [et al.] -- Glucocorticoid programming and PTSD risk / Jonathan R. Seckl and Michael J. Meaney -- Developing an agenda for translational studies of resilience and vulnerability following trauma exposure / Rachel Yehuda ... [et al.] -- Alexithymia in PTSD ; psychometric and FMRI studies / Paul A. Frewen ... [et al.] -- Neuroimaging of pain perception in Dutch veterans with and without posttraumatic stress disorder : preliminary results / Elbert Geuze ... [et al.] -- The relationship between the hippocampal volume and declarative memory in a population of combat veterans with and without PTSD / Lisa Tischler ... [et al.]>1573316199 (alk. paper) 9781573316194 (alk. paper) 0077-8923 ;14374534>Jefferson or Adams Building Reading Rooms RC552.P67; P759 2006|?Parker, Evelyn L.2006OThe sacred selves of adolescent girls : hard stories of race, class, and gender184 p. Cleveland Pilgrim PressTeenage girls Religious life. Feminist theology. Ethnicity North America. Minorities North America. North America Social conditions.6http://www.loc.gov/catdir/toc/ecip0619/2006025638.htmlr2006025638 edited by Evelyn L. Parker. 23 cm. Includes bibliographical references. Introduction / Evelyn L. Parker -- I's wide shut: eyelid surgery as a window into the spirituality of Korean American adolescent girls / Su Yon Pak -- Gods and grandmothers: spiritual values of resistance to racism among African American adolescent girls / Evelyn L. Parker -- From "wanton girle" to the woman who fell from the sky: the sacred selves of Native American girls / Laura E. Donaldson -- Latina adolescents: sliding between borders and the yearning to belong / Daisy Machado -- Love letters in a second-hand hope chest: working-class white girls delaying dreams and expanding soul / Dori Grinenko Baker -- "Okay with who I am": listening to lesbian young women talk about their spiritualities / Pat Davis -- Conclusion: nurturing the sacred selves of adolescent girls / Evelyn L. Parker.&0829816887 (pbk.) 9780829816884 (pbk.)14480357Jefferson or Adams Building Reading Rooms BV4551.3; .P37 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE BV4551.3; .P37 20065|?Thomas, W. E. G. Senninger, N.2006Short stay surgery x, 408 p.Springer surgery atlas seriesBerlinSpringerAmbulatory surgery.http://www.loc.gov/catdir/enhancements/fy0829/2005938807-b.html http://www.loc.gov/catdir/enhancements/fy0829/2005938807-d.html http://www.loc.gov/catdir/enhancements/fy0829/2005938807-t.html_2005938807 GBA599676 013343708 W.E.G. Thomas and N. Senninger (eds.). ill. (some col.) ; 28 cm.&3540411011 (hbk.) 9783540411017 (hbk.)14202126:Jefferson or Adams Building Reading Rooms RD110; .S56 2006fO|?Lippincott Williams & Wilkins.,2006IStedman's surgery words : includes anatomy, anesthesia, & pain managementxxi, 852, 125 p.Stedman's word book seriesBaltimore, Md.Lippincott Williams & Wilkins3rd1Surgery Terminology. Surgery Terminology English.vhttp://www.loc.gov/catdir/toc/ecip0512/2005012513.html http://www.loc.gov/catdir/enhancements/fy0712/2005012513-d.htmlk2005012513 101247117 ill. ; 23 cm. Includes bibliographical references (p. xvii-xxi). Stedman's word books.0781761794 9780781761796139492469Jefferson or Adams Building Reading Rooms RD16; .S74 2006:M|?UTrail, Ian Hayton, Michael Federation of European Societies for Surgery of the Hand.,2006cSurgery of the rheumatoid hand and wrist : Federation of European Societies for Surgery of the Handp.International congress series,no 1295Amsterdan ; San DiegoElsevier1stYWrist Surgery. Hand Surgery. Rheumatoid arthritis Surgery. Arthritis, Rheumatoid surgery.d2006048400 editors, Ian Trail and Michael Hayton. cm. Includes bibliographical references and index.>9780444528520 (alk. paper) 0444528520 (alk. paper) 0531-5131 ;14403852 |? Parens, Erik2006NSurgically shaping children : technology, ethics, and the pursuit of normality xxx, 274 p.Baltimore, Md.Johns Hopkins University PresspChildren Surgery Moral and ethical aspects. Abnormalities, Human Moral and ethical aspects. Surgery, Plastic Moral and ethical aspects. Children Surgery Decision making. Decision making in children. Reconstructive Surgical Procedures ethics. Achondroplasia surgery. Biomedical Technology ethics. Child. Cleft Palate surgery. Genitalia abnormalities. Social Perception.http://www.loc.gov/catdir/toc/ecip0519/2005027618.html http://www.loc.gov/catdir/enhancements/fy0623/2005027618-b.html http://www.loc.gov/catdir/enhancements/fy0623/2005027618-d.html2005027618 101257713 edited by Erik Parens. ill. ; 24 cm. Includes bibliographical references and index. Twisted lies: my journey in an imperfect body / Sherri G. Morrris -- Do I make you uncomfortable? Reflections on using surgery to reduce the distress of others / Cassandra Aspinall -- My shoe size stayed the same: maintaining a positive sense of identity with achondroplasia and limb-lengthening surgeries / Emily Sullivan Sanford -- The seduction of the surgical fix / Lisa Abelow Hedley -- Concepts of technology and their role in moral reflection / James C. Edwards -- Emily's scars: surgical shapings, technoluxe, and bioethics / Arthur W. Frank -- Thoughts on the desire for normality / Eva Feder Kittay -- To cut or not to cut? A surgeon's perspective on surgically shaping children / Jeffrey L. Marsh -- What's special about the surgical context? / Wendy E. Mouradian -- Are we helping children? Outcome assessments in craniofacial care / Wendy E. Mouradian ... [et al.] -- Who should decide and how? / Priscilla Alderson -- The power of parents and the agency of children / Hilde Lindemann -- "In their best interests": parents' experience of atypical genitalia / Ellen K. Feder -- Toward truly informed decisions about appearance-normalizing surgeries / Paul Steven Miller -- Appearance-altering surgery, children's sense of self, and parental love / Adrienne Asch -- What to expect when you have the child you weren't expecting / Alice Domurat Dreger.!0801883059 (hardcover alk. paper)14117696;Jefferson or Adams Building Reading Rooms RD137; .S846 2006\~?20066U.S. markets for specialty endoscopic surgery products1Newport Beach, CAMedtech Insight?Endoscope industry United States. Market surveys United States.S2007270403 US markets for specialty endoscopic surgery products 28 cm. Cover title.14826000?Jefferson or Adams Building Reading Rooms HD9995.E533; U69 2006|?6Abbassian, Ali Krishnanandan, Sarah James, Christopher2006$Operative surgery vivas for the MRCS164 p. CambridgeCambridge University Press!Surgery Problems, exercises, etc.http://www.loc.gov/catdir/enhancements/fy0701/2007273080-d.html http://www.loc.gov/catdir/enhancements/fy0701/2007273080-t.html http://www.loc.gov/catdir/enhancements/fy0732/2007273080-b.htmlf2007273080 GBA693530 013589009 Ali Abbassian, Sarah Krishnanandan and Christopher James. ill. ; 23 cm.&0521674417 (pbk.) 9780521674416 (pbk.)14793313Jefferson or Adams Building Reading Rooms RD37.2; .A33 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE RD37.2; .A33 2006|?,Apple, Robin F. Lock, James Peebles, Rebecka2006%Is weight loss surgery right for you?106 p.Oxford ; New YorkOxford University PressWObesity Surgery Popular works. Gastric bypass Popular works. Weight loss Popular works.vhttp://www.loc.gov/catdir/toc/ecip0610/2006007414.html http://www.loc.gov/catdir/enhancements/fy0635/2006007414-d.htmlF2006007414 GBA666296 013522152 (Robin Faye) Robin F. Apple, James Lock, and Rebecka Peebles. ill. ; 21 cm. Includes bibliographical references (p. 103-106). Introduction -- Is weight loss surgery right for you? -- Weight loss surgery procedures : what you need to know -- Navigating the system -- What to expect after surgery.<0195313151 (pbk. alk. paper) 9780195313154 (pbk. alk. paper)14282268Jefferson or Adams Building Reading Rooms RD540; .A65 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE RD540; .A65 2006|?,Apple, Robin F. Lock, James Peebles, Rebecka20063Preparing for weight loss surgery : therapist guide vi, 122 p.Treatments that workOxford ; New YorkOxford University PressObesity Surgery. Weight loss.uhttp://www.loc.gov/catdir/toc/ecip069/2006005938.html http://www.loc.gov/catdir/enhancements/fy0725/2006005938-d.html2006005938 GBA667916 GBA667907 013526820 013526811 (Robin Faye) Robin F. Apple, James Lock, Rebecka Peebles. 27 cm. Includes bibliographical references (p. 117-120). Introductory information for therapists -- Understanding your patient's eating behavior -- Helping your patient keep track of his or her eating -- Educating your patient about weighing behaviors -- Pleasurable alternative activities -- Challenging eating situations : people, places, and foods -- Teaching your patient about problem solving and cognitive restructuring -- Working with your patient on body image issues -- Congratulations! your patient is on the way to the O.R. -- What happens after surgery?{0195309278 (cloth alk. paper) 9780195309270 (cloth alk. paper) 0195189396 (pbk. alk. paper) 9780195189391 (pbk. alk. paper)14269999:Jefferson or Adams Building Reading Rooms RD540; .A67 2006N|?,Apple, Robin F. Lock, James Peebles, Rebecka2006,Preparing for weight loss surgery : workbook vi, 128 p.Treatments that workOxford ; New YorkOxford University PressObesity Surgery. Weight loss.uhttp://www.loc.gov/catdir/toc/ecip069/2006005938.html http://www.loc.gov/catdir/enhancements/fy0726/2006285884-d.html}2006285884 (Robin Faye) Robin F. Apple, James Lock, Rebecka Peebles. 28 cm. Includes bibliographical references (p. 123-126).&019518940X (pbk.) 9780195189407 (pbk.)14626566;Jefferson or Adams Building Reading Rooms RD540; .A675 2006~|?Buchan, Ana Doria2006Primitive surgery : an overview vi, 93 p.BAR international series1512OxfordJohn and Erica Hedges&Traditional medicine. Surgery History.4http://www.loc.gov/catdir/toc/fy0614/2006445245.html*2006445245 Ana Doria Buchan. ill. ; 30 cm. 184171747914479544=Jefferson or Adams Building Reading Rooms GN477.5; .B834 2006O|?Chitty, Joseph2006^A practical treatise on medical jurisprudence, with so much of anatomy, physiology, pathology, and the practice of medicine and surgery : as are essential to be known by members of Parliament, lawyers, coroners, magistrates, officers in the Army and Navy, and private gentlemen an all the laws relating to medical practioners, with explanatory plates Buffalo, NY W.S. Hein 1st American?Medical jurisprudence Early works to 1800. Anatomy. Physiology.2006043649 by J. Chitty. Originally published: 1st American ed. Philadelphia : Carey, Lea & Blanchard, 1835. Includes bibliographical references (p. ). 157588904814416530O|?*Cooper, Nicola Forrest, Kirsty Cramp, Paul2006Essential guide to acute carep. Malden, Mass.Blackwell Pub.2nd&Critical care medicine. Critical Care.http://www.loc.gov/catdir/toc/ecip066/2006000965.html http://www.loc.gov/catdir/enhancements/fy0802/2006000965-b.html http://www.loc.gov/catdir/enhancements/fy0802/2006000965-d.htmlW2006000965 Nicola Cooper, Kirsty Forrest, Paul Cramp. cm. Includes bibliographical references and index. Patients at risk -- Oxygen therapy -- Acid-base balance -- Respiratory failure -- Fluid balance and volume resuscitation -- Sepsis -- Acute renal failure -- Brain failure -- Optimising patients before surgery -- Pain control and sedation.29781405139724 (alk. paper) 1405139722 (alk. paper)14233646 O|?'Cotes, J. E. Chinn, D. J. Miller, M. R.2006CLung function : physiology, measurement and application in medicine xi, 636 p.Malden, Mass. ; OxfordBlackwell Pub.6thPulmonary function tests. Lungs Physiology. Respiration. Lung physiology. Lung Diseases physiopathology. Respiratory Function Tests. Respiratory Physiology.http://www.loc.gov/catdir/toc/ecip0519/2005026837.html http://www.loc.gov/catdir/enhancements/fy0802/2005026837-b.html http://www.loc.gov/catdir/enhancements/fy0802/2005026837-d.htmln 2005026837 101257124 J.E. Cotes, D.J. Chinn, M.R. Miller. ill. ; 29 cm. Includes bibliographical references and index. Early developments and future prospects -- Getting started -- Development and functional anatomy of the respiratory system -- Body size and anthropometric measurements -- Numerical interpretation of physiological variables -- Basic terminology and gas laws -- Basic equipment and measurement techniques -- Respiratory surveys -- Thoracic cage and respiratory muscles -- Lung volumes -- Lung and chest wall elasticity -- Forced ventilatory volumes and flows (ventilatory capacity) -- Determinants of maximal flows (flow limitation) -- Theory and measurement of respiratory resistance (including whole body plethysmography) -- Control of airway calibre and assessment of changes -- Distribution of ventilation -- Distribution and measurement of pulmonary blood flow -- Inter-relations between lung ventilation and perfusion -- Transfer of gases into blood in alveolar capillaries -- Transfer factor (diffusing capacity) for carbon monoxide and nitric oxide (Tl,co, Tl,no, Dm and Vc) -- The oxygenation of blood -- Gas exchange for carbon dioxide and acid-base balance -- Control of respiration -- Newborn babies, infants and young children (ages 0-6 years) -- Normal lung function from childhood to old age -- Reference values for lung function in white (caucasian) children and adults -- Genetic diversity : reference values in non-caucasians -- Physiology of exercise and changes resulting from lung disease -- Exercise testing and interpretation, including reference values -- Assessment of exercise limitation, disability and residual ability -- Exercise in children -- Investigation and physiology of breathing during sleep -- Assessment and treatment of sleep related breathing disorders -- Hypobaria : high altitude and aviation physiology and medicine -- Immersion in water, hyperbaria and hyperoxia including O2 therapy -- Cold, heat and the lungs -- Airborne respiratory hazards : features, protective mechanisms and consequences -- Patterns of abnormal function in lung disease -- Strategies for assessment -- Lung function in asthman, COPD, emphysema and diffuse lung fibrosis -- How individual diseases affect lung function (compendium) -- Lung function in relation to general anaesthesia and artificial ventilation -- Lung function in relation to surgery -- Pulmonary rehabilitation.0632064935 978063206493914112159=Jefferson or Adams Building Reading Rooms RC734.P84; C68 2006=|? Cullen, Ed2006Letter in a woodpile : essays138 p.Nashville, TN.Cool Springs Press?http://www.loc.gov/catdir/enhancements/fy0622/2006283451-d.html 2006283451 from NPR's All things considered comentator Ed Cullen. 22 cm. "The essays were broadcast on National Public Radio's 'All Things Considered' or published in The Sunday Advocate (Baton Rouge) in slightly different form"--Foreword (p. 11). My father's kite -- Generation shift -- Boar -- Fishing with Meredith -- Manta ray -- Tutti frutti girl -- New Orleans, the poem -- Bobby's marbles -- Night passage -- Prom night -- Truck repair, a revelation -- Leaf blowing -- Welcome to the pack -- Fishing with Malcolm -- Heart volcano -- Letter in the woodpile -- Block that stress! -- Tiger charge -- For cat's sake -- Aroma inventory -- Home schooling -- Flip-flops -- Elgin -- Hurricane game -- Necessity of repetition -- Learning from a new teacher -- Attic fan -- Around midnight -- Porch steps baseball -- Hale-Bopp -- Phoning Harry -- October best -- First fire -- Velvet purple coronet wind thing -- Best game I never (really) played -- Romancing the nose -- Hamsters -- Who is what they used to be -- Driver's ed -- Bobby's gun -- Amal is back -- Thunder happy -- Those high flying tree guys -- Winter cyclists -- Convenience stores offer look at culture -- Visitor -- Cat people -- Chilling during surgery -- Christmas calling. All things considered (Radio program) Sunday advocate (Baton Rouge, La.)9781591862499 159186249314611989?Jefferson or Adams Building Reading Rooms PN4874.C885; A25 2006|? Debas, Haile20069Gastrointestinal surgery : pathophysiology and managementNew YorkSpringer2005938353 Haile Debas.9780387290799 038729079614192098O|?Dhillon, R. S. East, C. A.2006LEar, nose, and throat and head and neck surgery : an illustrated colour textp.Edinburgh ; New YorkChurchill Livingstone/Elsevier3rdOtolaryngology, Operative. Head Surgery. Neck Surgery. Otorhinolaryngologic Diseases diagnosis. Otorhinolaryngologic Diseases therapy.c2005053763 R.S. Dhillon, C.A. East ; with contributions by A. Narula, G. Sandhu, J.-P. Jeannon. cm. 044307311214101614NO|?%Disa, Joseph J. Kuechel, Marie Czenko2006,100 questions & answers about breast surgery xxii, 217 p.Sudbury, Mass.Jones and Bartlett Publishers1stBreast Surgery Popular works.6http://www.loc.gov/catdir/toc/ecip0510/2005009008.html2005009008 Joseph J. Disa, Marie Czenko Kuechel. One hundred questions and answers about breast surgery 100 questions and answers about breast surgery ill. ; 23 cm. Breast surgery (questions 1-6) -- Where to begin (questions 7-16) -- Breast surgery and safety (questions 17-25) -- Breast implants (questions 26-39) -- Treating breast disease (question 40-49) -- Breast reconstruction (question 50-64) -- Breast reduction (question 65-72) -- Breast augmentation (question 73-79) -- Breast lift and other procedures (question 80-83) -- Other breast surgery procedures (question 84-88) -- Following breast surgery (question 89-94) -- Your future (question 95-100).0763730416 (pbk.)13914828Jefferson or Adams Building Reading Rooms RD539.8; .D57 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE RD539.8; .D57 2006|?)Dockery, Gary L. Crawford, Mary Elizabeth20069Lower extremity soft tissue and cutaneous plastic surgeryp.Edinburgh ; New YorkSaundersLeg Wounds and injuries Surgery. Surgery, Plastic. Skin Surgery. Lower Extremity surgery. Reconstructive Surgical Procedures methods. Skin Transplantation. Surgical Flaps.K2005040784 by Gary L. Dockery, Mary Elizabeth Crawford. cm. Includes index. 070202711113862069 O|?,Donald, Anna Stein, Michael Teo, James T. H.2006%The hands-on guide for junior doctors xviii, 278 p.Malden, Mass. ; OxfordBlackwell Pub.3rd=Residents (Medicine) Handbooks, manuals, etc. Medicine Handbooks, manuals, etc. Medical Staff, Hospital organization & administration Great Britain Handbooks. Clinical Competence Great Britain Handbooks. Internship and Residency organization & administration Great Britain Handbooks. Medicine Great Britain Handbooks.http://www.loc.gov/catdir/toc/ecip0515/2005017902.html http://www.loc.gov/catdir/enhancements/fy0802/2005017902-b.html http://www.loc.gov/catdir/enhancements/fy0802/2005017902-d.html32005017902 101250732 Anna Donald, Michael Stein ; with James T.H. Teo. ill. ; 19 cm. Rev. ed of: The hands-on guide for house officers. 2nd ed. 2002. Includes bibliographical references and index. Starting up -- Getting organized (the folder) -- Paperwork -- Accident and emergency -- Becoming a better doctor -- Cardiac arrests and crash calls -- Common calls -- Death and dying -- Drugs -- Handle with care -- Approach to the medical patient -- Pain -- Practical procedures -- Radiology -- Surgery -- Obstetrics and gynaecology -- General practice -- Self care.%140513609X (alk. paper) 978140513609914021126|?%Furtado, Margaret M. Schultz, Lynette2006XRecipes for life after weight-loss surgery : delicious dishes for nourishing the new you240 p.Healthy living cookbooksGloucester, MAFair Winds Press6Obesity Surgery Popular works. Reducing diets Recipes.http://www.loc.gov/catdir/toc/ecip071/2006031206.html http://www.loc.gov/catdir/enhancements/fy0701/2006031206-d.html http://www.loc.gov/catdir/enhancements/fy0737/2006031206-b.htmlj2006031206 GBA680580 013557875 Margaret M. Furtado and Lynette Schultz. col. ill. ; 24 cm. Includes index.,1592332269 9781592332267 9781592332267 (pbk)14572545Jefferson or Adams Building Reading Rooms RD540; .F95 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE RD540; .F95 2006 |? Grewal, D. S. Hathiram, Bachi T.2006$Atlas of surgery of the facial nervep.New Delhi New York0Jaypee Brothers Medical Publishers ; McGraw-HillFacial nerve Surgery Atlases. Facial Nerve Diseases surgery Atlases. Facial Nerve anatomy & histology Atlases. Facial Nerve Diseases pathology Atlases.http://www.loc.gov/catdir/enhancements/fy0666/2006046679-b.html http://www.loc.gov/catdir/enhancements/fy0666/2006046679-t.html>2006046679 D.S. Grewal, Bachi T. Hathiram. cm. Includes index. 007148576714441976^O|?vHaynes, David S. Huang, May Y. Roland, Peter S. American Academy of Otolaryngology--Head and Neck Surgery Foundation.,2006Cochlear implantsp.SIPacAlexandria, VADAmerican Academy of Otolaryngology--Head and Neck Surgery Foundation1stWCochlear implants Programmed instruction. Cochlear Implantation Programmed Instruction."An introduction that covers the cost-effectiveness of cochlear implantation; pre-operative evaluation of patients; functional parts of cochlear implant device and its components; the surgical procedure and post-operative complications - early and late; post-operative issues - effects of electrical stimulation, cochlear dysplasia, skull growth, meningitis, re-implantation, and auditory neuropathy"--Provided by publisher.6http://www.loc.gov/catdir/toc/ecip0616/2006020649.html2006020649 David S. Haynes, May Y. Huang, Peter S. Roland. cm. Includes bibliographical references. Continuing education program (American Academy of Otolaryngology--Head and Neck Surgery Foundation)<9781567721027 (pbk. alk. paper) 1567721028 (pbk. alk. paper)14424993~7LHeydar Aliyev Foundation., Washington Academy of Sciences (Washington D.C.),2006u1st International Conference "Traditional Medicine and Materia Medica in Medieval Manuscripts" Baku, June 12-14, 2006BakuHeydar Aliyev FoundationMateria medica Early works to 1800 Congresses. Materia medica Manuscripts Congresses. Manuscripts, Medieval Congresses. Traditional medicine Congresses. Medicine, Medieval Congresses.3Includes video and audio clips from the conference.z 2007585007 International Conference "Traditional Medicine and Materia Medica in Medieval Manuscripts" (1st : 2006 : Baku, Azerbaijan) [electronic resource] : Heydar Aliyev Foundation, Washington Academy of Sciences. 1 CD-ROM : sd., col. ; 4 3/4 in. System requirements: IBM-PC or compatible; Windows Multimedia Player. Title from disc label. Baku collection of medical manuscripts in the Memory of the World Collection / Farid Alakbarli -- Medical manuscripts in Arabic and Persian at the Library of Congress / Ibrahim Pourhadi -- Translating medical texts in the medieval Near East / Alain Touwaide -- Russian medicine in the Middle Ages / Mark Mirsky -- Bioethics and its constituents: the environmental ethics and the human aging morals -- First medical and scientific illustrations / Jean-Pierre Tricot -- General features of medieval sources on medicine / Nasib Goyushov -- Zakhravi's and Sabunchuoglu's works on surgery / Sari Nil -- Muhammad Bin Mahmud of Shirvan and his works / A. H. Bayat -- The "demon route": the transmission of demon possession and popular medicine, from Palestine to Rome / Peter Dendle -- Medical Isra'iliyyat? unusual Hellenistic (and other) teachings in early Islamic texts / Tzvi Langermann -- On the history of ophthalmology in Azarbaijan / Chingiz Jarullazadeh -- About physicians of medieval Azerbaijan and their manuscripts / Javad Tagdisi -- Hippocratic morals in a changing world / Athanasios Diamandopoulos -- Aristotle and anatomy / M. S. Abdullayev -- Concerning the history of the chemist's affairs in the Russian Empire at the end of the 19th-the beginning of the 20th century -- Some prayers and oaths from the history of medicine / David Wright -- Women's health in Iranian traditional medicine / Farzaneh Naghibi -- The healing system of Hildegard of Bingen (1098-1179): medieval medicine in 12th century Europe / Axel Helmstadter -- Medicine in Tartu (Dorpat) University founded in 1632 / Raik-Hiio Mikelsaar -- Treatment methods of shamans / Gyullu Yologhlu -- Medical activity in Georgian hagiograph literature / Nino Chikhladze -- Religious perspectives in dealing with AIDS / Faisal Alnasir -- Evaluation of "Kitab al-ajaib al-hayawanat" by Qazvini and its influence on Ottomans -- The first department on the history of medicine and medical ethics in Turkey and its importance / Oztan Oncel -- Ethnopharmacology of nepeta binaludensis jamzad: a highly threatened medicinal plant of Iran / Farsad Nadjafi -- Comments by Ibn Tumlus on a medical poem of Ibn Sina in an unpublished manuscript of the 12th century / Mahmoud Aroua -- History of inhalation therapy / Mostafa Shehata -- Biruni's and Avicenna's pharmacology studies and their influence on later studies -- A perspective on two books on medical ethics in Turkey of the twentieth century and some results / Ayshegul Demirhan -- Practical materia medica of the Jewish community of medieval Cairo according to Genizah fragments / Efraim Lev -- Some of the medieval medical achievements attributed to Western physicians / A. N. Kaadan -- Georgian medical manscript: typology and conception / Ramaz Shengelia. African & Middle Eastern Reading Room (Jefferson, LJ220) RS178; [2007 001046]15022768!English, Azerbaijani, and French.|?nNorris, Tom R. American Academy of Orthopaedic Surgeons., American Shoulder and Elbow Surgeons (Organization),2006Surgery of the shoulder and elbow : an international perspective : selected proceedings of the 9th International Congress on Surgery of the Shoulder xxv, 289 p.Rosemont, Ill.(American Academy of Orthopaedic SurgeonsoShoulder joint Surgery Congresses. Shoulder Diseases Congresses. Shoulder joint Wounds and injuries Congresses.2007276944 GBA679564 013551824 International Congress on Surgery of the Shoulder (9th : 2004 : Washington, D.C.) edited by Tom R. Norris ... [et al.]. ill., ports. ; 26 cm.0892033614 978089203361414922340<Jefferson or Adams Building Reading Rooms RD557.5; .I59 2004O|?Jackson, Barry2006Photoshop cosmetic surgery192 p.New York Lark Books1stHPhotography Retouching. Photography Digital techniques. Adobe Photoshop.5http://www.loc.gov/catdir/toc/ecip062/2005030171.htmlu2005030171 Barry Jackson. Cosmetic surgery col. ill. ; 26 cm. Includes bibliographical references (p. 192) and index.1579908004 (pbk.) 978157990800314141020:Jefferson or Adams Building Reading Rooms TR310; .J33 2006VO|?Kaminsky, Ben Kaminsky, Howard2006MBeyond Botox : 7 strategies for sexy, ageless skin without needles or surgery vi, 233 p.New YorkSpringboard Press1stSkin Care and hygiene.http://www.loc.gov/catdir/toc/ecip0610/2006009388.html http://www.loc.gov/catdir/enhancements/fy0742/2006009388-b.html http://www.loc.gov/catdir/enhancements/fy0917/2006009388-d.htmlh2006009388 Ben and Howard Kaminsky. 25 cm. Includes bibliographical references (p. [218]-223) and index.0821280023 9780821280027143083659Jefferson or Adams Building Reading Rooms RL87; .K26 2006i|?Kelly, Evelyn B.2006Obesity xv, 224 p. Health and medical issues today,Westport, Conn.Greenwood PressObesity. Obesity Popular Works.5http://www.loc.gov/catdir/toc/ecip066/2006001121.html 2006001121 GBA620954 013397198 101265180 Evelyn B. Kelly. ill. ; 25 cm. Includes bibliographical references (p. [213]-220) and index. section 1. Overview -- 1. Obesity : a perfect and costly epidemic -- 2. Obesity battles throughout the ages -- 3. The physiology of fat -- 4. The psychological and social aspects of obesity -- 5. Genetics of obesity -- 6. Obesity and exercise -- 7. Obesity and health problems -- section 2. Controversies and issues -- 8. Issue : is obesity a disease or an adaptation for survival? -- 9. Issue : are we creating generations of couch potatoes? -- 10. Issue : the great diet debate -- 11. Issue : can behavioral strategies result in weight loss? -- 12. Issue : should surgery be used as a weight-control method? -- 13. Issue : what is the government's role in the obesity crisis? -- 14. Can there be a fat-free future? -- section 3. Reference and resources -- A. Annotated primary source documents -- B. Timeline of obesity issues -- C. Glossary -- D. Weight loss programs and plans -- E. Further reading./0313334609 (alk. paper) 9780313334603 1558-759214233644:Jefferson or Adams Building Reading Rooms RC628; .K45 2006ՄO|?Kent, Christine Ann2006kSaving the whole woman : natural alternatives to surgery for pelvic organ prolapse and urinary incontinence xxvi, 206 p.Albuquerque, NM Bridgeworks2ndUterus Prolapse Alternative treatment Popular works. Pelvic floor Diseases Alternative treatment Popular works. Pelvic floor Surgery Risk factors Popular works.6http://www.loc.gov/catdir/toc/ecip0724/2007031421.html2007031421 Christine Ann Kent ; illustrations by Nikelle Marie Gessner. ill. ; 26 cm. + 1 CD-ROM (4 3/4 in.) Includes bibliographical references (p. [173]-187) and index.&9780970144010 (pbk.) 0970144016 (pbk.)14949789HSee Reference Staff. By Appt in Jefferson Main RR (MRC) RG361; .K46 2007O|?QKimmelman, Charles P. American Academy of Otolaryngology--Head and Neck Surgery.,2006Disorders of taste and smell56 p.SIPacAlexandria, VACAmerican Academy of Otolaryngology-Head and Neck Surgery Foundation3dSmell disorders Programmed instruction. Taste disorders Programmed instruction. Taste Disorders physiopathology Programmed Instruction. Olfaction Disorders physiopathology Programmed Instruction.P"A resource that covers the anatomy, physiology, and embryology of the olfactory and gustatory systems; pathology of the olfactory system, and pathologic disorders that may lead to gustatory dysfunction; evaluation and treatment strategies for patients with olfactory and gustatory dysfunctions are also covered"--Provided by publisher.6http://www.loc.gov/catdir/toc/ecip0616/2006021562.html2006021562 Charles P. Kimmelman. ill. ; 25 cm. Includes bibliographical references. Continuing education program (American Academy of Otolaryngology--Head and Neck Surgery Foundation)<9781567721034 (pbk. alk. paper) 1567721036 (pbk. alk. paper)14433464:Jefferson or Adams Building Reading Rooms RF341; .K55 2006|? Kirkup, John2006jThe evolution of surgical instruments : an illustrated history from ancient times to the twentieth centuryxviii, 510 p., 16 p. of platesNorman surgery seriesno 13Novato, Calif.Historyofscience.comlSurgical instruments and apparatus History. Surgery History. Medicine History. Surgical Instruments history.2001051194 101128156 John Kirkup ; with a foreword by James M. Edmonson. ill. (some col.) ; 29 cm. Includes bibliographical references (p. 449-465) and index. Norman science technology series ; no. 8.%0930405862 (alk. paper) 9780930405861125360639Jefferson or Adams Building Reading Rooms RD71; .K53 2006O|?rKohan, Darius Sikora, Andrew G. Lee, Kelvin American Academy of Otolaryngology--Head and Neck Surgery Foundation.,2006AIDS and the otolaryngologistp.SIPacAlexandria, VACAmerican Academy of Otolaryngology-Head and Neck Surgery Foundation2ndAIDS (Disease) Complications Programmed instruction. Otolaryngology Programmed instruction. Acquired Immunodeficiency Syndrome complications Programmed Instruction. HIV Infections complications Programmed Instruction. Otorhinolaryngologic Diseases etiology Programmed Instruction."A resource for medical and numerous otolaryngologic manifestations of AIDS, including common otologic problems seen in patients with AIDS, increased incidence of sinusitis, characteristics and appropriate management of oral and phyarngeal conditions seen with HIV infection, common conditions present in the neck/salivary glands, and pediatric considerations on HIV infection"--Provided by publisher.6http://www.loc.gov/catdir/toc/ecip0616/2006020648.html92006020648 Darius Kohan, Andrew G. Sikora, Kelvin Lee. cm. Approved for up to two hours of category 1 CME credit toward the AMA Physician's Recognition Award through Dec. 2009. Includes bibliographical references. Continuing education program (American Academy of Otolaryngology--Head and Neck Surgery Foundation)<9781567721010 (pbk. alk. paper) 156772101X (pbk. alk. paper)14424989O|?hKohan, Darius Sorin, Alexander Hanin, Laurie American Academy of Otolaryngology--Head and Neck Surgery.,2006;Evaluation and rehabilitation of the hearing impaired child104 p.SIPacAlexandria, VACAmerican Academy of Otolaryngology-Head and Neck Surgery Foundation2ndHearing disorders in children Examinations, questions, etc. Diagnosis Examinations, questions, etc. Hearing impaired children Rehabilitation Examinations, questions, etc. Hearing Disorders diagnosis Examination Questions. Child. Rehabilitation of Hearing Impaired Examination Questions.a"Presents information on the importance and impact of universal screening in children; protocols for early detection and high risk indicators for infant hearing loss; and an overview of modern habilitative techniques; also discussed, a comprehensive discussion of the etiology of infant hearing loss, diagnosis, and habilitation"--Provided by publisher.6http://www.loc.gov/catdir/toc/ecip0616/2006020650.htmlA2006020650 Darius Kohan, Alexander Sorin, Laurie Hanin. ill. ; 25 cm. Rev. ed. of: Evaluation and habilitation of the hearing-impaired child / Darius Kohan, Laurie Hanin. 1st ed. 2000. Includes bibliographical references. Continuing education program (American Academy of Otolaryngology--Head and Neck Surgery Foundation)<9781567721041 (pbk. alk. paper) 1567721044 (pbk. alk. paper)14424988?Jefferson or Adams Building Reading Rooms RF291.5.C45; K64 2006|?Lane, George Michael2006\A different kind of perfect : the story of a parents' choice and a special child's blessingsColumbus, OhioGom Pub.gLane, Amy Kathryn, 1987- Down syndrome Patients Biography. Down syndrome Patients Family relationships.uhttp://www.loc.gov/catdir/toc/ecip069/2006005095.html http://www.loc.gov/catdir/enhancements/fy0811/2006005095-b.html;2006005095 George Michael Lane. Includes bibliographical references and index. Part I: Life, love, and discernment -- God's little clowns? -- Keep it or kill it? -- Norma McCorvey, a.k.a. Jane Roe -- The pastor's visit -- Tough facts -- Meeting with the abortionist -- Giving God permission -- Love in quiet surprises -- Saint Joseph's-in-the-Hills -- In the dark woods -- Be still and know that I am God -- A winner never quits : a quitter never wins -- Coming to a dead end -- Where are you asking us to go with you Lord? -- Game six : ghosts of past failures -- Those feelings and haunches that are God? -- The ball that got away -- Tomorrow's child -- Part II: Welcome to Holland -- Choosing love -- Crossing home -- Miss Amy's heart surgery -- Life goes on -- A gift that keeps on giving? -- Children are not things to be molded -- But people to be unfolded? -- It's the journey, not the destination -- Naked to the world -- A mother's daughter -- Peter, Paul & Mary -- Part III: God's perfection -- A different kind of perfect -- A perfect day -- Good giving and perfect gifts.D9781932966541 (hardback alk. paper) 1932966544 (hardback alk. paper)14264986O|? Langone, John2006/How things work : everyday technology explained192 p.Washington, D.C.National Geographic SocietyNew3Technology Popular works. Inventions Popular works.N2007271140 John Langone ; art by Pete Samek, Andy Christie, and Bryan Christie. ill. ; 26 cm. Rev. ed. of : The new how things work : everyday technology explained. 2004. Includes index. At home : Cooking -- Refrigerators -- Vacuum cleaners -- Washers & dryers -- Home heating & cooling -- Hand tools -- Clocks -- Lightbulbs. Power & energy : Power stations -- Hydroelectricity -- Alternative power -- Nuclear power -- Fusion. Building : Skyscrapers -- Elements of construction -- Elevators & escalators -- Tunnels -- Bridges. Transportation : Automobiles -- Alternative fuels -- Bicycles -- Trains -- Electric & high-speed trains -- How boats stay afloat -- Sailboats -- Submersibles -- Principles of flight -- Propellers & jet engines -- Helicopters -- Super- & hypersonic planes. Materials : Synthetic fibers -- Incredible fabrics -- Sewing & weaving -- Glassmaking -- Plastics -- Papermaking -- Recycling. Manufacturing : Agriculture -- Biotechnology -- Aquaculture -- Hydroponics -- Steelmaking -- Coal mining -- Oil processing -- Industrial robotics. Entertainment : Making music -- Sending signals -- Radio -- Digitized music -- Television -- Video games -- Cameras -- Motion pictures -- Roller coasters -- Fireworks. Health & medicine : Endoscopy -- Implants -- Imaging -- Monitors -- Drugs -- Laser surgery. Information : Fiber optics & DSL -- Cell phones -- Satellite communications -- Printing presses -- Photocopiers -- Calculators -- Inside computers -- The Internet -- Bar codes & scanners -- The Stock Exchange. Other worlds : Lenses -- Night vision -- Microscopes -- Telescopes -- Space telescopes.9780792255697 079225569014703541Jefferson or Adams Building Reading Rooms T47; .L2923 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE T47; .L2923 2006O|?rLeach, Joseph Howard, Brian K. Gilmore, Jim American Academy of Otolaryngology--Head and Neck Surgery Foundation.,2006&Aesthetic surgery of the aging patient92 p.SIPacAlexandria, VACAmerican Academy of Otolaryngology-Head and Neck Surgery Foundation1steSurgery, Plastic Programmed instruction. Facelift Programmed instruction. Face Surgery Programmed instruction. Older people Surgery Programmed instruction. Cosmetic Techniques Programmed Instruction. Esthetics Programmed Instruction. Middle Aged Programmed Instruction. Skin Aging physiology Programmed Instruction. Skin Care methods Programmed Instruction.N"Presents information on facial aesthetic surgery in aging patients, including the aging process; cutaneous anatomy; patient consultation; concepts of aesthetic analysis of the brow, cheek, neck, lip, chin, and therapies directed at aging skin; also includes non-surgical development in the field of skin care"--Provided by publisher.6http://www.loc.gov/catdir/toc/ecip0616/2006020646.htmlB2006020646 Joseph Leach, Brian Howard, Jim Gilmore. ill. ; 25 cm. Approved for two hours of category 1 CME credit toward the AMA Physician's Recognition Award through December 31, 2009. Includes bibliographical references. Continuing education program (American Academy of Otolaryngology--Head and Neck Surgery Foundation)<9781567721003 (pbk. alk. paper) 1567721001 (pbk. alk. paper)14424994?Jefferson or Adams Building Reading Rooms RD119.5.F33; L43 2006wO|?Maynard, Charles W.2006 The technology of ancient Greece48 p.#The Technology of the ancient worldNew YorkRosen Pub. Group1stoTechnology Greece History To 146 B.C. Juvenile literature. Greece Civilization To 146 B.C. Juvenile literature.6http://www.loc.gov/catdir/toc/ecip0513/2005013899.html2005013899 (Charles William), Charles W. Maynard. ill. (some col.) ; 28 cm. Includes bibliographical references (p. 46) and index. Roman technology conquers the world -- The technology of agriculture and trade mills -- Vineyards -- Trade --- The technology of transportation -- Roads -- Bridges -- Ships -- Harbors -- Lighthouses -- The technology of warfare -- The army's organization -- Weapons -- Artillery -- Forts and sieges -- The technology of construction -- Roman building innovations -- Dwellings -- Aqueducts -- Public buildings -- Statues -- The technology of communication and calculation -- Writing -- Calendar -- The technology of medicine -- Surgery -- Childbirth -- Public health -- Timeline.1404205551 (library binding)139641228Jefferson or Adams Building Reading Rooms T16; .M39 2006b|?Maynard, Charles W.2006The technology of ancient Rome48 p.#The technology of the ancient worldNew YorkRosen Central Pub.STechnology Rome History Juvenile literature. Rome Civilization Juvenile literature.6http://www.loc.gov/catdir/toc/ecip0513/2005013902.html2005013902 (Charles William), Charles W. Maynard. col. ill., col. map ; 28 cm. Includes bibliographical references and index. Roman technology conquers the world -- The technology of agriculture and trade mills -- Vineyards -- Trade --- The technology of transportation -- Roads -- Bridges -- Ships -- Harbors -- Lighthouses -- The technology of warfare -- The army's organization -- Weapons -- Artillery -- Forts and sieges -- The technology of construction -- Roman building innovations -- Dwellings -- Aqueducts -- Public buildings -- Statues -- The technology of communication and calculation -- Writing -- Calendar -- The technology of medicine -- Surgery -- Childbirth -- Public health -- Timeline.140420556X (library binding)13964140JJefferson or Adams Building Reading Rooms - STORED OFFSITE T16; .M394 2006]~?Meilhan, Jean-Baptiste2006.On surgery along Brunnian links in 3-manifolds24 p. Kyoto, Japan>Research Institute for Mathematical Sciences, Kyoto UniversityL2006531989 by Jean-Baptiste Meilhan. ill. ; 21 cm. "RIMS-1538." Cover title.14676459JJefferson or Adams Building Reading Rooms - STORED OFFSITE MLCS 2006/47589V|?Mitchell, David A.20061An introduction to oral and maxillofacial surgery371 p.Oxford ; New YorkOxford University PressGMouth Surgery. Face Surgery. Maxilla Surgery. Oral Surgical Procedures.5http://www.loc.gov/catdir/toc/ecip062/2005030775.html2005030775 GBA581512 101259987 013300938 David A. Mitchell. col. ill. ; 28 cm. Includes bibliographical references and index. What is oral and maxillofacial surgery? -- Basic principles and getting started -- Asepsis, antisepsis and instruments -- Managing people, pain and anxiety -- Medical management of the oral and maxillofacial surgical patient -- Exodontia and its sequelae -- Surgical endodontics -- Third molar surgery -- Dentoalveolar surgery for orthodontics -- Orofacial infections -- Cysts of the jaws -- Benign surgical conditions of the mouth, jaws and neck -- Paranasal sinuses -- Temporomandibular joint -- Surgery for prosthodontics -- Maxillofacial trauma: hard tissue -- Maxillofacial trauma: soft tissue -- Facial skin cancer -- Orthognathic surgery -- Cleft and craniofacial anomalies -- Salivary gland disease -- Oral cancer -- Reconstruction of the mouth, jaws and face -- Aesthetic facial surgery -- Cutting edge -- Useful information.20192629646 (alk. paper) 9780192629647 (alk. paper)14151665:Jefferson or Adams Building Reading Rooms RK529; .M58 2006JO|?jOrlandi, Richard Snyderman, Carl H. American Academy of Otolaryngology--Head and Neck Surgery Foundation.,2006!Advanced endoscopic sinus surgery72 p.SIPacAlexandria, VACAmerican Academy of Otolaryngology-Head and Neck Surgery Foundation1stParanasal sinuses Endoscopic surgery. Paranasal Sinus Diseases surgery Programmed Instruction. Endoscopy methods Programmed Instruction. Paranasal Sinuses anatomy & histology Programmed Instruction.n"Presents the boundaries of the frontal recess; explains common causes of iatrogentic frontal sinus disease; multiple surgical approaches to frontal sinus disease and their indications; nonsurgical treatments of frontal sinus disease; indications for orbital decompression; and the degree of compression possible with an endoscopic technique"--Provided by publisher.6http://www.loc.gov/catdir/toc/ecip0615/2006020645.html;2006020645 Richard Orlandi, Carl H. Snyderman. ill. ; 25 cm. Approved for up to two hours of category 1 CME credit toward the AMA Physician's Recognition Award through Dec. 2009. Includes bibliographical references. Continuing education program (American Academy of Otolaryngology--Head and Neck Surgery Foundation)<9781567720990 (pbk. alk. paper) 1567720994 (pbk. alk. paper)14423263:Jefferson or Adams Building Reading Rooms RF421; .O75 2006|?)Reynard, John Brewster, S. Biers, Suzanne2006Oxford handbook of urology xx, 678 p.Oxford medical publicationsOxford ; New YorkOxford University PressUrology Handbooks, manuals, etc. Urinary organs Diseases Handbooks, manuals, etc. Urologic Diseases Handbooks. Urogenital Diseases Handbooks.6http://www.loc.gov/catdir/toc/ecip0513/2005015598.htmlp2005015598 John Reynard, Simon Brewster, Suzanne Biers. Handbook of urology ill. ; 19 cm. Includes bibliographical references and index. General principles of management of patients -- Significance and preliminary investigation of urological symptoms and signs -- Urological investigations -- Bladder outlet obstruction -- Incontinence -- Infections and inflammatory conditions -- Urological neoplasia -- Miscellaneous urological disease of the kidney -- Stone disease -- Upper tract obstruction, loin pain, hydonephrosis -- Trauma to the urinary tract and other urological emergencies -- Infertility -- Disorders of erectile function, ejaculation, and seminal vesicles -- Neuropathic bladder -- Urological problems in pregnancy -- Paediatric urology -- Urological surgery and equipment -- Basic science of relevance to urological practice -- Urological eponyms. Oxford handbooks.H9780198530954 (flexicover alk. paper) 0198530951 (flexicover alk. paper)13990237<Jefferson or Adams Building Reading Rooms RC872.9; .R49 2006%|? Sheff, Bob2006NThe medical mentor : get the health care you deserve in today's medical system249 p.New YorkStewart, Tabori, & ChangNMedical personnel and patient. Medical care Popular works. Consumer education.uhttp://www.loc.gov/catdir/toc/ecip064/2005034434.html http://www.loc.gov/catdir/enhancements/fy0630/2005034434-d.html2005034434 Bob Sheff. Get the health care you deserve in today's medical system 23 cm. Includes index. Foreword -- Why you need a medical mentor -- Who's in charge here anyway? -- Who'w in charge here anyway? -- The doctor's office - the art of the appointment -- Four ears are better than two - and other communication strategies -- Urgent versus emergent? You decide -- Now I'm in the emergency room! -- Tests and other procedures -- Follow-up - it's up to you -- There is more than one way to skin a cat -- Second opinions - how to make the call -- I'm going to the hospital -- I'm in the hospital -- When the doctor says surgery -- Recovery takes time -- Community care vs. university care -- Experimental treatment - is it for you? -- Internet - friend or foe? -- Dealing with a chronic illness -- Home care versus nursing home care -- Times of crisis -- Understanding your insurance plan -- Navigating your insurance policy -- Pharmacy aid - finding relief from rising health costs -- The insurance company is not boss!1584794887 978158479488214179042Reference - Science Reading Room (Adams, 5th Floor) R727; .S54 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE R727; .S54 2006BO|?Stone, Christopher2006Plastic surgery : facts xv, 574 p.Cambridge, UK ; New YorkCambridge University Press2nd'Surgery, Plastic. Plastische chirurgie.http://www.loc.gov/catdir/enhancements/fy0668/2006282556-d.html http://www.loc.gov/catdir/enhancements/fy0668/2006282556-t.htmlO2006282556 GBA582184 013301611 (pbk.) Christopher Stone. 25 cm. Includes index.0521674492 (pbk.) 978052167449214540176Jefferson or Adams Building Reading Rooms RD118; .S76 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE RD118; .S76 2006F|?Straus, Eugene Straus, Alex20067Medical marvels : the 100 greatest advances in medicine425 p. Amherst, N.Y.Prometheus BooksCMedicine History. Medical innovations History. History of Medicine.6http://www.loc.gov/catdir/toc/ecip0519/2005027624.html2005027624 Eugene W. Straus & Alex Straus ; illustrations by Bette Korman. ill. ; 24 cm. Includes bibliographical references (p. 403-413) and index. From abandonment to the idea of healing -- The Doctor-patient relationship -- The Hippocratic corpus -- The Discovery of microscopic life -- The Medical encounter and the history of the present illness -- Galenic medicine -- "On the fabric of the human body" by Andreas Vesalius -- The Physical examination -- To see for oneself at the autopsy -- "On the motion of the heart" by William Harvey -- Diagnostic x-ray examinations -- "Observations and experiments on the gastric juice and the physiology of digestion" by William Beaumont -- "Nervism" and the integration of the organ systems -- "Chemical messengers" and the discovery of hormones -- The Germ theory of disease -- Smallpox vaccination -- Aspirin -- The Initiation of insulin therapy -- Florence Nightingale and modern nursing -- The Development of sewage systems -- Public works and health -- Paul Ehrlich's "Magic Bullets" -- Eradication of smallpox by the World Health Organization -- Gregor Mendel's discovery of genetics -- Friedrich Miescher discovers DNA in pus -- Oswald Theodore Avery uncovers the function of DNA -- The Structure of DNA is elucidated by James Watson, Francis Crick, Maurice Wilkins, and Rosalind Franklin -- The Genetic Code -- Tropical Medicine -- Microscopes -- The Fool of pest -- Contraception -- George Seldes leads the fight to deal with tobacco-related illness -- Penicillin -- The Development of surgical anesthesia -- Blood transfusion -- Modern surgical techniques -- The Control of Polio -- Cardiac catheterization and related techniques -- Cholesterol and the metabolic basis of cardiovascular disease -- Lab rats tango in the Bronx - The Development of radioimmunoassay -- The Discovery of viruses -- Retroviruses and oncogenes -- Koch's postulates -- Victory at C and the concept of vitamins -- Carbolic acid wound dressing -- Dentistry -- The Relaxing factor that led to viagra -- Advanced imaging techniques -- Immunological tolerance and rejection -- Solid organ transplantation -- Kidney transplantation -- Liver transplantation - Heart transplantation -- Bone marrow transplantation -- Ancient and early surgery -- The Development of medical subspecialties -- The Development of surgical subspecialties -- Minimally invasive surgery -- Birthing care -- Hospitals -- Coronary care and other intensive care units -- Streptomycin and control of tuberculosis -- Digitalis -- The Pneumococcus from hell and understanding antibiotic resistance -- The Development of antiviral drugs and cures for childhood leukemia -- Chemotherapy for malignant disease -- Therapeutic radiation -- Rita Levi-Montalcini discovers nerve growth factor -- Hemodialysis -- Restoration of vision with cataract and retinal surgery -- Understanding retroviruses and the treatment of AIDS -- The Polymerase chain reaction (PCR) -- The Human genome project -- Gene therapy -- The Electrocardiogram -- Mitochondrial function and disease -- Freud and the realization of the unconscious mind -- Group and family therapy -- Twelve-step programs and the treatment of addictive behavior -- Methadone maintenance treatment -- Treatment of schizophrenia -- Treatment of depression -- "Introduction to the study of experimental medicine" by Claude Bernard, and the protection of experimental subjects -- Tissue culture --- Understanding alcohol and health -- Preprofessional healthcare and the development of fee-for-service -- Socialized medicine -- Single-payer systems -- The Fight to open medicine to women and minorities -- Health maintenance organizations -- Preventive medicine -- Refuse disposal -- Recalled to life by physical and occupational therapy -- The Molecular biology of learning and memory -- Neonatology and gerontology -- In vitro fertilization and bastocyst selection -- Stem cells and regenerative medicine -- Prospective, randomized, double-blind, controlled clinical trials -- Patient-advocacy.!1591023734 (hardcover alk. paper)141143839Jefferson or Adams Building Reading Rooms R131; .S83 2006|?Tilney, Nicholas L.2006cA perfectly striking departure : surgeons and surgery at the Peter Bent Brigham Hospital, 1912-1980 xi, 282 p.Sagamore Beach, MA Science History Publications/USA6Peter Bent Brigham Hospital. Dept. of Surgery History.[2006045026 Nicholas L. Tilney. ill. ; 24 cm. Includes bibliographical references and index.0881353825 (alk. paper)14359264;Jefferson or Adams Building Reading Rooms RD28.A1; T55 2006|? Tutt, Cedric2006/Small animal dentistry : a manual of techniques vi, 282 p.Oxford ; Ames, IowaBlackwell Pub.]Veterinary dentistry. Dogs Diseases Treatment. Cats Diseases Treatment. Dentistry veterinary.http://www.loc.gov/catdir/toc/ecip0612/2006012268.html http://www.loc.gov/catdir/enhancements/fy0802/2006012268-b.html http://www.loc.gov/catdir/enhancements/fy0802/2006012268-d.html2006012268 GBA639038 101273741 013442983 Cedric Tutt. col. ill. ; 28 cm. Includes bibliographical references and index. Tooth development (odontogenesis) -- Clinical examination -- Equipping a veterinary dental operatory -- Radiography -- Exodontics -- Jaw fracture repair -- Oral surgery -- Suture material -- Restoration -- Endodontic therapy -- Pain management -- Malocclusions and normal occlusion -- Cases to refer to your local veterinary dentist.D1405123729 (hardback alk. paper) 9781405123723 (hardback alk. paper)14337405:Jefferson or Adams Building Reading Rooms SF867; .T88 2006~?3Watanabe, Masaki Hirohata, Kazushi Ikeuchi, Hiroshi1977Shitsu kansetsu no geka 8, 423 p. Knee Surgery.577676668 27 cm. Romanized. Surgery of the knee joint.62322155Jefferson or Adams Building Reading Rooms RD561; .S54|?Insall, John N.1984Surgery of the kneexiv, 828 p., 4 p. of platesNew YorkChurchill Livingstone Knee Surgery.v83015075 edited by John N. Insall ; with 23 contributors. ill. (some col.) ; 27 cm. Includes bibliographies and index. 0443080879933905C|? Banks, S A.2006<Understanding knee arthroplasty kinematics: News you can use1-7Surgery of the knee2Scott, W. Norman PhiladelphiaElsevier4thQKnee Surgery. Arthroplasty. Knee Injuries surgery. Ligaments, Articular injuries.2006273273 [edited by] W. No&|?Jackson, J. P. Waugh, W.1984Surgery of the knee joint xiv, 473 p. PhiladelphiaJ.B. Lippincott Co. Knee Surgery.83082568 edited by J.P. Jackson and W. Waugh ; with illustrations by G. Lythe. ill. ; 24 cm. Includes bibliographies and index. 03975829194638715|?GAmerican Academy of Orthopaedic Surgeons. Committee on Rehabilitation.,1978NSymposium on reconstructive surgery of the knee, Rochester, New York, May 1976 xiv, 365 p. St. LouisMosby1Knee Surgery Congresses. Arthroplasty Congresses.78006486 American Academy of Orthopaedic Surgeons. ill. ; 26 cm. Papers presented at a course sponsored by the Committee on Rehabilitation of the American Academy of Orthopaedic Surgeons. Includes bibliographies and index. 080160132032089975Jefferson or Adams Building Reading Rooms RD561; .S95O|?Dandy, David J.1987#Arthroscopic management of the knee vi, 223 p. Current problems in orthopaedicsEdinburgh ; New YorkChurchill Livingstone2nd3Knee Endoscopic surgery. Arthroscopy. Knee surgery.86017609 £50.00 (U.K.) David J. Dandy. ill. (some col.) ; 29 cm. Rev. ed. of: Arthroscopic surgery of the knee, 1981. Includes bibliographies and index. 044302958X1933445:Jefferson or Adams Building Reading Rooms RD561; .D36 1987p|?Dandy, David J.1981 Arthroscopic surgery of the knee122 p. Current problems in orthopaedicsEdinburgh ; New YorkChurchill Livingstone>Knee Endoscopic surgery. Arthroscopy. Knee Surgery. Endoscopy.q80041772 GB81 £26.00 David J. Dandy ; foreword by R.W. Jackson. ill. ; 29 cm. Includes bibliographies and index. 04430204774664217o|?#Löhnert, Johannes Raunest, Jürgen1988 Arthroscopic surgery of the knee161 p.Stuttgart ; New York New York"Thieme ; Thieme Medical Publishers9Knee Endoscopic surgery. Arthroscopy. Knee Joint surgery.87026770 Arthroskopische Chirurgie des Kniegelenkes. English Johannes Löhnert and Jürgen Raunest ; translated by Rodney Price. ill. (some col.) ; 29 cm. Translation of: Arthroskopische Chirurgie des Kniegelenkes. Bibliography: p. 147-156. Includes index.9086577224X (Thieme Medical Publishers) 0865772746 (cover)3841414<Jefferson or Adams Building Reading Rooms RD561; .L6413 1988i|?Schonholtz, George J.1988,An atlas of arthroscopic surgery of the knee xi, 242 p.Springfield, Ill., U.S.A. C.C. ThomashKnee Endoscopic surgery Atlases. Arthroscopy Atlases. Arthroscopy methods atlases. Knee surgery atlases.R87018180 by George J. Schonholtz. ill. ; 26 cm. Includes bibliographies and index. 039805438X3840612 rman Scott. Insall & Scott surgery of the knee ill. (chiefly col.) ; 29 cm. + 1 laser optical disk (4 3/4 in.) Includes bibliographical references and index.044306671X (set)14285019:Jefferson or Adams Building Reading Rooms RD561; .S87 200611'O|?Soriano Hernández, Silvia1994)A propósito de la insurgencia en Chiapas227 p.MexicoYAsociación para el Desarrollo de la Investigación Científica y Humanística en Chiapas1.Chiapas (Mexico) History. Indians of Mexico Mexico Chiapas Social conditions. Social movements Mexico Chiapas History. Insurgency Mexico Chiapas History.d95237137 Silvia Soriano Hernández, coordinadora. ill. ; 22 cm. Includes bibliographical references. 96873850143047776:Jefferson or Adams Building Reading Rooms F1256; .P76 1994O|?Soriano Hernández, Silvia Universidad Nacional Autónoma de México. Centro de Investigaciones sobre América Latina y el Caribe.,2009-Los indígenas y su caminar por la autonomía251 p.Colección Miradas del centauro México, D.F.:Ediciones Eón : Universidad Nacional Autónoma de México1.RIndians of Mexico Politics and government Indians of Mexico Government relations. Indians of South America Bolivia Politics and government. Indians of South America Bolivia Government relations. Decentralization in government Mexico. Decentralization in government Bolivia. Mexico Politics and government. Bolivia Politics and government.2010447372 Silvia Soriano Hernández, coordinadora. ill., maps ; 22 cm. "CIALC, Centro de Investigaciones sobe América Latina y el Caribe"--P. [4] of cover. Includes bibliographical references.)9786077519492 (Eón) 9786070210174 (UNAM)16257694>Jefferson or Adams Building Reading Rooms F1219.3.P7; I53 2009LDK~?Beutelspacher Baigts, Ethel Soriano Hernández, Silvia Ramírez Espinosa, Armando González Blanco Garrido, Salomón Hernández de Valle Arizpe, Claudia Ruiz, Apen Fábregas, Andrés Cañas Domínguez, Manuel1993'[Poetry and prose from Chiapas, Mexico]Textos para abrir el milenio<8 >Tuxtla Gutiérrez, Mexico?Gobierno del Estado de Chiapas, Instituto Chiapaneco de Cultura1.Chiapas (Mexico)V94208378 28 cm. Includes bibliographical references. [1] Los tres diamantes / Ethel Beutelspacher Baigts -- [2] Los esclavos africanos y su mestizaje en la provincia de Chiapa / Silvia Soriano Hernández -- [3] De la memoria al llanto / Armando Ramírez Espinosa -- [4] Los sueños históricos de Benjamín / Salomón González Blanco Garrido -- [5] Otro es el tiempo / Claudia Hernández de Valle Arizpe -- [6] Cultura y poder en arqueología mesoamericana / Apen Ruiz -- [7] La antropología ante el nuevo tiempo / Andrés Fábergas Puig -- [8] Fray Matías de Córdoba / Manuel Cañas Domínguez664009:Jefferson or Adams Building Reading Rooms F1256; .P64 1993SM|?`Hernández Socorro, María de los Reyes Concepción Rodríguez, José Carbonell Soriano, Claudio2005:El patrimonio histórico de la Basílica del Pino de Teror195 p."Cuadernos de patrimonio histórico5Las Palmas de Gran CanariaCabildo de Gran Canaria1aBasílica de Nuestra Señora del Pino (Teror, Canary Islands) Church decoration and ornament Canary Islands Teror. Church architecture Conservation and restoration Canary Islands Teror. Cultural property Protection Canary Islands Teror. Teror (Canary Islands) Buildings, structures, etc.2006410253 María de los Reyes Hernández Socorro, José Concepción Rodríguez ; anexo, Claudio Carbonell Soriano. ill. ; 23 cm. Includes bibliographical references (p. 187-195). 848103420714314440>Jefferson or Adams Building Reading Rooms NA5811.T47; H47 2005|?5Pérez-Hernández, Roger Soriano, Pascual Lew, Daniel1994Marsupiales de Venezuela76 p.Cuadernos LagovenCaracas, VenezuelaLagovenoOpossums Venezuela Classification. Caenolestidae Venezuela Classification. Marsupials Venezuela Classification.94189070 Roger Pérez-Hernández, Pascual Soriano, Daniel Lew. ill. (some col.), maps ; 21 cm. Includes bibliographical references (p. [68]-[73]). 98025961243970168=Jefferson or Adams Building Reading Rooms QL737.M34; P47 1994|?2Soriano Hernández, Enrique Nadal Tárrega, Miquel1998GCasos prácticos de instituciones políticas de la Comunidad Valenciana159 p.ValenciaTirant lo BlanchAdministrative law Spain Valencia (Region) Problems, exercises, etc. Constitutional law Spain Valencia (Region) Problems, exercises, etc.t98156871 Enrique Soriano Hernández, Miquel Nadal Tárrega. 24 cm. Includes bibliographical references (p. 146-151). 84800258672622892?Law Library Reading Room (Madison, LM201) KKT8784.27; .S67 1998|?Soriano Hernández, Enrique2001?El estatuto de los parlamentarios de las comunidades autónomas540 p.Temas del Senado7MadridSecretaría General del SenadoeLegislative bodies Spain Autonomous communities. Parliamentary practice Spain Autonomous communities._2003398391 Enrique Soriano Hernández. 20 cm. Includes bibliographical references (p. 515-539). 848880248X13012009HReference - Law Library Reading Room (Madison, LM201) KKT2514; .S47 2001O|?Soriano Hernández, Silvia19944Lucha y resistencia indígena en el México colonial385 p.,México San Cristóbal de las Casas, ChiapasUniversidad Nacional Autónoma de México ; Universidad Nacional Autónoma de México, Centro de Investigaciones Humanísticas de Mesoamérica y el Estado de Chiapas1.Indians of Mexico History. Indians, Treatment of Mexico History. Indians of Mexico Government relations. Mexico History Spanish colony, 1540-1810.k96124685 Silvia Soriano Hernández. ill., maps ; 23 cm. Includes bibliographical references (p. [319]-338). 96836299031168347:Jefferson or Adams Building Reading Rooms F1219; .S67 1994M|?Soriano Hernández, Silvia2006'Mujeres y guerra en Guatemala y Chiapas289 p.Serie Nuestra América64México)Universidad Nacional Autónoma de México1.Women Guatemala Social conditions. Women Mexico Chiapas Social conditions. Guatemala History Civil War, 1960-1996 Women. Chiapas (Mexico) History Peasant Uprising, 1994- Women. Mujeres Guerra Guatemala Mujeres Guerra Chiapas2008475570 Silvia Soriano Hernández. 21 cm. "Centro Coordinador y Difusor de Estudios Latinoamericanos"--P. opp. t.p. Includes bibliographical references (p. [255]-284) and index. Nuestra América ; 64.9703231888 978970323188115532566;Jefferson or Adams Building Reading Rooms HQ1477; .S69 2006Q|?RHoppenfeld, Stanley2009&Clinical Examination of the Knee Joint181-206.1Physical examination of the spine and extremitiesBudapestMedicinagSpine Examination. Extremities (Anatomy) Examination. Extremities. Spine. Physical examination Methods.76001486 Stanley Hoppenfeld, in collaboration with Richard Hutton ; medical ill. by Hugh Thomas. 0|t74Hart, J. Omolo, B. Boone, W. R. Brown, C. Ashton, A.2007GReliability of three methods of computer-aided thermal pattern analysis175-85J Can Chiropr Assoc513 2007/09/22BACKGROUND: The objective of this study was to assess three methods of computer-aided thermal pattern analysis for a) examiner reliability, b) inter-method differences, and c) determine which method yields the highest percent-similarity between paired test-retest scans. METHODS: Three examiners compared two sets of thermal scans from the same 30 subjects using three different methods of scan alignment. The results were evaluated by the Intraclass Correlation Coefficient and the Wilcoxon signed-rank test, at the 5% level of significance. RESULTS: Intra and inter-examiner ICC scores for all methods were acceptable (> 0.75). There were no statistically significant differences (at the Bonferroni-corrected level of significance of 0.0004%) in percent similarity of the scans between the three methods CONCLUSIONS: The results contribute evidence to the reliability of TPC program software. Manually aligning the readings plays an important role in obtaining precise TPC percent-similarities.+http://www.ncbi.nlm.nih.gov/pubmed/17885680Hart, John Omolo, Bernard Boone, W R Brown, Charlene Ashton, Andrew Canada The Journal of the Canadian Chiropractic Association J Can Chiropr Assoc. 2007;51(3):175-85.%0008-3194 (Print) 0008-3194 (Linking)197844917885680cSherman College of Straight Chiropractic, Spartanburg, South Carolina 29304, USA. jhart@sherman.edueng |t7eUhlig, T. Lillemo, S. Moe, R. H. Stamm, T. Cieza, A. Boonen, A. Mowinckel, P. Kvien, T. K. Stucki, G.20078Reliability of the ICF Core Set for rheumatoid arthritis1078-84 Annals of the Rheumatic Diseases668 2007/01/16 Activities of Daily Living Adult Aged Arthritis, Rheumatoid/*diagnosis *Disability Evaluation Female Health Status Indicators Humans Interviews as Topic Male Middle Aged Observer Variation Occupational Therapy Physical Therapy (Specialty) Sensitivity and SpecificityAuggBACKGROUND: The comprehensive ICF Core Set for rheumatoid arthritis (RA) is a selection of 96 categories from the International Classification of Functioning, Disability and Health (ICF), representing relevant aspects in the functioning of RA patients. OBJECTIVES: To study the reliability of the ICF Core Set for RA in rheumatological practice, and to explore the metric of the qualifiers' scale. METHODS: 25 RA patients from an outpatient department of rheumatology were interviewed using the ICF Core Set for RA (76% females, mean (SD) age 57.5 (12.5) years, disease duration 15.9 (14.6) years). Interviews were performed independently by both a physiotherapist and an occupational therapist on the same day and again after one week by one of them. The severity of the patients' problems was quantified on a qualifier scale ranging from 0 (no problem) to 4 (complete problem). Analyses of intra-rater and inter-rater agreement, kappa statistics, and Rasch analyses were applied. RESULTS: Mean intra-rater (inter-rater) complete agreement for all categories was seen in 59% (47%) of observations, ranging from 29% (0%) to 96% (80%) for individual categories. Weighted kappa statistics with value > or =0.4 showed reliability in 86% of categories within raters, and in 43% of categories between raters. Improved inter-rater and intra-rater reliability was observed with a reduced number of qualifiers for the categories. CONCLUSIONS: Inter-rater and intra-rater reliability of the ICF Core Set of RA was low to moderate. The metric of the qualifiers' scale may be improved by reducing the number of qualifiers to three for all components.+http://www.ncbi.nlm.nih.gov/pubmed/17223659&Uhlig, Till Lillemo, Solvar Moe, Rikke Helene Stamm, Tanja Cieza, Alarcos Boonen, Annelies Mowinckel, Petter Kvien, Tore Kristian Stucki, Gerold Evaluation Studies Research Support, Non-U.S. Gov't England Annals of the rheumatic diseases Ann Rheum Dis. 2007 Aug;66(8):1078-84. Epub 2007 Jan 12.%0003-4967 (Print) 0003-4967 (Linking)195472017223659National Resource Center for Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Postboks 23 Vinderen, N-0319 Oslo, Norway. till.uhlig@nrrk.no-ard.2006.058693 [pii] 10.1136/ard.2006.058693eng3||7 Boone, D.1998dInternal consistency reliability of the Personality Assessment Inventory with psychiatric inpatients839-43J Clin Psychol546 1998/10/23Adolescent Adult Female Humans Male Mental Disorders/classification/*diagnosis/psychology Middle Aged *Patient Admission Personality Assessment/*statistics & numerical data Personality Disorders/classification/*diagnosis/psychology Psychometrics Reproducibility of ResultsOctInternal consistency reliability (Cronbach's alpha) estimates and standard errors of measurement were determined for the Personality Assessment Inventory (PAI; Morey, 1991) with a group of psychiatric inpatients (N = 111). Full-scale reliabilities were large and acceptable, averaging .82. Subscale reliabilities were lower, averaging .66. Reliability estimates for full scales and subscales were comparable to those reported for the clinical portion of the PAI standardization group. Of the 20 full scales examined, only 2 (Somatization and Paranoia) had reliabilities (.85 and .80, respectively) that were significantly lower than comparable values reported for the standardization group. Despite statistically significant differences, these values were still considered large and acceptable.*http://www.ncbi.nlm.nih.gov/pubmed/9783665\Boone, D United states Journal of clinical psychology J Clin Psychol. 1998 Oct;54(6):839-43.%0021-9762 (Print) 0021-9762 (Linking)9783665:Trenton Psychiatric Hospital, West Trenton, NJ 08628, USA.D10.1002/(SICI)1097-4679(199810)54:6<839::AID-JCLP12>3.0.CO;2-M [pii]engt||7 Boone, D.1994OReliability of the MMPI-2 Subtle and Obvious scales with psychiatric inpatients346-51 J Pers Assess622 1994/04/01Adjustment Disorders/classification/diagnosis/psychology Adolescent Adult Female *Hospitalization Humans MMPI/*statistics & numerical data Male Mental Disorders/classification/*diagnosis/psychology Middle Aged Mood Disorders/classification/diagnosis/psychology Personality Disorders/classification/*diagnosis/psychology Psychometrics Reproducibility of Results Schizophrenia/classification/diagnosis Schizophrenic Psychology Substance-Related Disorders/classification/diagnosis/psychologyAprInternal consistency reliability estimates were determined for the Wiener and Harmon (1948) Subtle and Obvious scales of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) with a group of psychiatric inpatients. Except for Subtle Scale 3 (Hy), Subtle scale reliabilities were unacceptably low, ranging from .32 to .59. In each case, inclusion of the Subtle items attenuated the reliability of the corresponding Full clinical scale. Removing the Subtle items resulted in comparable reliabilities across all Minnesota Multiphasic Personality Inventory-2 (MMPI-2) scales, ranging from .75 to .92. It was hypothesized that the poor reliability of the Subtle scales may attenuate the validity of the Full clinical scales.*http://www.ncbi.nlm.nih.gov/pubmed/8189342^Boone, D United states Journal of personality assessment J Pers Assess. 1994 Apr;62(2):346-51.%0022-3891 (Print) 0022-3891 (Linking)8189342DDrake Complex, Trenton Psychiatric Hospital, West Trenton, NJ 08628.eng||7 Boone, D. E.19925Reliability of the WAIS-R with psychiatric inpatients72-6J Clin Psychol481 1992/01/01Adjustment Disorders/diagnosis/psychology Adolescent Adult Female *Hospitalization Humans Male Mental Disorders/diagnosis/*psychology Middle Aged Mood Disorders/diagnosis/psychology Personality Disorders/diagnosis/psychology Psychometrics Reproducibility of Results Schizophrenia/diagnosis Schizophrenic Psychology Substance-Related Disorders/diagnosis/psychology Wechsler Scales/*statistics & numerical dataJannWAIS-R subtest and composite scale reliabilities, standard errors of measurement, and standard errors of estimate were determined for a sample of psychiatric inpatients (N = 100). For Digit Span and Digit Symbol, test-retest stability coefficients were obtained; split-half reliability coefficients were calculated for all other subtests. With the exception of Object Assembly (rxx = .38), all subtest and composite scale reliability coefficients were large and acceptable. Based on the standard error of measure, the most reliable WAIS-R subtests were Digit Symbol (.77), Information (1.04), and Picture Completion (1.07). Reliability coefficients for the psychiatric inpatient sample were, in general, comparable to those values reported for the standardization group (Wechsler, 1981). Significant differences were obtained only on the Object Assembly and Vocabulary subtests.*http://www.ncbi.nlm.nih.gov/pubmed/1556220\Boone, D E United states Journal of clinical psychology J Clin Psychol. 1992 Jan;48(1):72-6.%0021-9762 (Print) 0021-9762 (Linking)1556220'Trenton Psychiatric Hospital, NJ 08628.eng ||7Azen, S. P. Irvine, A. R. Davis, M. D. Stern, W. Lonn, L. Hilton, G. Schwartz, A. Boone, D. Quillen-Thomas, B. Lyons, M. et al.,1989]The validity and reliability of photographic documentation of proliferative vitreoretinopathy352-7 Ophthalmology963 1989/03/01Clinical Trials as Topic Diabetic Retinopathy/classification/*diagnosis/surgery *Fluorescein Angiography Humans Prognosis Random Allocation Retinal Detachment/classification/*diagnosis/surgery Scleral Buckling/methods Silicone Oils Vitrectomy/methodsMarThe Silicone Study is a multicentered, randomized surgical trial designed to compare the tamponade effectiveness of silicone oil versus long-acting gas in the treatment of proliferative vitreoretinopathy (PVR) by vitrectomy and associated techniques. Fundus photographs are taken to provide documentation of the anatomic status of eyes proposed for entry and are graded at an independent Reading Center. This article describes the protocol for photographic documentation of PVR as a continuum of increasing pathology, in which the pathology may only be present in the anterior retina, and the retina is usually highly elevated. In a validity and reliability study, agreement between photographic and clinical observation within one step was obtained for 88% of the eyes; intra- and inter-observer agreement within one step was 85 and 80%, respectively. Differences between the surgeon's grade and the Reading Center's were caused about equally by disagreement regarding extent of fixed folds and width of the funnel. Rarely did peripheral folds not visible in the photographs appear to be the sole explanation of the disagreement. Differences among readers were concerned mainly with differentiation of true full-thickness fixed folds from folds due to simple redundancy of the detached retina. These results demonstrate that complicated retinal detachment (RD) can be photographically documented and independently assessed.*http://www.ncbi.nlm.nih.gov/pubmed/26520293Azen, S P Irvine, A R Davis, M D Stern, W Lonn, L Hilton, G Schwartz, A Boone, D Quillen-Thomas, B Lyons, M EY05571/EY/NEI NIH HHS/United States Clinical Trial Comparative Study Randomized Controlled Trial Research Support, U.S. Gov't, P.H.S. United states Ophthalmology Ophthalmology. 1989 Mar;96(3):352-7.%0161-6420 (Print) 0161-6420 (Linking)2652029XDepartment of Preventive Medicine, University of Southern California, Los Angeles 90033.engy||73Boone, R. M. van Venrooij, G. E. van der Gon, J. J.1979Two-dimensional echo-encephalography. 2. Clinical use and reliability of two-dimensional echo-encephalography in neurology and neurosurgery9-21Acta Neurochir (Wien)491-2 1979/01/01Brain Diseases/*diagnosis Brain Neoplasms/diagnosis *Echoencephalography/methods Evaluation Studies as Topic Follow-Up Studies HumansMore than two hundred patients with intracranial lesions were examined by means of B-scan echo equipment specially adapted for the detectionof weak reflections. An impression of the accuracy of the method is demonstrated by the results obtained in those patients where the diagnosis had been verified at surgery or autopsy. It appeared that B scanning is a quite reliable diagnostic method. It was found that intracranial tumours showed typical echo-patterns. Furthermore, we found that B scanning may be an important diagnostic aid in follow-up examinations of patients. However, the ultrasound technique as used by us has also a restriction: it is unsuited for the estimation of the precise extension of pathological areas and for the estimation of the nature of pathology.)http://www.ncbi.nlm.nih.gov/pubmed/525467tBoone, R M van Venrooij, G E van der Gon, J J Austria Acta neurochirurgica Acta Neurochir (Wien). 1979;49(1-2):9-21.%0001-6268 (Print) 0001-6268 (Linking)525467engW||7@Boone, D. C. Azen, S. P. Lin, C. M. Spence, C. Baron, C. Lee, L.1978'Reliability of goniometric measurements1355-60 Phys Ther5811 1978/11/01Adult Analysis of Variance Arm/physiology Extremities/*physiology Humans Joints/*physiology Leg/physiology Male Middle Aged *Movement Weights and MeasuresNov%This study determined the intratester and intertester variability and reliability of goniometric measurements taken by four physical therapists on upper and lower extremity motions of normal male subjects. The same subjects were measured once weekly for four weeks by testers with varied experience in goniometry. Data were analyzed by analyses of variance with repeated measures. Intratester variation for all measurements was less than intertester variation. Further, intertester variation was less for the three upper extremity motions than for those of the lower extremity. These findings indicate the necessity for using the same tester when effects of treatment are evaluated. When the same tester measures the same movement, increases in joint motion of at least three to four degrees determine improvement for either the upper or lower extremity. When more than one tester, however, measures the same movement, increases in joint motion should exceed five degrees for the upper extremity and six degrees for the lower extremity to determine improvement.)http://www.ncbi.nlm.nih.gov/pubmed/704684zBoone, D C Azen, S P Lin, C M Spence, C Baron, C Lee, L United states Physical therapy Phys Ther. 1978 Nov;58(11):1355-60.%0031-9023 (Print) 0031-9023 (Linking)704684eng ||76Tóth, K. Sisak, K. Nagy, J. Manó, S. Csernátony, Z.2010tRetrograde stem removal in revision hip surgery: removing a loose or broken femoral component with a retrograde nail813-8Arch Orthop Trauma Surg1307 2010/02/19JulINTRODUCTION: Removal of a cemented femoral stem during revision total hip arthroplasty is a technically demanding procedure that requires a multitude of surgical techniques and tools. To gain full access to the cement and the stem, distal fenestration or a transfemoral approach is often required. This paper presents a technique of retrograde removal of femoral stems and cement from the distal femur. MATERIALS AND METHODS: The authors present five clinical cases. In two cases the femoral component and the surrounding cement was removed using this technique. In the other three cases, due to femoral component fracture, the distal fragment of the femoral component with its cement mantle was removed using the same technique. In an experimental study, we simulated the above technique and compared it with a windowing technique on six, paired cadaveric femora (12 femurs in all). RESULTS: In all of the clinical cases the stem and the cement were removed completely without any complications. The cadaveric experiments clearly showed that the biomechanical resistance of the femur against compression and torsion forces is greatly decreased by using a window to access the proximal femur, compared with the retrograde technique, which shows no significant change. CONCLUSION: Retrograde component removal provides a simple, rapid, and less invasive technique for stem and cement extraction in elective revision hip arthroplasty.+http://www.ncbi.nlm.nih.gov/pubmed/20165860Toth, K Sisak, K Nagy, J Mano, S Csernatony, Z Germany Archives of orthopaedic and trauma surgery Arch Orthop Trauma Surg. 201 ||76Papp, M. Csernatony, Z. Kazai, S. Karolyi, Z. Rode, L.2007dThe patella and tibial condyle position after combined and after closing wedge high tibial osteotomy769-80#Knee Surg Sports Traumatol Arthrosc156 2007/02/07Adult Aged Female Follow-Up Studies Humans Male Middle Aged Osteoarthritis, Knee/surgery Osteotomy/adverse effects/*methods Patella/*radiography Tibia/*radiography/*surgeryJun= High tibial osteotomy changes the patella and tibial condyle position, which makes the subsequent total knee replacement technically demanding. From 1 January 1993 to 31 December 2000, combined osteotomy [After the first osteotomy made 2 cm distally to the joint line, a bone wedge is removed based laterally. Its tip ends at the center of the tibial condyle (half bone wedge). The distal part of the tibia is placed into the valgus position and the half bone wedge is placed into the gap opened medially.] was performed on 103 knees and closing wedge osteotomy was performed on 47 consecutive knees. Eighty combined (group A) and 41 closing wedge (group B) osteotomy were studied. All knees were assessed radiologically before surgery, in the 10th postoperative week, in the 12th postoperative month and at the time of the final follow-up (in group A-66.15 months, in group B-66.61 months). We examined the change of the femorotibial angle, of the patellar height according to the method of Insall and Salvati, of the tibial slope angle according to the method of Bonnin, of the tibial condylar offset according to the method of Yoshida and of the distance between the lateral tibial plateau and the top of the fibular head. In group A and B, the recurrence of the varus deformity was not noted and valgus alignment did not increase in any case. In group-A, the Insall-Salvati ratio remained unchanged in 65% of knees. The tibial slope angle decreased in both groups. There was correlation between the change of the tibial condylar offset and the angle of the correction in both groups. There was correlation between the change of the distance between the lateral tibial plateau and the top of the fibular head. After combined osteotomy, the transposition of the tibial condyle and the decrease of the distance between the lateral tibial plateau and the top of the fibular head was less than after closing wedge osteotomy, although the average angle of correction was more after combined osteotomy (11.835 degrees ), than after closing wedge osteotomy (9.465 degrees ). Theoretically, the recurrence of the varus deformity, the increase of the valgus alignment and (in majority of cases) the shortening of the patellar tendon do not compromise the likelihood of successful conversion to the subsequent total knee replacement, either after combined or after closing wedge osteotomy. The combined osteotomy does not lead to considerable transposition of the tibial condyle and to considerable lateral tibial bone loss; therefore, theoretically, the combined osteotomy does not impair the subsequent total knee replacement.+http://www.ncbi.nlm.nih.gov/pubmed/17279426Papp, Miklos Csernatony, Zoltan Kazai, Sandor Karolyi, Zoltan Rode, Laszlo Comparative Study Germany Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA Knee Surg Sports Traumatol Arthrosc. 2007 Jun;15(6):769-80. Epub 2007 Feb 6.%0942-2056 (Print) 0942-2056 (Linking)17279426Department of Orthopaedic Surgery, Borsod County Hospital, 72-76 Szentpeteri kapu str., Miskolc 3501, Hungary. drpapp.miklos@hotmail.com10.1007/s00167-006-0271-yeng l||7+Molnar, S. Mano, S. Kiss, L. Csernatony, Z.2006[Ex vivo and in vitro determination of the axial rotational axis of the human thoracic spineE984-91Spine (Phila Pa 1976)3126 2006/12/19Aged Biomechanics Cadaver Female Humans Magnetic Resonance Imaging Male Models, Biological *Rotation Thoracic Vertebrae/*anatomy & histology/*physiology Tomography, X-Ray ComputedDec 15STUDY DESIGN: Different geometrical and biomechanical evaluations were performed to determine the axial rotational axis of the thoracic spine. OBJECTIVE: Our research group has been dealing with the determination of the axial rotational axis of the thoracic spine. Here, we would like to present the geometrical and experimental results of our trials. With our experiments, we are trying to evaluate the contradictions of the related literature. SUMMARY OF BACKGROUND DATA: In the present state, we know quite a lot about the biomechanics of healthy and pathologic spines. Nevertheless, for a seemingly simple question like the position of the axial rotation of the thoracic spine, the literature gives contradicting results. During correction of a scoliotic deformity, when trying to correct the pathologic rotation, not knowing the physiologic rotation can be hazardous. METHODS: We wanted to clarify this question, so we examined the thoracic spine in many different ways. First, we examined the problem from a geometrical point of view then we modeled the different rotational axes by studying the change in volume of the spinal canal. Finally, we used cadaver spines that we rotated and examined with radiographs and digital pictures. RESULTS: Based on the results, we made the following establishments: most of the center points fell on the anterior half of the vertebral body or into the spinal canal, basically on the midsagittal axis of the vertebra. The rib cage has a significant effect on the place of the axis. After removing the ribs, the axis of axial rotation moved forward. CONCLUSIONS: After evaluating the results, we determined that the most likely place for the rotational axis is on the median-sagittal plane, in the anterior portion of the spinal canal.+http://www.ncbi.nlm.nih.gov/pubmed/17172989Molnar, Szabolcs Mano, Sandor Kiss, Laszlo Csernatony, Zoltan Research Support, Non-U.S. Gov't United States Spine Spine (Phila Pa 1976). 2006 Dec 15;31(26):E984-91.*1528-1159 (Electronic) 0362-2436 (Linking)17172989Department of Orthopaedics, Polyclinic of the Hospitaller Brothers of St. John of God in Budapest, Budapest, Hungary. sz0798@freemail.huA10.1097/01.brs.0000250183.97746.51 00007632-200612150-00016 [pii]eng}||7^Szepesi, K. Posan, E. Harsfalvi, J. Ajzner, E. Szucs, G. Gaspar, L. Csernatony, Z. Udvardy, M.2004aThe most severe forms of Perthes' disease associated with the homozygous Factor V Leiden mutation426-9J Bone Joint Surg Br863 2004/05/06Activated Protein C Resistance/complications Adolescent Adult Child Child, Preschool Factor V/*genetics Female Hip Joint/radiography Homozygote Humans Legg-Perthes Disease/complications/*genetics/radiography Male Point Mutation/genetics Retrospective Studies Severity of Illness IndexAprIt has recently been postulated that thrombophilia may have a role in the aetiology of Perthes' disease. The published reports, however, remain conflicting. In this study a retrospective analysis of the coagulation parameters was made in 47 patients with Perthes' disease and the results compared with the clinical data. Five patients with Factor V Leiden mutation were found (10.6%) and surprisingly four of them had a homozygous pattern. These four patients showed the most severe form of the disease, Catterall group IV, with flattening of the entire epiphysis, involvement of the metaphysis, shortening and broadening of the femoral neck, trochanteric overgrowth and developed mushroom-shaped aspherical laterally displaced femoral heads in dysplastic acetabula. We would like to suggest that the homozygous form of Factor V Leiden mutation has some role in the clinical course of Perthes' disease and particularly its most severe form.+http://www.ncbi.nlm.nih.gov/pubmed/15125132Szepesi, K Posan, E Harsfalvi, J Ajzner, E Szucs, G Gaspar, L Csernatony, Z Udvardy, M England The Journal of bone and joint surgery. British volume J Bone Joint Surg Br. 2004 Apr;86(3):426-9.%0301-620X (Print) 0021-9355 (Linking)15125132pDepartment of Orthopaedic Surgery, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary.eng ||7FFarkas, C. Hargitai, Z. Gaspar, L. Kuki, A. Csernatony, Z. Szepesi, K.2004;Histological changes in the symptomatic mediopatellar plica103-8Knee112 2004/04/07Adolescent Adult Female Humans Immunohistochemistry Knee Joint/*pathology Male Middle Aged Neurofilament Proteins/analysis Pain/etiology/*pathology Synovial Membrane/chemistry/*pathologyAprOne of the causes of anterior knee pain may be symptomatic mediopatellar plica. The pain is usually attributed to the mechanical damage caused by the plica inside the joint, or, more precisely, to the synovitis induced as a result. Recent observations seem to suggest, however, that the pain is, in addition, likely to be engendered by an increased number of nerve-elements present in the substance of the plica. The present study used up-to-date histochemical methods to reveal in the symptomatic mediopatellar plicae nerve-elements that may be made responsible for the pain. Semi-quantitative methods were used to establish the number of nerve-elements in the tissue samples obtained from 21 symptomatic mediopatellar plicae (Group 'A'), exposing them to view with the aid of synaptophysin and neurofilament serum, coupled with routine light microscope as well as polarising microscope examinations following H&E and van Gieson staining. Tissue samples taken from the asymptomatic mediopatellar plica of 11 patients served as control (Group 'B'). A significantly larger number of nerve-elements were found in the substance of the plicae of Group 'A' 6.9 (S.D.+/-2.9) than in Group 'B' 3 (S.D.+/-1.2). Within Group 'A', more nerve-elements were revealed in trauma-related case histories than in those with no recollections of trauma (an average of 9.6 vs. 5.2, respectively). Similarly, the reduction of pain achieved by surgery was greater in the trauma-related group than in the non-traumatic one (3.0 vs. 1.8, respectively). Relying on our observations, we claim that the painfulness of the knee joint plicae is in all probability also attributable to the fact that their tissue substance contains an increased number of nerve-elements. A major trauma in a particular case history contributes, in all likelihood, to an increase in the number of nerve-elements, but further examinations are required to clarify the pathomechanism involved.+http://www.ncbi.nlm.nih.gov/pubmed/15066619Farkas, Csaba Hargitai, Zoltan Gaspar, Levente Kuki, Attila Csernatony, Zoltan Szepesi, Kalman Research Support, Non-U.S. Gov't England The Knee Knee. 2004 Apr;11(2):103-8.%0968-0160 (Print) 0968-0160 (Linking)15066619Department of Orthopaedics, University of Debrecen, Medical and Health Science Centre, Nagyerdei krt. 98. H 4012 Debrecen, Hungary. farkas@josa.szabinet.hu510.1016/S0968-0160(02)00143-6 S0968016002001436 [pii]eng||7RGaspar, L. Dezso, B. Csernatony, Z. Szabo, J. Szekanecz, Z. Szepesi, K. Matesz, K.2004zCapsular neuronal elements and their relation to pain reduction and functional improvement following total hip replacement142-5International Orthopaedics283 2004/02/06*Arthroplasty, Replacement, Hip Health Status Indicators Humans Immunohistochemistry Joint Capsule/*innervation/metabolism Nerve Fibers/*metabolism Osteoarthritis/*physiopathology/*surgery Pain Measurement Treatment OutcomeJunWe studied changes of pain intensity and functional impairment in 22 patients with osteoarthrosis undergoing total hip replacement. Using a visual analogue scale, the mean scores for pain and disability before surgery were 71.7 and 70.9 respectively. Both scores showed gradual improvement during a 1-year follow-up period, with more than 90% of the total improvement occurring within the first 3 months. After 1 year, the scores for pain and disability were 11.9 and 4.1 respectively. The hip joint capsule was studied using immunohistochemistry to detect neurofilaments. Neurofilament immunoreactivity was observed in 16/22 cases and was correlated with pain and disability scores. However, there were no correlations between pre- and postoperative pain scores, the score changes, and the quantity of capsular neurofilaments. Thus, other factors than capsular neurofilaments influence the scores of pain and disability in osteoarthritis.+http://www.ncbi.nlm.nih.gov/pubmed/14762693Gaspar, Levente Dezso, Balazs Csernatony, Zoltan Gaspar, Lilla Szabo, Janos Szekanecz, Zoltan Szepesi, Kalman Matesz, Klara Research Support, Non-U.S. Gov't Germany International orthopaedics Int Orthop. 2004 Jun;28(3):142-5. Epub 2004 Feb 5.%0341-2695 (Print) 0341-2695 (Linking)14762693Department of Orthopaedic Surgery, Medical Health and Science Center, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary. lgaspar@jaguar.dote.hu10.1007/s00264-004-0539-0eng ||7]Posan, E. Szepesi, K. Gaspar, L. Csernatony, Z. Harsfalvi, J. Ajzner, E. Toth, A. Udvardy, M.2003OThrombotic and fibrinolytic alterations in the aseptic necrosis of femoral head243-8Blood Coagul Fibrinolysis143 2003/04/16KAdolescent Adult Aged Aged, 80 and over Biological Markers/blood Blood Coagulation/*physiology Case-Control Studies Child Child, Preschool Factor V/physiology Female Femur Head Necrosis/*blood/etiology Fibrinolysis/*physiology Hemostasis/*physiology Humans Legg-Perthes Disease/blood/etiology Male Middle Aged Retrospective StudiesAprZRecent reports seem to support the role of the thrombophilia and decreased fibrinolysis in the aetiopathogenesis of aseptic necrosis of bone. In the present study, haemostatic disturbances were analysed in adults (n = 49) and patients in childhood (Perthes disease) (n = 47) with aseptic necrosis of the femoral head. Fibrinolytic parameters (in vitro clot lysis, plasminogen, plasmatic plasminogen activator inhibitor-1 activity, D-dimer) along with lipoprotein (a) [Lp(a)] and fibrinogen were measured. von Willebrand factor, platelet activation and some thrombophilic factors (activated protein C resistance and factor V Leiden mutation, protein C, protein S activity) were also determined. Impaired fibrinolysis, an increased Lp(a) level along with slow clot lysis and increased platelet activation were found in adult cases. We detected five cases of factor V Leiden mutations (one heterozygotic and four homozygotic) among patients with Perthes disease. The clinical course of the heterozygous case was similar to the usual form of Perthes disease. The most severe form of Perthes disease has been observed in homozygous factor V Leiden mutation cases. The mutation of factor V Leiden per se probably does not induce the development of aseptic necrosis of bone tissue in childhood, but it does play a role in its acceleration. Homozygous factor V Leiden mutation definitely runs a more severe course. On the other hand, in adult cases, the disturbances of haemostasis, impaired fibrinolysis, elevated Lp(a) level, increased platelet activation and slight elevation of fibrinogen might have clinical relevance. Further studies should focus on proving the role of the haemostatic alterations in the pathogenesis of severe forms of aseptic bone necrosis. The use of antithrombotic drugs in order to slow the process of aseptic necrosis also has to be addressed in future surveys.+http://www.ncbi.nlm.nih.gov/pubmed/12695746,Posan, Emoke Szepesi, Kalman Gaspar, Levente Csernatony, Zoltan Harsfalvi, Jolan Ajzner, Eva Toth, Aniko Udvardy, Miklos Research Support, Non-U.S. Gov't England Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Blood Coagul Fibrinolysis. 2003 Apr;14(3):243-8.%0957-5235 (Print) 0957-5235 (Linking)126957462nd Department of Medicine, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, 4012 Debrecen, Hungary. eposan@jaguar.dote.hu"10.1097/01.mbc.0000061299.28953.34eng||77Csernatony, Z. Kiss, L. Mano, S. Gaspar, L. Szepesi, K.2003KMultilevel callus distraction: a novel idea to shorten the lengthening time494-7Med Hypotheses604 2003/03/05Bone Lengthening/*instrumentation/*methods Bony Callus Humans Ilizarov Technique Leg Length Inequality Models, Theoretical Time FactorsAprLower extremity inequality is a common problem in everyday orthopaedic practice. The leg discrepancy can lead to variety of other problems, i.e., spinal problems. Surgical intervention is very demanding and requires patient compliance. Wagner's and Ilizarov's elongation technique are most commonly used worldwide, but it gives satisfactory results only in a long period of time and as we know there could be several inconvenient outcomes. Our idea aims at shortening this time period, and avoiding some of the inconvenient outcomes. Unfortunately we do not have the opportunity to go further in our investigations, but we hope that someone interested in this field will have an idea which would make continuation possible.+http://www.ncbi.nlm.nih.gov/pubmed/12615506tCsernatony, Z Kiss, L Mano, S Gaspar, L Szepesi, K Scotland Medical hypotheses Med Hypotheses. 2003 Apr;60(4):494-7.%0306-9877 (Print) 0306-9877 (Linking)12615506rLaboratory of Biomechanics, Medical Health and Science Center, University of Debrecen, Hungary. csz@jaguar.dote.huS0306987702004322 [pii]engR||7IGaspar, L. Szekanecz, Z. Dezso, B. Szegedi, G. Csernatony, Z. Szepesi, K.2003WTechnique of synovial biopsy of metacarpophalangeal joints using the needle arthroscope50-2#Knee Surg Sports Traumatol Arthrosc111 2003/01/28Adult Arthritis, Rheumatoid/*pathology *Arthroscopes Arthroscopy/methods Biopsy, Needle Female Humans Metacarpophalangeal Joint/*pathology Middle Aged Synovial Fluid/*cytologyJanyWe demonstrate the technique, advantages, and disadvantages of metacarpophalangeal joint examination with needle arthroscope. We evaluated our experience from biopsies of 10 metacarpophalangeal joints of eight rheumatoid women aged 41-45 years. The procedures were performed using a 1-mm needle arthroscope. The synovium biopsy was taken with a microforceps. The procedure was performed under local anesthesia. The tight tension of the joint and traction of the finger is necessary for good visualization, but despite this visibility can be difficult. Needle biopsy is a useful method for the early diagnosis of rheumatoid arthritis.+http://www.ncbi.nlm.nih.gov/pubmed/12548452Gaspar, Levente Szekanecz, Zoltan Dezso, Balazs Szegedi, Gyula Csernatony, Zoltan Szepesi, Kalman Germany Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA Knee Surg Sports Traumatol Arthrosc. 2003 Jan;11(1):50-2. Epub 2002 Dec 10.%0942-2056 (Print) 0942-2056 (Linking)12548452Department of Orthopedics, Medical Health and Science CenterUniversity of Debrecen, Nagyerdei krt. 98, 4012, Debrecen, Hungary. lgaspar@jaguar.dote.hu10.1007/s00167-002-0329-4eng||7/Csernatony, Z. Gaspar, L. Jonas, Z. Szepesi, K.2002?Modified unit rod technique in scoliosis surgery--a case report481-2Acta Orthop Scand734 2002/10/03QChild Female Humans Scoliosis/radiography/*surgery Spinal Fusion/*instrumentationAug+http://www.ncbi.nlm.nih.gov/pubmed/12358127Csernatony, Zoltan Gaspar, Levente Jonas, Zoltan Szepesi, Kalman Case Reports Norway Acta orthopaedica Scandinavica Acta Orthop Scand. 2002 Aug;73(4):481-2.%0001-6470 (Print) 0001-6470 (Linking)12358127xDepartment of Orthopaedic Surgery, University of Debrecen, Medical and Health Science Center, Hungary. csz@jaguar.dote.h10.1080/00016470216325eng||7.Csernatony, Z. Szepesi, K. Gaspar, L. Kiss, L.2002HContradictions of derotation in scoliosis surgery using the CD principle498-502Med Hypotheses586 2002/09/278Humans Orthopedic Procedures/*methods Scoliosis/*surgeryJunCurrent literature has increasingly emphasized the problem of derotation in scoliotic deformities. The Cotrel-Dubousset (CD) principle as a means of correcting rotation has been questioned by various authors. This paper aims to draw attention, using algebraic methods, to the importance of the remaining rotational deformities, and to suggest the introduction of the notion 'rotational balance'.+http://www.ncbi.nlm.nih.gov/pubmed/12323117nCsernatony, Z Szepesi, K Gaspar, L Kiss, L Scotland Medical hypotheses Med Hypotheses. 2002 Jun;58(6):498-502.%0306-9877 (Print) 0306-9877 (Linking)12323117|Department of Orthopaedics, Medical Health and Science Center, University of Debrecen, Debrecen, Hungary. csz@jaguar.dote.huS0306987701914707 [pii]eng ||7MCseri, J. Szappanos, H. Szigeti, G. P. Csernatony, Z. Kovacs, L. Csernoch, L.2002VA purinergic signal transduction pathway in mammalian skeletal muscle cells in culture731-8 Pflugers Arch4435-6 2002/03/13)Adenosine Triphosphate/*analogs & derivatives/pharmacology Anesthetics, Local/pharmacology Animals Antineoplastic Agents/pharmacology Calcium/metabolism Calcium Channel Blockers/pharmacology Cells, Cultured Dose-Response Relationship, Drug Humans Mammals Mice Muscle Fibers, Skeletal/cytology/*physiology Muscle, Skeletal/*cytology/growth & development Nicotinic Antagonists/pharmacology Receptors, Purinergic P2/agonists/*physiology Signal Transduction/drug effects/*physiology Tetrodotoxin/pharmacology Tubocurarine/pharmacology Verapamil/pharmacologyMarThe effects of adenosine 5'-triphosphate (ATP) on human and mouse skeletal muscle fibres in primary culture were investigated. ATP-evoked changes in intracellular calcium concentration ([Ca(2+)](i)) were measured and compared with those induced by agonists of the nicotinic acetylcholine (Ach)- and P2X purinoreceptors. While ATP was effective on both myoblasts and multi-nucleated myotubes in the micromolar range, Ach failed to induce any change in [Ca(2+)](i) at early stages of development. In contrast, myofibres with peripheral nuclei showed little response to ATP but responded to Ach with a large change in [Ca(2+)](i). The responsiveness of the myotubes to Ach paralleled that to potassium. The removal of external calcium abolished the response to ATP. P2X receptor agonists mimicked the response to ATP with the order of potency being ATP>2',3'- O-(4-benzoyl)-benzoyl-ATP>beta,gamma-methylene-ATP>alpha,beta-methylene-AT P. Under voltage-clamp conditions ATP induced an inward current that showed little inactivation. These results are consistent with the existence of P2X receptor-mediated signal transduction pathway in cultured mammalian skeletal muscle cells.+http://www.ncbi.nlm.nih.gov/pubmed/11889570Cseri, Julianna Szappanos, Henrietta Szigeti, Gyula Peter Csernatony, Zoltan Kovacs, Laszlo Csernoch, Laszlo Research Support, Non-U.S. Gov't Germany Pflugers Archiv : European journal of physiology Pflugers Arch. 2002 Mar;443(5-6):731-8. Epub 2001 Dec 4.%0031-6768 (Print) 0031-6768 (Linking)11889570xDepartment of Physiology, Medical and Health Science Centre, University of Debrecen, Debrecen, P.O.Box 22, 4012 Hungary.10.1007/s00424-001-0757-xeng||79Csernatony, Z. Szepesi, K. Gaspar, L. Dezso, Z. Jonas, Z.2000The 'rotational preconstraint'203-6Med Hypotheses542 2000/05/03Humans Models, Biological Muscle, Skeletal/physiopathology Scoliosis/*etiology/*physiopathology Spine/*physiopathology Stress, MechanicalFebfThis model provides a novel view of the etiology of some scolioses and can answer some of the biomechanical questions regarding pathogenesis of dorsal curves. According to our findings, paravertebral muscular imbalance is likely to favour such a pathological condition which, with the interference of the postural reflexes and the body weight-related vertical loading, might lead to the formation of a true scoliotic curve. Review of earlier research studies in the light of our findings reveals controversy in some authors' reported results and their own interpretations and seems to generally support our theory.+http://www.ncbi.nlm.nih.gov/pubmed/10790753vCsernatony, Z Szepesi, K Gaspar, L Dezso, Z Jonas, Z Scotland Medical hypotheses Med Hypotheses. 2000 Feb;54(2):203-6.%0306-9877 (Print) 0306-9877 (Linking)10790753fRoyal National Orthopaedic Hospital, Institute of Orthopaedics, Stanmore, Middlesex, UK. cszuk@aol.com210.1054/mehy.1999.0019 S0306-9877(99)90019-1 [pii]eng||7@Abd-el Wahab, M. Szepesi, K. Szucs, G. Farkas, C. Csernatony, Z.1998MFunctional improvement after knee arthroplasty without resurfacing of patella59-66Acta Chir Hung371-2 1999/04/10Adult Aged Aged, 80 and over Arthritis/surgery Arthritis, Rheumatoid/surgery *Arthroplasty, Replacement, Knee/adverse effects Female Femur/pathology Follow-Up Studies Humans Incidence Knee Injuries/complications/surgery Knee Joint/*physiology/surgery Locomotion/physiology Male Middle Aged Osteoarthritis, Knee/surgery Patella/*pathology/surgery Range of Motion, Articular/physiology Treatment Outcome Weight-Bearing/physiologyTThere has been no universal agreement so far regarding the necessity of patellar resurfacing in total knee arthroplasty. As resurfacing has been reported to be associated with high incidence of complications, this practice has been avoided in our Department. A report is given on the analysis of the functional outcome of 60 knee arthroplasties without patellar resurfacing in 53 patients (7 bilateral) followed up for twelve to thirty months, with special regard to the functions closely related to patelloformal articulation. The underlying diagnosis was osteoarthritis in 78.3%, rheumatoid arthritis in 13.3%, and posttraumatic arthritis in 8.3% of the patients. Graded according to the modified knee-rating system of the Hospital for Special Surgery, excellent or good results were obtained in the case of 55 knees (91.6%) and the mean score improved from 53.6 points preoperatively to 82.6 points following arthroplasty. Subjective and objective functional assessment of stair climbing and transfer activities have shown no functional deficit attributed to the patellofemoral joint of the replaced knee.+http://www.ncbi.nlm.nih.gov/pubmed/10196612Abd-el Wahab, M Szepesi, K Szucs, G Farkas, C Csernatony, Z Hungary Acta chirurgica Hungarica Acta Chir Hung. 1998;37(1-2):59-66.%0231-4614 (Print) 0231-4614 (Linking)10196612IDepartment of Orthopaedics, University Medical School, Debrecen, Hungary.eng;||70Gaspar, L. Farkas, C. Szepesi, K. Csernatony, Z.1997RTherapeutic value of continuous passive motion after anterior cruciate replacement104-5Acta Chir Hung361-4 1997/01/01Adult Anterior Cruciate Ligament/injuries/*surgery Arthroscopy Endoscopy Evaluation Studies as Topic Exercise Therapy Female Follow-Up Studies Humans Joint Instability/rehabilitation/surgery Knee Injuries/rehabilitation/*surgery Male *Motion Therapy, Continuous Passive/methods Muscle Contraction Patient Discharge Patient Satisfaction Postoperative Complications Range of Motion, ArticularThe aim of this study is the evaluation of the therapeutic value of continuous passive motion after ACL replacement. After 41 ACL reconstruction in 13 cases only active motion, in 28 cases active motion and CPM were used postoperatively. Stability, the range of motion and complications were evaluated at the time of discharge, 3 and 6 months after the operation. The flexion-extension in the CPM group was significantly greater at the time of discharge, but this difference was practically eliminated in 6 months after the operation. There were not any other significant difference between the two groups. The CPM gives only a little advantage in the rehabilitation after the ACL replacement.*http://www.ncbi.nlm.nih.gov/pubmed/9408304rGaspar, L Farkas, C Szepesi, K Csernatony, Z Hungary Acta chirurgica Hungarica Acta Chir Hung. 1997;36(1-4):104-5.%0231-4614 (Print) 0231-4614 (Linking)9408304RDepartment of Orthopaedic Surgery, University Medical School of Debrecen, Hungary.eng||7$Gaspar, L. Farkas, C. Csernatony, Z.1997Acute arthroscopy100-3Acta Chir Hung361-4 1997/01/01Adolescent Adult Anterior Cruciate Ligament/injuries/surgery *Arthroscopy Athletic Injuries/diagnosis/surgery Dislocations/diagnosis/surgery *Endoscopy Evaluation Studies as Topic Female Femur/injuries/surgery Humans Knee Injuries/diagnosis/*surgery Male Medial Collateral Ligament, Knee/injuries/surgery Menisci, Tibial/injuries/surgery Middle Aged Occupational Diseases/diagnosis/surgery Patellar Ligament/transplantation Posterior Cruciate Ligament/injuries/surgery Rupture Tendons/transplantationThe role and significance of acute arthroscopy have been evaluated in the treatment of knee joint injuries on the basis of findings during 59 arthroscopic operations which were conducted within two weeks after the accident. The injuries developed isolated in more than half of the cases (65%) whereas they appeared in a combination of two or more in 26% and in 9%, respectively. Injuries requiring operation were found in 91.5%, most of which were ruptures of the ACL (33 cases) and menisci (23 cases). In the case of ACL rupture, in the acute phase on sportsmen and physical workers primary arthroscopically assisted transligamental replacement was performed with patellar graft while in the case of proximal rupture of the ACL reinsertion and augmentation were carried out with semitendinosus tendon. The ruptures of dislocated eminentia were refixed in each case. In the case of the rupture of meniscus the refixation of the meniscus of resection of the ruptured part was attempted. By means of acute arthroscopy the lesion of the intraarticular structures or that of their combinations can be exactly diagnosed. Depending on the findings of arthroscopy the injuries can be treated immediately or operated on at a later time, thus preventing the joint from further deterioration.*http://www.ncbi.nlm.nih.gov/pubmed/9408303gGaspar, L Farkas, C Csernatony, Z Hungary Acta chirurgica Hungarica Acta Chir Hung. 1997;36(1-4):100-3.%0231-4614 (Print) 0231-4614 (Linking)9408303RDepartment of Orthopaedic Surgery, University Medical School of Debrecen, Hungary.eng { ||7`Csernátony, Z. Gáspár, L. Benkő, K. Fekete, Z. Soós, P. Nyulasi, T. Szepesi, K. Jónás, Z.1997YExperimental studies for the surgical correction and fixation of dorsal spine deformities51-3Acta Chir Hung361-4 1997/01/01 Cadaver Dissection Equipment Design Humans Internal Fixators Kyphosis/surgery *Orthopedic Fixation Devices/adverse effects Osteoporosis/complications Rotation Scoliosis/radiography/*surgery Spinal Fractures/etiology Spine/radiography/*surgery Stress, Mechanical Tomography, X-Ray ComputedOne of the specific features of the scoliosis operations with a posterior approach is that both the correction of the deformity and then the maintaining of the corrected situation are carried out with the help of the implants. With the currently applied systems based on the CD principle it is still difficult to control the rotational component of the scoliotic curve. To complement the systems based on the CD principle, we have developed an implant family whose application makes the correction of the dorsal deformity generally simplier and derotation more effective. Our method is based on the application of such hooks which, linked to the longitudinal rods and hooked on both transverse processes of the instrumented vertebrae, transmit the concerted forces exerting their influence in the direction of the correction. Depending on their symmetrical relations, the hooks are capable of tilting in the frontal plane and derotating in the horizontal plane simultaneously, in the direction of our choice. The stability and applicability of the hooks were tested in implants into cadavers, and then the intimate relations of the implants were examined by means of radiological tests and dissection on instrumen|~7#Szepesi, K. Rigo, J. Csernatony, Z.1993l[Experience with the implantation of porous coated hip endoprostheses and primary stability of implantation]253-9*Magy Traumatol Ortop Kezseb Plasztikai Seb363 1993/01/01Adult Female Femoral Neck Fractures/complications/surgery Femur Head Necrosis/etiology/surgery Hip Dislocation, Congenital/*complications/surgery Hip Prosthesis/*methods Humans Joint Instability/rehabilitation Male Middle Aged Osteoarthritis, Hip/etiology/*surgery Prosthesis DesignNThe use of porous coated cementless prosthesis, shows a worldwide spread in consequence of the advantages given by the "live" connection between the implant and the bone. Based on 40 implantations of prostheses of this type (Duraloc 1200 acetabulum, AML shaft) authors report on the technique of the implantation and the primary stability reached. In consequence of the formation, the variety of size and the properly usable instruments for implantation, the prostheses could be used for every kind of deformed, dysplastic hips and good primary stability was reached in every case operated.*http://www.ncbi.nlm.nih.gov/pubmed/8364660Szepesi, K Rigo, J Csernatony, Z English Abstract Hungary Magyar traumatologia, ortopedia, kezsebeszet, plasztikai sebeszet Magy Traumatol Ortop Kezseb Plasztikai Seb. 1993;36(3):253-9.8364660mTapaztalataink porosus bevonatu csipoprothesis beultetesi technikajaval es a beultetes primer stabilitasaval.DDebreceni Orvostudomanyi Egyetem Ortopediai Klinikajanak kozlemenye.hun||7$Csernatony, Z. Gaspar, L. Morocz, I.1991+[Synovial chondromatosis of the knee joint]53-6&Magy Traumatol Orthop Helyreallito Seb341 1991/01/01Adolescent Chondromatosis, Synovial/etiology/radiography/*surgery Female Humans Knee Injuries/*complications Knee Joint/radiography/surgeryAuthors removed more than hundred free bodies from the knee joint of a young female patient. In connection with their case the criteria of the synovial chondromatosis, the theories concerning the pathogenesis and the therapy to be chosen are described, based on literary data.*http://www.ncbi.nlm.nih.gov/pubmed/1672718Csernatony, Z Gaspar, L Morocz, I Case Reports English Abstract Review Hungary Magyar traumatologia, orthopaedia es helyreallito sebeszet Magy Traumatol Orthop Helyreallito Seb. 1991;34(1):53-6.%0025-0317 (Print) 0025-0317 (Linking)1672718&Terdizuleti synovialis chondromatosis.DDebreceni Orvostudomanyi Egyetem Ortopediai Klinikajanak kozlemenye.hun||7$Mandi, A. Csernatony, Z. Szepesi, K.1989Z[Results in Miacalcic therapy in the analgesic treatment of patients with bone metastases]145-50&Magy Traumatol Orthop Helyreallito Seb322 1989/01/01Analgesics/therapeutic use Bone Neoplasms/*drug therapy/surgery Calcitonin/*therapeutic use Humans Pain, Intractable/*drug therapy Palliative Care Postoperative CareAuthors have administered between 1984--87 in 30 patients with bone metastasis weekly 3 X 100 iu Miacalcic injections to relieve pain. The literature dealing with the pain relieving effect of calcitonin is summarized and their own results are assessed from more viewpoints. The use of Miacalcic injection is suggested as it was found a modern and very effective palliative medicine for pain relieving.*http://www.ncbi.nlm.nih.gov/pubmed/2476638Mandi, A Csernatony, Z Szepesi, K English Abstract Hungary Magyar traumatologia, orthopaedia es helyreallito sebeszet Magy Traumatol Orthop Helyreallito Seb. 1989;32(2):145-50.%0025-0317 (Print) 0025-0317 (Linking)2476638\Miacalcic kezelessel elert eredmenyeink a csontmetastasisos betegek fajdalomcsillapitasaban.hun<||7PTolan, L. Barna, V. Szigeti, I. Tecsa, D. Gavris, C. Csernatony, O. Buchwald, I.19694[The use of bilberry powder in dyspepsia in infants]375-9Pediatria (Bucur)184 1969/07/018Dyspepsia/*drug therapy Humans Infant *Plants, MedicinalJul-Aug*http://www.ncbi.nlm.nih.gov/pubmed/5355704Tolan, L Barna, V Szigeti, I Tecsa, D Gavris, C Csernatony, O Buchwald, I Romania Pediatria Pediatria (Bucur). 1969 Jul-Aug;18(4):375-9.%0031-3904 (Print) 0031-3904 (Linking)53557046Utilizarea prafului de afine in dispepsille sugarului.rum (27-30 Biomech HungII2@ emoval in revision hip surgery: removing a loose or broken femoral component with a retrograde nail813-818*Archives of Orthopaedic and Trauma Surgery1307revision hip arthroplasty intramedullary nail cement removal retrograde cadaveric experiment cement removal bone-cement arthroplasty device polymethylmethacrylate osteotomyJul_Removal of a cemented femoral stem during revision total hip arthroplasty is a technically demanding procedure that requires a multitude of surgical techniques and tools. To gain full access to the cement and the stem, distal fenestration or a transfemoral approach is often required. This paper presents a technique of retrograde removal of femoral stems and cement from the distal femur. The authors present five clinical cases. In two cases the femoral component and the surrounding cement was removed using this technique. In the other three cases, due to femoral component fracture, the distal fragment of the femoral component with its cement mantle was removed using the same technique. In an experimental study, we simulated the above technique and compared it with a windowing technique on six, paired cadaveric femora (12 femurs in all). In all of the clinical cases the stem and the cement were removed completely without any complications. The cadaveric experiments clearly showed that the biomechanical resistance of the femur against compression and torsion forces is greatly decreased by using a window to access the proximal femur, compared with the retrograde technique, which shows no significant change. Retrograde component removal provides a simple, rapid, and less invasive technique for stem and cement extraction in elective revision hip arthroplasty.://000279297800001-617RD Times Cited:0 Cited References Count:32 0936-8051Arch Orthop Traum SuISI:000279297800001MToth, K Univ Szeged, Dept Orthopaed, 6 Semmelweis St, H-6725 Szeged, Hungary Univ Szeged, Dept Orthopaed, 6 Semmelweis St, H-6725 Szeged, Hungary Univ Szeged, Dept Orthopaed, H-6725 Szeged, Hungary Semmelweis Hosp, Dept Traumatol, H-6400 Kiskunhalas, Hungary Univ Debrecen Med Hlth & Sci Ctr, Dept Orthopaed, H-4032 Debrecen, HungaryDOI 10.1007/s00402-010-1063-xEnglish<7BJonas, Z. Kiss, L. Szabo, J. Soltesz, I. Gaspar, L. Csernatony, Z.2010@Our experiences with the surgical treatment of plantar fasciitis225-2278European Journal of Orthopaedic Surgery and Traumatology203eplantar fasciitis surgical treatment retrospective study heel pain chronic heel pain outcomes releaseAprThe authors present the results of surgical treatment of plantar fasciitis done at the University of Debrecen, Department of Orthopaedics, between 1996 and 2004 on 52 feet of 42 patients. The surgical indication was heel pain unresponsive to at least 6 months of conservative treatment with the exclusion of all differential diagnosis. During surgery, the partial detachment of the plantar aponeurosis origin was performed. The American Orthopaedic Foot and Ankle Society score was used for assessment. The average preoperative score of 43 increased to 85 postoperatively. Postoperatively 69% of the patients had excellent (86-100), 12% good (71-85), 4% average (61-70) and 15% had bad (fewer than 60) results. The patients 66% was very satisfied, 11% was satisfied, 12% was slightly satisfied, and 11% was unsatisfied with the surgical result. Based on our retrospective study, we recommend the surgical treatment of plantar fasciitis unresponsive to conservative treatment.://000276263500006-577ZR Times Cited:0 Cited References Count:14 1633-8065Eur J Orthop Surg TrISI:000276263500006Jonas, Z Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthopaed, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthopaed, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthopaed, H-4012 Debrecen, HungaryDOI 10.1007/s00590-009-0553-4English !<76Gaspar, L. Jonas, Z. Kiss, L. Vereb, G. Csernatony, Z.2009Coccygectomy has a favorable effect on the intensity, manifestation, and characteristics of pain caused by coccygodynia: a retrospective evaluation of 34 patients followed for 3-18 years403-4078European Journal of Orthopaedic Surgery and Traumatology196dcoccygodynia coccygectomy long-term results pain retrospective evaluation coccydynia etiology coccyxAugACoccygodynia can cause severe pain and disability in patients. There are contradictions in the literature regarding the final results of coccygectomy for coccygodynia. We evaluated the long-term effects of coccygectomy on the intensity, characteristics, and manifestation of pain caused by coccygodynia to determine the adequacy of operation among treatment modalities. Thirty-four patients with coccygodynia were treated by coccygectomy. In 22 cases, trauma, and in one case childbirth was the cause. 11 cases were regarded as idiopathic. The intensity, characteristics of pain, and the most painful activities were evaluated at an average of 7.6 (3-18) years of follow-up time. Before the operation, all 34 patients had pain while sitting, moreover, 26 of them had pain during standing, walking, at night or a combination of these. 21 patients had intolerable or very intensive, mainly acute, sharp or burning pain. 11 patients had dyschesia, 2 had dysuria and 6 had dyspareunia. At follow-up, 7 patients were completely free of pain, 15 others had moderate, 11 medium, and only one patient had severe, but none had intolerable pain. Only seven patients had acute, sharp or burning pain postoperatively. The decrease of average pain score from 8.0 to 3.2 was significant (P < 10(-12)). The number of the patients with dyschesia and dyspareunia decreased from 11 to 7 and from 6 to 3, respectively. Two patients had dysuria, but their complaints did not change after the operation. One of the two patients who needed reoperation had an excellent final result, while the other remained unchanged. 12 and 16 patients (together 82%) regarded the final result of the operation excellent and good, respectively. The condition of five others did not change, while one became worse. The patients with younger age, smaller body mass index, and less co-morbidities had better final result. There were no serious complications. Coccygectomy for coccygodynia is a safe method to decrease the intensity of pain and other complaints of the patients. The operation can be the choice of treatment if conservative measures fail.://000268777200004-480ZX Times Cited:0 Cited References Count:18 1633-8065Eur J Orthop Surg TrISI:000268777200004dGaspar, L Debrecen Univ Med, Hlth & Sci Ctr, Dept Orthoped, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Debrecen Univ Med, Hlth & Sci Ctr, Dept Orthoped, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Debrecen Univ Med, Hlth & Sci Ctr, Dept Orthoped, H-4012 Debrecen, Hungary Debrecen Univ Med, Hlth & Sci Ctr, Dept Biophys & Cell Biol, H-4012 Debrecen, HungaryDOI 10.1007/s00590-009-0442-xEnglish,<7 Csernatony, Z. Kiss, L. Mano, S.2008DA new technique of wedge osteotomy to diminish undesirable fractures485-4888European Journal of Orthopaedic Surgery and Traumatology187Hosteotomy finite element drill hole juxtacortical biomechanical analysisOctOpening and closing wedge osteotomy is a frequent procedure in orthopedics. Interestingly, the technique did not considerably change over the years. In this paper, we would like to introduce a new technique to make the cut easier and to decrease the fracture at the opposite cortex. Our proposal is that by making a juxtacortical drill hole on the opposite side and performing the osteotomy after, decreases the stress on the cortex therefore making it safer and easier to open or close. We demonstrate our idea through three cases.://000259369300001,350QX Times Cited:0 Cited References Count:4 1633-8065Eur J Orthop Surg TrISI:000259369300001ECsernatony, Z Debrecen Univ Med, Hlth & Sci Ctr, Dept Orthoped, Biomech Res Lab, Nagyerdei Krt 98, H-4032 Debrecen, Hungary Debrecen Univ Med, Hlth & Sci Ctr, Dept Orthoped, Biomech Res Lab, Nagyerdei Krt 98, H-4032 Debrecen, Hungary Debrecen Univ Med, Hlth & Sci Ctr, Dept Orthoped, Biomech Res Lab, H-4032 Debrecen, HungaryDOI 10.1007/s00590-008-0339-0English{<76Papp, M. Csernatony, Z. Kazai, S. Karolyi, Z. Rode, L.2007dThe patella and tibial condyle position after combined and after closing wedge high tibial osteotomy769-780,Knee Surgery Sports Traumatology Arthroscopy156(osteoarthritis of the knee high tibial osteotomy combined osteotomy closing wedge osteotomy malalignment total knee arthroplasty term-follow-up medial compartment osteoarthritis ligament-deficient knees long-term varus gonarthrosis chondromalacia patellae internal-fixation early motion arthritisJun; High tibial osteotomy changes the patella and tibial condyle position, which makes the subsequent total knee replacement technically demanding. From 1 January 1993 to 31 December 2000, combined osteotomy [After the first osteotomy made 2 cm distally to the joint line, a bone wedge is removed based laterally. Its tip ends at the center of the tibial condyle (half bone wedge). The distal part of the tibia is placed into the valgus position and the half bone wedge is placed into the gap opened medially.] was performed on 103 knees and closing wedge osteotomy was performed on 47 consecutive knees. Eighty combined (group A) and 41 closing wedge (group B) osteotomy were studied. All knees were assessed radiologically before surgery, in the 10th postoperative week, in the 12th postoperative month and at the time of the final follow-up (in group A-66.15 months, in group B-66.61 months). We examined the change of the femorotibial angle, of the patellar height according to the method of Insall and Salvati, of the tibial slope angle according to the method of Bonnin, of the tibial condylar offset according to the method of Yoshida and of the distance between the lateral tibial plateau and the top of the fibular head. In group A and B, the recurrence of the varus deformity was not noted and valgus alignment did not increase in any case. In group-A, the Insall-Salvati ratio remained unchanged in 65% of knees. The tibial slope angle decreased in both groups. There was correlation between the change of the tibial condylar offset and the angle of the correction in both groups. There was correlation between the change of the distance between the lateral tibial plateau and the top of the fibular head. After combined osteotomy, the transposition of the tibial condyle and the decrease of the distance between the lateral tibial plateau and the top of the fibular head was less than after closing wedge osteotomy, although the average angle of correction was more after combined osteotomy (11.835 degrees), than after closing wedge osteotomy (9.465 degrees). Theoretically, the recurrence of the varus deformity, the increase of the valgus alignment and (in majority of cases) the shortening of the patellar tendon do not compromise the likelihood of successful conversion to the subsequent total knee replacement, either after combined or after closing wedge osteotomy. The combined osteotomy does not lead to considerable transposition of the tibial condyle and to considerable lateral tibial bone loss; therefore, theoretically, the combined osteotomy does not impair the subsequent total knee replacement.://000247242700017-178TJ Times Cited:2 Cited References Count:73 0942-2056Knee Surg Sport Tr AISI:000247242700017bCsernatony, Z Univ Debrecen, Med & Hlth Sci Ctr, Dept Orthopaed Surg, 98 Nagyerdei Krt, H-4012 Debrecen, Hungary Univ Debrecen, Med & Hlth Sci Ctr, Dept Orthopaed Surg, 98 Nagyerdei Krt, H-4012 Debrecen, Hungary Univ Debrecen, Med & Hlth Sci Ctr, Dept Orthopaed Surg, H-4012 Debrecen, Hungary Borsod Cty Hosp, Dept Orthopaed Surg, H-3501 Miskolc, HungaryDOI 10.1007/s00167-006-0271-yEnglish<7%Szakal, Z. Zsoldos, I. Csernatony, Z.2005;Design and manufacturing process of skull defect prosthesis641-644GCross-Disciplinary Applied Research in Materials Science and Technology480-481We want to help to the technical preparation of the implantation of individual prosthesis by using the newest means of computer aided manufacturing. There are such cases when the factory-made implantations available are not suitable to replace the missing bone or joint. We have solved the replacement of an osteal skull defect with the Rapid Prototyping method in this paper. The advanced techniques has assured greater accuracy and simpler operative-technique in this case.://000228157300104DBbw59 Times Cited:0 Cited References Count:8 Materials Science Forum 0255-5476Mater Sci ForumISI:000228157300104uSzakal, Z Szent Istvan Univ, Godollo, Hungary Szent Istvan Univ, Godollo, Hungary Szent Istvan Univ, Godollo, HungaryEnglish<7]Gaspar, L. Dezso, B. Csernatony, Z. Gaspar, L. Szabo, J. Szekanecz, Z. Szepesi, K. Matesz, K.2004zCapsular neuronal elements and their relation to pain reduction and functional improvement following total hip replacement142-145International Orthopaedics283rnerve growth-factor osteoarthritis hyperalgesia arthritis inflammation arthroplasty pressure patient surgery fluidJunWe studied changes of pain intensity and functional impairment in 22 patients with osteoarthrosis undergoing total hip replacement. Using a visual analogue scale, the mean scores for pain and disability before surgery were 71.7 and 70.9 respectively. Both scores showed gradual improvement during a 1-year follow-up period, with more than 90% of the total improvement occurring within the first 3 months. After 1 year, the scores for pain and disability were 11.9 and 4.1 respectively. The hip joint capsule was studied using immunohistochemistry to detect neurofilaments. Neurofilament immunoreactivity was observed in 16/22 cases and was correlated with pain and disability scores. However, there were no correlations between pre- and postoperative pain scores, the score changes, and the quantity of capsular neurofilaments. Thus, other factors than capsular neurofilaments influence the scores of pain and disability in osteoarthritis.://000221885000004-827FN Times Cited:0 Cited References Count:20 0341-2695 Int OrthopISI:000221885000004Gaspar, L Univ Debrecen, Med Hlth & Sci Ctr, Dept Orthopaed Surg, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Univ Debrecen, Med Hlth & Sci Ctr, Dept Orthopaed Surg, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Univ Debrecen, Med Hlth & Sci Ctr, Dept Orthopaed Surg, H-4012 Debrecen, Hungary Univ Debrecen, Dept Pathol, MHSC, H-4012 Debrecen, Hungary Univ Debrecen, Dept Med 3, Rheumatol Div MHSC, H-4012 Debrecen, Hungary Univ Debrecen, Dept Anat, MHSC, H-4012 Debrecen, HungaryDOI 10.1007/s00264-004-0539-0English<7^Szepesi, K. Posan, E. Harsfalvi, J. Ajzner, E. Szucs, G. Gaspar, L. Csernatony, Z. Udvardy, M.2004aThe most severe forms of Perthes' disease associated with the homozygous Factor V Leiden mutation426-4290Journal of Bone and Joint Surgery-British Volume86B3activated protein-c platelet activation thrombophilia resistance children blood risk hypofibrinolysis abnormalities pathogenesisAprIt has recently been postulated that thrombophilia may have a role in the aetiology of Perthes' disease. The published reports, however, remain conflicting. In this study a retrospective analysis of the coagulation parameters was made in 47 patients with Perthes' disease and the results compared with the clinical data. Five patients with Factor V Leiden mutation were found (10.6%) and surprisingly four of them had a homozygous pattern. These four patients showed the most severe form of the disease, Catterall group IV, with flattening of the entire epiphysis, involvement of the metaphysis, shortening and broadening of the femoral neck, trochanteric overgrowth and developed mushroom-shaped aspherical laterally displaced femoral heads in dysplastic acetabula. We would like to suggest that the homozygous form of Factor V Leiden mutation has some role in the clinical course of Perthes' disease and particularly its most severe form.://000221041000017.815KK Times Cited:11 Cited References Count:22 0301-620XJ Bone Joint Surg BrISI:000221041000017Szepesi, K Univ Debrecen, Med & Hlth Sci Ctr, Dept Orthopaed Surg, Nagyerdei Str 98, H-4012 Debrecen, Hungary Univ Debrecen, Med & Hlth Sci Ctr, Dept Orthopaed Surg, Nagyerdei Str 98, H-4012 Debrecen, Hungary Univ Debrecen, Med & Hlth Sci Ctr, Dept Orthopaed Surg, H-4012 Debrecen, Hungary Univ Debrecen, Med & Hlth Sci Ctr, Dept Med, H-4012 Debrecen, Hungary Univ Debrecen, Med & Hlth Sci Ctr, Dept Clin Biochem & Mol Pathol, H-4012 Debrecen, Hungary Doi 10.1302/0301-620x.86b3.13442English (<7FFarkas, C. Hargitai, Z. Gaspar, L. Kuki, A. Csernatony, Z. Szepesi, K.2004;Histological changes in the symptomatic mediopatellar plica103-108Knee112_knee mediopatellar plica neural elements anterior knee pain synovial plicae anatomy shelf jointAprOne of the causes of anterior knee pain may be symptomatic mediopatellar plica. The pain is usually attributed to the mechanical damage caused by the plica inside the joint, or, more precisely, to the synovitis induced as a result. Recent observations seem to suggest, however, that the pain is, in addition, likely to be engendered by an increased number of nerve-elements present in the substance of the plica. The present study used up-to-date histochemical methods to reveal in the symptomatic mediopatellar plicae nerve-elements that may be made responsible for the pain. Semi-quantitative methods were used to establish the number of nerve-elements in the tissue samples obtained from 21 symptomatic mediopatellar plicae (Group `A'), exposing them to view with the aid of synaptophysin and neurofilament serum, coupled with routine light microscope as well as polarising microscope examinations following H&E and van Gieson staining. Tissue samples taken from the 'symptomatic mediopatellar plica of 11 patients served as control (Group `B'). A significantly larger number of nerve-elements were found in the substance of the plicae of Group `A' 6.9 (S.D. +/- 2.9) than in Group `B' 3 (S.D. +/- 1.2). Within Group `A', more nerve-elements were revealed in trauma-related case histories than in those with no recollections of trauma (an average of 9.6 vs. 5.2, respectively). Similarly, the reduction of pain achieved by surgery was greater in the trauma-related group than in the non-traumatic one (3.0 vs. 1.8, respectively). Relying on our observations, we claim that the painfulness of the knee joint plicae is in all probability also attributable to the fact that their tissue substance contains an increased number of nerve-elements. A major trauma in a particular case history contributes, in all likelihood, to an increase in the number of nerve-elements, but further examinations are required to clarify the pathomechanism involved. (C) 2002 Elsevier Science B.V. All rights reserved.://000221020600005-815CO Times Cited:4 Cited References Count:21 0968-0160KneeISI:000221020600005Farkas, C Andras Josa Mem Cty Hosp Szabolcs Szatmar Bereg C, H-4400 Nyiregyhaza, Hungary Andras Josa Mem Cty Hosp Szabolcs Szatmar Bereg C, H-4400 Nyiregyhaza, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Dept Math & Informat, H-4012 Debrecen, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Dept Pathol, H-4012 Debrecen, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Dept Orthopaed, H-4012 Debrecen, HungaryPii S0968-0160(02)00143-6English <7 ]Posan, E. Szepesi, K. Gaspar, L. Csernatony, Z. Harsfalvi, J. Ajzner, E. Toth, A. Udvardy, M.2003OThrombotic and fibrinolytic alterations in the aseptic necrosis of femoral head243-248 Blood Coagulation & Fibrinolysis143fibrinolysis thrombophilia aseptic necrosis perthes disease activated protein-c factor-v-leiden calve-perthes disease viii-related antigen nontraumatic necrosis thrombophilia resistance osteonecrosis children riskAprRecent reports seem to support the role of the thrombophilia and decreased fibrinolysis in the aetiopathogenesis of aseptic necrosis of bone. In the present study, haemostatic disturbances were analysed in adults (n = 49) and patients in childhood (Perthes disease) (n = 47) with aseptic necrosis of the femoral head. Fibrinolytic parameters (in vitro clot lysis, plasminogen, plasmatic plasminogen activator inhibitor-1 activity, D-dimer) along with lipoprotein (a) [Lp(a)] and fibrinogen were measured. von Willebrand factor, platelet activation and some thrombophilic factors (activated protein C resistance and factor V Leiden mutation, protein C, protein S activity) were also determined. Impaired fibrinolysis, an increased Lp(a) level along with slow clot lysis and increased platelet activation were found in adult cases. We detected five cases of factor V Leiden mutations (one heterozygotic and four homozygotic) among patients with Perthes disease. The clinical course of the heterozygous case was similar to the usual form of Perthes disease. The most severe form of Perthes disease has been observed in homozygous factor V Leiden mutation cases. The mutation of factor V Leiden per se probably does not induce the development of aseptic necrosis of bone tissue in childhood, but it does play a role in its acceleration. Homozygous factor V Leiden mutation definitely runs a more severe course. On the other hand, in adult cases, the disturbances of haemostasis, impaired fibrinolysis, elevated Lp(a) level, increased platelet activation and slight elevation of fibrinogen might have clinical relevance. Further studies should focus on proving the role of the haemostatic alterations in the pathogenesis of severe forms of aseptic bone necrosis. The use of antithrombotic drugs in order to slow the process of aseptic necrosis also has to be addressed in future surveys. (C) 2003 Lippincott Williams Wilkins.://000183024100004-681EN Times Cited:9 Cited References Count:39 0957-5235Blood Coagul FibrinISI:000183024100004Posan, E Debrecen Univ Med, Med & Hlth Sci Ctr, Fac Med, Dept Med 2, H-4012 Debrecen, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Fac Med, Dept Med 2, H-4012 Debrecen, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Fac Med, Dept Med 2, H-4012 Debrecen, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Dept Orthoped Surg, H-4012 Debrecen, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Dept Clin Biochem & Mol Pathol, H-4012 Debrecen, Hungary&DOI 10.1097/01.mbc.0000061299.28953.34English<7 7Csernatony, Z. Kiss, L. Mano, S. Gaspar, L. Szepesi, K.2003KMultilevel callus distraction: a novel idea to shorten the lengthening time494-497Medical Hypotheses604AprLower extremity inequality is a common problem in everyday orthopaedic practice. The leg discrepancy can lead to variety of other problems, i.e., spinal problems. Surgical intervention is very demanding and requires patient compliance. Wagner's and llizarov's elongation technique are most commonly used worldwide, but it gives satisfactory results only in a long period of time and as we know there could be several inconvenient outcomes. Our idea aims at shortening this time period, and avoiding some of the inconvenient outcomes. Unfortunately we do not have the opportunity to go further in our investigations, but we hope that someone interested in this field will have an idea which would make continuation possible. (C) 2003 Elsevier Science Ltd. All rights reserved.://000181731700007,658QM Times Cited:1 Cited References Count:4 0306-9877Med HypothesesISI:000181731700007QCsernatony, Z Debrecen Univ Med, Med Hlth & Sci Ctr, Biomech Lab, Pf 16, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Biomech Lab, Pf 16, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Biomech Lab, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthoped, H-4012 Debrecen, Hungary!Doi 10.1016/S0306-9877(02)00432-2English<7 IGaspar, L. Szekanecz, Z. Dezso, B. Szegedi, G. Csernatony, Z. Szepesi, K.2003WTechnique of synovial biopsy of metacarpophalangeal joints using the needle arthroscope50-52,Knee Surgery Sports Traumatology Arthroscopy111needle arthroscope synovial biopsy metacarpophalangeal joint rheumatoid arthritis rheumatoid-arthritis clinical improvement knee osteoarthritis abnormalities expressionJanyWe demonstrate the technique, advantages, and disadvantages of metacarpophalangeal joint examination with needle arthroscope. We evaluated our experience from biopsies of 10 metacarpophalangeal joints of eight rheumatoid women aged 41-45 years. The procedures were performed using a 1-mm needle arthroscope. The synovium biopsy was taken with a microforceps. The procedure was performed under local anesthesia. The tight tension of the joint and traction of the finger is necessary for good visualization, but despite this visibility can be difficult. Needle biopsy is a useful method for the early diagnosis of rheumatoid arthritis.://000181123000010-647ZB Times Cited:1 Cited References Count:18 0942-2056Knee Surg Sport Tr AISI:000181123000010Gaspar, L Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthoped, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthoped, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthoped, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Internal Med 3, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Pathol, H-4012 Debrecen, HungaryDOI 10.1007/s00167-002-0329-4EnglishP<7 .Csernatony, Z. Szepesi, K. Gaspar, L. Kiss, L.2002HContradictions of derotation in scoliosis surgery using the CD principle498-502Medical Hypotheses586 cotrel-dubousset instrumentationJunCurrent literature has increasingly emphasized the problem of derotation in scoliotic deformities. The Cotrel-Dubousset (CD) principle as a means of correcting rotation has been questioned by various authors. This paper aims to draw attention, using algebraic methods, to the importance of the remaining rotational deformities, and to suggest the introduction of the notion 'rotational balance'. (C) 2002 Published by Elsevier Science Ltd.://000178196400011,596ZG Times Cited:0 Cited References Count:6 0306-9877Med HypothesesISI:000178196400011 Csernatony, Z Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthopaed, Pf 16, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthopaed, Pf 16, H-4012 Debrecen, Hungary Debrecen Univ Med, Med Hlth & Sci Ctr, Dept Orthopaed, H-4012 Debrecen, HungaryDOI 10.1054/mehy.2001.1470English<7 /Csernatony, Z. Gaspar, L. Jonas, Z. Szepesi, K.2002@Modified unit rod technique in scoliosis surgery - a case report481-482Acta Orthopaedica Scandinavica734Aug://000178025900021,594AD Times Cited:0 Cited References Count:4 0001-6470Acta Orthop ScandISI:0001780259000210Csernatony, Z Debrecen Univ Med, Med & Hlth Sci Ctr, Dept Orthopaed Surg, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Dept Orthopaed Surg, Nagyerdei Krt 98, H-4012 Debrecen, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Dept Orthopaed Surg, H-4012 Debrecen, HungaryEnglishz<7MCseri, J. Szappanos, H. Szigeti, G. P. Csernatony, Z. Kovacs, L. Csernoch, L.2002VA purinergic signal transduction pathway in mammalian skeletal muscle cells in culture731-738.Pflugers Archiv-European Journal of Physiology4435-6human skeletal muscle culture atp purinoreceptors development intracellular calcium intracellular calcium extracellular atp human myotubes receptor gene p2x receptors ion channels differentiation cloning ca2+ metabolismMarThe effects of adenosine 5'-triphosphate (ATP) on human and mouse skeletal muscle fibres in primary culture were investigated. ATP-evoked changes in intracellular calcium concentration ([Ca2+](i)) were measured and compared with those induced by agonists of the nicotinic acetylcholine (Ach)- and P2X purinoreceptors. While ATP was effective on both myoblasts and multinucleated myotubes in the micromolar range, Ach failed to induce any change in [Ca2+](i) at early stages of development. In contrast, myofibres with peripheral nuclei showed little response to ATP but responded to Ach with a large change in [Ca2+](i). The responsiveness of the myotubes to Ach paralleled that to potassium. The removal of external calcium abolished the response to ATP. P2X receptor agonists mimicked the response to ATP with the order of potency being ATP>2',3'-O-(4-benzoyl)-benzoyl-ATP> beta,'gamma-methylene-ATP>(alpha,beta-methylene-ATP. Under voltage-clamp conditions ATP induced an inward current that showed little inactivation. These results are consistent with the existence of P2X receptor-mediated signal transduction pathway in cultured mammalian skeletal muscle cells.://000174667300008.535VP Times Cited:20 Cited References Count:36 0031-6768Pflug Arch Eur J PhyISI:000174667300008JCsernoch, L Univ Debrecen, Med & Hlth Sci Ctr, Dept Physiol, POB 22, H-4012 Debrecen, Hungary Univ Debrecen, Med & Hlth Sci Ctr, Dept Physiol, POB 22, H-4012 Debrecen, Hungary Univ Debrecen, Med & Hlth Sci Ctr, Dept Physiol, H-4012 Debrecen, Hungary Univ Debrecen, Med & Hlth Sci Ctr, Dept Orthopaed Surg, H-4012 Debrecen, HungaryDOI 10.1007/s00424-001-0757-xEnglish<7<Csernatony, Z. Szepesi, K. Gaspar, L. Dezso, Z. S. Jonas, Z.2000oThe 'rotational preconstraint' - Kinetic model of a possible new mechanism in the etiopathogenesis of scoliosis203-206Medical Hypotheses542FebThis model provides a novel view of the etiology of some scolioses and can answer some of the biomechanical questions regarding pathogenesis of dorsal curves. According to our findings, paravertebral muscular imbalance is likely to favour such a pathological condition which, with the inteference of the postural reflexes and the body weight-related vertical loading, might lead to the formation of a true scoliotic curve. Review of earlier research studies in the light of our findings reveals controversy in some authors' reported results and their own interpretations and seems to generally support our theory. (C) 2000 Harcourt Publishers Ltd.://000086104500012-297VZ Times Cited:0 Cited References Count:19 0306-9877Med HypothesesISI:000086104500012Csernatony, Z Royal Natl Orthopaed Hosp, Inst Orthopaed, Orchard Court 10B,Brockley Hill, Stanmore HA7 4LP, Middx, England Royal Natl Orthopaed Hosp, Inst Orthopaed, Orchard Court 10B,Brockley Hill, Stanmore HA7 4LP, Middx, England Royal Natl Orthopaed Hosp, Inst Orthopaed, Stanmore HA7 4LP, Middx, England Debrecen Univ Med, Biomed Engn Lab, Dept Orthopaed Surg, H-4012 Debrecen, HungaryEnglish ||7(Austin, R. M. Onisko, A. Druzdzel, M. J.2010FThe Pittsburgh Cervical Cancer Screening Model: a risk assessment tool744-50Arch Pathol Lab Med1345 2010/05/06Adenocarcinoma/*diagnosis Cervical Intraepithelial Neoplasia/*diagnosis Early Detection of Cancer/*methods Female Humans Papillomavirus Infections/diagnosis Risk Assessment Risk Factors Uterine Cervical Neoplasms/*diagnosis Vaginal SmearsMay4CONTEXT: Evaluation of cervical cancer screening has grown increasingly complex with the introduction of human papillomavirus (HPV) vaccination and newer screening technologies approved by the US Food and Drug Administration. OBJECTIVE: To create a unique Pittsburgh Cervical Cancer Screening Model (PCCSM) that quantifies risk for histopathologic cervical precancer (cervical intraepithelial neoplasia [CIN] 2, CIN3, and adenocarcinoma in situ) and cervical cancer in an environment predominantly using newer screening technologies. DESIGN: The PCCSM is a dynamic Bayesian network consisting of 19 variables available in the laboratory information system, including patient history data (most recent HPV vaccination data), Papanicolaou test results, high-risk HPV results, procedure data, and histopathologic results. The model's graphic structure was based on the published literature. Results from 375 441 patient records from 2005 through 2008 were used to build and train the model. Additional data from 45 930 patients were used to test the model. RESULTS: The PCCSM compares risk quantitatively over time for histopathologically verifiable CIN2, CIN3, adenocarcinoma in situ, and cervical cancer in screened patients for each current cytology result category and for each HPV result. For each current cytology result, HPV test results affect risk; however, the degree of cytologic abnormality remains the largest positive predictor of risk. Prior history also alters the CIN2, CIN3, adenocarcinoma in situ, and cervical cancer risk for patients with common current cytology and HPV test results. The PCCSM can also generate negative risk projections, estimating the likelihood of the absence of histopathologic CIN2, CIN3, adenocarcinoma in situ, and cervical cancer in screened patients. CONCLUSIONS: The PCCSM is a dynamic Bayesian network that computes quantitative cervical disease risk estimates for patients undergoing cervical screening. Continuously updatable with current system data, the PCCSM provides a new tool to monitor cervical disease risk in the evolving postvaccination era.+http://www.ncbi.nlm.nih.gov/pubmed/20441506Austin, R Marshall Onisko, Agnieszka Druzdzel, Marek J United States Archives of pathology & laboratory medicine Arch Pathol Lab Med. 2010 May;134(5):744-50.*1543-2165 (Electronic) 0003-9985 (Linking)20441506Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213-3180, USA. raustin@magee.edu!10.1043/1543-2165-134.5.744 [pii]eng ~t7ZCasey, S. E. Mitchell, K. T. Amisi, I. M. Haliza, M. M. Aveledi, B. Kalenga, P. Austin, J.2009wUse of facility assessment data to improve reproductive health service delivery in the Democratic Republic of the Congo12 Confl Health3 2009/12/23 BACKGROUND: Prolonged exposure to war has severely impacted the provision of health services in the Democratic Republic of the Congo (DRC). Health infrastructure has been destroyed, health workers have fled and government support to health care services has been made difficult by ongoing conflict. Poor reproductive health (RH) indicators illustrate the effect that the prolonged crisis in DRC has had on the on the reproductive health (RH) of Congolese women. In 2007, with support from the RAISE Initiative, the International Rescue Committee (IRC) and CARE conducted baseline assessments of public hospitals to evaluate their capacities to meet the RH needs of the local populations and to determine availability, utilization and quality of RH services including emergency obstetric care (EmOC) and family planning (FP). METHODS: Data were collected from facility assessments at nine general referral hospitals in five provinces in the DRC during March, April and November 2007. Interviews, observation and clinical record review were used to assess the general infrastructure, EmOC and FP services provided, and the infection prevention environment in each of the facilities. RESULTS: None of the nine hospitals met the criteria for classification as an EmOC facility (either basic or comprehensive). Most facilities lacked any FP services. Shortage of trained staff, essential supplies and medicines and poor infection prevention practices were consistently documented. All facilities had poor systems for routine monitoring of RH services, especially with regard to EmOC. CONCLUSIONS: Women's lives can be saved and their well-being improved with functioning RH services. As the DRC stabilizes, IRC and CARE in partnership with the local Ministry of Health and other service provision partners are improving RH services by: 1) providing necessary equipment and renovations to health facilities; 2) improving supply management systems; 3) providing comprehensive competency-based training for health providers in RH and infection prevention; 4) improving referral systems to the hospitals; 5) advocating for changes in national RH policies and protocols; and 6) providing technical assistance for monitoring and evaluation of key RH indicators. Together, these initiatives will improve the quality and accessibility of RH services in the DRC - services which are urgently needed and to which Congolese women are entitled by international human rights law.+http://www.ncbi.nlm.nih.gov/pubmed/20025757Casey, Sara E Mitchell, Kathleen T Amisi, Immaculee Mulamba Haliza, Martin Migombano Aveledi, Blandine Kalenga, Prince Austin, Judy England Conflict and health Confl Health. 2009 Dec 21;3:12.*1752-1505 (Electronic) 1752-1505 (Linking)280904020025757RAISE Initiative, Heilbrunn Department of Population and Family Health, Mailman School of Public Health, Columbia University, New York, USA.+1752-1505-3-12 [pii] 10.1186/1752-1505-3-12eng~t75Hayes, T. L. Hagler, S. Austin, D. Kaye, J. Pavel, M.2009QUnobtrusive assessment of walking speed in the home using inexpensive PIR sensors7248-51Conf Proc IEEE Eng Med Biol Soc2009 2009/12/08Aged Aging/*physiology Biomechanics Biomedical Engineering Disability Evaluation Gait/physiology Humans Infrared Rays Monitoring, Ambulatory/*instrumentation/methods Telemetry/instrumentation/methods Walking/*physiologyWalking speed and activity are important measures of functional ability in the elderly. Our earlier studies have suggested that continuous monitoring may allow us to detect changes in walking speed that are also predictive of cognitive changes. We evaluated the use of passive infrared (PIR) sensors for measuring walking speed in the home on an ongoing basis. In comparisons with gait mat estimates (ground truth) and the results of a timed walk test (the clinical gold standard) in 18 subjects, we found that the clinical measure overestimated typical walking speed, and the PIR sensor estimations of walking speed were highly correlated to actual gait speed. Examination of in-home walking patterns from more than 100,000 walking speed samples for these subjects suggested that we can accurately assess walking speed in the home. We discuss the potential of this approach for continuous assessment.+http://www.ncbi.nlm.nih.gov/pubmed/19965096cHayes, Tamara L Hagler, Stuart Austin, Daniel Kaye, Jeffrey Pavel, Misha P30 AG008017-16/AG/NIA NIH HHS/United States P30 AG024978-05/AG/NIA NIH HHS/United States P30AG024978/AG/NIA NIH HHS/United States P30AG08017/AG/NIA NIH HHS/United States R01 AG024059-03/AG/NIA NIH HHS/United States R01AG024059/AG/NIA NIH HHS/United States Research Support, N.I.H., Extramural United States Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Conf Proc IEEE Eng Med Biol Soc. 2009;2009:7248-51.%1557-170X (Print) 1557-170X (Linking)284682619965096tThe Biomedical Engineering division, Oregon Health & Science University, Portland, OR 97239, USA. hayest@bme.ogi.edu10.1109/IEMBS.2009.5334746eng ;||7Salpekar, J. A. Plioplys, S. Siddarth, P. Bursch, B. Shaw, R. J. Asato, M. R. LaFrance, W. C., Jr. Weisbrot, D. M. Dunn, D. W. Austin, J. K. Olson, D. M. Caplan, R.2010HPediatric psychogenic nonepileptic seizures: a study of assessment tools50-5Epilepsy Behav171 2009/12/022Adolescent Anxiety/diagnosis/etiology Checklist Child Depression/diagnosis/etiology Disability Evaluation Female Humans Male Parent-Child Relations Parents/psychology *Pediatrics Psychophysiologic Disorders/*diagnosis/psychology Seizures/complications/*psychology Somatoform Disorders/*diagnosis/psychologyJanIThe goal of this study was to identify assessment tools and associated behavioral domains that differentiate children with psychogenic nonepileptic seizures (PNES) from those with epilepsy. A sample of 24 children with PNES (mean age 14.0 years, 14 female), 24 children with epilepsy (mean age 13.6 years, 13 female), and their parents were recruited from five epilepsy centers in the United States. Participants completed a battery of behavioral questionnaires including somatization, anxiety, and functional disability symptoms. Children with PNES had significantly higher scores on the Childhood Somatization and Functional Disability Inventories, and their parents reported more somatic problems on the Child Behavior Checklist (CBCL). Depression, anxiety, and alexithymia instruments did not differentiate the groups. Measures of somatization and functional disability may be promising tools for differentiating the behavioral profile of PNES from that of epilepsy. Increased somatic awareness and perceived disability emphasize the similarity of PNES to other pediatric somatoform disorders.+http://www.ncbi.nlm.nih.gov/pubmed/19948427#Salpekar, Jay A Plioplys, Sigita Siddarth, Prabha Bursch, Brenda Shaw, Richard J Asato, Miya R LaFrance, W Curt Jr Weisbrot, Deborah M Dunn, David W Austin, Joan K Olson, Donald M Caplan, Rochelle United States Epilepsy & behavior : E&B Epilepsy Behav. 2010 Jan;17(1):50-5. Epub 2009 Nov 30.*1525-5069 (Electronic) 1525-5050 (Linking)19948427Department of Psychiatry and Behavioral Sciences, Children's National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA. jsalpeka@cnmc.org7S1525-5050(09)00557-5 [pii] 10.1016/j.yebeh.2009.10.002eng#|t75Hagler, S. Austin, D. Hayes, T. L. Kaye, J. Pavel, M.2010qUnobtrusive and ubiquitous in-home monitoring: a methodology for continuous assessment of gait velocity in elders813-20IEEE Trans Biomed Eng574 2009/11/26AprGait velocity has been shown to quantitatively estimate risk of future hospitalization, a predictor of disability, and has been shown to slow prior to cognitive decline. In this paper, we describe a system for continuous and unobtrusive in-home assessment of gait velocity, a critical metric of function. This system is based on estimating walking speed from noisy time and location data collected by a "sensor line" of restricted view passive infrared motion detectors. We demonstrate the validity of our system by comparing with measurements from the commercially available GAITRite walkway system gait mat. We present the data from 882 walks from 27 subjects walking at three different subject-paced speeds (encouraged to walk slowly, normal speed, or fast) in two directions through a sensor line. The experimental results show that the uncalibrated system accuracy (average error) of estimated velocity was 7.1 cm/s (SD = 11.3 cm/s), which improved to 1.1 cm/s (SD = 9.1 cm/s) after a simple calibration procedure. Based on the average measured walking speed of 102 cm/s, our system had an average error of less than 7% without calibration and 1.1% with calibration.+http://www.ncbi.nlm.nih.gov/pubmed/19932989Hagler, Stuart Austin, Daniel Hayes, Tamara L Kaye, Jeffrey Pavel, Misha P30AG008017/AG/NIA NIH HHS/United States P30AG024978/AG/NIA NIH HHS/United States R01AG024059/AG/NIA NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States IEEE transactions on bio-medical engineering IEEE Trans Biomed Eng. 2010 Apr;57(4):813-20. Epub 2009 Nov 20.*1558-2531 (Electronic) 0018-9294 (Linking)289502319932989vDivision of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA. haglers@bme.ogi.edu10.1109/TBME.2009.2036732eng||7&Rathod, D. Pickering, S. Austin, M. W.2010+Virtual assessment and glaucoma shared care1121 Eye (Lond)246 2009/11/17Jun+http://www.ncbi.nlm.nih.gov/pubmed/19911019Rathod, D Pickering, S Austin, M W Comment Letter England Eye (London, England) Eye (Lond). 2010 Jun;24(6):1121. Epub 2009 Nov 13.*1476-5454 (Electronic) 0950-222X (Linking)19911019%eye2009273 [pii] 10.1038/eye.2009.273eng ||7QBakas, T. Farran, C. J. Austin, J. K. Given, B. A. Johnson, E. A. Williams, L. S.2009UStroke caregiver outcomes from the Telephone Assessment and Skill-Building Kit (TASK)105-21Top Stroke Rehabil162 2009/07/08*Adaptation, Psychological Aged Analysis of Variance Caregivers/*psychology Depression/*psychology Female Health Education Health Services Needs and Demand/statistics & numerical data Humans Indiana Male Middle Aged Patient Education as Topic Patient Satisfaction/statistics & numerical data Quality of Life/*psychology Questionnaires Stroke/psychology/*rehabilitation Survivors/*psychology Telephone Time Factors Treatment OutcomeMar-Apr PURPOSE: Stroke caregivers often express the need for information about stroke and assistance with stroke-related care in the early discharge period. The Telephone Assessment and Skill-Building Kit (TASK) is an 8-week program that addresses caregiver needs. This study explored the efficacy of the TASK program in improving stroke caregiver outcomes. METHOD: Guided by a conceptual model, 6 outcomes (optimism, task difficulty, threat appraisal, depressive symptoms, life changes, general health perceptions) were measured in 40 caregivers randomized to the TASK (n=21) or an attention control group (n=19). Data were analyzed using analysis of covariance (ANCOVA), controlling for baseline scores and minutes spent with the nurse. RESULTS: Significant increases in optimism at 4 weeks, 8 weeks, and 12 weeks were found, with medium effect sizes for the TASK group relative to the control group (p<.05). Significant improvements in task difficulty at 4 weeks, and threat appraisal at both 8 weeks and 12 weeks were also found (p<.05). CONCLUSION: Caregivers receiving the TASK intervention improved in optimism, task difficulty, and threat appraisal. Further testing of an enhanced version of the TASK program is warranted, with attention directed toward more distal stroke caregiver outcomes.+http://www.ncbi.nlm.nih.gov/pubmed/19581197.Bakas, Tamilyn Farran, Carol J Austin, Joan K Given, Barbara A Johnson, Elizabeth A Williams, Linda S K01 NR008712/NR/NINR NIH HHS/United States Randomized Controlled Trial Research Support, N.I.H., Extramural United States Topics in stroke rehabilitation Top Stroke Rehabil. 2009 Mar-Apr;16(2):105-21.%1074-9357 (Print) 1074-9357 (Linking)19581197AIndiana University School of Nursing, Indianapolis, Indiana, USA.*R51R852247275180 [pii] 10.1310/tsr1602-105eng(||7EReeser, J. C. Austin, D. M. Jaros, L. M. Mukesh, B. N. McCarty, C. A.2008pInvestigating Perceived Institutional Review Board Quality and Function Using the IRB Researcher Assessment Tool25-34J Empir Res Hum Res Ethics31 2009/04/24MarTHE INSTITUTIONAL REVIEW BOARD-RESEARCHER ASSESSMENT TOOL (IRB-RAT) was designed to assess the relative importance of various factors to the effective functioning of IRBs. We employed the IRB-RAT to gain insight into the ways in which our IRB is perceived to be deficient by those who routinely interact with our Office of Research Integrity and Protections. Respondents ranked qualities thought to be characteristic of an "ideal" IRB and then compared our IRB to that internal standard. We observed that the rate of study participation varied by role. The composite relative ranking of the 45 items that comprise the IRB-RAT differed significantly from the rank order reported by Keith-Spiegel et al. Our data furthermore suggest that role influences scoring of the IRB-RAT (e.g., investigators awarded our IRB significantly higher scores in several areas than did research coordinators). Additional research is warranted to determine if the observed role-dependent differences in the perceived quality of our IRB simply reflect the local research culture or if they are indicative of a more fundamental and generalizable difference in outlook between investigators and research coordinators.+http://www.ncbi.nlm.nih.gov/pubmed/19385780Reeser, Jonathan C Austin, Diane M Jaros, Linda M Mukesh, Bickol N McCarty, Catherine A United States Journal of empirical research on human research ethics : JERHRE J Empir Res Hum Res Ethics. 2008 Mar;3(1):25-34.1556-2646 (Print)19385780&Marshfield Clinic Research Foundation.10.1525/jer.2008.3.1.25eng I||7qHamilton, A. M. Fowler, J. L. Hersh, B. Austin, C. A. Finn, S. E. Tharinger, D. J. Parton, V. Stahl, K. Arora, P.2009Q"Why won't my parents help me?": Therapeutic assessment of a child and her family108-20 J Pers Assess912 2009/02/12Behavior Therapy/*methods Child Child Behavior/*psychology Child Development Communication Barriers Depression/diagnosis/*therapy Female Humans *Parent-Child Relations Parents/*psychology Personality Assessment Self Concept Treatment OutcomeMar9We present a case study of a child's psychological assessment using the methods of Therapeutic Assessment (TA). The case illustrates how TA can help assessors understand the process and structure of a family by highlighting how maladaptive family processes and interactions impact a child's development. It also illustrates how TA with a child can serve as a family intervention. In this case, it became apparent that the child's social difficulties were significant, not minor as initially reported by the parents, and were rooted in an insecure attachment, underlying depression, an idiosyncratic view of the world, and longing for attention, all of which were hidden or expressed in grandiose, expansive, and off-putting behaviors. In addition, the familial hierarchy was inverted; the parents felt ineffective and the child felt too powerful, leading to enhanced anxiety for the child. Intervention throughout, punctuated by the family session and feedback sessions, allowed the parents to develop a new "story" about their child and for the child to experience a new sense of safety. Following the TA, the parents and child indicated high satisfaction, enhanced family functioning, and decreased child symptomatology. Subsequent family therapy sessions allowed the family to further implement the interventions introduced in the TA.+http://www.ncbi.nlm.nih.gov/pubmed/19205932Hamilton, Amy M Fowler, Johnathan L Hersh, Brooke Austin, Cynthia A Finn, Stephen E Tharinger, Deborah J Parton, Victoria Stahl, Katharine Arora, Prerna Case Reports United States Journal of personality assessment J Pers Assess. 2009 Mar;91(2):108-20.*1532-7752 (Electronic) 0022-3891 (Linking)19205932qDepartment of Educational Psychology, The University of Texas at Austin, Texas, USA. amy.seligman@mail.utexas.edu)908608176 [pii] 10.1080/00223890802633995eng||7(Kavlock, R. J. Austin, C. P. Tice, R. R.2009SToxicity testing in the 21st century: implications for human health risk assessment485-7; discussion 492-7 Risk Anal294 2008/12/17Animals *Health Status History, 21st Century Humans National Institutes of Health (U.S.) *Risk Assessment Toxicity Tests/*methods United States United States Environmental Protection AgencyApr+http://www.ncbi.nlm.nih.gov/pubmed/19076321Kavlock, Robert J Austin, Christopher P Tice, Raymond R Comment Historical Article United States Risk analysis : an official publication of the Society for Risk Analysis Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7. Epub 2008 Dec 9.*1539-6924 (Electronic) 0272-4332 (Linking)19076321National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Kavlock.Robert@epamail.epa.gov/RISK1168 [pii] 10.1111/j.1539-6924.2008.01168.xeng'||7JJohnson, M. Stone, S. Lou, C. Vu, C. M. Ling, J. Mizrahi, P. Austin, M. J.2008CFamily assessment in child welfare services: instrument comparisons57-90J Evid Based Soc Work51-2 2008/12/10Child Child Abuse *Child Welfare Child, Preschool Decision Making *Family/psychology Humans Interviews as Topic Needs Assessment *Parenting/psychology Psychometrics Questionnaires Social Work/*instrumentation/*methodsFamily assessment instruments can enhance the clinical judgment of child welfare practitioners by structuring decision-making processes and demonstrating the linkages between assessment, service provision, and child and family outcomes. This article describes the concept of family assessment in the child welfare context and provides an overview of the theoretical and disciplinary influences in the family assessment field. Based on a structured review of 85 instruments, the article discusses 21 that appear to the be the most valid and reliable for evaluating four federally-defined domains of family assessment: (1) patterns of social interaction, (2) parenting practices, (3) background and history of the parents or caregivers, and (4) problems in access to basic necessities such as income, employment, and adequate housing. Key measurement criteria as well as practical considerations in the selection and implementation of family assessment instrumentation in child welfare are discussed.+http://www.ncbi.nlm.nih.gov/pubmed/19064445Johnson, Michelle Stone, Susan Lou, Christine Vu, Catherine M Ling, Jennifer Mizrahi, Paola Austin, Michael J Review United States Journal of evidence-based social work J Evid Based Soc Work. 2008;5(1-2):57-90.*1543-3722 (Electronic) 1543-3714 (Linking)19064445BUniversity of California, Berkeley, School of Social Welfare, USA.eng||7&D'Andrade, A. Austin, M. J. Benton, A.2008CRisk and safety assessment in child welfare: instrument comparisons31-56J Evid Based Soc Work51-2 2008/12/10Actuarial Analysis/methods/standards Child *Child Abuse *Child Welfare/ethnology Child, Preschool Ethnic Groups Humans Questionnaires/standards Reproducibility of Results *Risk Assessment/methods/standards Social Work/*methodsThe assessment of risk is a critical part of child welfare agency practice. This review of the research literature on different instruments for assessing risk and safety in child welfare focuses on instrument reliability, validity, outcomes, and use with children and families of color. The findings suggest that the current actuarial instruments have stronger predictive validity than consensus-based instruments. This review was limited by the variability in definitions and measures across studies, the relatively small number of studies examining risk assessment instruments, and the lack of studies on case decision points other than the initial investigation.+http://www.ncbi.nlm.nih.gov/pubmed/19064444D'Andrade, Amy Austin, Michael J Benton, Amy Review United States Journal of evidence-based social work J Evid Based Soc Work. 2008;5(1-2):31-56.*1543-3722 (Electronic) 1543-3714 (Linking)19064444gBay Area Social Services Consortium, School of Social Welfare, University of California, Berkeley, USA.eng ||72Bandyopadhyay, S. Austin, R. M. Dabbs, D. Zhao, C.2008Adjunctive human papillomavirus DNA testing is a useful option in some clinical settings for disease risk assessment and triage of females with ASC-H Papanicolaou test results1874-81Arch Pathol Lab Med13212 2008/12/09Adolescent Adult Aged Cervical Intraepithelial Neoplasia/*diagnosis/epidemiology/pathology/virology Cervix Uteri/pathology/virology Child Colposcopy DNA, Viral/*analysis Female Humans Microtomy Middle Aged Papillomaviridae/*genetics Retrospective Studies Risk Factors Sensitivity and Specificity Triage Tumor Virus Infections/*diagnosis/epidemiology/pathology Uterine Cervical Neoplasms/*diagnosis/epidemiology/pathology/virology Vaginal Smears/standards/*statistics & numerical data Young AdultDecDCONTEXT: Recent guidelines recommend colposcopy for women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H). objective: To determine whether adjunctive high-risk human papillomavirus (hrHPV) testing is useful for disease risk assessment in females with ASC-H Papanicolaou (Pap) test results. DESIGN: High-risk HPV prevalence and histopathologic follow-up data on 1187 females with ASC-H ThinPrep Pap test (TPPT) and hrHPV test results were analyzed. RESULTS: ASC-H was reported in 1646 (0.59%) [corrected] of 277 400 (270 338 TPPT and 7062 conventional) Pap test results. The difference in ASC-H detection rates between TPPTs and conventional Pap smears was statistically significant (0.60% vs 0.38%; P = .02). High-risk HPV was detected in 589 (49.6%) of 1187 females with ASC-H TPPT and hrHPV testing. The hrHPV DNA-positive rate in females younger than 40 years was 54.7%, significantly higher than the 36.5% in women 40 years and older. Among 505 females with histopathologic follow-up, cervical intraepithelial neoplasia 2/3 was identified in 32.7% of hrHPV-positive females compared with 1.2% in hrHPV-negative females. The sensitivity, specificity, positive predictive value, and negative predictive value of ASC-H cytology in conjunction with hrHPV DNA testing results for detection of cervical intraepithelial neoplasia 2/3 were 96.1% versus 100.0%, 54.0% versus 68.4%, 35.8% versus 20.8%, and 98.1% versus 100.0% in females younger than 40 years and women 40 years and older, respectively. CONCLUSIONS: Our data suggest that reflex hrHPV testing is a highly useful option for women with ASC-H Pap tests. Females with ASC-H and negative hrHPV testing may be more efficiently managed by follow-up with regular Pap and hrHPV testing rather than universal colposcopy, especially for women 40 years and older.+http://www.ncbi.nlm.nih.gov/pubmed/19061283Bandyopadhyay, Sudeshna Austin, R Marshall Dabbs, David Zhao, Chengquan United States Archives of pathology & laboratory medicine Arch Pathol Lab Med. 2008 Dec;132(12):1874-81.*1543-2165 (Electronic) 0003-9985 (Linking)19061283sDepartment of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.2008-0214-OA [pii]eng||7+Rathod, D. Win, T. Pickering, S. Austin, M.2008lIncorporation of a virtual assessment into a care pathway for initial glaucoma management: feasibility study543-6Clin Experiment Ophthalmol366 2008/10/29Adult Aged Aged, 80 and over Diagnostic Techniques, Ophthalmological/*standards Feasibility Studies Female Glaucoma/*diagnosis Humans Male Middle Aged Prospective Studies Reference Standards Sensitivity and Specificity Single-Blind Method TriageAugPURPOSE: To investigate the feasibility of a glaucoma triage assessment based on the consideration of clinical data in a virtual clinic environment. METHODS: One hundred consecutive new patients were assessed by masked observers for a possible diagnosis of glaucoma or ocular hypertension by evaluation of clinical data compiled by a technician in the absence of the patient. The virtual clinic diagnoses were compared with those made by actual examination of the patient in the outpatient clinic. RESULTS: A total of 22% of subjects were excluded from interobserver comparison because of atypical scanning laser ophthalmoscopy. Of the 78% of subjects completing virtual and actual clinical assessments diagnostic agreement was good, weighted Kappa was of 0.72 (95% confidence interval 0.85 to 0.59), sensitivity 94.4% and specificity 86.7%. No case of glaucoma was misdiagnosed as normal by virtual assessment. CONCLUSION: Clinical findings and data relating to glaucoma may be evaluated in a virtual clinic with satisfactory diagnostic accuracy.+http://www.ncbi.nlm.nih.gov/pubmed/18954317Rathod, Dinesh Win, Thein Pickering, Susan Austin, Michael Comparative Study Evaluation Studies Australia Clinical & experimental ophthalmology Clin Experiment Ophthalmol. 2008 Aug;36(6):543-6.*1442-9071 (Electronic) 1442-6404 (Linking)18954317=Department of Ophthalmology, Singleton Hospital, Swansea, UK..CEO1831 [pii] 10.1111/j.1442-9071.2008.01831.xeng||7bTharinger, D. J. Finn, S. E. Austin, C. A. Gentry, L. B. Bailey, K. E. Parton, V. T. Fisher, M. E.2008uFamily sessions as part of child psychological assessment: goals, techniques, clinical utility, and therapeutic value547-58 J Pers Assess906 2008/10/18rChild Behavior Disorders/*therapy *Child Psychology Child, Preschool *Family *Goals Humans *Personality AssessmentNovIncluding a family session in a child assessment can significantly advance the assessor's and parents' understanding of the child's problems and enhance the likelihood that parents will follow through on recommendations after the assessment. A family session allows the assessor to observe the child in the family context, test systemic hypotheses, better understand the meaning of individual test results, and try out possible interventions. A family session may also help parents see systemic aspects of their child's problems, help the child feel less blamed, foster positive experiences among family members, and offer the family a glimpse of family therapy. We describe methods and techniques for structuring family sessions and offer guidance on preparing for and conducting such sessions depending on one's case conceptualization. Detailed case examples illustrate each technique and demonstrate the immediate and subsequent impact of family sessions as well as their therapeutic value. We also address common clinical and pragmatic issues.+http://www.ncbi.nlm.nih.gov/pubmed/18925495Tharinger, Deborah J Finn, Stephen E Austin, Cynthia A Gentry, Lauren B Bailey, Karen Elaine Parton, Victoria T Fisher, Melissa E United States Journal of personality assessment J Pers Assess. 2008 Nov;90(6):547-58.*1532-7752 (Electronic) 0022-3891 (Linking)18925495xEducational Psychology Department, University of Texas at Austin, Austin, TX 78712-1294, USA. dtharinger@mail.utexas.edu)904257064 [pii] 10.1080/00223890802388400eng$}|7+Austin, M. P. Priest, S. R. Sullivan, E. A.2008PAntenatal psychosocial assessment for reducing perinatal mental health morbidityCD005124Cochrane Database Syst Rev4 2008/10/10Anxiety Disorders/*diagnosis/prevention & control Depression, Postpartum/*diagnosis/prevention & control Female Humans Mental Health Pregnancy *Prenatal Care Puerperal Disorders/*diagnosis/prevention & control/psychology Randomized Controlled Trials as Topicy BACKGROUND: Mental health conditions arising in the perinatal period, including depression, have the potential to impact negatively on not only the woman but also her partner, infant, and family. The capacity for routine, universal antenatal psychosocial assessment, and thus the potential for reduction of morbidity, is very significant. OBJECTIVES: To evaluate the impact of antenatal psychosocial assessment on perinatal mental health morbidity. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register, the Cochrane Depression, Anxiety and Neurosis Group's Trials Register (CCDAN TR-Studies), HSRProj in the National Library of Medicine (USA), and the Current Controlled Trials website: http://www.controlled trials.com/ and the UK National Research Register (last searched March 2008). SELECTION CRITERIA: Randomised and quasi-randomised controlled trials. DATA COLLECTION AND ANALYSIS: At least two review authors independently assessed trials for eligibility; they also extracted data from included trials and assessed the trials for potential bias. MAIN RESULTS: Two trials met criteria for an RCT of antenatal psychosocial assessment. One trial examined the impact of an antenatal tool (ALPHA) on clinician awareness of psychosocial risk, and the capacity of the antenatal ALPHA to predict women with elevated postnatal Edinburgh Depression Scale (EDS) scores, finding a trend towards increased clinician awareness of 'high level' psychosocial risk where the ALPHA intervention had been used (relative risk (RR) 4.61 95% confidence interval (CI) 0.99 to 21.39). No differences between groups were seen for numbers of women with antenatal EDS scores, a score of greater than 9 being identified by ALPHA as of concern for depression (RR 0.69 95% CI 0.35 to 1.38); 139 providers. The other trial reported no differences in EPS scores greater than 12 at 16 weeks postpartum between the intervention (communication about the EDS scores with the woman and her healthcare providers plus a patient information booklet) and the standard care groups (RR 0.86 95% CI 0.61 to 1.21; 371 women). AUTHORS' CONCLUSIONS: While the use of an antenatal psychosocial assessment may increase the clinician's awareness of psychosocial risk, neither of these small studies provides sufficient evidence that routine antenatal psychosocial assessment by itself leads to improved perinatal mental health outcomes. Further studies with better sample size and statistical power are required to further explore this important public health issue. It will also be important to examine outcomes up to one year postpartum not only for mother, but also infant and family.+http://www.ncbi.nlm.nih.gov/pubmed/18843682Austin, Marie-Paule Priest, Susan R Sullivan, Elizabeth A Review England Cochrane database of systematic reviews (Online) Cochrane Database Syst Rev. 2008 Oct 8;(4):CD005124.*1469-493X (Electronic) 1361-6137 (Linking)18843682Black Dog Institute/School of Psychiatry, University of New South Wales, Hospital Road, Sydney, New South Wales, Australia, 2052. m.austin@unsw.edu.au10.1002/14651858.CD005124.pub2eng ;||7 4Priest, S. R. Austin, M. P. Barnett, B. B. Buist, A.2008oA psychosocial risk assessment model (PRAM) for use with pregnant and postpartum women in primary care settings307-17Arch Womens Ment Health115-6 2008/08/30-Female Humans Interview, Psychological Mental Disorders/*diagnosis/epidemiology New South Wales/epidemiology Postpartum Period/*psychology Pregnancy Pregnancy Complications/*diagnosis/epidemiology Pregnant Women/*psychology Primary Health Care Psychological Tests Risk Assessment/*methods Risk FactorsDec6Recognition of high rates of mental health morbidity and mortality that affect women during the perinatal period has prompted the development of psychosocial risk assessment programs. Designed to identify women, at risk, during routine health checks and delivered by primary care health service providers, these fit within a primary prevention and early intervention strategic approach to the reduction of perinatal mental illness and reflect an integrated approach to perinatal health services delivery. This paper describes the development and use of the psychosocial risk assessment model (PRAM) at the Royal Hospital for Women in Sydney, Australia. Data is presented on 2,142 women who attended the Antenatal Midwives Clinic between 2002 and 2005. The PRAM guides primary care staff to quickly identify women experiencing emotional distress and/or psychosocial problems during pregnancy or postnatal checks. Measures used in pregnancy are the symptom-based Edinburgh Depression Scale and the psychosocial risk-based Antenatal Risk Questionnaire. In postnatal setting the Postnatal Risk Questionnaire is used. Scores can be used to compute a Psychosocial Risk Index (PRI) to guide individualized care planning, define needs for referral and classify groups for clinical and research purposes. Based on the PRI, among 2,142 women assessed in pregnancy 70.6% were classified as low/no risk (no interventions indicated currently), 24.1% as medium risk (in need of monitoring), and 5.3% as high risk (complex). The PRAM offers a conceptual framework, methods and measures for brief psychosocial assessment with clinical and research applications. Postpartum follow up studies of women assessed during pregnancy have commenced. Randomized controlled trials and cross-cultural studies are now indicated to strengthen the evidence base for the model.+http://www.ncbi.nlm.nih.gov/pubmed/18726142Priest, S R Austin, M-P Barnett, B B Buist, A Research Support, Non-U.S. Gov't Austria Archives of women's mental health Arch Womens Ment Health. 2008 Dec;11(5-6):307-17. Epub 2008 Aug 23.1435-1102 (Electronic)18726142School of Medicine and Public Health, Perinatal and Infant Psychiatry Program, University of Newcastle, Newcastle, NSW, Australia. Susan.Priest@newcastle.edu.au10.1007/s00737-008-0028-3engV|t7!"Austin, Z. Gregory, P. A. Chiu, S.2008dUse of reflection-in-action and self-assessment to promote critical thinking among pharmacy students48Am J Pharm Educ723 2008/08/14Adult *Education, Pharmacy Educational Measurement Female *Health Knowledge, Attitudes, Practice Humans Male Motivation Questionnaires *Self Assessment (Psychology) Students, Pharmacy/*psychology Task Performance and Analysis *ThinkingJun 15OBJECTIVE: To examine whether self-assessment and reflection-in-action improves critical thinking among pharmacy students. METHODS: A 24-item standardized test of critical thinking was developed utilizing previously-validated questions. Participants were divided into 2 groups (conditions). Those in condition 1 completed the test with no interference; those in condition 2 completed the test but were prompted at specific points during the test to reflect and self-assess. RESULTS: A total of 94 undergraduate (BScPhm) pharmacy students participated in this study. Significant differences (p < 0.05) were observed between those who completed the test under condition 1 and condition 2, suggesting reflection and self-assessment may contribute positively to improvement in critical thinking. CONCLUSIONS: Structured opportunities to reflect-in-action and self-assess may be associated with improvements among pharmacy students in performance of tasks related to critical thinking.+http://www.ncbi.nlm.nih.gov/pubmed/18698383Austin, Zubin Gregory, Paul Am Chiu, Stephanie Comparative Study Research Support, Non-U.S. Gov't United States American journal of pharmaceutical education Am J Pharm Educ. 2008 Jun 15;72(3):48.*1553-6467 (Electronic) 0002-9459 (Linking)250871118698383~Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto ON M5S3M2, Canada. zubin.austin@utoronto.caeng||7"#Austin, Z. Gregory, P. A. Galli, M.2008~"I just don't know what I'm supposed to know": evaluating self-assessment skills of international pharmacy graduates in Canada115-24Res Social Adm Pharm42 2008/06/17Adult *Clinical Competence Education, Pharmacy Educational Measurement/*standards Female Humans Male *Self Assessment (Psychology) Students, Pharmacy/*psychologyJunBACKGROUND: Self-assessment skills are an integral part of pharmacy education and practice, yet there is very little empirical evidence in health professions to indicate that students and practitioners possess adequate and appropriate self-assessment skills. OBJECTIVES: To evaluate self-assessment skills of international pharmacy graduates (pharmacists from outside Canada or the United States seeking licensure in Canada). METHODS: An 8-station objective structured clinical examination was used. Within each station, 2 trained and experienced pharmacist raters completed analytical and global assessments of participants. After each station, participants themselves completed the same assessments, as well as providing additional anecdotal feedback regarding their performance. In stations possessing sufficient interrater reliability, comparisons were made between raters' assessments and self-assessments. RESULTS: Across all performance quartiles there was a discrepancy between self-assessments and rater assessments of clinical performance. The discrepancy was largest in the lowest quartiles, suggesting impairment of self-assessment may be greatest amongst those who have the weakest skills. CONCLUSIONS: Not all individuals possess adequate and appropriate self-assessment skills. Further work is required to elucidate the link between clinical competence and self-assessment and to determine methods for improving self-assessment skills.+http://www.ncbi.nlm.nih.gov/pubmed/18555965Austin, Zubin Gregory, Paul A M Galli, Michael United States Research in social & administrative pharmacy : RSAP Res Social Adm Pharm. 2008 Jun;4(2):115-24.1551-7411 (Print)18555965Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada. zubin.austin@utoronto.ca9S1551-7411(07)00025-3 [pii] 10.1016/j.sapharm.2007.03.002eng||7#IAustin, M. S. Ghanem, E. Joshi, A. Trappler, R. Parvizi, J. Hozack, W. J.2008RThe assessment of intraoperative prosthetic knee range of motion using two methods515-21J Arthroplasty234 2008/06/03.Aged Aged, 80 and over *Arthrometry, Articular *Arthroplasty, Replacement, Knee Body Mass Index Female Humans Intraoperative Period Knee Joint/*physiology Knee Prosthesis Male Middle Aged Prospective Studies Range of Motion, Articular/*physiology Sensitivity and Specificity *Surgery, Computer-AssistedJunThe commonly used standard goniometer has been shown to underestimate knee flexion. Computer-assisted navigation for total knee arthroplasty offers itself as an alternative method to quantify knee flexion. The goal of our study was to determine the reliability of each instrument in measuring intraoperative range of motion during total knee arthroplasty. We prospectively performed intraoperative measurements using both methods on 99 knees. We assessed the variability between the 2 devices and the confounding effect of body mass index. The mean difference between the goniometric and navigation measurements was significant for flexion, extension, and range of motion. Increasing body mass index accentuated this difference. The goniometric method underestimated flexion measurements as compared to navigation, especially in patients with high body mass index. Our study confirms that navigation is a reliable tool for performing in vivo assessment of range of motion.+http://www.ncbi.nlm.nih.gov/pubmed/18514867Austin, Matthew S Ghanem, Elie Joshi, Ashish Trappler, Rachel Parvizi, Javad Hozack, William J Comparative Study Research Support, Non-U.S. Gov't United States The Journal of arthroplasty J Arthroplasty. 2008 Jun;23(4):515-21. Epub 2008 Apr 15.%0883-5403 (Print) 0883-5403 (Linking)18514867eRothman Institute of Orthopedics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.6S0883-5403(07)00727-9 [pii] 10.1016/j.arth.2007.12.011eng ||7$Zhao, C. Austin, R. M.2008Adjunctive high-risk human papillomavirus DNA testing is a useful option for disease risk assessment in patients with negative Papanicolaou tests without an endocervical/transformation zone sample242-8Cancer1144 2008/05/203Adolescent Adult Age Factors Aged *Cell Transformation, Neoplastic Cervix Uteri/*pathology DNA, Viral/*analysis Female Humans Middle Aged Papillomaviridae/*isolation & purification Precancerous Conditions/*diagnosis Retrospective Studies Risk Assessment Uterine Cervical Neoplasms/*diagnosis *Vaginal SmearsAug 25 BACKGROUND: Current guidelines recommend that women with negative Papanicolaou (Pap) test results and no endocervical/transformation zone (EC/TZ) sample return for screening within 12 months. For some women, this represents earlier follow-up than advocated in several routine screening guidelines. Controversy remains with regard to the correlation between sampling of the EC/TZ, Pap test quality, and disease risk assessment. METHODS: A retrospective study was conducted reviewing the results from 143,438 liquid-based cervical Pap tests performed at a large academic women's hospital between July 2005 and December 2006. Vaginal Pap tests were excluded from the study. Women with any Pap result, women with low-grade squamous intraepithelial lesions (LSILs), and patients with high-grade squamous intraepithelial lesion (HSIL) Pap test results were stratified by 10-year age groups and according to the presence or absence of an EC/TZ sample (EC/TZS). Women with LSIL and HSIL Pap test results with and without an EC/TZS were also compared for rates of high-risk human papillomavirus (hrHPV) DNA detection. RESULTS: Of the total of 143,438 cervical Pap tests performed, 27,359 (19.1%) were reported to be lacking an EC/TZS. The absence of an EC/TZS was found to be highest in adolescents and in mature women aged >or=50 years. The overall detection rate of LSIL was 4.29% and that of HSIL was 0.64%. Both the LSIL and HSIL rates were found to be significantly higher in Pap tests with an EC/TZS compared with Pap tests without an EC/TZS (LSIL: 4.51% vs 3.37% and HSIL: 0.72% vs 0.29%). However, when women with LSILs and HSILs were divided into a group in which EC/TZS was present and a group in which EC/TZS was absent, no significant differences were found to be present with regard to hrHPV DNA rates between the 2 groups. CONCLUSIONS: Adjunctive hrHPV DNA testing is effective in stratifying risk for the presence of SIL in women with and without an EC/TZS. This finding is consistent with recently reported data from >9000 patients with negative Pap results, which found that hrHPV DNA-positive test rates are independent of the presence or absence of an EC/TZS. hrHPV DNA results provide a useful new optional adjunctive tool for the objective stratification of disease risk in women with negative Pap tests and no EC/TZS.+http://www.ncbi.nlm.nih.gov/pubmed/18484643YZhao, Chengquan Austin, R Marshall United States Cancer Cancer. 2008 Aug 25;114(4):242-8.%0008-543X (Print) 0008-543X (Linking)18484643Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, 300 Halket Street, Pittsburgh, PA 15213, USA. zhaoc@UPMC.edu10.1002/cncr.23598eng |t7%ICho, M. H. Niles, A. Huang, R. Inglese, J. Austin, C. P. Riss, T. Xia, M.2008fA bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker1099-106Toxicol In Vitro224 2008/04/11Cell Line Cell Line, Tumor Cell Membrane/*drug effects Humans Kidney/cytology/drug effects/metabolism Luminescence Luminescent Measurements/*methods Mesangial Cells/drug effects/metabolism Peptide Hydrolases/metabolism *Toxicity Tests Xenobiotics/*toxicityJunMeasurement of cell membrane integrity has been widely used to assess chemical cytotoxity. Several assays are available for determining cell membrane integrity including differential labeling techniques using neutral red and trypan blue dyes or fluorescent compounds such as propidium iodide. Other common methods for assessing cytotoxicity are enzymatic "release" assays which measure the extra-cellular activities of lactate dehydrogenase (LDH), adenylate kinase (AK), or glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in culture medium. However, all these assays suffer from several practical limitations, including multiple reagent additions, scalability, low sensitivity, poor linearity, or requisite washes and medium exchanges. We have developed a new cytotoxicity assay which measures the activity of released intracellular proteases as a result of cell membrane impairment. It allows for a homogenous, one-step addition assay with a luminescent readout. We have optimized and miniaturized this assay into a 1536-well format, and validated it by screening a library of known compounds from the National Toxicology Program (NTP) using HEK 293 and human renal mesangial cells by quantitative high-throughput screening (qHTS). Several known and novel membrane disrupters were identified from the library, which indicates that the assay is robust and suitable for large scale library screening. This cytotoxicity assay, combined with the qHTS platform, allowed us to quickly and efficiently evaluate compound toxicities related to cell membrane integrity.+http://www.ncbi.nlm.nih.gov/pubmed/18400464Cho, Ming-Hsuang Niles, Andrew Huang, Ruili Inglese, James Austin, Christopher P Riss, Terry Xia, Menghang NIH0012050276/PHS HHS/United States Z01 HG200319-04/HG/NHGRI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural England Toxicology in vitro : an international journal published in association with BIBRA Toxicol In Vitro. 2008 Jun;22(4):1099-106. Epub 2008 Mar 4.%0887-2333 (Print) 0887-2333 (Linking)238656318400464NIH Chemical Genomics Center, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892-3370, USA.5S0887-2333(08)00048-9 [pii] 10.1016/j.tiv.2008.02.013eng|t7&Austin, Z. Gregory, P. A.2007DEvaluating the accuracy of pharmacy students' self-assessment skills89Am J Pharm Educ715 2007/11/14Educational Measurement/methods/*standards Humans Research Design/*standards *Self Assessment (Psychology) *Students, Pharmacy/psychologyOct 15OBJECTIVES: To evaluate the accuracy of self-assessment skills of senior-level bachelor of science pharmacy students. METHODS: A method proposed by Kruger and Dunning involving comparisons of pharmacy students' self-assessment with weighted average assessments of peers, standardized patients, and pharmacist-instructors was used. RESULTS: Eighty students participated in the study. Differences between self-assessment and external assessments were found across all performance quartiles. These differences were particularly large and significant in the third and fourth (lowest) quartiles and particularly marked in the areas of empathy, and logic/focus/coherence of interviewing. CONCLUSIONS: The quality and accuracy of pharmacy students' self-assessment skills were not as strong as expected, particularly given recent efforts to include self-assessment in the curriculum. Further work is necessary to ensure this important practice competency and life skill is at the level expected for professional practice and continuous professional development.+http://www.ncbi.nlm.nih.gov/pubmed/17998986Austin, Zubin Gregory, Paul A M Comparative Study Evaluation Studies United States American journal of pharmaceutical education Am J Pharm Educ. 2007 Oct 15;71(5):89.*1553-6467 (Electronic) 0002-9459 (Linking)206488717998986[Leslie Dan Faculty of Pharmacy, University of Toronto, ON M5S 3M2. zubin.austin@utoronto.caengg||7'qWalker, M. L. Austin, A. G. Banke, G. M. Foxx, S. R. Gaetano, L. Gardner, L. A. McElhiney, J. Morris, K. Penn, L.20077Reference group data for the functional gait assessment1468-77 Phys Ther8711 2007/09/06Adult Aged Aged, 80 and over *Disability Evaluation Female Gait/*physiology Humans Male Middle Aged Postural Balance/*physiology Reference Values Reproducibility of ResultsNovBACKGROUND AND PURPOSE: The Functional Gait Assessment (FGA) is a clinical tool for evaluating performance in walking. The purpose of this study was to determine age-referenced norms for performance on the FGA in community-living older adults. SUBJECTS: Subjects were 200 adults, ages 40 to 89 years, living independently. METHODS: Each subject completed the FGA one time and was scored simultaneously by 2 testers. RESULTS: The intraclass correlation coefficient for interrater reliability was .93. Mean scores for the FGA ranged from 29/30 for adults in their 40s to 21/30 for adults in their 80s. DISCUSSION AND CONCLUSION: Patient performance on the FGA can be compared with age-referenced norms for expected performance. Further research is needed to determine the FGA's usefulness in tracking clinical changes or predicting falls. The FGA is a reliable test for people without disease, and it is able to detect decreases in gait performance among typical older adults.+http://www.ncbi.nlm.nih.gov/pubmed/17785375Walker, Martha L Austin, Alvis G Banke, Gina M Foxx, Suzanne R Gaetano, Lynn Gardner, Laurie A McElhiney, Jill Morris, Kisiah Penn, Liz United States Physical therapy Phys Ther. 2007 Nov;87(11):1468-77. Epub 2007 Sep 4.%0031-9023 (Print) 0031-9023 (Linking)17785375School of Physical Therapy, Health Sciences Building, Room 3118, Old Dominion University, Norfolk, VA 23529, USA. mlwalker@odu.edu'ptj.20060344 [pii] 10.2522/ptj.20060344engl||7(WRamalingam, S. Honkanen, P. Young, L. Shimura, T. Austin, J. Steeg, P. S. Nishizuka, S.2007VQuantitative assessment of the p53-Mdm2 feedback loop using protein lysate microarrays6247-52 Cancer Res6713 2007/07/10Cell Line, Tumor Feedback, Physiological *Gene Expression Regulation *Gene Expression Regulation, Neoplastic Genes, p53 Humans Image Processing, Computer-Assisted Immunohistochemistry Models, Biological Models, Theoretical Phosphorylation Protein Array Analysis/*methods Proto-Oncogene Proteins/chemistry Proto-Oncogene Proteins c-mdm2/*metabolism Tumor Suppressor Protein p53/*metabolismJul 1Mathematical simulations of the p53-Mdm2 feedback loop suggest that both proteins will exhibit impulsive expression characteristics in response to high cellular stress levels. However, little quantitative experimental evaluation has been done, particularly of the phosphorylated forms. To evaluate the mathematical models experimentally, we used lysate microarrays from an isogenic pair of gamma-ray-irradiated cell lysates from HCT116 (p53(+/+) and p53(-/-)). Both p53 and Mdm2 proteins showed expected pulses in the wild type, whereas no pulses were seen in the knockout. Based on experimental observations, we determined model parameters and generated an in silico "knockout," reflecting the experimental data, including phosphorylated proteins.+http://www.ncbi.nlm.nih.gov/pubmed/17616682Ramalingam, Sundhar Honkanen, Peter Young, Lynn Shimura, Tsutomu Austin, John Steeg, Patricia S Nishizuka, Satoshi N01-CO12400/CO/NCI NIH HHS/United States Research Support, N.I.H., Extramural United States Cancer research Cancer Res. 2007 Jul 1;67(13):6247-52.%0008-5472 (Print) 0008-5472 (Linking)17616682XMolecular Therapeutics Program, National Cancer Institute, NIH, Bethesda, Maryland, USA..67/13/6247 [pii] 10.1158/0008-5472.CAN-07-0342eng 3||7)pSzarewski, A. Cadman, L. Mallett, S. Austin, J. Londesborough, P. Waller, J. Wardle, J. Altman, D. G. Cuzick, J.2007iHuman papillomavirus testing by self-sampling: assessment of accuracy in an unsupervised clinical setting34-42 J Med Screen141 2007/03/17SAdult Age Distribution Aged Algorithms Cervical Intraepithelial Neoplasia/diagnosis/virology Female Humans Middle Aged Papillomaviridae/*isolation & purification Patient Acceptance of Health Care Reference Standards Self-Examination/*methods Sensitivity and Specificity Uterine Cervical Neoplasms/diagnosis/virology Vaginal Smears/*methods^OBJECTIVES: To compare the performance and acceptability of unsupervised self-sampling with clinician sampling for high-risk human papillomavirus (HPV) types for the first time in a UK screening setting. SETTING: Nine hundred and twenty women, from two demographically different centres, attending for routine cervical smear testing. METHODS: Women performed an unsupervised HPV self-test. Immediately afterwards, a doctor or nurse took an HPV test and cervical smear. Women with an abnormality on any test were offered colposcopy. RESULTS: Twenty-one high-grade and 39 low-grade cervical intraepithelial neoplasias (CINs) were detected. The sensitivity for high-grade disease (CIN2+) for the self HPV test was 81% (95% confidence interval [CI] 60-92), clinician HPV test 100% (95% CI 85-100), cytology 81% (95% CI 60-92). The sensitivity of both HPV tests to detect high- and low-grade cervical neoplasia was much higher than that of cytology (self-test 77% [95%CI 65-86], clinician test 80% [95% CI 68-88], cytology 48% [95% CI 36-61]). For both high-grade alone, and high and low grades together, the specificity was significantly higher for cytology (greater than 95%) than either HPV test (between 82% and 87%). The self-test proved highly acceptable to women and they reported that the instructions were easy to understand irrespective of educational level. CONCLUSIONS: Our results suggest that it would be reasonable to offer HPV self-testing to women who are reluctant to attend for cervical smears. This approach should now be directly evaluated among women who have been non-attenders in a cervical screening programme.+http://www.ncbi.nlm.nih.gov/pubmed/17362570Szarewski, Anne Cadman, Louise Mallett, Susan Austin, Janet Londesborough, Philip Waller, Jo Wardle, Jane Altman, Douglas G Cuzick, Jack Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't England Journal of medical screening J Med Screen. 2007;14(1):34-42.%0969-1413 (Print) 0969-1413 (Linking)17362570Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK. anne.szarewski@cancer.org.uk10.1258/096914107780154486eng ||7*/Malic, C. C. Karoo, R. O. Austin, O. Phipps, A.2007AResuscitation burn card--a useful tool for burn injury assessment195-9Burns332 2007/01/16Adult Burn Units Burns/*pathology/therapy Child Clinical Competence/standards Equipment Design Fluid Therapy/instrumentation Humans Manikins Medical Records/*standards Medical Staff, Hospital/standards Nomograms Observer Variation Pilot Projects Resuscitation/*instrumentationMarzIt is well recognised that the initial assessment of body surface area affected by a burn is often over estimated in Accident and Emergency Departments. A useful aide-memoir in the acute setting is Wallace's "rule of nines" or using the patients' palmar surface of the hand, which approximates 1% of the total body surface area, as a method of assessment. Unfortunately, as with every system, limitations apply. Factors such as patient size and the interpretation of what is exactly the 'palmar surface' may significantly influence burn size estimations and subsequently fluid resuscitation. Our aim is to develop a simple, quick and easy reproducible method of calculating burn injuries for medical professionals in the acute setting. Worldwide, the dimensions of a credit card are standardized (8.5 cm x 5.3 cm), thus producing a surface area of 45 cm2. We created a resuscitation burn card (RBC) using these exact same proportions, upon which a modified body surface area (BSA) nomogram was printed. Knowing the patient height and weight, we calculated the surface area of the card as percentage of total body surface area (TBSA). On the opposite site of the RBC, a Lund and Browder chart was printed, as well as the Parkland formula and a formula to calculate paediatric burn fluid requirements. The plastic, flexible RBC conformed well to the body contour and was designed for single use. We used the resuscitation burn card in the initial assessment of simulated burns in a Regional Burn Centre and in an Accident and Emergency Department. The information present on the card was found to be clear and straightforward to use. The evaluation of burn extent was found to be more accurately measured than the estimation obtained without the RBC. The resuscitation burn card can be a valuable tool in the hands of less experienced medical professionals for the early assessment and fluid resuscitation of a burn.+http://www.ncbi.nlm.nih.gov/pubmed/17222978Malic, C C Karoo, R O S Austin, O Phipps, A Evaluation Studies England Burns : journal of the International Society for Burn Injuries Burns. 2007 Mar;33(2):195-9. Epub 2007 Jan 12.%0305-4179 (Print) 0305-4179 (Linking)17222978YResearch Registrar, Pinderfields General Hospital, Wakefield, UK. claudemalic@yahoo.co.uk7S0305-4179(06)00224-5 [pii] 10.1016/j.burns.2006.07.019eng||7+ Austin, L. J.2006.Spiritual assessment: a chaplain's perspective540-2 Explore (NY)26 2006/11/23Nov-DecrEvery hospital and medical center is a dynamic, shifting terrain; each develops its own culture. Even within a single hospital system that is attempting to integrate a strong mission statement, providers routinely experience differences in culture between departments, floors and campuses! These differences are characterized largely by the quality of the past history of the organization combined with the human beings currently working together as staff. Even though the cultural sands are continually shifting, Chaplain Larry Austin's voice is clear, unburdened and practical. He identifies a problem of lack of collaboration between health care professionals of diverse disciplines, as well as a resultant lack of understanding and specificity of professional functions and concepts. These include the challenge of shared languages. While each of the powerful realities identified below offers readers the opportunity for further reflection and dialogue, his starting points for standards in spirituality in health care are symphonic; they stress the wisdom of collaboration between disciplines. Music to the integrative medicine ear!+http://www.ncbi.nlm.nih.gov/pubmed/17113496]Austin, Larry J United States Explore (New York, N.Y.) Explore (NY). 2006 Nov-Dec;2(6):540-2.1550-8307 (Print)171134969S1550-8307(06)00420-4 [pii] 10.1016/j.explore.2006.08.010eng ||7,CAustin, P. C. Mamdani, M. M. Juurlink, D. N. Alter, D. A. Tu, J. V.2006Missed opportunities in the secondary prevention of myocardial infarction: an assessment of the effects of statin underprescribing on mortality969-75 Am Heart J1515 2006/04/29XAged Aged, 80 and over Canada/epidemiology Cohort Studies Drug Prescriptions/*statistics & numerical data Female *Hospitalization Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use Male Middle Aged Mortality Myocardial Infarction/drug therapy/*mortality/*prevention & control/*therapy Patient Discharge Retrospective StudiesMayBACKGROUND: The benefits of statins for the secondary prevention of coronary heart disease are well established. Previous research indicates that patients at the greatest risk of cardiovascular events are the least likely to receive statins. We explored the potential reduction in mortality at the population level that could result from improving statin prescribing among patients least likely to be prescribed a statin after acute myocardial infarction (AMI). METHODS: Simulation analysis of detailed clinical data for a population-based sample of 7285 AMI survivors discharged from 102 hospitals between April 1, 1999, and March 31, 2001 in Ontario, Canada, was done. Using estimates obtained from randomized controlled trials, we estimated the reduction in 3-year all-cause mortality associated with improved statin prescribing at hospital discharge. RESULTS: Overall, 35.6% of patients received a statin prescription at hospital discharge. We estimate that increasing statin prescribing among patients least likely to receive them (ie, the lowest quintile of propensity to receive a prescription at discharge) from the current rate of 7.8% to the rate among all patients (35.6%) could decrease AMI mortality by 83 deaths in Ontario per year (2.1% of all post-AMI deaths within 3 years of discharge). Increasing statin prescribing to 70% among all patients with AMI could avert 312 deaths per year in Ontario. Factoring in low rates of adherence to statin therapy would reduce these estimates to 33 and 126, respectively. CONCLUSIONS: Modest increases in statin prescribing for patients least likely to receive one could decrease post-AMI mortality at the population level.+http://www.ncbi.nlm.nih.gov/pubmed/16644313Austin, Peter C Mamdani, Muhammad M Juurlink, David N Alter, David A Tu, Jack V Research Support, Non-U.S. Gov't United States American heart journal Am Heart J. 2006 May;151(5):969-75.*1097-6744 (Electronic) 0002-8703 (Linking)16644313]Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. peter.austin@ices.on.ca5S0002-8703(05)00651-4 [pii] 10.1016/j.ahj.2005.06.034eng F||7-Presley, S. M. Rainwater, T. R. Austin, G. P. Platt, S. G. Zak, J. C. Cobb, G. P. Marsland, E. J. Tian, K. Zhang, B. Anderson, T. A. Cox, S. B. Abel, M. T. Leftwich, B. D. Huddleston, J. R. Jeter, R. M. Kendall, R. J.2006TAssessment of pathogens and toxicants in New Orleans, LA following Hurricane Katrina468-74Environ Sci Technol402 2006/02/14Animals Animals, Wild Calibration *Disasters Environmental Pollutants/*analysis Gas Chromatography-Mass Spectrometry Louisiana *Soil Microbiology *Water MicrobiologyJan 15Storm surge associated with Hurricane Katrina and the breach of levees protecting New Orleans, Louisiana allowed floodwaters from Lake Pontchartrain to inundate 80% of the city. Environmental samples were collected during September 16-18, 2005 to determine immediate human and wildlife health hazards from pathogens and toxicants in the floodwaters. Baseline information on potential long-term environmental damage resulting from contaminants in water and sediments pumped into Lake Pontchartrain was also collected. Concentrations of aldrin, arsenic, lead, and seven semivolatile organic compounds in sediments/soils exceeded one or more United States Environmental Protection Agency (USEPA) thresholds for human health soil screening levels and high priority bright line screening levels. High numbers of Aeromonas spp., pathogenic Vibrio spp., and other coliform bacteria were found in floodwater samples. Alligator and snake tissues did not contain excessive toxicant concentrations. Initial findings suggest numerous environmental contaminants are present in New Orleans and support the need for further evaluation of the extent of those threats.+http://www.ncbi.nlm.nih.gov/pubmed/16468391Presley, Steven M Rainwater, Thomas R Austin, Galen P Platt, Steven G Zak, John C Cobb, George P Marsland, Eric J Tian, Kang Zhang, Baohong Anderson, Todd A Cox, Stephen B Abel, Michael T Leftwich, Blair D Huddleston, Jennifer R Jeter, Randall M Kendall, Ronald J Research Support, Non-U.S. Gov't United States Environmental science & technology Environ Sci Technol. 2006 Jan 15;40(2):468-74.%0013-936X (Print) 0013-936X (Linking)16468391Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock 79409-1163, USA. steve.presley@tiehh.ttu.edueng @||7.^Cosgrove, S. D. Steele, G. Austin, T. K. Plumb, A. P. Stensland, B. Ferrari, E. Roberts, K. J.2005Understanding the polymorphic behavior of sibenadet hydrochloride through detailed studies integrating structural and dynamical assessment2403-15 J Pharm Sci9411 2005/10/04fCalorimetry, Differential Scanning Crystallization Hydrogen Bonding Magnetic Resonance Spectroscopy Microscopy, Electron, Scanning Powders Receptors, Adrenergic, beta-2/agonists Receptors, Dopamine D2/agonists Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman Surface Properties Temperature Thiazoles/*chemistry/pharmacology X-Ray DiffractionNovThree polymorphs of sibenadet hydrochloride (AR-C68397AA, Viozan) have been shown to exist at ambient temperature and have been characterized. Each undergoes a solid-state transition to a common high temperature form, which melts at approximately 220 degrees C. X-ray powder diffraction (XRPD) indicates that Polymorphs I and II share a similar layered structure not exhibited by Polymorph III. All three ambient temperature polymorphs show evidence of varying degrees of dynamic disorder of the terminal phenyl group as shown by solid-state NMR spectroscopy. Furthermore, the carbons alpha to the ether link also undergo different rates of mobility in Polymorphs I and II. This variation in the extent of dynamic disorder results in an alteration in the short-range structure resulting in distinct polymorphs. Polymorph I is the thermodynamically stable form at room temperature as indicated by solution calorimetry and assessment by thermodynamically driven solution mediated phase transition studies. The present study aims to address the types of discriminatory data required to make a clear distinction between physical forms and define, unequivocally, the presence of polymorphism.+http://www.ncbi.nlm.nih.gov/pubmed/16200581Cosgrove, S D Steele, G Austin, T K Plumb, A P Stensland, B Ferrari, E Roberts, K J United States Journal of pharmaceutical sciences J Pharm Sci. 2005 Nov;94(11):2403-15.%0022-3549 (Print) 0022-3549 (Linking)16200581Preformulation and Biopharmaceutics, Pharmaceutical and Analytical Research and Development, AstraZeneca R and D Charnwood, Bakewell Road, Loughborough, LE11 5RH, United Kingdom. steve.cosgrove@astrazeneca.com10.1002/jps.20412eng ||7/OAustin, M. Fanovich, T. Joseph, S. Ryan, D. Ramdath, D. D. Pinto Pereira, L. M.2004nAssessment of risk for type 2 diabetes mellitus in a Caribbean population with high diabetes-related morbidity387-91West Indian Med J536 2005/04/09Adult Blood Glucose/analysis Body Mass Index Diabetes Mellitus, Type 2/*epidemiology/ethnology/mortality Female Glucose Intolerance Glucose Tolerance Test Humans Male Middle Aged Questionnaires Risk Assessment/*methods Risk Factors Trinidad and Tobago/epidemiology Waist-Hip RatioDecKDiabetes mellitus is a major cause of morbidity in Trinidad and Tobago. Screening programmes are not incorporated in the health sector and the population at risk remains unaware of the benefits of screening. We investigated the risk of developing Type 2 diabetes mellitus in office workers with one risk factor. Participants were randomly selected from the urban corporate sector in Port of Spain. Fasting capillary blood glucose and the American Diabetes Association (ADA) questionnaire for major diabetes risk factors were used to assess risk. Student pharmacists approached 482 persons, of whom 317 consented to participate (66% response rate). There were 101 (32%) men and 216 (68%) women, 37 (39%) were of African ancestry and 28% each were of East Indian and mixed ancestry. Family history was positive in 54%. Thirty per cent (95) of the volunteers were at risk of developing Type 2 diabetes mellitus (41 men; 54 women). Based on the ADA questionnaire, 82% (78) of volunteers were at high risk for developing Type 2 diabetes mellitus. The ADA risk test and Impaired Fasting Glucose were both positive in 13 (14%) volunteers. In subjects at risk, Body Mass Index (BMI) was > 25 kg/m2 in 74% (78) and the waist/hip ratio was 0.85. Approximately 30% of office staff was at risk of developing diabetes mellitus. The ADA questionnaire is a useful non-invasive measure which pharmacists can use to assess risk for Type 2 diabetes mellitus. The glucometer can be used for risk assessment providing that it is associated with a quality assurance programme and that diagnosis is confirmed with laboratory testing.+http://www.ncbi.nlm.nih.gov/pubmed/15816266Austin, M Fanovich, T Joseph, S Ryan, D Ramdath, D D Pinto Pereira, L M Jamaica The West Indian medical journal West Indian Med J. 2004 Dec;53(6):387-91.%0043-3144 (Print) 0043-3144 (Linking)15816266aFaculty of Medical Sciences, The University of the West Indies, Trinidad and Tobago, West Indies.eng B||706Liu, D. Lawrence, M. L. Ainsworth, A. J. Austin, F. W.2005rComparative assessment of acid, alkali and salt tolerance in Listeria monocytogenes virulent and avirulent strains373-8FEMS Microbiol Lett2432 2005/02/03Acids/*pharmacology Alkalies/*pharmacology Animals Colony Count, Microbial Culture Media Humans Hydrogen-Ion Concentration Listeria monocytogenes/*drug effects/growth & development/pathogenicity Sodium Chloride/*pharmacology TemperatureFeb 15?Listeria monocytogenes is an opportunistic bacterial pathogen of man and animals that has the capacity to survive under extreme environmental conditions. While our knowledge on L. monocytogenes and its ability to sustain within wide pH and temperature ranges and salt concentrations has been largely built on the virulent strains of this species, relatively little is known about avirulent strains in this regard. In this study, we extend our analysis on avirulent L. monocytogenes strains. By subjecting three virulent (EGD, 874 and ATCC 19196) and three avirulent (ATCC 19114, HCC23 and HCC25) strains to various pH and salt concentrations, it was found that L. monocytogenes recovered well after treatment with 100 mM Tris at pH 12.0, and to a lesser extent at pH 3.0. Interestingly, avirulent L. monocytogenes strains showed a somewhat higher tolerance to alkali than virulent strains. This unique feature of avirulent L. monocytogenes strains may potentially be exploited for the development of a rapid technique for differentiation between avirulent and virulent strains. Furthermore, all L. monocytogenes strains tested were resistant to saturated NaCl (about 7 M, or 40% w/v) for a long period of time (20 h and possibly longer). Together, these results highlight that acid, alkali, and/or salt treatments commonly used in food product processing may not be sufficient to eliminate L. monocytogenes, and therefore stringent quality control measures at the beginning and end of the food manufacturing process is essential to ensure that such food products are free of listerial contamination.+http://www.ncbi.nlm.nih.gov/pubmed/15686837Liu, Dongyou Lawrence, Mark L Ainsworth, A Jerald Austin, Frank W Comparative Study Research Support, U.S. Gov't, Non-P.H.S. Netherlands FEMS microbiology letters FEMS Microbiol Lett. 2005 Feb 15;243(2):373-8.%0378-1097 (Print) 0378-1097 (Linking)15686837Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Mississippi, MS 39762, USA. liu@cvm.msstate.edu8S0378-1097(04)00927-9 [pii] 10.1016/j.femsle.2004.12.025eng||71Lydy, M. J. Austin, K. R.2005nToxicity assessment of pesticide mixtures typical of the Sacramento-San Joaquin Delta using Chironomus tentans49-55Arch Environ Contam Toxicol481 2005/01/20Acute Toxicity Tests Animals California Chironomidae/*drug effects/physiology Drug Synergism Fresh Water Larva/drug effects/physiology Pesticides/*toxicity Water Pollutants, Chemical/standards/*toxicityJanThis study examined the effects of nine commonly detected pesticides in the Sacramento-San Joaquin Delta on the aquatic midge Chironomus tentans. Pesticides were chosen from a variety of chemical classes including organophosphate (OP) insecticides as well as triazine, triazinone, and substituted urea herbicides. Both single toxicant and binary mixture bioassays were performed. In addition, midges were pre-exposed to DDE at environmentally relevant concentrations and then challenged by exposing them to chlorpyrifos or diazinon in single-toxicant acute bioassays. Results indicate that most of the binary mixtures elicited additive responses in C. tentans, whereas OP insecticides in combination with various herbicides caused greater-than-additive responses. Pre-exposures with DDE did not have a significant impact on subsequent OP challenges at DDE concentrations of 0.2, 2, and 20 microg/kg. This study represents an important first step in understanding the interactions among various pesticides commonly detected throughout the Delta.+http://www.ncbi.nlm.nih.gov/pubmed/15657805Lydy, M J Austin, K R Research Support, Non-U.S. Gov't United States Archives of environmental contamination and toxicology Arch Environ Contam Toxicol. 2005 Jan;48(1):49-55.%0090-4341 (Print) 0090-4341 (Linking)15657805Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901, USA. mlydy@siu.edu10.1007/s00244-004-0056-6eng ||72DKasper, M. L. Reeson, A. F. Cooper, S. J. Perry, K. D. Austin, A. D.2004Assessment of prey overlap between a native (Polistes humilis) and an introduced (Vespula germanica) social wasp using morphology and phylogenetic analyses of 16S rDNA2037-48Mol Ecol137 2004/06/11Animals Computational Biology DNA Primers *Diet Gastrointestinal Contents/*chemistry Phylogeny Predatory Behavior/*physiology RNA, Ribosomal, 16S/genetics Sequence Analysis, DNA South Australia Species Specificity Wasps/genetics/*physiologyJulAbstract In newly invaded communities, interspecific competition is thought to play an important role in determining the success of the invader and its impact on the native community. In southern Australia, the native Polistes humilis was the predominant social wasp prior to the arrival of the exotic Vespula germanica (Hymenoptera: Vespidae). Both species forage for similar resources (water, pulp, carbohydrate and protein prey), and concerns have arisen about potential competition between them. The aim of this study was to identify the protein foods that these wasps feed on. As many prey items are masticated by these wasps to the degree that they cannot be identified using conventional means, morphological identification was complemented by sequencing fragments of the mitochondrial 16S rRNA gene. GenBank searches using blast and phylogenetic analyses were used to identify prey items to at least order level. The results were used to construct complete prey inventories for the two species. These indicate that while P. humilis is restricted to feeding on lepidopteran larvae, V. germanica collects a variety of prey of invertebrate and vertebrate origin. Calculated values of prey overlap between the two species are used to discuss the implications of V. germanica impacting on P. humilis. Results obtained are compared to those gained by solely 'conventional' methods, and the advantages of using DNA-based taxonomy in ecological studies are emphasized.+http://www.ncbi.nlm.nih.gov/pubmed/15189224Kasper, Marta L Reeson, Andrew F Cooper, Steven J B Perry, Kym D Austin, Andrew D Comparative Study Research Support, Non-U.S. Gov't England Molecular ecology Mol Ecol. 2004 Jul;13(7):2037-48.%0962-1083 (Print) 0962-1083 (Linking)15189224Environmental Biology, School of Earth and Environmental Sciences, The University of Adelaide, South Australia 5005, Australia..10.1111/j.1365-294X.2004.02193.x MEC2193 [pii]eng||733Kwak, M. M. Ervin, R. A. Anderson, M. Z. Austin, J.2004zAgreement of function across methods used in school-based functional assessment with preadolescent and adolescent students375-401 Behav Modif283 2004/04/24Adolescent Child Child Behavior Disorders/*diagnosis/epidemiology Humans *Motivation *Observer Variation *Questionnaires School Health Services/*organization & administrationMayAs we begin to apply functional assessment procedures in mainstream educational settings, there is a need to explore options for identifying behavior function that are not only effective but efficient and practical for school personnel to employ. Attempts to simplify the functional assessment process are evidenced by the development of informant assessment measures (e.g., interviews, rating scales). In this study, the agreement (i.e., on relative rankings and primary function) across sources of information regarding behavior function was examined for 19 students in a middle school setting. These measures included teacher ratings, student ratings, student interviews, observer ratings, and conditional probabilities. In addition, for 1 student, whether information obtained through these sources was consistent with that obtained through a brief analog analysis of function was examined. Results indicated low agreement regarding rank order of behavior function and on primary function across all sources of information.+http://www.ncbi.nlm.nih.gov/pubmed/15104868Kwak, Meg M Ervin, Ruth A Anderson, Mary Z Austin, John United States Behavior modification Behav Modif. 2004 May;28(3):375-401.%0145-4455 (Print) 0145-4455 (Linking)15104868!Western Michigan University, USA.10.1177/0145445503258990eng||74$Austin, P. C. Alter, D. A. Tu, J. V.2003uThe use of fixed- and random-effects models for classifying hospitals as mortality outliers: a Monte Carlo assessment526-39Med Decis Making236 2003/12/16#*Hospital Mortality Hospitals/*classification/standards Humans *Models, Statistical Monte Carlo Method Myocardial Infarction/complications/mortality Ontario Outcome Assessment (Health Care)/*methods Outliers, DRG Risk Adjustment/*methods Sensitivity and Specificity Severity of Illness IndexNov-DecBACKGROUND: There is an increasing movement towards the release of hospital "report-cards. "However, there is a paucity of research into the abilities of the different methods to correctly classify hospitals as performance outliers. OBJECTIVE: To examine the ability of risk-adjusted mortality rates computed using conventional logistic regression and random-effects logistic regression models to correctly identify hospitals that have higher than acceptable mortality. RESEARCH DESIGN: Monte Carlo simulations. MEASURES: Sensitivity, specificity, and positive predictive value of a classification as a high-outlier for identifying hospitals with higher than acceptable mortality rates. RESULTS: When the distribution of hospital specific log-odds of death was normal, random-effects models had greater specificity and positive predictive value than fixed-effects models. However, fixed-effects models had greater sensitivity than random-effects models. CONCLUSIONS: Researchers and policy makers need to carefully consider the balance between false positives and false negatives when choosing statistical models for determining which hospitals have higher than acceptable mortality in performance profiling.+http://www.ncbi.nlm.nih.gov/pubmed/14672113Austin, Peter C Alter, David A Tu, Jack V Comparative Study Research Support, Non-U.S. Gov't Validation Studies United States Medical decision making : an international journal of the Society for Medical Decision Making Med Decis Making. 2003 Nov-Dec;23(6):526-39.%0272-989X (Print) 0272-989X (Linking)14672113]Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. peter.austin@ices.on.ca10.1177/0272989X03258443eng||75 Austin, M. P.2003Psychosocial assessment and management of depression and anxiety in pregnancy. Key aspects of antenatal care for general practice119-26Aust Fam Physician323 2003/04/02*Anxiety Disorders/diagnosis/therapy *Depressive Disorder/diagnosis/therapy Family Practice Female Humans Infant, Newborn Pregnancy Pregnancy Complications/diagnosis/*psychology/therapy Pregnancy Outcome Prenatal Care Puerperal Disorders/diagnosis/therapyMarBACKGROUND: Psychological morbidity, and especially depression and anxiety arising antenatally, are as common as that seen postnatally. Approximately one-third of women will remain depressed postpartum, sometimes for prolonged periods--with the attendant morbidity for mother and infant that this brings. Morbidity is greatest where there is associated drug and alcohol use, domestic violence and personality disorder. OBJECTIVE: This article aims to provide an overview of psychosocial assessment and the detection and management of depression and anxiety disorders in pregnancy. DISCUSSION: Psychosocial assessment of all pregnant women is an integral part of good antenatal care. The Edinburgh Postnatal Depression Scale is a useful adjunct in the detection and monitoring of anxiety and depression antenatally. Many women will decline medication and thus psychological interventions will often be first line treatments. Where medication is required, prospective controlled studies suggest antidepressants are not associated with increased rates of teratogenicity and are thus relatively 'safe'. Management of more severe and/or complex cases needs to be in association with a psychiatrist and a mental health or drug and alcohol team and may require antenatal notification of an 'at risk' offspring.+http://www.ncbi.nlm.nih.gov/pubmed/12666348dAustin, Marie-Paule Australia Australian family physician Aust Fam Physician. 2003 Mar;32(3):119-26.%0300-8495 (Print) 0300-8495 (Linking)126663486Royal Hospital for Women, Sydney. m.austin@unsw.edu.aueng||76Austin, J. Ali, T.2003pTracheomalacia and bronchomalacia in children: pathophysiology, assessment, treatment and anaesthesia management3-11Paediatr Anaesth131 2003/01/22Anesthesia, General Anesthesia, Local *Bronchial Diseases/diagnosis/physiopathology/surgery Bronchoscopy Child Child, Preschool Humans Infant Spirometry Tomography, X-Ray Computed Tracheal Diseases/diagnosis/physiopathology/surgeryJanTracheomalacia and bronchomalacia are becoming increasingly well recognized. Although pathologically benign conditions, they are responsible for considerable morbidity, occasional mortality and significant difficulties in the operating theatre and intensive care unit. We performed an extensive literature search to identify causal associations, methods of clinical and investigative assessment, treatment modalities and anaesthetic experience with these conditions.+http://www.ncbi.nlm.nih.gov/pubmed/12535032dAustin, James Ali, Tariq Review France Paediatric anaesthesia Paediatr Anaesth. 2003 Jan;13(1):3-11.%1155-5645 (Print) 1155-5645 (Linking)12535032ADepartment of Anaesthesia, Royal Berkshire Hospital, Reading, UK. 802 [pii]eng||77)DiMango, E. A. Lubetsky, H. Austin, J. H.2002\Assessment of bronchial wall thickening on posteroanterior chest radiographs in acute asthma255-61J Asthma393 2002/06/05Acute Disease Adult Aged Asthma/*pathology/*radiography Bronchi/*pathology Bronchography/*methods Female Humans Male Middle AgedMayA central bronchus that is readily visible end-on in approximately 50% of normal frontal chest radiographs is the bronchus to the anterior segment of either upper lobe. Bronchial wall thickening, or "cuffing," is considered to be a radiographic sign of an asthmatic exacerbation and is cited as a useful sign in a number of leading textbooks; however, to the authors' knowledge, no prior chest radiographic study has quantitatively assessed this specific sign in a population of asthmatics suffering an acute exacerbation. Posterior chest radiographs were reviewed retrospectively for 51 nonasthmatic, nonsmoking control subjects and for 45 adult asthmatic subjects during an acute exacerbation of moderate to severe asthma. Readers were blinded as to whether the radiograph was from an asthmatic or control subject. If visible end-on, the bronchus to the anterior segment of either upper lobe was assessed by measuring the diameter of the lumen and the thickness of the bronchial wall. At least one clearly defined bronchus to the anterior segment of an upper lobe was visible end-on in 22 patients (43%) in the control group and in 21 patients (47%) in the asthma group (p = NS). Mean wall thickness was 0.7 +/- 0.1 mm in the control group and 0.8 +/- 0.1 mm in the asthma group (p = 0.04). Lumen/wall thickness was 3.1 +/- 0.2 (SEM) in the control group and 2.5 +/- 0.2 in the asthma group (p = 0.055). The presence of bronchial wall thickness does not reliably distinguish radiographs of acutely asthmatic from normal individuals.+http://www.ncbi.nlm.nih.gov/pubmed/12043857DiMango, Emily A Lubetsky, Herman Austin, John H M United States The Journal of asthma : official journal of the Association for the Care of Asthma J Asthma. 2002 May;39(3):255-61.%0277-0903 (Print) 0277-0903 (Linking)12043857Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. ead3@columbia.edueng ||78@Dunn, D. W. Harezlak, J. Ambrosius, W. T. Austin, J. K. Hale, B.2002CTeacher assessment of behaviour in children with new-onset seizures169-75Seizure113 2002/05/23Adolescent Child Child Behavior Child Behavior Disorders/epidemiology/*psychology Comorbidity Epilepsy/epidemiology/*psychology *Faculty Female Humans Male Risk Factors Sampling Studies Time FactorsApr RATIONALE: Recent data suggest that children with new-onset seizures may be at increased risk for behaviour problems. Teachers are an excellent source of data about such problems. They do not have the potential bias that a parent worried about a new onset of seizures might have and, furthermore, they are accustomed to comparing performance of children and work in an environment in which the behavioural problems associated with epilepsy may be quite evident. We obtained teachers' reports of behaviour problems in children in the 2 months prior to their first recognized seizure. We also obtained similar data on children with new-onset, moderate severity asthma. In addition to comparing behavioural scores between children with seizures and children with asthma, we compared teachers' assessments of behaviour in children with no prior seizures to those of children with previously unrecognized seizures. METHODS: We evaluated 192 children with new-onset seizures, including 129 children with no prior episodes and 63 children with recognized prior seizure-like episodes. The comparison group consisted of 78 children with new-onset, moderate severity asthma. Behaviour was assessed by the teacher's report form (TRF) of the child behaviour checklist (CBCL) or the caregiver-teacher report form for ages 2-5 (C-TRF). Mean scores were compared by two-sample t -tests and analysis of variance (ANOVA). RESULTS: The children with new-onset seizures had more thought problems than children with asthma. In comparison to children with no prior seizures, the children with prior unrecognized seizures had higher scores in total behaviour problems, internalizing problems, somatic complaints, anxious/depressed, thought problems, and attention problems. CONCLUSIONS: In this sample, children with prior unrecognized seizures were already at increased risk of teacher-rated behaviour problems before starting medication and before any possible stigma effects related to seizures. This sequence suggests underlying neurological problems causing both behavioural problems and seizures.+http://www.ncbi.nlm.nih.gov/pubmed/12018960Dunn, David W Harezlak, Jaroslaw Ambrosius, Walter T Austin, Joan K Hale, Bradford R01 NS22416/NS/NINDS NIH HHS/United States Comparative Study Research Support, U.S. Gov't, P.H.S. England Seizure : the journal of the British Epilepsy Association Seizure. 2002 Apr;11(3):169-75.%1059-1311 (Print) 1059-1311 (Linking)12018960PIndiana University School of Medicine, Indianapolis, 46202, USA. ddunn@iupui.edu.10.1053/seiz.2001.0612 S1059131101906120 [pii]engc||79dSwift, R. D. Kiraly, A. P. Sherbondy, A. J. Austin, A. L. Hoffman, E. A. McLennan, G. Higgins, W. E.2002[Automatic axis generation for virtual bronchoscopic assessment of major airway obstructions103-18Comput Med Imaging Graph262 2002/01/31Airway Obstruction/*radiography Algorithms Bronchoscopy/*methods Humans *Image Processing, Computer-Assisted Phantoms, Imaging Tomography, X-Ray Computed United States *User-Computer InterfaceMar-Apr Virtual bronchoscopy (VB) has emerged as a paradigm for more effective 3D CT image evaluation. Systematic evaluation of a 3D CT chest image using VB techniques, however, requires precomputed guidance data. This guidance data takes the form of central axes, or centerlines, through the major airways. We propose an axes-generation algorithm for VB assessment of 3D CT chest images. For a typical high-resolution 3D CT chest image, the algorithm produces a series of airway-tree axes, corresponding airway cross-sectional area measurements, and a segmented airway tree in a few minutes on a standard PC. Results for phantom and human airway-obstruction cases demonstrate the efficacy of the algorithm. Also, the algorithm is demonstrated in the context of VB-based 3D CT assessment.+http://www.ncbi.nlm.nih.gov/pubmed/11818189rSwift, R D Kiraly, A P Sherbondy, A J Austin, A L Hoffman, E A McLennan, G Higgins, W E CA74325/CA/NCI NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society Comput Med Imaging Graph. 2002 Mar-Apr;26(2):103-18.%0895-6111 (Print) 0895-6111 (Linking)11818189}Department of Electrical Engineering, Penn State University, 121 Electrical Engineering East, University Park, PA 16802, USA.S0895611101000350 [pii]eng B||7:xArendash, G. W. Gordon, M. N. Diamond, D. M. Austin, L. A. Hatcher, J. M. Jantzen, P. DiCarlo, G. Wilcock, D. Morgan, D.2001Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory737-44 DNA Cell Biol2011 2002/01/15'Alzheimer Disease/immunology/*physiopathology Amyloid beta-Protein/*administration & dosage/immunology/metabolism Animals *Behavior, Animal Brain/metabolism/pathology *Memory Mice Mice, Transgenic Peptide Fragments/*administration & dosage/immunology/metabolism Vaccines/*administration & dosageNovKLong-term vaccinations with human beta-amyloid peptide 1-42 (Abeta1-42) have recently been shown to prevent or markedly reduce Abeta deposition in the PDAPP transgenic model of Alzheimer's disease (AD). Using a similar protocol to vaccinate 7.5-month-old APP (Tg2576) and APP+PS1 transgenic mice over an 8-month period, we previously reported modest reductions in brain Abeta deposition at 16 months. In these same mice, Abeta vaccinations had no deleterious behavioral effects and, in fact, benefited the mice by providing partial protection from age-related deficits in spatial working memory in the radial arm water maze task (RAWM) at 15.5 months. By contrast, control-vaccinated transgenic mice exhibited impaired performance throughout the entire RAWM test period at 15.5 months. The present study expands on our initial report by presenting additional behavioral results following long-term Abeta vaccination, as well as correlational analyses between cognitive performance and Abeta deposition in vaccinated animals. We report that 8 months of Abeta vaccinations did not reverse an early-onset balance beam impairment in transgenic mice. Additionally, in Y-maze testing at 16 months, all mice showed comparable spontaneous alternation irrespective of genotype or vaccination status. Strong correlations were nonetheless present between RAWM performance and extent of "compact" Abeta deposition in both the hippocampus and the frontal cortex of vaccinated APP+PS1 mice. Our results suggest that the behavioral protection of long-term Abeta vaccinations is task specific, with preservation of hippocampal-associated working memory tasks most likely to occur. In view of the early short-term memory deficits exhibited by AD patients, Abeta vaccination of presymptomatic AD patients could be an effective therapeutic to protect against such cognitive impairments.+http://www.ncbi.nlm.nih.gov/pubmed/11788052DArendash, G W Gordon, M N Diamond, D M Austin, L A Hatcher, J M Jantzen, P DiCarlo, G Wilcock, D Morgan, D AG15490/AG/NIA NIH HHS/United States AG18478/AG/NIA NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States DNA and cell biology DNA Cell Biol. 2001 Nov;20(11):737-44.%1044-5498 (Print) 1044-5498 (Linking)11788052The Alzheimer's Research Consortium, Department of Biology, University of South Florida, Tampa, Florida 33620, USA. arendash@chuma.cas.usf.edu10.1089/10445490152717604eng||7;FFerris, S. J. Kempton, R. A. Deary, I. J. Austin, E. J. Shotter, M. V.2001#Carryover bias in visual assessment1363-73 Perception3011 2002/01/05Adolescent Adult Analysis of Variance Discrimination (Psychology)/*physiology Female Humans Least-Squares Analysis Linear Models Male *Models, Statistical Observer Variation Psychophysics Statistics, NonparametricJCarryover of stimuli in sequential judgments was studied for a visual assessment task involving estimation of the percentage cover of black circles on a white image. Seven image types with different levels of cover density were arranged in a sequentially balanced design in which each image type was preceded the same number of times by all image types. In the absence of carryover, when images were preceded by images with the same cover density, the response scores were well fitted by a power function of percentage cover with a mean exponent of 0.73 over subjects. Carryover took the form of an assimilation, so that the cover estimate for a target image was generally higher when preceded by an image with higher cover, and lower when preceded by an image with lower cover. However, the magnitude of the carryover effect showed little evidence of increasing with difference in cover between successive images. Nonparametric and parametric methods for testing for carryover are presented. The need for development of psychological models to explain the proposed statistical models is discussed.+http://www.ncbi.nlm.nih.gov/pubmed/11768489Ferris, S J Kempton, R A Deary, I J Austin, E J Shotter, M V Research Support, Non-U.S. Gov't England Perception Perception. 2001;30(11):1363-73.%0301-0066 (Print) 0301-0066 (Linking)117684896Biomathematics and Statistics Scotland, Edinburgh, UK.eng||7< Austin, J. H.1999HPulmonary emphysema: imaging assessment of lung volume reduction surgery1-3 Radiology2121 1999/07/16*Diagnostic Imaging Forced Expiratory Volume/*physiology Humans *Pneumonectomy Prognosis Pulmonary Emphysema/classification/*diagnosis/surgery Tomography, X-Ray Computed Treatment OutcomeJul+http://www.ncbi.nlm.nih.gov/pubmed/10405713UAustin, J H Comment Editorial United states Radiology Radiology. 1999 Jul;212(1):1-3.%0033-8419 (Print) 0033-8419 (Linking)10405713eng *||7=dDiaz, J. I. Mora, L. B. Austin, P. F. Muro-Cacho, C. A. Cantor, A. B. Nicosia, S. V. Pow-Sang, J. M.1999tPredictability of PSA failure in prostate cancer by computerized cytometric assessment of tumoral cell proliferation931-8Urology535 1999/05/01Aged Cell Division Diagnosis, Computer-Assisted Humans Male Middle Aged *Ploidies Prostate-Specific Antigen/*blood Prostatic Hyperplasia/blood/genetics/pathology Prostatic Neoplasms/*blood/genetics/*pathology Treatment FailureMayOBJECTIVES: To evaluate the relationship of DNA ploidy and cell proliferation (CP) with Gleason score (GS) and clinical outcome in prostate cancer. METHODS: Sixteen patients with benign prostatic hyperplasia (BPH) and 65 patients with prostate cancer classified by GS (four groups: 2 to 4, 5 to 6, 7, and 8 to 10) were studied. All patients with carcinoma underwent prostatectomy and were separated into prostate-specific antigen (PSA) failure and nonfailure groups (failure if PSA 0.1 ng/mL or more three times after surgery). Tumoral CP (Ki-67 inmunostaining and SG2M phase) and DNA ploidy were evaluated by computerized cytometry. RESULTS: BPH were diploid with low CP (8% SG2M cells or less). Carcinomas were either diploid with high CP (greater than 8% SG2M cells) or aneuploid. CP was significantly higher (P <0.001) in tumors with GS 7 or greater than in tumors with GS less than 7 (mean percent Ki-67 cells 18.3% versus 7.8%, respectively). PSA failure increased with GS (7.1% in GS 2 to 4, 21% in GS 5 to 6, 28.6% in GS 7, and 50% in GS 8 to 10), as well as with aneuploidy (18.5% in diploid tumors versus 72.7% in aneuploid tumors). Those experiencing PSA failure had significantly higher (P <0.001) CP than those not failing (mean percent Ki-67 cells 24% and mean percent SG2M 30.4% versus 8.7% and 13.5%, respectively). Cox regression analysis showed GS, DNA ploidy, Ki-67, and SG2M to each be univariately prognostic for time to PSA failure; however, Ki-67 and SG2M were more highly significant (P <0.0001 for both) than GS (P = 0.007) or DNA ploidy (P = 0.002). After adjusting for either SG2M or Ki-67 measures of CP, neither ploidy nor GS contained additional prognostic value. CONCLUSIONS: Tumor CP and DNA ploidy can be reliably determined in prostate cancer by computerized cytometry. On the basis of our preliminary results, CP correlates well with GS and predicts PSA failure better than DNA ploidy or GS.+http://www.ncbi.nlm.nih.gov/pubmed/10223486Diaz, J I Mora, L B Austin, P F Muro-Cacho, C A Cantor, A B Nicosia, S V Pow-Sang, J M United states Urology Urology. 1999 May;53(5):931-8.%0090-4295 (Print) 0090-4295 (Linking)10223486Department of Pathology, University of South Florida College of Medicine and H. Lee Moffitt Cancer and Research Institute, Tampa 33612, USA.S0090429598006256 [pii]eng ||7>PParker, G. Roussos, J. Hadzi-Pavlovic, D. Mitchell, P. Wilhelm, K. Austin, M. P.1997The development of a refined measure of dysfunctional parenting and assessment of its relevance in patients with affective disorders1193-203 Psychol Med275 1997/09/23Adolescent Adult Aged Analysis of Variance Anxiety Disorders/classification/psychology Child Child Abuse/psychology/statistics & numerical data Cross-Sectional Studies Depressive Disorder/classification/*psychology Factor Analysis, Statistical *Family Health Female Humans Male Middle Aged Parent-Child Relations *Parenting Psychometrics/*methods Retrospective Studies Sampling StudiesSepBACKGROUND: The Parental Bonding Instrument (PBI) measures fundamental parenting dimensions (care and over-protection), but does not directly assess abusive parenting. METHODS: We describe the development of the Measure of Parenting Style (the MOPS), comprising refined PBI scales assessing parental indifference and over-control, as well as a scale assessing parental abuse. RESULTS: We examine psychometric properties of the MOPS, while several analyses build to the concurrent validity of the abuse scale as an experimental measure. We examine the extent to which both the PBI and the MOPS scales showed specificity of dysfunctional parenting to the non-melancholic depressive subtype, and across a range of anxiety disorders. Non-melancholic depressed patients returned anomalous parenting scale scores (compared to melancholic subjects), but only when such subtyping decisions were clinician-generated. Those receiving DSM-III-R lifetime anxiety diagnoses of panic disorder and of social phobia returned higher PBI protection and MOPS over-control scores than non-anxious subjects, while differences were not established for those with generalized anxiety disorder or obsessive compulsive disorder. CONCLUSIONS: We consider the likely utility of the MOPS scale and note the module capacity of separate MOPS and PBI scales, which allow a set of options for assessing perceived parenting characteristics.*http://www.ncbi.nlm.nih.gov/pubmed/9300523Parker, G Roussos, J Hadzi-Pavlovic, D Mitchell, P Wilhelm, K Austin, M P Research Support, Non-U.S. Gov't England Psychological medicine Psychol Med. 1997 Sep;27(5):1193-203.%0033-2917 (Print) 0033-2917 (Linking)9300523CMood Disorders Unit, Prince Henry Hospital, Sydney, NSW, Australia.eng~|7?Austin, S. Joseph, S.19968Assessment of bully/victim problems in 8 to 11 year-olds447-56Br J Educ Psychol 66 ( Pt 4) 1996/12/01_Child Female *Hierarchy, Social Humans Male *Peer Group Psychometrics/*methods *Social BehaviorDecwThe aim of the present study was to develop two six-item self-report scales (the Bullying-Behaviour Scale and the Peer-Victimisation Scale) to assess bully-victim problems at school. These scales were designed so that they could be immersed within the Self-Perception Profile for Children (SPPC: Harter, 1985) thus reducing the saliency of the items. Internal reliability of both scales was found to be satisfactory (Cronbach's alpha = 0.83 and 0.82 respectively). Data are reported on the association between scores on both scales and scores on the SPPC and the Birleson Depression Inventory (Birleson, 1981) with 425 children (204 boys and 221 girls) ranging from 8 to 11 years (mean = 9.2 years). Forty-six per cent of the children were classified as bullies, victims, or both: 22 per cent were classified as victims only, 15 per cent as bully/victims, and 9 per cent as bullies only.*http://www.ncbi.nlm.nih.gov/pubmed/9008423xAustin, S Joseph, S England The British journal of educational psychology Br J Educ Psychol. 1996 Dec;66 ( Pt 4):447-56.%0007-0998 (Print) 0007-0998 (Linking)9008423>Department of Psychology, University of Essex, Colchester, UK.eng O||7@]Giannoni, C. el-Naggar, A. K. Ordonez, N. G. Tu, Z. N. Austin, J. Luna, M. A. Batsakis, J. G.1995^c-erbB-2/neu oncogene and Ki-67 analysis in the assessment of palatal salivary gland neoplasms391-8Otolaryngol Head Neck Surg1123 1995/03/01Adolescent Adult Aged Aged, 80 and over Carcinoma, Adenoid Cystic/genetics/metabolism/secondary/therapy Cohort Studies Female Follow-Up Studies Forecasting *Gene Expression Regulation, Neoplastic Genes, erbB-2/*genetics Humans Ki-67 Antigen Male Middle Aged Multivariate Analysis Neoplasm Proteins/*analysis/genetics Nuclear Proteins/*analysis/genetics Palatal Neoplasms/*genetics/metabolism/therapy Salivary Gland Neoplasms/*genetics/metabolism/therapy Salivary Glands, Minor/*metabolism Survival Rate Treatment OutcomeMarZTo evaluate the role of the Ki-67 proliferation antigen and c-erbB-2/neu oncogene expression in the clinical assessment of salivary gland tumors, we followed up 71 patients with minor salivary tumors of the palate. All benign neoplasms (n = 18) showed low Ki-67 scores (< 12%), whereas 26% (14 of 53) of malignant neoplasms manifested high Ki-67 scores (> 12%). A significant statistical difference between Ki-67 scores for benign and malignant neoplasms was observed (p < 0.001). Ki-67 index also correlated significantly with malignant tumor grade (p = 0.04) and patient survival (p = 0.02). Only 1 of the 18 benign tumors had c-erbB-2/neu oncogene overexpression. A significant difference between c-erbB-2/neu overexpression in benign and malignant tumors was observed (p = 0.01). Overexpression of c-erbB-2/neu oncogene was noted in 38% (16 of 42) of malignant tumors and was significantly associated with aggressive tumor behavior (p < 0.001). Multivariate analysis of significant factors revealed that gender, tumor stage, and c-erbB-2/neu oncogene overexpression were jointly predictive of survival. Our data indicate that although the Ki-67 proliferating antigen and c-erbB-2/neu oncogene expression may reflect certain intrinsic biologic properties of these neoplasms, only c-erbB-2/neu overexpression is significantly associated with their biologic aggression.*http://www.ncbi.nlm.nih.gov/pubmed/7870438Giannoni, C el-Naggar, A K Ordonez, N G Tu, Z N Austin, J Luna, M A Batsakis, J G United states Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Otolaryngol Head Neck Surg. 1995 Mar;112(3):391-8.%0194-5998 (Print) 0194-5998 (Linking)7870438FDepartment of Otolaryngology, Baylor College of Medicine, Houston, TX.S0194599895000635 [pii]eng||7A*Scadding, G. K. Darby, Y. C. Austin, C. E.1994wAcoustic rhinometry compared with anterior rhinomanometry in the assessment of the response to nasal allergen challenge451-4Clin Otolaryngol Allied Sci195 1994/10/01Administration, Intranasal Adolescent Adult Aged Allergens/administration & dosage/*diagnostic use Humans *Manometry Middle Aged Nasal Obstruction/etiology Rhinitis, Allergic, Perennial/complications/*diagnosis Skin TestsOctAcoustic rhinometry was used to assess nasal airway patency objectively and was compared with the more established method of anterior rhinomanometry. Ten patients with allergic rhinitis underwent 15 nasal challenges with allergen to which they showed positive skin-prick tests. Responses were assessed by measuring the minimum nasal cross-sectional area (Amin.) using acoustic rhinometry and by measuring nasal airway resistance (NAR) using anterior rhinomanometry. The measurements of Amin. and NAR showed a significant negative correlation. Acoustic rhinometry appears to be superior to anterior rhinomanometry in quantifying the response to nasal allergen challenge and may be particularly useful in patients with initial nasal blockage.*http://www.ncbi.nlm.nih.gov/pubmed/7834890Scadding, G K Darby, Y C Austin, C E England Clinical otolaryngology and allied sciences Clin Otolaryngol Allied Sci. 1994 Oct;19(5):451-4.%0307-7772 (Print) 0307-7772 (Linking)78348909Royal National Throat, Nose and Ear Hospital, London, UK.eng||7B*Zwiebel, B. R. Austin, J. H. Grimes, M. M.1991hBronchial carcinoid tumors: assessment with CT of location and intratumoral calcification in 31 patients483-6 Radiology1792 1991/05/01Adolescent Adult Aged Bronchial Neoplasms/pathology/*radiography Calcinosis/pathology/radiography Carcinoid Tumor/pathology/*radiography Female Humans Male Middle Aged Retrospective Studies *Tomography, X-Ray ComputedMayBronchial carcinoid tumors (BCT) have long been regarded as predominantly central and rarely calcified. The authors retrospectively reviewed computed tomographic (CT) findings in 31 patients (thin-section CT studies in 18) who were seen at their institution with the histopathologic diagnosis of BCT (27 typical, four atypical) during the years 1978-1989. Eighteen BCT (58%) were central and 13 (42%) peripheral, with peripheral defined as located more than 2 cm distal to the origin of the appropriate segmental bronchus. CT scans revealed varied patterns of calcification in seven (39%) of the 18 central BCT and in one (8%) of the 13 peripheral BCT (P less than .1); overall, CT scans revealed calcification in eight (26%) of the BCT. The eight calcified tumors were each of the typical histopathologic type. Peripheral BCT (42%) were nearly as common as central BCT (58%), and CT detection of calcification in BCT was not uncommon (39% of central lesions; 26%, overall).*http://www.ncbi.nlm.nih.gov/pubmed/2014296^Zwiebel, B R Austin, J H Grimes, M M United states Radiology Radiology. 1991 May;179(2):483-6.%0033-8419 (Print) 0033-8419 (Linking)2014296RDepartment of Radiology, Columbia-Presbyterian Medical Center, New York, NY 10032.eng||7C Austin, J. K.1990QAssessment of coping mechanisms used by parents and children with chronic illness98-102MCN Am J Matern Child Nurs152 1990/03/01*Adaptation, Psychological Adult Attitude to Health Child Chronic Disease/nursing/*psychology Family/*psychology Humans Models, Psychological *Nursing AssessmentMar-Apr*http://www.ncbi.nlm.nih.gov/pubmed/2108304Austin, J K R01 NS22416/NS/NINDS NIH HHS/United States Research Support, U.S. Gov't, P.H.S. United states MCN. The American journal of maternal child nursing MCN Am J Matern Child Nurs. 1990 Mar-Apr;15(2):98-102.%0361-929X (Print) 0361-929X (Linking)21083043Indiana University School of Nursing, Indianapolis.engT|t7D^Glazer, E. R. Johnson, L. F. Thompson, V. R. Staggers, F. E. Jackson, J. B., Jr. Austin, D. F.1989YAssessment of potential for cancer control by Golden State Medical Association physicians437-46J Natl Med Assoc814 1989/04/01Adult *African Continental Ancestry Group California Female Humans Male Middle Aged Neoplasms/diagnosis/mortality/*prevention & control *Physicians *Societies, MedicalApr,To gather data on which to base the design of an intervention program to decrease cancer mortality in the black population of California, physician members of the Golden State Medical Association were surveyed to determine their current practices relating to early cancer detection and cancer prevention. Respondents' estimates of the proportions of their patients in various categories indicated that at least 60% to 70% of their patients were potential subjects for intensive early cancer detection and cancer prevention efforts. Thirty-four percent of respondents reported that they were performing early cancer detection examinations on all their patients. On the average, respondents estimated that about 70% of their patients (more than 80% of patients of primary care physicians) were receiving either routine check-ups or specific early cancer detection examinations. Patient education about various aspects of cancer and cancer prevention emerged as the most readily attainable means to reduce cancer mortality in blacks. It was most frequently mentioned both as something that physicians could do to help achieve this goal and as an outside resource physicians would find useful in their practices. Its lack was cited as the greatest barrier to early cancer detection and cancer prevention in the black population.*http://www.ncbi.nlm.nih.gov/pubmed/2738953Glazer, E R Johnson, L F Thompson, V R Staggers, F E Jackson, J B Jr Austin, D F 1RO3 CA41156/CA/NCI NIH HHS/United States Research Support, U.S. Gov't, P.H.S. United states Journal of the National Medical Association J Natl Med Assoc. 1989 Apr;81(4):437-46.%0027-9684 (Print) 0027-9684 (Linking)26259862738953eng=||7EAustin, H. Delzell, E. Cole, P.1988FBenzene and leukemia. A review of the literature and a risk assessment419-39Am J Epidemiol1273 1988/03/01Benzene/*adverse effects Environmental Exposure Humans Leukemia/*chemically induced Maximum Allowable Concentration Risk FactorsMarTBenzene is widely recognized as a leukemogen, and the Occupational Safety and Health Administration is currently attempting to limit exposure to it more strictly. The proposed new regulation is a limit of an eight-hour time-weighted average of 1 ppm in place of the current limit of 10 ppm. The fundamental rationale for the change is a perception that the current standard is associated with an inordinate excess of leukemia. The epidemiologic literature on benzene and leukemia supports the inference that benzene causes acute myelocytic leukemia. However, the available data are too sparse, or suffer other limitations, to substantiate the idea that this causal association applies at low levels (i.e., 1-10 ppm) of benzene. Nonetheless, under the assumption that causation does apply at such low levels, a number of authors, including ourselves, have performed risk assessments using similar data but different methodologies. The assessments that we consider acceptable suggest that, among 1,000 men exposed to benzene at 10 ppm for a working lifetime of 30 years, there would occur about 50 excess deaths due to leukemia in addition to the baseline expectation of seven deaths. However, this estimate is speculative and whether or not enough confidence can be placed in it to justify a lower occupational benzene standard remains a decision for policy makers.*http://www.ncbi.nlm.nih.gov/pubmed/3277397Austin, H Delzell, E Cole, P CA29968/CA/NCI NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review United states American journal of epidemiology Am J Epidemiol. 1988 Mar;127(3):419-39.%0002-9262 (Print) 0002-9262 (Linking)3277397_Department of Epidemiology, School of Public Health, University of Alabama at Birmingham 35294.eng||7F Austin, R. H.1987bPolitical risk assessment, from an elected safety belt law advocate's point of view and experience719-25J Trauma277 1987/07/01*Accidents, Traffic Humans Legislation as Topic/*trends Michigan *Politics Public Opinion *Seat Belts Wounds and Injuries/*prevention & controlJulVoters of Michigan have elected Secretary Austin, prominent safety belt law advocate, to four successive four year terms, by substantial margins. He is now the longest serving black statewide official in the USA. Michigan's Secretary of State, in addition to being the State's official record keeper and elections supervisor, is responsible for motor vehicle administration and driver licensing. He serves as chairman of the state's traffic safety commission. In his first campaign for election in 1970, Austin included in his traffic safety program a proposal for safety belt legislation, as the best way to encourage usage. His opponent was opposed. In each of three campaigns for re-election and at every opportunity, Austin urged usage and advocated mandatory safety belt legislation. Michigan enacted a safety belt law in 1985, culminating a 14-year struggle for Austin. In this article he shares some of his experience and views.*http://www.ncbi.nlm.nih.gov/pubmed/3612843PAustin, R H United states The Journal of trauma J Trauma. 1987 Jul;27(7):719-25.%0022-5282 (Print) 0022-5282 (Linking)3612843eng||7G Austin, J. H.1984QThe lateral chest radiograph in the assessment of nonpulmonary health and disease687-98Radiol Clin North Am223 1984/09/01Adult Aged Arthritis, Rheumatoid/complications Bone Neoplasms/secondary Brachiocephalic Trunk/radiography Breast Neoplasms/pathology Calcinosis/radiography Cholelithiasis/radiography Dislocations/radiography Female Heart Neoplasms/radiography Humans Kyphosis/radiography Male Middle Aged Mitral Valve Insufficiency/radiography Myxoma/radiography Pericarditis/radiography *Radiography, Thoracic/methods Sternum/radiography Subclavian Artery/abnormalitiesSepFThe lateral chest radiograph contains a wealth of data on the status of the thoracic cage, pleura, heart, pericardium, bronchi, and upper abdomen. The appearances of slightly oblique projections deviating from the "true" lateral projection are reviewed. Careful attention to these common variations of projection is advocated.*http://www.ncbi.nlm.nih.gov/pubmed/6382428qAustin, J H Review United states Radiologic clinics of North America Radiol Clin North Am. 1984 Sep;22(3):687-98.%0033-8389 (Print) 0033-8389 (Linking)6382428eng||7HPCleaton-Jones, P. Austin, J. C. Fatti, L. P. Valcke, C. F. McInnes-Ledoux, P. M.1983Pulpal responses evaluated by two assessment systems. Use of Nobetec as negative and Super-Syntrex as positive control materials310-6Oral Surg Oral Med Oral Pathol563 1983/09/01Animals Dental Pulp/*drug effects Dentin/anatomy & histology/pathology Dentin, Secondary/anatomy & histology Evaluation Studies as Topic Haplorhini Silicate Cement/*pharmacology Time Factors Zinc Oxide-Eugenol Cement/*pharmacologySeplIn the assessment of pulpal responses to dental materials there is no general agreement regarding which system should be used in the selection of histologic sections for assessment and which negative and positive control materials should be used. The present study is an evaluation, on 227 sections, of two pulpal assessment systems and three section-selection methods using a negative (zinc oxide and eugenol cement) and a positive (silicate) control material. The results indicate that, depending on which system is used, considerable variation in response can be noted. Better standardization of methods is necessary.*http://www.ncbi.nlm.nih.gov/pubmed/6415564Cleaton-Jones, P Austin, J C Fatti, L P Valcke, C F McInnes-Ledoux, P M Comparative Study United states Oral surgery, oral medicine, and oral pathology Oral Surg Oral Med Oral Pathol. 1983 Sep;56(3):310-6.%0030-4220 (Print) 0030-4220 (Linking)6415564eng\||7I:Marshall, V. R. Ryall, R. L. Austin, M. L. Sinclair, G. R.1983pThe use of urinary flow rates obtained from voided volumes less than 150 ml in the assessment of voiding ability28-33 Br J Urol551 1983/02/01Adult Aged Aging Humans Male Middle Aged Urinary Bladder/physiology/physiopathology Urination Urination Disorders/*physiopathology *UrodynamicsFebThe initial slope of the curve relating peak urinary flow rate to voided volume was found to predict an individual's flow rate at bladder volumes of 200 ml or more in normal subjects and those with symptoms of outflow obstruction. The numerical value of this initial slope was found to decline in a hyperbolic fashion with increasing age. A similar decrease was observed for peak urinary flow rates at bladder volumes between 200 and 300 ml. The use of initial slope as an index of voiding ability would appear to be just as effective in discriminating between normal and obstructed men as a single flow rate determination at a large volume and would be of most benefit in those patients unable to void large volumes of urine.*http://www.ncbi.nlm.nih.gov/pubmed/6824862Marshall, V R Ryall, R L Austin, M L Sinclair, G R Research Support, Non-U.S. Gov't England British journal of urology Br J Urol. 1983 Feb;55(1):28-33.%0007-1331 (Print) 0007-1331 (Linking)6824862eng ||7JBAustin, E. H. Oldham, H. N., Jr. Sabiston, D. C., Jr. Jones, R. H.1983aEarly assessment of rest and exercise left ventricular function following coronary artery surgery159-69Ann Thorac Surg352 1983/02/01*Aged Angina Pectoris/physiopathology/radionuclide imaging/surgery *Coronary Artery Bypass Coronary Vessels/radionuclide imaging Heart/*physiology Heart Function Tests Hemodynamics Humans Male Middle Aged Myocardial Contraction *Physical Exertion Postoperative Period Rest Stroke Volume Time FactorsFebRadionuclide assessment of rest and exercise left ventricular function was performed in 14 patients before, eight days after, and three months after coronary artery bypass grafting (CABG). Resting function was unaltered after operation, although mild increases in heart rate and end-diastolic volume were observed on the eighth postoperative day. In contrast, exercise function was significantly improved at both postoperative time periods. Exercise ejection fraction was 0.54 +/- 0.10 before operation, 0.73 +/- 0.12 at eight days, and 0.64 +/- 0.13 at three months. Before CABG, the exercise-induced increase in stroke volume was achieved by an increase in end-diastolic volume, whereas eight days after CABG this increase was achieved by an increase in contractility (systolic blood pressure/end-systolic volume). By three months, both contractility and end-diastolic volume increased with exercise. Thus, improvement in left ventricular function during exercise can be documented as early as eight days after coronary revascularization. This change may be less pronounced after three months of convalescence, but considerable improvement in ventricular function persists compared to preoperative assessment.*http://www.ncbi.nlm.nih.gov/pubmed/6337569Austin, E H Oldham, H N Jr Sabiston, D C Jr Jones, R H Comparative Study Research Support, Non-U.S. Gov't Review United states The Annals of thoracic surgery Ann Thorac Surg. 1983 Feb;35(2):159-69.%0003-4975 (Print) 0003-4975 (Linking)6337569engt||7K'Champion, V. L. Austin, J. K. Tzeng, O.1982\Assessment of relationship between self-concept and body image using multivariate techniques299-315Issues Ment Health Nurs44 1982/01/01Adolescent Adult *Body Image Child Factor Analysis, Statistical Female Humans Male Middle Aged Psychiatric Nursing Psychotherapy Regression Analysis *Self Concept *Semantic Differential*http://www.ncbi.nlm.nih.gov/pubmed/6927617|Champion, V L Austin, J K Tzeng, O United states Issues in mental health nursing Issues Ment Health Nurs. 1982;4(4):299-315.%0161-2840 (Print) 0161-2840 (Linking)6927617eng||7L<Austin, J. H. Yount, B. G., Jr. Thomas, H. M., 3rd Enson, Y.1979zRadiologic assessment of pulmonary arterial pressure and blood volume in chronic, diffuse, interstitial pulmonary diseases9-17 Invest Radiol141 1979/01/01IAdult Blood Pressure Blood Volume Female Heart/radiography *Hemodynamics Humans Lung/blood supply/pathology/radiography Lung Diseases/physiopathology/*radiography Male Middle Aged Myocardium/pathology Pulmonary Artery/pathology/*radiography Pulmonary Circulation Pulmonary Fibrosis/physiopathology/radiography Regression AnalysisJan-Feb<Chronic, diffuse, interstitial pulmonary diseases may cause an increase in mean pulmonary arterial pressure (PAP) and a decrease in pulmonary blood volume (PBV). We compared 12 cardiovascular and three parenchymal assessments on plain chest radiographs with values of PAP and PBV obtained during cardiac catheterization in 29 patients with such diseases (progressive systemic sclerosis 20, sarcoidosis six, miscellaneous three) and normal pulmonary venous pressures. PAP ranged from 10 to 40 torr (mean 19, SD +/- 7), PBV from 6.4 to 10.8% of total blood volume (mean 8.4, SD +/- 1.2). PBV was significantly related to eight radiologic variables. PAP was significantly related to the severity of parenchymal disease and size of the central pulmonary arteries, both of which were assessed radiologically. Diversion of blood flow to upper zones was significantly related to restriction of the pulmonary vascular bed, but was not necessarily a sign of increased PAP. In general, pulmonary hemodynamic abnormalities appeared proportional to the radiologic severity of parenchymal disease.)http://www.ncbi.nlm.nih.gov/pubmed/478798Austin, J H Yount, B G Jr Thomas, H M 3rd Enson, Y Research Support, U.S. Gov't, P.H.S. United states Investigative radiology Invest Radiol. 1979 Jan-Feb;14(1):9-17.%0020-9996 (Print) 0020-9996 (Linking)478798eng(||7MEReeser, J. C. Austin, D. M. Jaros, L. M. Mukesh, B. N. McCarty, C. A.2008pInvestigating Perceived Institutional Review Board Quality and Function Using the IRB Researcher Assessment Tool25-34J Empir Res Hum Res Ethics31 2009/04/24MarTHE INSTITUTIONAL REVIEW BOARD-RESEARCHER ASSESSMENT TOOL (IRB-RAT) was designed to assess the relative importance of various factors to the effective functioning of IRBs. We employed the IRB-RAT to gain insight into the ways in which our IRB is perceived to be deficient by those who routinely interact with our Office of Research Integrity and Protections. Respondents ranked qualities thought to be characteristic of an "ideal" IRB and then compared our IRB to that internal standard. We observed that the rate of study participation varied by role. The composite relative ranking of the 45 items that comprise the IRB-RAT differed significantly from the rank order reported by Keith-Spiegel et al. Our data furthermore suggest that role influences scoring of the IRB-RAT (e.g., investigators awarded our IRB significantly higher scores in several areas than did research coordinators). Additional research is warranted to determine if the observed role-dependent differences in the perceived quality of our IRB simply reflect the local research culture or if they are indicative of a more fundamental and generalizable difference in outlook between investigators and research coordinators.+http://www.ncbi.nlm.nih.gov/pubmed/19385780Reeser, Jonathan C Austin, Diane M Jaros, Linda M Mukesh, Bickol N McCarty, Catherine A United States Journal of empirical research on human research ethics : JERHRE J Empir Res Hum Res Ethics. 2008 Mar;3(1):25-34.1556-2646 (Print)19385780&Marshfield Clinic Research Foundation.10.1525/jer.2008.3.1.25eng||7N(Kavlock, R. J. Austin, C. P. Tice, R. R.2009SToxicity testing in the 21st century: implications for human health risk assessment485-7; discussion 492-7 Risk Anal294 2008/12/17Animals *Health Status History, 21st Century Humans National Institutes of Health (U.S.) *Risk Assessment Toxicity Tests/*methods United States United States Environmental Protection AgencyApr+http://www.ncbi.nlm.nih.gov/pubmed/19076321Kavlock, Robert J Austin, Christopher P Tice, Raymond R Comment Historical Article United States Risk analysis : an official publication of the Society for Risk Analysis Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7. Epub 2008 Dec 9.*1539-6924 (Electronic) 0272-4332 (Linking)19076321National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Kavlock.Robert@epamail.epa.gov/RISK1168 [pii] 10.1111/j.1539-6924.2008.01168.xeng'||7OJJohnson, M. Stone, S. Lou, C. Vu, C. M. Ling, J. Mizrahi, P. Austin, M. J.2008CFamily assessment in child welfare services: instrument comparisons57-90J Evid Based Soc Work51-2 2008/12/10Child Child Abuse *Child Welfare Child, Preschool Decision Making *Family/psychology Humans Interviews as Topic Needs Assessment *Parenting/psychology Psychometrics Questionnaires Social Work/*instrumentation/*methodsFamily assessment instruments can enhance the clinical judgment of child welfare practitioners by structuring decision-making processes and demonstrating the linkages between assessment, service provision, and child and family outcomes. This article describes the concept of family assessment in the child welfare context and provides an overview of the theoretical and disciplinary influences in the family assessment field. Based on a structured review of 85 instruments, the article discusses 21 that appear to the be the most valid and reliable for evaluating four federally-defined domains of family assessment: (1) patterns of social interaction, (2) parenting practices, (3) background and history of the parents or caregivers, and (4) problems in access to basic necessities such as income, employment, and adequate housing. Key measurement criteria as well as practical considerations in the selection and implementation of family assessment instrumentation in child welfare are discussed.+http://www.ncbi.nlm.nih.gov/pubmed/19064445Johnson, Michelle Stone, Susan Lou, Christine Vu, Catherine M Ling, Jennifer Mizrahi, Paola Austin, Michael J Review United States Journal of evidence-based social work J Evid Based Soc Work. 2008;5(1-2):57-90.*1543-3722 (Electronic) 1543-3714 (Linking)19064445BUniversity of California, Berkeley, School of Social Welfare, USA.eng||7P&D'Andrade, A. Austin, M. J. Benton, A.2008CRisk and safety assessment in child welfare: instrument comparisons31-56J Evid Based Soc Work51-2 2008/12/10Actuarial Analysis/methods/standards Child *Child Abuse *Child Welfare/ethnology Child, Preschool Ethnic Groups Humans Questionnaires/standards Reproducibility of Results *Risk Assessment/methods/standards Social Work/*methodsThe assessment of risk is a critical part of child welfare agency practice. This review of the research literature on different instruments for assessing risk and safety in child welfare focuses on instrument reliability, validity, outcomes, and use with children and families of color. The findings suggest that the current actuarial instruments have stronger predictive validity than consensus-based instruments. This review was limited by the variability in definitions and measures across studies, the relatively small number of studies examining risk assessment instruments, and the lack of studies on case decision points other than the initial investigation.+http://www.ncbi.nlm.nih.gov/pubmed/19064444D'Andrade, Amy Austin, Michael J Benton, Amy Review United States Journal of evidence-based social work J Evid Based Soc Work. 2008;5(1-2):31-56.*1543-3722 (Electronic) 1543-3714 (Linking)19064444gBay Area Social Services Consortium, School of Social Welfare, University of California, Berkeley, USA.eng ||7Q2Bandyopadhyay, S. Austin, R. M. Dabbs, D. Zhao, C.2008Adjunctive human papillomavirus DNA testing is a useful option in some clinical settings for disease risk assessment and triage of females with ASC-H Papanicolaou test results1874-81Arch Pathol Lab Med13212 2008/12/09Adolescent Adult Aged Cervical Intraepithelial Neoplasia/*diagnosis/epidemiology/pathology/virology Cervix Uteri/pathology/virology Child Colposcopy DNA, Viral/*analysis Female Humans Microtomy Middle Aged Papillomaviridae/*genetics Retrospective Studies Risk Factors Sensitivity and Specificity Triage Tumor Virus Infections/*diagnosis/epidemiology/pathology Uterine Cervical Neoplasms/*diagnosis/epidemiology/pathology/virology Vaginal Smears/standards/*statistics & numerical data Young AdultDecDCONTEXT: Recent guidelines recommend colposcopy for women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H). objective: To determine whether adjunctive high-risk human papillomavirus (hrHPV) testing is useful for disease risk assessment in females with ASC-H Papanicolaou (Pap) test results. DESIGN: High-risk HPV prevalence and histopathologic follow-up data on 1187 females with ASC-H ThinPrep Pap test (TPPT) and hrHPV test results were analyzed. RESULTS: ASC-H was reported in 1646 (0.59%) [corrected] of 277 400 (270 338 TPPT and 7062 conventional) Pap test results. The difference in ASC-H detection rates between TPPTs and conventional Pap smears was statistically significant (0.60% vs 0.38%; P = .02). High-risk HPV was detected in 589 (49.6%) of 1187 females with ASC-H TPPT and hrHPV testing. The hrHPV DNA-positive rate in females younger than 40 years was 54.7%, significantly higher than the 36.5% in women 40 years and older. Among 505 females with histopathologic follow-up, cervical intraepithelial neoplasia 2/3 was identified in 32.7% of hrHPV-positive females compared with 1.2% in hrHPV-negative females. The sensitivity, specificity, positive predictive value, and negative predictive value of ASC-H cytology in conjunction with hrHPV DNA testing results for detection of cervical intraepithelial neoplasia 2/3 were 96.1% versus 100.0%, 54.0% versus 68.4%, 35.8% versus 20.8%, and 98.1% versus 100.0% in females younger than 40 years and women 40 years and older, respectively. CONCLUSIONS: Our data suggest that reflex hrHPV testing is a highly useful option for women with ASC-H Pap tests. Females with ASC-H and negative hrHPV testing may be more efficiently managed by follow-up with regular Pap and hrHPV testing rather than universal colposcopy, especially for women 40 years and older.+http://www.ncbi.nlm.nih.gov/pubmed/19061283Bandyopadhyay, Sudeshna Austin, R Marshall Dabbs, David Zhao, Chengquan United States Archives of pathology & laboratory medicine Arch Pathol Lab Med. 2008 Dec;132(12):1874-81.*1543-2165 (Electronic) 0003-9985 (Linking)19061283sDepartment of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.2008-0214-OA [pii]eng||7R+Rathod, D. Win, T. Pickering, S. Austin, M.2008lIncorporation of a virtual assessment into a care pathway for initial glaucoma management: feasibility study543-6Clin Experiment Ophthalmol366 2008/10/29Adult Aged Aged, 80 and over Diagnostic Techniques, Ophthalmological/*standards Feasibility Studies Female Glaucoma/*diagnosis Humans Male Middle Aged Prospective Studies Reference Standards Sensitivity and Specificity Single-Blind Method TriageAugPURPOSE: To investigate the feasibility of a glaucoma triage assessment based on the consideration of clinical data in a virtual clinic environment. METHODS: One hundred consecutive new patients were assessed by masked observers for a possible diagnosis of glaucoma or ocular hypertension by evaluation of clinical data compiled by a technician in the absence of the patient. The virtual clinic diagnoses were compared with those made by actual examination of the patient in the outpatient clinic. RESULTS: A total of 22% of subjects were excluded from interobserver comparison because of atypical scanning laser ophthalmoscopy. Of the 78% of subjects completing virtual and actual clinical assessments diagnostic agreement was good, weighted Kappa was of 0.72 (95% confidence interval 0.85 to 0.59), sensitivity 94.4% and specificity 86.7%. No case of glaucoma was misdiagnosed as normal by virtual assessment. CONCLUSION: Clinical findings and data relating to glaucoma may be evaluated in a virtual clinic with satisfactory diagnostic accuracy.+http://www.ncbi.nlm.nih.gov/pubmed/18954317Rathod, Dinesh Win, Thein Pickering, Susan Austin, Michael Comparative Study Evaluation Studies Australia Clinical & experimental ophthalmology Clin Experiment Ophthalmol. 2008 Aug;36(6):543-6.*1442-9071 (Electronic) 1442-6404 (Linking)18954317=Department of Ophthalmology, Singleton Hospital, Swansea, UK..CEO1831 [pii] 10.1111/j.1442-9071.2008.01831.xeng||7SbTharinger, D. J. Finn, S. E. Austin, C. A. Gentry, L. B. Bailey, K. E. Parton, V. T. Fisher, M. E.2008uFamily sessions as part of child psychological assessment: goals, techniques, clinical utility, and therapeutic value547-58 J Pers Assess906 2008/10/18rChild Behavior Disorders/*therapy *Child Psychology Child, Preschool *Family *Goals Humans *Personality AssessmentNovIncluding a family session in a child assessment can significantly advance the assessor's and parents' understanding of the child's problems and enhance the likelihood that parents will follow through on recommendations after the assessment. A family session allows the assessor to observe the child in the family context, test systemic hypotheses, better understand the meaning of individual test results, and try out possible interventions. A family session may also help parents see systemic aspects of their child's problems, help the child feel less blamed, foster positive experiences among family members, and offer the family a glimpse of family therapy. We describe methods and techniques for structuring family sessions and offer guidance on preparing for and conducting such sessions depending on one's case conceptualization. Detailed case examples illustrate each technique and demonstrate the immediate and subsequent impact of family sessions as well as their therapeutic value. We also address common clinical and pragmatic issues.+http://www.ncbi.nlm.nih.gov/pubmed/18925495Tharinger, Deborah J Finn, Stephen E Austin, Cynthia A Gentry, Lauren B Bailey, Karen Elaine Parton, Victoria T Fisher, Melissa E United States Journal of personality assessment J Pers Assess. 2008 Nov;90(6):547-58.*1532-7752 (Electronic) 0022-3891 (Linking)18925495xEducational Psychology Department, University of Texas at Austin, Austin, TX 78712-1294, USA. dtharinger@mail.utexas.edu)904257064 [pii] 10.1080/00223890802388400eng$}|7T+Austin, M. P. Priest, S. R. Sullivan, E. A.2008PAntenatal psychosocial assessment for reducing perinatal mental health morbidityCD005124Cochrane Database Syst Rev4 2008/10/10Anxiety Disorders/*diagnosis/prevention & control Depression, Postpartum/*diagnosis/prevention & control Female Humans Mental Health Pregnancy *Prenatal Care Puerperal Disorders/*diagnosis/prevention & control/psychology Randomized Controlled Trials as Topicy BACKGROUND: Mental health conditions arising in the perinatal period, including depression, have the potential to impact negatively on not only the woman but also her partner, infant, and family. The capacity for routine, universal antenatal psychosocial assessment, and thus the potential for reduction of morbidity, is very significant. OBJECTIVES: To evaluate the impact of antenatal psychosocial assessment on perinatal mental health morbidity. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register, the Cochrane Depression, Anxiety and Neurosis Group's Trials Register (CCDAN TR-Studies), HSRProj in the National Library of Medicine (USA), and the Current Controlled Trials website: http://www.controlled trials.com/ and the UK National Research Register (last searched March 2008). SELECTION CRITERIA: Randomised and quasi-randomised controlled trials. DATA COLLECTION AND ANALYSIS: At least two review authors independently assessed trials for eligibility; they also extracted data from included trials and assessed the trials for potential bias. MAIN RESULTS: Two trials met criteria for an RCT of antenatal psychosocial assessment. One trial examined the impact of an antenatal tool (ALPHA) on clinician awareness of psychosocial risk, and the capacity of the antenatal ALPHA to predict women with elevated postnatal Edinburgh Depression Scale (EDS) scores, finding a trend towards increased clinician awareness of 'high level' psychosocial risk where the ALPHA intervention had been used (relative risk (RR) 4.61 95% confidence interval (CI) 0.99 to 21.39). No differences between groups were seen for numbers of women with antenatal EDS scores, a score of greater than 9 being identified by ALPHA as of concern for depression (RR 0.69 95% CI 0.35 to 1.38); 139 providers. The other trial reported no differences in EPS scores greater than 12 at 16 weeks postpartum between the intervention (communication about the EDS scores with the woman and her healthcare providers plus a patient information booklet) and the standard care groups (RR 0.86 95% CI 0.61 to 1.21; 371 women). AUTHORS' CONCLUSIONS: While the use of an antenatal psychosocial assessment may increase the clinician's awareness of psychosocial risk, neither of these small studies provides sufficient evidence that routine antenatal psychosocial assessment by itself leads to improved perinatal mental health outcomes. Further studies with better sample size and statistical power are required to further explore this important public health issue. It will also be important to examine outcomes up to one year postpartum not only for mother, but also infant and family.+http://www.ncbi.nlm.nih.gov/pubmed/18843682Austin, Marie-Paule Priest, Susan R Sullivan, Elizabeth A Review England Cochrane database of systematic reviews (Online) Cochrane Database Syst Rev. 2008 Oct 8;(4):CD005124.*1469-493X (Electronic) 1361-6137 (Linking)18843682Black Dog Institute/School of Psychiatry, University of New South Wales, Hospital Road, Sydney, New South Wales, Australia, 2052. m.austin@unsw.edu.au10.1002/14651858.CD005124.pub2eng ;||7U4Priest, S. R. Austin, M. P. Barnett, B. B. Buist, A.2008oA psychosocial risk assessment model (PRAM) for use with pregnant and postpartum women in primary care settings307-17Arch Womens Ment Health115-6 2008/08/30-Female Humans Interview, Psychological Mental Disorders/*diagnosis/epidemiology New South Wales/epidemiology Postpartum Period/*psychology Pregnancy Pregnancy Complications/*diagnosis/epidemiology Pregnant Women/*psychology Primary Health Care Psychological Tests Risk Assessment/*methods Risk FactorsDec6Recognition of high rates of mental health morbidity and mortality that affect women during the perinatal period has prompted the development of psychosocial risk assessment programs. Designed to identify women, at risk, during routine health checks and delivered by primary care health service providers, these fit within a primary prevention and early intervention strategic approach to the reduction of perinatal mental illness and reflect an integrated approach to perinatal health services delivery. This paper describes the development and use of the psychosocial risk assessment model (PRAM) at the Royal Hospital for Women in Sydney, Australia. Data is presented on 2,142 women who attended the Antenatal Midwives Clinic between 2002 and 2005. The PRAM guides primary care staff to quickly identify women experiencing emotional distress and/or psychosocial problems during pregnancy or postnatal checks. Measures used in pregnancy are the symptom-based Edinburgh Depression Scale and the psychosocial risk-based Antenatal Risk Questionnaire. In postnatal setting the Postnatal Risk Questionnaire is used. Scores can be used to compute a Psychosocial Risk Index (PRI) to guide individualized care planning, define needs for referral and classify groups for clinical and research purposes. Based on the PRI, among 2,142 women assessed in pregnancy 70.6% were classified as low/no risk (no interventions indicated currently), 24.1% as medium risk (in need of monitoring), and 5.3% as high risk (complex). The PRAM offers a conceptual framework, methods and measures for brief psychosocial assessment with clinical and research applications. Postpartum follow up studies of women assessed during pregnancy have commenced. Randomized controlled trials and cross-cultural studies are now indicated to strengthen the evidence base for the model.+http://www.ncbi.nlm.nih.gov/pubmed/18726142Priest, S R Austin, M-P Barnett, B B Buist, A Research Support, Non-U.S. Gov't Austria Archives of women's mental health Arch Womens Ment Health. 2008 Dec;11(5-6):307-17. Epub 2008 Aug 23.1435-1102 (Electronic)18726142School of Medicine and Public Health, Perinatal and Infant Psychiatry Program, University of Newcastle, Newcastle, NSW, Australia. Susan.Priest@newcastle.edu.au10.1007/s00737-008-0028-3engV|t7V"Austin, Z. Gregory, P. A. Chiu, S.2008dUse of reflection-in-action and self-assessment to promote critical thinking among pharmacy students48Am J Pharm Educ723 2008/08/14Adult *Education, Pharmacy Educational Measurement Female *Health Knowledge, Attitudes, Practice Humans Male Motivation Questionnaires *Self Assessment (Psychology) Students, Pharmacy/*psychology Task Performance and Analysis *ThinkingJun 15OBJECTIVE: To examine whether self-assessment and reflection-in-action improves critical thinking among pharmacy students. METHODS: A 24-item standardized test of critical thinking was developed utilizing previously-validated questions. Participants were divided into 2 groups (conditions). Those in condition 1 completed the test with no interference; those in condition 2 completed the test but were prompted at specific points during the test to reflect and self-assess. RESULTS: A total of 94 undergraduate (BScPhm) pharmacy students participated in this study. Significant differences (p < 0.05) were observed between those who completed the test under condition 1 and condition 2, suggesting reflection and self-assessment may contribute positively to improvement in critical thinking. CONCLUSIONS: Structured opportunities to reflect-in-action and self-assess may be associated with improvements among pharmacy students in performance of tasks related to critical thinking.+http://www.ncbi.nlm.nih.gov/pubmed/18698383Austin, Zubin Gregory, Paul Am Chiu, Stephanie Comparative Study Research Support, Non-U.S. Gov't United States American journal of pharmaceutical education Am J Pharm Educ. 2008 Jun 15;72(3):48.*1553-6467 (Electronic) 0002-9459 (Linking)250871118698383~Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto ON M5S3M2, Canada. zubin.austin@utoronto.caeng||7W#Austin, Z. Gregory, P. A. Galli, M.2008~"I just don't know what I'm supposed to know": evaluating self-assessment skills of international pharmacy graduates in Canada115-24Res Social Adm Pharm42 2008/06/17Adult *Clinical Competence Education, Pharmacy Educational Measurement/*standards Female Humans Male *Self Assessment (Psychology) Students, Pharmacy/*psychologyJunBACKGROUND: Self-assessment skills are an integral part of pharmacy education and practice, yet there is very little empirical evidence in health professions to indicate that students and practitioners possess adequate and appropriate self-assessment skills. OBJECTIVES: To evaluate self-assessment skills of international pharmacy graduates (pharmacists from outside Canada or the United States seeking licensure in Canada). METHODS: An 8-station objective structured clinical examination was used. Within each station, 2 trained and experienced pharmacist raters completed analytical and global assessments of participants. After each station, participants themselves completed the same assessments, as well as providing additional anecdotal feedback regarding their performance. In stations possessing sufficient interrater reliability, comparisons were made between raters' assessments and self-assessments. RESULTS: Across all performance quartiles there was a discrepancy between self-assessments and rater assessments of clinical performance. The discrepancy was largest in the lowest quartiles, suggesting impairment of self-assessment may be greatest amongst those who have the weakest skills. CONCLUSIONS: Not all individuals possess adequate and appropriate self-assessment skills. Further work is required to elucidate the link between clinical competence and self-assessment and to determine methods for improving self-assessment skills.+http://www.ncbi.nlm.nih.gov/pubmed/18555965Austin, Zubin Gregory, Paul A M Galli, Michael United States Research in social & administrative pharmacy : RSAP Res Social Adm Pharm. 2008 Jun;4(2):115-24.1551-7411 (Print)18555965Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada. zubin.austin@utoronto.ca9S1551-7411(07)00025-3 [pii] 10.1016/j.sapharm.2007.03.002eng||7XIAustin, M. S. Ghanem, E. Joshi, A. Trappler, R. Parvizi, J. Hozack, W. J.2008RThe assessment of intraoperative prosthetic knee range of motion using two methods515-21J Arthroplasty234 2008/06/03.Aged Aged, 80 and over *Arthrometry, Articular *Arthroplasty, Replacement, Knee Body Mass Index Female Humans Intraoperative Period Knee Joint/*physiology Knee Prosthesis Male Middle Aged Prospective Studies Range of Motion, Articular/*physiology Sensitivity and Specificity *Surgery, Computer-AssistedJunThe commonly used standard goniometer has been shown to underestimate knee flexion. Computer-assisted navigation for total knee arthroplasty offers itself as an alternative method to quantify knee flexion. The goal of our study was to determine the reliability of each instrument in measuring intraoperative range of motion during total knee arthroplasty. We prospectively performed intraoperative measurements using both methods on 99 knees. We assessed the variability between the 2 devices and the confounding effect of body mass index. The mean difference between the goniometric and navigation measurements was significant for flexion, extension, and range of motion. Increasing body mass index accentuated this difference. The goniometric method underestimated flexion measurements as compared to navigation, especially in patients with high body mass index. Our study confirms that navigation is a reliable tool for performing in vivo assessment of range of motion.+http://www.ncbi.nlm.nih.gov/pubmed/18514867Austin, Matthew S Ghanem, Elie Joshi, Ashish Trappler, Rachel Parvizi, Javad Hozack, William J Comparative Study Research Support, Non-U.S. Gov't United States The Journal of arthroplasty J Arthroplasty. 2008 Jun;23(4):515-21. Epub 2008 Apr 15.%0883-5403 (Print) 0883-5403 (Linking)18514867eRothman Institute of Orthopedics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.6S0883-5403(07)00727-9 [pii] 10.1016/j.arth.2007.12.011eng ||7YZhao, C. Austin, R. M.2008Adjunctive high-risk human papillomavirus DNA testing is a useful option for disease risk assessment in patients with negative Papanicolaou tests without an endocervical/transformation zone sample242-8Cancer1144 2008/05/203Adolescent Adult Age Factors Aged *Cell Transformation, Neoplastic Cervix Uteri/*pathology DNA, Viral/*analysis Female Humans Middle Aged Papillomaviridae/*isolation & purification Precancerous Conditions/*diagnosis Retrospective Studies Risk Assessment Uterine Cervical Neoplasms/*diagnosis *Vaginal SmearsAug 25 BACKGROUND: Current guidelines recommend that women with negative Papanicolaou (Pap) test results and no endocervical/transformation zone (EC/TZ) sample return for screening within 12 months. For some women, this represents earlier follow-up than advocated in several routine screening guidelines. Controversy remains with regard to the correlation between sampling of the EC/TZ, Pap test quality, and disease risk assessment. METHODS: A retrospective study was conducted reviewing the results from 143,438 liquid-based cervical Pap tests performed at a large academic women's hospital between July 2005 and December 2006. Vaginal Pap tests were excluded from the study. Women with any Pap result, women with low-grade squamous intraepithelial lesions (LSILs), and patients with high-grade squamous intraepithelial lesion (HSIL) Pap test results were stratified by 10-year age groups and according to the presence or absence of an EC/TZ sample (EC/TZS). Women with LSIL and HSIL Pap test results with and without an EC/TZS were also compared for rates of high-risk human papillomavirus (hrHPV) DNA detection. RESULTS: Of the total of 143,438 cervical Pap tests performed, 27,359 (19.1%) were reported to be lacking an EC/TZS. The absence of an EC/TZS was found to be highest in adolescents and in mature women aged >or=50 years. The overall detection rate of LSIL was 4.29% and that of HSIL was 0.64%. Both the LSIL and HSIL rates were found to be significantly higher in Pap tests with an EC/TZS compared with Pap tests without an EC/TZS (LSIL: 4.51% vs 3.37% and HSIL: 0.72% vs 0.29%). However, when women with LSILs and HSILs were divided into a group in which EC/TZS was present and a group in which EC/TZS was absent, no significant differences were found to be present with regard to hrHPV DNA rates between the 2 groups. CONCLUSIONS: Adjunctive hrHPV DNA testing is effective in stratifying risk for the presence of SIL in women with and without an EC/TZS. This finding is consistent with recently reported data from >9000 patients with negative Pap results, which found that hrHPV DNA-positive test rates are independent of the presence or absence of an EC/TZS. hrHPV DNA results provide a useful new optional adjunctive tool for the objective stratification of disease risk in women with negative Pap tests and no EC/TZS.+http://www.ncbi.nlm.nih.gov/pubmed/18484643YZhao, Chengquan Austin, R Marshall United States Cancer Cancer. 2008 Aug 25;114(4):242-8.%0008-543X (Print) 0008-543X (Linking)18484643Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, 300 Halket Street, Pittsburgh, PA 15213, USA. zhaoc@UPMC.edu10.1002/cncr.23598eng |t7ZICho, M. H. Niles, A. Huang, R. Inglese, J. Austin, C. P. Riss, T. Xia, M.2008fA bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker1099-106Toxicol In Vitro224 2008/04/11Cell Line Cell Line, Tumor Cell Membrane/*drug effects Humans Kidney/cytology/drug effects/metabolism Luminescence Luminescent Measurements/*methods Mesangial Cells/drug effects/metabolism Peptide Hydrolases/metabolism *Toxicity Tests Xenobiotics/*toxicityJunMeasurement of cell membrane integrity has been widely used to assess chemical cytotoxity. Several assays are available for determining cell membrane integrity including differential labeling techniques using neutral red and trypan blue dyes or fluorescent compounds such as propidium iodide. Other common methods for assessing cytotoxicity are enzymatic "release" assays which measure the extra-cellular activities of lactate dehydrogenase (LDH), adenylate kinase (AK), or glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in culture medium. However, all these assays suffer from several practical limitations, including multiple reagent additions, scalability, low sensitivity, poor linearity, or requisite washes and medium exchanges. We have developed a new cytotoxicity assay which measures the activity of released intracellular proteases as a result of cell membrane impairment. It allows for a homogenous, one-step addition assay with a luminescent readout. We have optimized and miniaturized this assay into a 1536-well format, and validated it by screening a library of known compounds from the National Toxicology Program (NTP) using HEK 293 and human renal mesangial cells by quantitative high-throughput screening (qHTS). Several known and novel membrane disrupters were identified from the library, which indicates that the assay is robust and suitable for large scale library screening. This cytotoxicity assay, combined with the qHTS platform, allowed us to quickly and efficiently evaluate compound toxicities related to cell membrane integrity.+http://www.ncbi.nlm.nih.gov/pubmed/18400464Cho, Ming-Hsuang Niles, Andrew Huang, Ruili Inglese, James Austin, Christopher P Riss, Terry Xia, Menghang NIH0012050276/PHS HHS/United States Z01 HG200319-04/HG/NHGRI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural England Toxicology in vitro : an international journal published in association with BIBRA Toxicol In Vitro. 2008 Jun;22(4):1099-106. Epub 2008 Mar 4.%0887-2333 (Print) 0887-2333 (Linking)238656318400464NIH Chemical Genomics Center, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892-3370, USA.5S0887-2333(08)00048-9 [pii] 10.1016/j.tiv.2008.02.013eng ||7[2Myles, C. M. Rowe, P. J. Nutton, R. W. Burnett, R.2006The effect of patella resurfacing in total knee arthroplasty on functional range of movement measured by flexible electrogoniometry733-9Clin Biomech (Bristol, Avon)217 2006/04/11cAged Aged, 80 and over Arthroplasty, Replacement, Knee/*instrumentation/*methods Biomechanics/methods Double-Blind Method Equipment Failure Analysis Female Humans Knee Joint/*physiopathology/*surgery Male Middle Aged Patella/physiopathology/*surgery Prospective Studies Prosthesis Design *Range of Motion, Articular *Recovery of Function Treatment OutcomeAug`BACKGROUND: The need for patella resurfacing remains an area of considerable controversy in total knee replacement surgery. There would appear to be no reported evidence on the effect of patella resurfacing on knee function, as measured by functional range of movement used in a series of tasks, in patients undergoing knee replacement. The object of this study was to measure knee joint motion during functional activities both prior to and following total knee replacement in a randomised group of patients with and without patella resurfacing and to compare these patient groups with a group of normal age-matched subjects. METHODS: The study design was a double blinded, randomised, prospective, controlled trial. The knee joint functional ranges of movement of a group of patients (n=50, mean age=70 years) with knee osteoarthritis were investigated prior to and following total knee arthroplasty (4 months and 18-24 months) along with a group of normal subjects (n=20, mean age=67). Patients were randomly allocated into two groups, those who received patella resurfacing (n=25) and those who did not (n=25). Flexible electrogoniometry was used to measure the flexion-extension angle of the knees with respect to time in eleven functional activities. FINDINGS: No statistically significant differences (alpha level 0.05) in joint excursion of the affected knee were found between patients who received patella resurfacing and those who did not. INTERPRETATION: Routine patella resurfacing in a typical knee arthroplasty population does not result in an increase in the functional range of movement used after knee replacement.+http://www.ncbi.nlm.nih.gov/pubmed/16603285Myles, Christine M Rowe, Philip J Nutton, Richard W Burnett, Richard Randomized Controlled Trial Research Support, Non-U.S. Gov't England Clinical biomechanics (Bristol, Avon) Clin Biomech (Bristol, Avon). 2006 Aug;21(7):733-9. Epub 2006 Apr 5.%0268-0033 (Print) 0268-0033 (Linking)16603285XSchool of Health Sciences, Queen Margaret University College, Edinburgh, United Kingdom.=S0268-0033(06)00051-9 [pii] 10.1016/j.clinbiomech.2006.02.008engI 27 cm.21669515Jefferson or Adams Building Reading Rooms QP303; .W58||7\HCleffken, B. van Breukelen, G. van Mameren, H. Brink, P. Olde Damink, S.2007Test-retest reproducibility of elbow goniometric measurements in a rigid double-blinded protocol: intervals for distinguishing between measurement error and clinical change 788-794 e2J Shoulder Elbow Surg166 2007/10/31,Adult Arthrometry, Articular/instrumentation/*methods/standards Cross-Over Studies Double-Blind Method Elbow Joint/*physiology/physiopathology/surgery Female Humans Male Observer Variation Orthopedic Procedures *Range of Motion, Articular Reference Values Reproducibility of Results Treatment OutcomeNov-DecIncreasingly, goniometry of elbow motion is used for qualification of research results. Expression of reliability is in parameters not suitable for comparison of results. We modified Bland and Altman's method, resulting in the smallest detectable differences (SDDs). Two raters measured elbow excursions in 42 individuals (144 ratings per test person) with an electronic digital inclinometer in a classical test-retest crossover study design. The SDDs were 0 +/- 4.2 degrees for active extension; 0 +/- 8.2 degrees for active flexion, both without upper arm fixation; 0 +/- 6.3 degrees for active extension; 0 +/- 5.7 degrees for active flexion; 0 +/- 7.4 degrees for passive flexion with upper arm fixation; 0 +/- 10.1 degrees for active flexion with upper arm retroflexion; and 0 +/- 8.5 degrees and 0 +/- 10.8 degrees for active and passive range of motion. Differences smaller than these SDDs found in clinical or research settings are attributable to measurement error and do not indicate improvement.+http://www.ncbi.nlm.nih.gov/pubmed/17967547$Cleffken, Berry van Breukelen, Gerard van Mameren, Henk Brink, Peter Olde Damink, Steven Randomized Controlled Trial United States Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.] J Shoulder Elbow Surg. 2007 Nov-Dec;16(6):788-794.e2. Epub 2007 Oct 29.*1532-6500 (Electronic) 1058-2746 (Linking)17967547fDepartment of Surgery, University Hospital Maastricht, Maastricht, The Netherlands. bcl@surgery.azm.nl5S1058-2746(07)00360-6 [pii] 10.1016/j.jse.2007.02.134eng ||7]HCleffken, B. van Breukelen, G. Brink, P. van Mameren, H. Olde Damink, S.2007zDigital goniometric measurement of knee joint motion. Evaluation of usefulness for research settings and clinical practice385-9Knee145 2007/08/09Adult Arthrometry, Articular/*methods Cross-Over Studies Humans Knee Joint/*physiology Male Movement/*physiology Range of Motion, Articular/*physiology Reproducibility of ResultsOctUAn accurate and reproducible measurement method for joint motion is essential for classification of success or failure in therapeutic intervention. Digital goniometry is increasingly used as a method of classification for knee joint excursion. The reliability of goniometry however remains debatable. Aim of the study was to determine both intra- and inter-rater reproducibility in degrees, with an electronic digital inclinometer (EDI 320) for active and passive maximum flexion and active maximum extension of the knee joint and to determine the reproducibility of active and passive range of motion. A classical crossover design, with strict measurement protocol was used. Two raters measured 72 knee motions each, in 42 healthy subjects in four sessions. The smallest detectable difference (SDD) was calculated by using adjusted Bland and Altman plots for each knee excursion. No differences in joint excursions between the sexes were found. Passive maximum flexion showed larger excursions than active maximum flexion with additional higher levels of reproducibility. SDDs for inter-rater comparisons yielded: 0+/-3.9 degrees for active maximum extension, 0+/-7.4 degrees for active maximum flexion, 0+/-6.4 degrees for passive maximum flexion, 0+/-7.6 degrees for AROM and 0+/-5.4 degrees for PROM. Intra-rater SDDs showed increased reproducibility by 0.4-1.9 degrees. We conclude that interpretation of knee joint excursions in clinical settings is with these SDDs. Clinical and statistical differences in research settings within these SDDs are not a true difference but should be attributed to measurement error.+http://www.ncbi.nlm.nih.gov/pubmed/17683940Cleffken, Berry van Breukelen, Gerard Brink, Peter van Mameren, Henk Olde Damink, Steven England The Knee Knee. 2007 Oct;14(5):385-9. Epub 2007 Aug 1.%0968-0160 (Print) 0968-0160 (Linking)17683940Department of Surgery, University Hospital Maastricht, Maastricht University, PO-box 5800, 6202 AZ, Maastricht, The Netherlands. bcl@surgery.azm.nl6S0968-0160(07)00100-7 [pii] 10.1016/j.knee.2007.07.004eng@?^xMartin-Hernandez C, Guillen-Soriano M, Castro-Sauras A, Ballester-Jimenez JJ, Espallargas-Doñate T, Fuertes-Vallcorba A2009WComparison of high-flex and conventional implants for bilateral total knee arthroplasty+The Internet Journal of Orthopaedic Surgery141http://www.ispub.com ill. ; 29 cm. Bibliog|?_#Hoppenfeld, Stanley Hutton, Richard19761Physical examination of the spine and extremities xi, 276 p.New YorkAppleton-Century-CroftsgSpine Examination. Extremities (Anatomy) Examination. Extremities. Spine. Physical examination Methods.76001486 Stanley Hoppenfeld, in collaboration with Richard Hutton ; medical ill. by Hugh Thomas. ill. ; 29 cm. Bibliography: p. 265. Includes index. 083857853531781085Jefferson or Adams Building Reading Rooms RD734; .H66qraphy: p. 265. Includes index. 083857853531781085Jefferson or Adams Building Reading Rooms RD734; .H667 jing Rooms QP303; .G75 2006 Jefferson or Adams Building Reading Rooms - STORED OFFSITE QP303; .G75 20068 QF|7`GYue, B. Varadarajan, K. M. Moynihan, A. L. Liu, F. Rubash, H. E. Li, G.2010xKinematics of medial osteoarthritic knees before and after posterior cruciate ligament retaining total knee arthroplasty J Orthop Res 2010/07/08Jul 6Total knee arthroplasty (TKA) is a widely accepted surgical procedure for the treatment of patients with end-stage osteoarthritis (OA). However, the function of the knee is not always fully recovered after TKA. We used a dual fluoroscopic imaging system to evaluate the in vivo kinematics of the knee with medial compartment OA before and after a posterior cruciate ligament-retaining TKA (PCR-TKA) during weight-bearing knee flexion, and compared the results to those of normal knees. The OA knees displayed similar internal/external tibial rotation to normal knees. However, the OA knees had less overall posterior femoral translation relative to the tibia between 0 degrees and 105 degrees flexion and more varus knee rotation between 0 degrees and 45 degrees flexion, than in the normal knees. Additionally, in the OA knees the femur was located more medially than in the normal knees, particularly between 30 degrees and 60 degrees flexion. After PCR-TKA, the knee kinematics were not restored to normal. The overall internal tibial rotation and posterior femoral translation between 0 degrees and 105 degrees knee flexion were dramatically reduced. Additionally, PCR-TKA introduced an abnormal anterior femoral translation during early knee flexion, and the femur was located lateral to the tibia throughout weight-bearing flexion. The data help understand the biomechanical functions of the knee with medial compartment OA before and after contemporary PCR-TKA. They may also be useful for improvement of future prostheses designs and surgical techniques in treatment of knees with end-stage OA. (c) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.+http://www.ncbi.nlm.nih.gov/pubmed/20607694Journal article Journal of orthopaedic research : official publication of the Orthopaedic Research Society J Orthop Res. 2010 Jul 6.*1554-527X (Electronic) 0736-0266 (Linking)20607694Bioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St., GRJ 1215, Boston, Massachusetts 02114.10.1002/jor.21203Eng||7aIHanson, G. R. Moynihan, A. L. Suggs, J. F. Kwon, Y. M. Johnson, T. Li, G.2009LKinematics of medial unicondylar knee arthroplasty: an in vivo investigation237-42 J Knee Surg223 2009/07/29Aged Arthroplasty, Replacement, Knee/*methods Biomechanics Female Fluoroscopy Humans Imaging, Three-Dimensional Knee Joint/*physiology/*radiography/surgery *Knee Prosthesis Male Range of Motion, Articular/physiology Retrospective StudiesJul6This study investigated the weight-bearing flexion of 7 knees with previous medial unicondylar knee arthroplasty (UKA), using a dual fluoroscopic imaging system. The data indicated that the patients had consistent posterior translation of the medial femoral condyle and consistent internal rotation of the tibia with flexion. The articular contact location remained just anterior and medial to the center of the polyethylene insert throughout the range of motion. Femoral condylar lift-off was found in 2 patients at a maximum flexion angle of 130.7 +/- 10.2 degrees. The other 5 patients had a maximum flexion angle of 113.9 +/- 7.2 degrees. The small range of tibiofemoral contact excursion in both anteroposterior and mediolateral directions indicated a medial pivot contact pattern during flexion, corresponding to the observed internal tibial rotation. This may help reduce tibial loosening, thus increasing implant longevity. The observed coincidence between condylar lift-off and higher flexion angles may reveal the causative factors that enhance knee flexion after UKA.+http://www.ncbi.nlm.nih.gov/pubmed/19634728Hanson, George R Moynihan, Angela L Suggs, Jeremy F Kwon, Young-Min Johnson, Todd Li, Guoan Research Support, Non-U.S. Gov't United States The journal of knee surgery J Knee Surg. 2009 Jul;22(3):237-42.%1538-8506 (Print) 1538-8506 (Linking)19634728Bioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, GRJ 1215, Boston, MA 02114, USA.engT||7bgMoynihan, A. L. Varadarajan, K. M. Hanson, G. R. Park, S. E. Nha, K. W. Suggs, J. F. Johnson, T. Li, G.2010bIn vivo knee kinematics during high flexion after a posterior-substituting total knee arthroplasty497-503International Orthopaedics344 2009/04/24Aged Arthroplasty, Replacement, Knee/*methods Biomechanics Female Fluoroscopy Humans Knee Joint/*physiopathology/radiography Middle Aged *Range of Motion, Articular Stress, Mechanical Weight-BearingApr2The objective of this study was to investigate biomechanics of TKA patients during high flexion. Six patients (seven knees) with a posterior-substituting TKA and weight-bearing flexion >130 degrees were included in the study. The six degree-of-freedom kinematics, tibiofemoral contact, and cam-post contact were measured during a deep knee bend using dual-plane fluoroscopy. The patients achieved average weight-bearing flexion of 139.5 +/- 4.5 degrees. Posterior femoral translation and internal tibial rotation increased steadily beyond 90 degrees flexion, and a sharp increase in varus rotation was noted at maximum flexion. Initial cam-post engagement was observed at 100.3 +/- 6.7 degrees flexion. Five knees had cam-post disengagement before maximum flexion. Lateral femoral condylar lift-off was found in five out of seven knees at maximum flexion, and medial condylar lift-off was found in one knee. Future studies should investigate if the kinematic characteristics of posterior-substituting TKA knees noted in this study are causative factors of high knee flexion.+http://www.ncbi.nlm.nih.gov/pubmed/19387643Moynihan, Angela L Varadarajan, Kartik M Hanson, George R Park, Sang-Eun Nha, Kyung Wook Suggs, Jeremy F Johnson, Todd Li, Guoan Research Support, Non-U.S. Gov't Germany International orthopaedics Int Orthop. 2010 Apr;34(4):497-503. Epub 2009 Apr 22.*1432-5195 (Electronic) 0341-2695 (Linking)19387643Department of Orthopaedic Surgery, Bioengineering Laboratory, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRJ 1215, Boston, MA 02114, USA.10.1007/s00264-009-0777-2eng W||7cCVaradarajan, K. M. Moynihan, A. L. D'Lima, D. Colwell, C. W. Li, G.2008In vivo contact kinematics and contact forces of the knee after total knee arthroplasty during dynamic weight-bearing activities2159-68 J Biomech4110 2008/06/10Aged Aged, 80 and over Arthroplasty, Replacement, Knee/methods Biomechanics/*methods Equipment Design Female Humans Knee/anatomy & histology/pathology Knee Joint/*surgery Knee Prosthesis Male Polyethylene Range of Motion, Articular Weight-BearingJul 19Analysis of polyethylene component wear and implant loosening in total knee arthroplasty (TKA) requires precise knowledge of in vivo articular motion and loading conditions. This study presents a simultaneous in vivo measurement of tibiofemoral articular contact forces and contact kinematics in three TKA patients. These measurements were accomplished via a dual fluoroscopic imaging system and instrumented tibial implants, during dynamic single leg lunge and chair rising-sitting. The measured forces and contact locations were also used to determine mediolateral distribution of axial contact forces. Contact kinematics data showed a medial pivot during flexion of the knee, for all patients in the study. Average axial forces were higher for lunge compared to chair rising-sitting (224% vs. 187% body weight). In this study, we measured peak anteroposterior and mediolateral forces averaging 13.3% BW during lunge and 18.5% BW during chair rising-sitting. Mediolateral distributions of axial contact force were both patient and activity specific. All patients showed equitable medial-lateral loading during lunge but greater loads at the lateral compartment during chair rising-sitting. The results of this study may enable more accurate reproduction of in vivo loads and articular motion patterns in wear simulators and finite element models. This in turn may help advance our understanding of factors limiting longevity of TKA implants, such as aseptic loosening and polyethylene component wear, and enable improved TKA designs.+http://www.ncbi.nlm.nih.gov/pubmed/18538328$Varadarajan, Kartik M Moynihan, Angela L D'Lima, Darryl Colwell, Clifford W Li, Guoan R21 EB00458/EB/NIBIB NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Journal of biomechanics J Biomech. 2008 Jul 19;41(10):2159-68. Epub 2008 Jun 5.%0021-9290 (Print) 0021-9290 (Linking)18538328}Bioengineering Laboratory, Orthopaedic Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA.:S0021-9290(08)00213-3 [pii] 10.1016/j.jbiomech.2008.04.021eng ||7d=Suggs, J. F. Hanson, G. R. Park, S. E. Moynihan, A. L. Li, G.2008oPatient function after a posterior stabilizing total knee arthroplasty: cam-post engagement and knee kinematics290-6#Knee Surg Sports Traumatol Arthrosc163 2008/01/16Aged Arthroplasty, Replacement/*rehabilitation Biomechanics Cohort Studies Fluoroscopy Humans Knee Joint/*physiology *Range of Motion, Articular Retrospective StudiesMarEven though posterior substituting total knee arthroplasty has been widely used in surgery, how the cam-post mechanism (posterior substituting mechanism) affects knee joint kinematics and function in patients is not known. The objective of the present study was to investigate posterior femoral translation, internal tibial rotation, tibiofemoral contact, and cam-post engagement of total knee arthroplasty patients during in vivo weight-bearing flexion. Twenty-four knees with a PS TKA were investigated while performing a single leg weight-bearing lunge from full extension to maximum flexion as images were recorded using a dual fluoroscopic system. The in vivo knee position at each targeted flexion angle was reproduced using 3D TKA models and the fluoroscopic images. The kinematics of the knee was measured from the series of the total knee arthroplasty models. The cam-post engagement was determined when the surface model of the femoral cam overlapped with that of the tibial post. The mean maximum flexion angle for all the subjects was 112.5 +/- 13.1 degrees . The mean flexion angle where cam-post engagement was observed was 91.1 +/- 10.9 degrees . The femur moved anteriorly from 0 degrees to 30 degrees and posteriorly through the rest of the flexion range. The internal tibial rotation increased approximately 6 degrees from full extension to 90 degrees of flexion and decreased slightly with further flexion. Both the medial and lateral contact point moved posteriorly from 0 degrees to 30 degrees , remained relatively constant from 30 degrees to 90 degrees , and then moved further posterior from 90 degrees to maximum flexion. The in vivo cam-post engagement corresponded to increased posterior translation and reduced internal tibial rotation at high flexion of the posterior substituting total knee arthroplasty. The initial cam-post engagement was also mildly correlated with the maximum flexion angle of the knee (R = 0.51, p = 0.019). A later cam-post engagement might indicate an environment conducive to greater flexion. If the factors that affect cam-post engagement timing can be established, proper manipulation of those factors may improve the function of the knee after posterior substituting total knee arthroplasty.+http://www.ncbi.nlm.nih.gov/pubmed/18196219Suggs, Jeremy F Hanson, George R Park, Sang Eun Moynihan, Angela L Li, Guoan Research Support, Non-U.S. Gov't Germany Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA Knee Surg Sports Traumatol Arthrosc. 2008 Mar;16(3):290-6. Epub 2008 Jan 9.%0942-2056 (Print) 0942-2056 (Linking)18196219Bioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St., GRJ 1215, Boston, MA 02114, USA. jsuggs@exponent.com10.1007/s00167-007-0467-9eng .||7eXHanson, G. R. Park, S. E. Suggs, J. F. Moynihan, A. L. Nha, K. W. Freiberg, A. A. Li, G.2007PIn vivo kneeling biomechanics after posterior stabilized total knee arthroplasty476-83 J Orthop Sci125 2007/10/03Aged *Arthroplasty, Replacement, Knee Female Humans Knee Joint/*physiology/surgery Knee Prosthesis Pressure Range of Motion, Articular/*physiology Recovery of Function Weight-Bearing/physiologySepBACKGROUND: Kneeling is one of the activities sought by patients after total knee arthroplasty (TKA). This study investigated the six degrees of freedom (DOF) kinematics and three-dimensional (3D) contact during weight-bearing kneeling. METHODS: A total of 16 South Korean female patients (22 knees) after posteriorly stabilized (PS) TKA (LPS-Flex) were randomly recruited and had the same surgeon. The patients were imaged using a dual fluoroscopic technique while they kneeled from initial to maximum flexion. The acquired images and 3D models were then used to recreate the in vivo pose of the components. Contact was determined by locating the surface intersections in the tibiofemoral and cam/post (between the femoral cam and tibial post) articular compartments. RESULTS: Patients flexed, on average, from 107.3 degrees to 128.0 degrees during the kneeling activity. Changes in kinematics included 1.0 mm of proximal, 0.9 mm of medial, and 7.6 mm of posterior translation and 1.7 degrees of varus rotation (P < 0.04). A difference in internal tibial rotation was not detected. Articular contact moved posteriorly by 5.9 mm and 6.4 mm in the medial and lateral compartments, respectively. Contact also moved medially by 3.2 mm and 5.8 mm in the medial and lateral compartments. A decrease in articular contact was observed in both condyles, and lateral condylar lift-off increased with flexion (P = 0.0001). More than 80% of the patients demonstrated cam/post engagement, which always occurred in the distal portion of the post. CONCLUSIONS: In this patient cohort, the knee joint was constrained during the weight-bearing activity such that femoral subluxation and dislocation were not observed. Furthermore, posterior cam/post engagement occurred only in the distal portion of the tibial post, which may improve the longevity of the post. The tibiofemoral and cam/post articular contact data presented in this study further suggest that kneeling may be performed by patients after clinically successful PS TKA who feel comfortable with the activity and are free of pain.+http://www.ncbi.nlm.nih.gov/pubmed/17909934>Hanson, George R Park, Sang E Suggs, Jeremy F Moynihan, Angela L Nha, Kyung W Freiberg, Andrew A Li, Guoan Randomized Controlled Trial Research Support, Non-U.S. Gov't Japan Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association J Orthop Sci. 2007 Sep;12(5):476-83. Epub 2007 Sep 28.%0949-2658 (Print) 0949-2658 (Linking)17909934Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRJ 1215, Boston, MA 02114, USA.10.1007/s00776-007-1165-7eng ||7f4Hagemeister, N. Parent, G. Husse, S. de Guise, J. A.2008A simple and rapid method for electromagnetic field distortion correction when using two Fastrak sensors for biomechanical studies1813-7 J Biomech418 2008/04/09lBiomechanics/*instrumentation/*methods Calibration *Electromagnetic Fields Gait Humans Knee Joint/physiology3The article presents a simple and rapid method for the correction of electromagnetic distortions when using electromagnetic Fastrak (Polhemus, USA) sensors. It is based on the minimization of objective functions composed of derivative polynomial functions, hence estimating the distortion of the electromagnetic field. The polynomial functions composing the objective function each contain 35 deformation coefficients. These coefficients are then used to correct the electromagnetic measures in position and orientation. Preliminary results on the efficacy of the method are presented for two subjects who walked on a treadmill, and for whom relative movement of the lower leg with respect to the thigh was recorded using two Fastrak sensors. The corrected Fastrak measurements were compared with optoelectronic measurements (Vicon, USA), which are not affected by distortions as electromagnetic sensors are. Results showed that after 3 min of calibrating a volume of approximately 1m(3), the method proved to be efficient in correcting errors in orientation (56% (2.72-1.12 degrees ), 78% (4.4-0.89 degrees ), and 56% (2.25-0.90 degrees ) of error reduction in the respective flexion/extension, ab/adduction and tibial internal/external rotation) and position (53% (18.9-8.9 mm), 21% (6.6-4.6mm), and 48% (15.9-8.1mm) of error reduction in the respective medial/lateral, anterior/posterior and proximal/distal translations) (values are overall means for two subjects and four calibration procedures). That amount of correction compared favorably with values presented in the literature.+http://www.ncbi.nlm.nih.gov/pubmed/18396289Hagemeister, Nicola Parent, Gerald Husse, Sabine de Guise, Jacques A Evaluation Studies United States Journal of biomechanics J Biomech. 2008;41(8):1813-7. Epub 2008 Apr 8.%0021-9290 (Print) 0021-9290 (Linking)18396289Departement de Genie de la Production Automatisee, Ecole de Technologie Superieure, 1100 Notre Dame Ouest, Montreal, Quebec, Canada. nicola.hagemeister@etsmtl.ca:S0021-9290(08)00106-1 [pii] 10.1016/j.jbiomech.2008.02.030eng?||7gEWigderowitz, C. A. Scott, I. Jariwala, A. Arnold, G. P. Abboud, R. J.2007XAdapting the Fastrak system for three-dimensional measurement of the motion of the wrist700-4J Hand Surg Eur Vol326 2007/11/13Adult Diagnosis, Computer-Assisted/*instrumentation Electrodiagnosis/*instrumentation Electromagnetic Phenomena/*instrumentation Equipment Design Humans Motor Activity/physiology Range of Motion, Articular/*physiology Reference Values Reproducibility of Results Wrist Joint/*physiologyDecqThe Polhemus Fastrak short-range miniature transmitter and mini-receivers allow wrist motion to be measured continually in three dimensions, registering patterns of motion, which until now were difficult to quantify. The current study aimed to determine the applicability and repeatability of the Fastrak system when assessing wrist movements during a set protocol of activities. The device was found to be easy to use and repeatable; the Fastrak system showed a mean error of up to 3 degrees in all movements tested. Its assessment of range of motion correlated with the results in the literature. The Fastrakv system was suitable for continuous registration of movements during the performance of set tasks in either of the wrists. It has the potential to be used for documentation of wrist motion in clinics for various pathologies and for assessing outcomes in wrist surgeries.+http://www.ncbi.nlm.nih.gov/pubmed/17993435Wigderowitz, C A Scott, I Jariwala, A Arnold, G P Abboud, R J England The Journal of hand surgery, European volume J Hand Surg Eur Vol. 2007 Dec;32(6):700-4. Epub 2007 Oct 24.1753-1934 (Print)17993435{Department of Orthopaedics and Trauma Surgery, TORT Centre, Ninewells Hospital, Dundee, Scotland. cawigderowitz@lineone.net6S1753-1934(07)00444-X [pii] 10.1016/j.jhse.2007.06.019eng ||7hZJordan, K. Haywood, K. L. Dziedzic, K. Garratt, A. M. Jones, P. W. Ong, B. N. Dawes, P. T.2004qAssessment of the 3-dimensional Fastrak measurement system in measuring range of motion in ankylosing spondylitis2207-15 J Rheumatol3111 2004/11/02<Adult Aged Anthropometry/*methods Biomechanics Cervical Vertebrae/*physiopathology Electromagnetic Fields Female Humans Imaging, Three-Dimensional/*instrumentation/methods Male Middle Aged *Range of Motion, Articular Reproducibility of Results Shoulder Joint/*physiopathology Spondylitis, Ankylosing/*physiopathologyNovOBJECTIVE: To assess the repeatability and validity of the electromagnetic 3-dimensional tracking system, Fastrak, in measuring cervical spine and shoulder movement in patients with ankylosing spondylitis (AS). METHODS: Fifty patients with AS had their cervical spine and shoulder movements measured on up to 3 occasions with the Fastrak. Patients also completed disease-specific and generic patient assessed health instruments, and their spinal mobility was assessed by tape measure methods. Repeatability over 2 weeks was assessed using intraclass correlation coefficients (ICC). Fastrak measurements were compared between patients with different self-ratings of AS related health. Comparisons between the Fastrak measurements and patient assessed health instruments and tape measurements were made using Spearman correlations and multilevel modeling. RESULTS: Patients with AS tended to be limited in both cervical spine and shoulder movements. ICC were all > 0.80 (except shoulder extension, 0.75), indicating substantial reliability. Fastrak was able to differentiate between patients with a high self-rating of AS related health and those with a poorer rating. Cervical spine flexion and shoulder flexion and abduction were most strongly related to the patient assessed health instruments, although the shoulder movements had limited relationships with the tape measurements of spinal mobility. CONCLUSION: The Fastrak appears to be reliable and valid in an AS population. Shoulder movements tended to have a stronger relationship with the patient assessed health instruments than cervical spine movements. Shoulder movement may be more related to everyday function measured by these instruments, which indicates the importance of this joint in assessment of AS.+http://www.ncbi.nlm.nih.gov/pubmed/15517634Jordan, Kelvin Haywood, Kirstie L Dziedzic, Krysia Garratt, Andrew M Jones, Peter W Ong, Bie Nio Dawes, Peter T Research Support, Non-U.S. Gov't Canada The Journal of rheumatology J Rheumatol. 2004 Nov;31(11):2207-15.%0315-162X (Print) 0315-162X (Linking)15517634kPrimary Care Sciences Research Centre, Keele University, Keele, United Kingdom. k.p.jordan@cphc.keele.ac.uk0315162X-31-2207 [pii]eng F~|7i_Rahmatalla, A. Chockalingam, N. Dangerfield, P. Ahmed el, N. Cochrane, T. Dove, J. Maffulli, N.20025Movement analysis of scoliotic subjects using Fastrak162-6Stud Health Technol Inform91 2004/10/02 Adolescent Adult Child *Electromagnetic Fields Female Humans Image Processing, Computer-Assisted/*instrumentation Imaging, Three-Dimensional/*instrumentation Male Reproducibility of Results Scoliosis/*diagnosis/physiopathology Spine/*physiopathology Torsion AbnormalityAn attempt has been made to simplify the measurement of composite movement involving abnormal rotation in scoliosis, which is considered to have an important role in the diagnosis and treatment of the condition. Analysis of three-dimensional movement provides pertinent information concerning the morphological description of scoliotic deformities. The description of this movement is of clinical interest for aiding diagnosis and/or prognosis of spinal deformity evolution. Previous studies have indicated that idiopathic scoliosis is a three-dimensional deformity accompanied by a generalised torsion phenomenon and attempts have been made to associate the geometric torsion index with the curvi-linear shape of idiopathic scoliosis. Although previous investigations have documented the three-dimensional reconstruction of scoliotic spine, most methods either expose the subject to a high level of radiation, as in stereo-radiographs, or demand a high degree of technical input and time, as in video based gait analysis systems. This study employs an electro magnetic field capturing system (FASTRAK) to estimate the spinal movements. This simple system is inexpensive and highly portable. Furthermore, it can give instant graphic and numerical values of the composite movement. The results of this study indicate the usefulness this system in the diagnosis of scoliosis and highlights the possibility of its uses in screening school children and other surveys.+http://www.ncbi.nlm.nih.gov/pubmed/15457716Rahmatalla, Aziz Chockalingam, Nachiappan Dangerfield, Peter Ahmed, El-Nasri Cochrane, Tom Dove, John Maffulli, Nicola Netherlands Studies in health technology and informatics Stud Health Technol Inform. 2002;91:162-6.%0926-9630 (Print) 0926-9630 (Linking)15457716RHartshill Orthopaedic Centre, North Staffordshire Hospital, Stoke on Trent ST46QG.eng ||7jLHuynh, T. Cox, J. L. Massel, D. Davies, C. Hilbe, J. Warnica, W. Daly, P. A.2004Predictors of intracranial hemorrhage with fibrinolytic therapy in unselected community patients: a report from the FASTRAK II project86-91 Am Heart J1481 2004/06/25Aged Female Fibrinolytic Agents/adverse effects/therapeutic use Humans Hypertension/complications Intracranial Hemorrhages/*chemically induced Logistic Models Male Middle Aged Myocardial Infarction/complications/*drug therapy Prognosis Prospective Studies Registries Risk Factors Sex Factors Streptokinase/adverse effects/therapeutic use Stroke/chemically induced Thrombolytic Therapy/*adverse effects Tissue Plasminogen Activator/adverse effects/therapeutic use Treatment OutcomeJulBACKGROUND: Patients at high risk for intracranial hemorrhage (ICH) are generally excluded from thrombolytic trials. Because the frequency and predictors of ICH reported from these studies may not be widely applicable, we sought to examine this matter further in unselected patients with acute myocardial infarction in the community. METHODS: FASTRAK II is a prospective ongoing registry of acute coronary syndromes involving 111 Canadian hospitals. Trained medical personnel recorded admission, treatment, and discharge data on patients admitted with acute coronary syndromes. RESULTS: From January 1, 1998, to December 31, 2000, 12,739 patients received fibrinolytic therapy for acute myocardial infarction. Of these, 146 patients (1.15%) sustained strokes and 82 patients (0.65%) had an ICH. Advanced age, female sex, history of cerebrovascular event, and systolic hypertension on arrival (systolic blood pressure >160 mm Hg) were identified with a multivariate logistic regression model to be important independent risks factors for ICH. Patients receiving streptokinase had a lower risk of ICH. Among the patients at high risk for ICH, the ICH rates remained low, ranging from 0.7% to 1.8%. CONCLUSION: ICH is an infrequent event after fibrinolytic therapy in ST-elevation MI; this low rate supports broad penetration of this therapy. Simple clinical characteristics are useful in predicting the risk of ICH and allow a clinician to individualize the risk-benefit assessment of this therapy.+http://www.ncbi.nlm.nih.gov/pubmed/15215796Huynh, Thao Cox, Jafna L Massel, David Davies, Cheryl Hilbe, Joseph Warnica, Wayne Daly, Paul A FASTRAK II Network Multicenter Study Research Support, Non-U.S. Gov't United States American heart journal Am Heart J. 2004 Jul;148(1):86-91.*1097-6744 (Electronic) 0002-8703 (Linking)15215796oMontreal General Hospital, McGill Health University Center, Montreal, Quebec, Canada. thao.huynh@muhc.mcgill.ca110.1016/j.ahj.2004.02.006 S0002870304000973 [pii]engF||7k%Amiri, M. Jull, G. Bullock-Saxton, J.2003Measuring range of active cervical rotation in a position of full head flexion using the 3D Fastrak measurement system: an intra-tester reliability study176-9Man Ther83 2003/08/12Adult Biomechanics Cervical Vertebrae/*physiology Female *Head Humans Male Manipulation, Spinal/*instrumentation Posture *Range of Motion, Articular Reference Values Reproducibility of Results *Rotation Sensitivity and SpecificityAugMost external assessments of cervical range of motion assess the upper and lower cervical regions simultaneously. This study investigated the within and between days reliability of the clinical method used to bias this movement to the upper cervical region, namely measuring rotation of the head and neck in a position of full cervical flexion. Measurements were made using the Fastrak measurement system and were conducted by one operator. Results indicated high levels of within and between days repeatability (range of ICC2,1 values: 0.85-0.95). The ranges of axial rotation to right and left, measured with the neck positioned in full flexion, were approximately 56% and 50%, respectively of total cervical rotation, which relates well to the proportional division of rotation in the upper and lower cervical regions. These results suggest that this method of measuring rotation would be appropriate for use in subject studies where movement dysfunction is present in the upper cervical region, such as those with cervicogenic headache.+http://www.ncbi.nlm.nih.gov/pubmed/12909439YAmiri, M Jull, G Bullock-Saxton, J Scotland Manual therapy Man Ther. 2003 Aug;8(3):176-9.%1356-689X (Print) 1356-689X (Linking)12909439fDepartment of Physiotherapy, The University of Queensland, Brisbane, Australia. m.amiri@shrs.uq.edu.auS1356689X03000092 [pii]eng ||7l<Jordan, K. Dziedzic, K. Jones, P. W. Ong, B. N. Dawes, P. T.2000The reliability of the three-dimensional FASTRAK measurement system in measuring cervical spine and shoulder range of motion in healthy subjects382-8Rheumatology (Oxford)394 2000/05/19Adult Anthropometry Biomechanics Cervical Vertebrae/*physiology Female Humans Male Middle Aged Observer Variation *Range of Motion, Articular Reproducibility of Results Shoulder Joint/*physiologyAprYOBJECTIVES: To assess the inter-observer and intra-observer reliability of a new three-dimensional measurement system, the FASTRAK, in measuring cervical spine flexion/extension, lateral flexion and rotation and shoulder flexion/extension, abduction and external rotation in healthy subjects. METHODS: The study was conducted in two parts. One part assessed inter-observer reliability with two observers measuring 40 subjects. The other part assessed intra-observer reliability with one observer measuring 32 subjects on three occasions. All subjects had unrestricted, pain-free cervical spine and shoulder movement. Reliability was measured by the intraclass correlation coefficient [ICC(2,1)]. RESULTS: The inter-observer ICCs for the cervical spine ranged from 0.61 to 0.89 and for the shoulder from 0.68 to 0.75. After removal of outliers, all ICCs were above 0.70. Intra-observer ICCs for the cervical spine ranged from 0.54 to 0.82 and for the shoulder from 0.62 to 0.81. After removal of outliers, all ICCs were above 0.70 except for shoulder abduction (0.62). CONCLUSIONS: Whilst all movements measured by the FASTRAK showed good reliability, the reliability of the whole movement in a plane (e.g. left plus right lateral flexion) was better than for the separate movements (e.g. left and right lateral flexion taken separately). Inter-observer reliability was generally better than intra-observer reliability for most cervical spine movements, suggesting that variability of movement within subjects (e.g. over a period of days) for these movements was greater than variability between measures on the same occasion.+http://www.ncbi.nlm.nih.gov/pubmed/10817770Jordan, K Dziedzic, K Jones, P W Ong, B N Dawes, P T Research Support, Non-U.S. Gov't England Rheumatology (Oxford, England) Rheumatology (Oxford). 2000 Apr;39(4):382-8.%1462-0324 (Print) 1462-0324 (Linking)10817770VCentre for Health Planning & Management, Darwin Building, Keele University, Keele, UK.eng||7m3Poelstra, K. A. Eijkelkamp, M. F. Veldhuizen, A. G.2000|The geometry of the human paraspinal muscles with the aid of three-dimensional computed tomography scans and 3-Space Isotrak2176-9Spine (Phila Pa 1976)2517 2000/09/06Aged Biomechanics Cadaver Humans Image Processing, Computer-Assisted/*methods Male Models, Biological Movement/*physiology Muscle, Skeletal/*anatomy & histology/physiology Spine/*anatomy & histology/physiology Tomography, X-Ray Computed/*methodsSep 1STUDY DESIGN: Accurate determination of the three-dimensional coordinates of paraspinal muscles is presented. OBJECTIVES: To determine the precise position and the size of the paraspinal muscles. SUMMARY OF BACKGROUND DATA: The accurate measurements of the muscle moment arms are important in the evaluation of computer models for spinal movement. It has been reported that a change in the modelling of the erector spinae muscles can alter the compressive forces in the spinal column by 20% and can increase the offsetting shear forces. Classic studies used measurements from cross-sectional anatomic diagrams of human cadavers, scaled to the width and depth of the trunk of the subject, to calculate the moment that produces the joint torque. METHODS: Computed tomography scans of two male cadavers provided data on the bony elements. Three-dimensional coordinates of the origins and insertions of the muscle-fascicles of the paraspinal muscles were obtained with the use of 3-Space Isotrak equipment. The bony and muscle coordinates were combined in the ANSYS (version 5.4; Swanson Analysis Systems, Canonsberg, PA) program. RESULTS: Results of this combination and the three-dimensional coordinates of the paraspinal muscles as acquired by the 3-Space Isotrak are given. CONCLUSION: The position and the moment arms of paraspinal muscles were accurately determined. This is important for further evaluation of mathematical models.+http://www.ncbi.nlm.nih.gov/pubmed/10973399rPoelstra, K A Eijkelkamp, M F Veldhuizen, A G United states Spine Spine (Phila Pa 1976). 2000 Sep 1;25(17):2176-9.%0362-2436 (Print) 0362-2436 (Linking)10973399kDepartment of Orthopaedic Surgery, University Hospital Groningen, University of Groningen, The Netherlands.eng||7n)McGill, S. M. Cholewicki, J. Peach, J. P.1997rMethodological considerations for using inductive sensors (3SPACE ISOTRAK) to monitor 3-D orthopaedic joint motion190-194Clin Biomech (Bristol, Avon)123 1997/04/01AprxOBJECTIVE: To assess and improve methodological constraints of the 3SPACE ISOTRAK. DESIGN: Several data sets were used to evaluate the following constraints: the performance is adversely affected by close proximity of metallic objects or electromagnetic fields; the3SPACE field contaminates electromyography recordings; and cross-talk from one axis to the other two occurs if the Euler rotation sequence is not matched to the orthopaedic description and function of the joint in question. BACKGROUND: The 3SPACE ISOTRAK is one of the few instruments suitable for measurement of relative three-dimensional joint rotation, however several methodological constraints exist. RESULTS AND CONCLUSIONS: Generally, accuracy can be maintained by restricting offending objects from the sensitive zone between the transmitter and sensor and using long leads to afford the subject distance from computers and other electrical instrumentation; while contamination of EMG amplitude in the time domain can be minimized by using quality instrumentation, and on occasion modifying electrode orientation. Contamination of the EMG frequency content appears unavoidable at low levels of muscle contraction; and cross-talk between axes is minimized by matching the first Euler rotation with the axis of the joint that is characterized by the greatest expected angular displacement. RELEVANCE: The 3SPACE ISOTRAK is one of the few instruments available that is suitable for measuring three axes of relative joint motion (local joint axes that rotate with the joint -- not global). This paper suggests several techniques to increase the accuracy and viability of this instrument.+http://www.ncbi.nlm.nih.gov/pubmed/11415693kJournal article Clinical biomechanics (Bristol, Avon) Clin Biomech (Bristol, Avon). 1997 Apr;12(3):190-194.*1879-1271 (Electronic) 0268-0033 (Linking)11415693Occupational Biomechanics and Safety Laboratories, Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, ON, Canada.S0268003397000636 [pii]Eng ||7oCKessner, D. Brezesinski, G. Funari, S. S. Dobner, B. Neubert, R. H.2010Impact of the long chain omega-acylceramides on the stratum corneum lipid nanostructure. Part 1: Thermotropic phase behaviour of CER[EOS] and CER[EOP] studied using X-ray powder diffraction and FT-Raman spectroscopy42-50Chem Phys Lipids1631 2009/11/11Ceramides/*chemistry Lipids/*chemistry Nanostructures/*chemistry Skin/*chemistry Spectrum Analysis, Raman Temperature X-Ray DiffractionJanThe stratum corneum (SC), the outermost layer of the mammalian skin, is the main skin barrier. Ceramides (CERs) as the major constituent of the SC lipid matrix are of particular interest. At the moment, 11 classes of CERs are identified, but the effect of each single ceramide species is still not known. Therefore in this article, the thermotropic behaviour of the long chain omega-acylceramides CER[EOS] and CER[EOP] was studied using X-ray powder diffraction and FT-Raman spectroscopy. It was found that the omega-acylceramides CER[EOS] and CER[EOP] do not show a pronounced polymorphism which is observed for shorter chain ceramides as a significant feature. The phase behaviour of both ceramides is strongly influenced by the extremely long acyl-chain residue. The latter has a much stronger influence compared with the structure of the polar head group, which is discussed as extremely important for the appearance of a rich polymorphism. Despite the strong influence of the long chain, the additional OH-group of the phyto-sphingosine type CER[EOP] influences the lamellar repeat distance and the chain packing. The less polar sphingosine type CER[EOS] is stronger influenced by the long acyl-chain residue. Hydration is necessary for the formation of an extended hydrogen-bonding network between the polar head groups leading to the appearance of a long-periodicity phase (LPP). In contrast, the more polar CER[EOP] forms the LPP with densely packed alkyl chains already in the dry state.+http://www.ncbi.nlm.nih.gov/pubmed/19900430Kessner, Doreen Brezesinski, Gerald Funari, Sergio S Dobner, Bodo Neubert, Reinhard H H Research Support, Non-U.S. Gov't Ireland Chemistry and physics of lipids Chem Phys Lipids. 2010 Jan;163(1):42-50. Epub .*1873-2941 (Electronic) 0009-3084 (Linking)19900430eInstitute of Pharmacy, Martin-Luther-University, Wolfgang-Langenbeck-Strasse 4, 06120 Halle, Germany.=S0009-3084(09)00345-4 [pii] 10.1016/j.chemphyslip.2009.10.007eng .||7pGSapin, E. Briot, K. Kolta, S. Gravel, P. Skalli, W. Roux, C. Mitton, D.2008XBone mineral density assessment using the EOS low-dose X-ray device: a feasibility study1263-71Proc Inst Mech Eng H2228 2009/01/16Absorptiometry, Photon/*instrumentation Bone Density/*physiology Equipment Design *Equipment Failure Analysis Feasibility Studies Humans Radiation Dosage Reproducibility of Results Sensitivity and Specificity Spine/*physiology/*radiographyNovTo predict bone strength in the case of osteoporosis, it could be a real benefit to assess the three-dimensional (3D) geometry and the bone mineral density (BMD) with a single low-dose X-ray device, such as the EOS system (Biospace Med, Paris, France). EOS 3D reconstructions of the spine have already been validated. Thus, this study aims at evaluating the accuracy of this low-dose system as a densitometer first ex vivo. The European Spine Phantom (ESP) (number 129) was scanned ten times using both the EOS and a Hologic device (Hologic, Inc., Massachusetts, USA). Accuracy was given by the sum of the systematic error (difference between BMDs assessed and true values given by the phantom manufacturer) and the random error (coefficient of variation). EOS BMDs and Hologic BMDs of 41 ex-vivo vertebrae were calculated and compared. The reproducibility of the method evaluating the EOS BMD was assessed giving the coefficient of variation of three measurements of the 41 vertebrae. The accuracy of the EOS system is below 5.2 per cent, versus 7.2 per cent for the Hologic system in the same conditions. EOS BMDs are significantly higher than Hologic BMDs, but they are strongly correlated. The reproducibility of the method of assessment is equal to 0.95 per cent. The EOS system is accurate for ex-vivo BMD assessments, which is promising regarding the use of this new system to predict vertebral strength.+http://www.ncbi.nlm.nih.gov/pubmed/19143419Sapin, E Briot, K Kolta, S Gravel, P Skalli, W Roux, C Mitton, D Evaluation Studies England Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine Proc Inst Mech Eng H. 2008 Nov;222(8):1263-71.%0954-4119 (Print) 0954-4119 (Linking)19143419gLaboratoire de Biomecanique, LBM, Arts et Metier ParisTech, CNRS, Paris, France. emilie.sapin@gmail.comeng||7qKJim, M. H. Ho, H. H. Ko, R. L. Siu, C. W. Yiu, K. H. Lau, C. P. Chow, W. H.2010TPaclitaxel-eluting stents for chronically occluded saphenous vein grafts (EOS) study40-5J Interv Cardiol231 2010/05/15FebPOBJECTIVES: The aim of this study was to report the feasibility, short- and medium-term results of percutaneous coronary intervention (PCI) on saphenous vein graft (SVG) chronic total occlusions (CTO) using paclitaxel-eluting stents (PES). BACKGROUND: In postbypass patients, PCI on SVG CTO, rather than native vessel CTO, is another treatment option. However, the acute procedural and medium-term outcomes are unknown. METHODS: Twenty-two consecutive, symptomatic postbypass patients underwent PCI on SVG CTO; angiographic success was seen in 16 patients (73%). The successful cases were evaluated at 1 year; restudy angiography was performed at 11 +/- 5 months in 15 patients (94%). RESULTS: The patients had a mean age of 73 years with predominance of male (68%); the mean SVG age was 14 years. On average, patients received 3.4 PESs per lesion; the stent size was 3.5 +/- 0.4 mm with a total stent length of 98 +/- 34 mm. The use of embolic protection devices and glycoprotein IIb/ IIIa inhibitors was observed in 6 (38%) and 5 (31%) patients, respectively. The in-hospital major adverse cardiac event (MACE) was 13%, accountable by 2 patients with postprocedure myocardial infarction. At follow-up, 6 patients had angiographic restenosis (40%); there was 1 noncardiac death and 3 target vessel revascularizations. The 1-year MACE was 25%; the graft survival free of occlusion and revascularization was 56%. CONCLUSIONS: PCI on SVG CTO is a feasible approach with a fairly high success and low in-hospital complication. However, it is associated with a relatively high angiographic restenosis and MACE at 1 year.+http://www.ncbi.nlm.nih.gov/pubmed/20465719Jim, Man-Hong Ho, Hee-Hwa Ko, Ryan Lap-Yan Siu, Chung-Wah Yiu, Kai-Hang Lau, Chu-Pak Chow, Wing-Hing United States Journal of interventional cardiology J Interv Cardiol. 2010 Feb;23(1):40-5.*1540-8183 (Electronic) 0896-4327 (Linking)20465719:Cardiac Medical Unit, Grantham Hospital, Hong Kong, China..JOIC525 [pii] 10.1111/j.1540-8183.2009.00525.xeng||7rTSilva, M. R. Ximenes, R. M. da Costa, J. G. Leal, L. K. de Lopes, A. A. Viana, G. S.2010Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice415-26#Naunyn Schmiedebergs Arch Pharmacol3815 2010/03/20Animals Anticonvulsants/administration & dosage/isolation & purification/*pharmacology Brazil Cymbopogon/*chemistry Disease Models, Animal Dose-Response Relationship, Drug Female Humans Injections, Intraperitoneal Male Medicine, Traditional Mice Oils, Volatile/administration & dosage/isolation & purification/*pharmacology Plant Leaves Seizures/*drug therapy Sleep/drug effects gamma-Aminobutyric Acid/metabolismMayS The fresh leaves of Cymbopogon citratus are a good source of an essential oil (EO) rich in citral, and its tea is largely used in the Brazilian folk medicine as a sedative. A similar source of EO is Cymbopogon winterianus, rich in citronellal. The literature presents more studies on the EO of C. citratus and their isolated bioactive components, but only a few are found on the EO of C. winterianus. The objective of the present study was then to study, in a comparative way, the effects of both EOs on three models of convulsions (pentylenetetrazol, pilocarpine, and strychnine) and on the barbiturate-induced sleeping time on male Swiss mice. The animals (20-30 g) were acutely treated with 50, 100, and 200 mg kg(-1), intraperitoneally, of each EO, and 30 min later, the test was initiated. The observed parameters were: latency to the first convulsion and latency to death in seconds. Furthermore, the in vitro effects of the EOs were also studied on myeloperoxidase (MPO; a biomarker for inflammation) and lactate dehydrogenase (LDH; an index of cytotoxicity) releases from human neutrophils. The EOs radical-scavenging activities were also evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The results showed that both EOs were more active on the pentylenetetrazol-induced convulsion model, and C. citratus was even more efficient in increasing latency to the first convulsion and latency to death. Both parameters were potentiated in the presence of a lower dose of diazepam (reference drug) when associated to a lower dose of each EO (25 mg kg(-1)). Besides, their anticonvulsant effects were blocked by flumazenil, a known benzodiazepine antagonist. This effect was somewhat lower on the pilocarpine-induced convulsion, and better effects were seen only with the EOs' higher doses (200 mg kg(-1)). A similar result was observed on the strychnine-induced convulsion model. Both EOs potentiated the barbiturate-induced sleeping time. However, C. citratus was more efficient. Interestingly, both EOs completely blocked the MPO release from human neutrophils and showed no cytotoxic effect on the LDH release from human neutrophils. On the other hand, only a very low or no effect on the DPPH assay was observed with C. winterianus and C. citratus, respectively, indicating that the radical scavenging activity did not play a role on the EOs' effects. We conclude that the mechanism of action of the anticonvulsant effect of the EOs studied is, at least in part, dependent upon the GABAergic neurotransmission. In addition, their effects on inflammatory biomarkers can also contribute to their central nervous system activity.+http://www.ncbi.nlm.nih.gov/pubmed/20237771LSilva, Monalisa Ribeiro Ximenes, Rafael Matos da Costa, Jose Galberto Martins Leal, L Kalyne A M de Lopes, Amanda A Viana, Glauce Socorro de Barros Comparative Study Research Support, Non-U.S. Gov't Germany Naunyn-Schmiedeberg's archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):415-26. Epub 2010 Mar 17.*1432-1912 (Electronic) 0028-1298 (Linking)20237771Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara (UFC), Rua Cel. Nunes de Melo 1127, Fortaleza 60430-270, Ceara, Brazil.10.1007/s00210-010-0494-9eng s||7s8Azmy, C. Guerard, S. Bonnet, X. Gabrielli, F. Skalli, W.2010\EOS orthopaedic imaging system to study patellofemoral kinematics: assessment of uncertainty28-36Orthop Traumatol Surg Res961 2010/02/237Aged Algorithms Arthroplasty, Replacement, Knee Biomechanics Cadaver Female Femur/*physiology Humans Image Processing, Computer-Assisted/*instrumentation Imaging, Three-Dimensional/*instrumentation Knee Joint/*physiology Male Middle Aged Patella/*physiology Reproducibility of Results Rotation Tibia/*physiologyFebw BACKGROUND: Accurate knowledge of knee joint kinematics, especially patellofemoral joint kinematics,is essential for prosthetic evaluation so as to further improve total knee arthroplasty performances. Improving the evaluation of the functioning of the extensor apparatus appears,in this respect, particularly important in this optimization effort. OBJECTIVES: The aim of this study was to propose a new experimental setup for the analysis of knee joint kinematics and to validate its relevance in terms of accuracy and uncertainty.The technique developed herein combines 3D reconstruction imaging with the use of a motion capture system. MATERIAL AND METHODS: Eight pairs of fresh-frozen cadaver specimens with no evidence of previous knee surgery were studied using a new test rig where the femur remains fixed and the tibia is free to rotate. The flexion-extension cycles were executed using computer-controlled traction of the quadriceps tendon combined with an antagonist force applied to the distal part of the tibia. Knee joint kinematics were tracked using an optoelectronic motion capture system after a preliminary stage of data acquisition of bone geometry and markers position. This stage was carried out using a new digital stereophotogrammetric system, EOS, combined with specific 3D reconstruction software that also determined the coordinate system used in the kinematic analysis. The resulting uncertainty was assessed as was its impact on the estimated kinematics. RESULTS: Test results on eight knees validated the setup designed for the analysis of knee joint kinematics during the flexion-extension cycle. More specifically, the statistical results show that measurement uncertainty for rotations and translations remains below 0.4 and 1.8 mm,respectively, for the tibia and 0.4 and 1.2 mm for the patella (+/- 2 S.D. for all four measurements). DISCUSSION: The combination of 3D imaging and motion capture enables the proposed method to track the real-time motion of any bone segment during knee flexion-extension cycle. In particular,the new test rig introduced in this paper allows in vitro measurements of the patello femoral and tibiofemoral kinematics with a good level of accuracy. Moreover, this personalized experimental analysis can provide a more objective approach to the evaluation of knee implants as well as the validation of the finite-elements-based models of the patellofemoral joint.+http://www.ncbi.nlm.nih.gov/pubmed/20170853Azmy, C Guerard, S Bonnet, X Gabrielli, F Skalli, W France Orthopaedics & traumatology, surgery & research : OTSR Orthop Traumatol Surg Res. 2010 Feb;96(1):28-36.1877-0568 (Electronic)20170853Centre hospitalier intercommunal de Villeneuve-Saint-Georges, 40, allee de la source, 94195 Villeneuve-Saint-Georges cedex, France. charafazmy@hotmail.com6S1877-0517(09)00428-6 [pii] 10.1016/j.rcot.2009.12.003eng||7t'Groen, D. Gooris, G. S. Bouwstra, J. A.2010iModel membranes prepared with ceramide EOS, cholesterol and free fatty acids form a unique lamellar phase4168-75Langmuir266 2010/02/04Ceramides/*chemistry Cholesterol/*chemistry Fatty Acids, Nonesterified/*chemistry *Membranes, Artificial Molecular Conformation Spectroscopy, Fourier Transform Infrared X-Ray DiffractionMar 16JThe lipid matrix present in the human stratum corneum (the thin, uppermost layer of the skin) is considered to play a crucial role in the skin barrier function. The lipid matrix consists of ceramides, cholesterol, and free fatty acids. The 13 nm lamellar phase present in the lipid matrix of the stratum corneum is very characteristic and plays an important role in the skin barrier function. One subclass of ceramides with a linoleic acid linked to a very long acyl (referred to as EOS) plays a crucial role in the formation of the 13 nm lamellar phase. In this article, we focus on the lipid phase behavior of EOS mixed with cholesterol or with cholesterol and free fatty acids. Our studies reveal that an equimolar ratio of EOS, cholesterol, and free fatty acids forms a lamellar phase with a very long repeat distance of approximately 14.7 nm. This phase exhibits exceptional behavior in that in the thermotropic response the fatty acid chains and the ceramide chains undergo an order-disorder transition in different temperature ranges while part of the hydrocarbon chains of ceramides and fatty acids are mixing in the orthorhombic lattice. On the basis of these observations, a molecular model for the 14.7 nm phase has been proposed in which the lipids are organized in a lamellar phase with three different lipid layers in a symmetric unit cell.+http://www.ncbi.nlm.nih.gov/pubmed/20121267Groen, Daniel Gooris, Gert S Bouwstra, Joke A United States Langmuir : the ACS journal of surfaces and colloids Langmuir. 2010 Mar 16;26(6):4168-75.*1520-5827 (Electronic) 0743-7463 (Linking)20121267Division of Drug Delivery Technology, P.O. Box 9502, 2300 RA, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.10.1021/la9047038eng~F|7uKJim, M. H. Ho, H. H. Ko, R. L. Siu, C. W. Yiu, K. H. Lau, C. P. Chow, W. H.2010TPaclitaxel-Eluting Stents for Chronically Occluded Saphenous Vein Grafts (EOS) StudyJ Interv Cardiol 2010/01/15Jan 7mObjectives:The aim of this study was to report the feasibility, short- and medium-term results of percutaneous coronary intervention (PCI) on saphenous vein graft (SVG) chronic total occlusions (CTO) using paclitaxel-eluting stents (PES). Background:In postbypass patients, PCI on SVG CTO, rather than native vessel CTO, is another treatment option. However, the acute procedural and medium-term outcomes are unknown. Methods:Twenty-two consecutive, symptomatic postbypass patients underwent PCI on SVG CTO; angiographic success was seen in 16 patients (73%). The successful cases were evaluated at 1 year; restudy angiography was performed at 11 +/- 5 months in 15 patients (94%). Results:The patients had a mean age of 73 years with predominance of male (68%); the mean SVG age was 14 years. On average, patients received 3.4 PESs per lesion; the stent size was 3.5 +/- 0.4 mm with a total stent length of 98 +/- 34 mm. The use of embolic protection devices and glycoprotein IIb/ IIIa inhibitors was observed in 6 (38%) and 5 (31%) patients, respectively. The in-hospital major adverse cardiac event (MACE) was 13%, accountable by 2 patients with postprocedure myocardial infarction. At follow-up, 6 patients had angiographic restenosis (40%); there was 1 noncardiac death and 3 target vessel revascularizations. The 1-year MACE was 25%; the graft survival free of occlusion and revascularization was 56%. Conclusions:PCI on SVG CTO is a feasible approach with a fairly high success and low in-hospital complication. However, it is associated with a relatively high angiographic restenosis and MACE at 1 year. (J Interven Cardiol 2010;**:1-6).+http://www.ncbi.nlm.nih.gov/pubmed/20070476RJournal article Journal of interventional cardiology J Interv Cardiol. 2010 Jan 7.*1540-8183 (Electronic) 0896-4327 (Linking)20070476:Cardiac Medical Unit, Grantham Hospital, Hong Kong, China..JOIC525 [pii] 10.1111/j.1540-8183.2010.00525.xEng ~|7vD'Aronco, M. A.2009Ad vesice dolorem et ad eos qui urinam non faciunt (For bladder pain and when a person cannot urinate): nephrological disorders in Anglo-Saxon medicine42-9 J Nephrol 22 Suppl 14 2009/12/17zHerbal Medicine/history History, Medieval Humans Kidney Diseases/history Manuscripts, Medical/*history Nephrology/*historyNov-DecThe attitude of 19th century (and even of 20th century) scholars toward medieval and, particularly, Anglo-Saxon medicine has been of severe criticism. According to them it was filled with superstition and stupidities. However, in these last fifty years research has proved that, compared with the Continent, Anglo-Saxon England was not a backwater. At the end of the ninth century, medical compendia in Old English began to appear, similar in structure and contents to the Latin dynamidia and to the Latin herbals. These medical treatises were written in the vernacular of the Anglo-Saxons, not in Latin, the western European language for all significant and valuable works on medicine. Bladder, kidney and urinating problems are mentioned throughout the Old English medical treatises together with their cures, that is remedies from herbs and animals. These texts contain no theoretical reflections, only very concise descriptions of symptoms (pain in the bladder, in the kidneys, difficulty in urinating etc.), while prognosis is limited to affirmations such as "he will heal very quickly," "soon there will be no pain," "it will soon be healed," etc. Remedies are made basically out of a body of medicinal plants and materials which can be traced to Greek and Roman medicine. The remedies from plants reflect a wide rational and practical knowledge of medicinal herbs. As a matter of fact, not only there is no amuletic use of plants, but most of the herbs that appear in these recipes have diuretic or analgesic properties and have been in use for centuries.+http://www.ncbi.nlm.nih.gov/pubmed/20013730jD'Aronco, Maria A Historical Article Italy Journal of nephrology J Nephrol. 2009 Nov-Dec;22 Suppl 14:42-9.%1121-8428 (Print) 1121-8428 (Linking)20013730qDepartment of Germanic and Romance Languages and Literatures, University of Udine, Udine, Italy. daronco@uniud.it*6C34CB5A-255A-49DD-8D6F-43893096C288 [pii]eng||7w_Hotta, A. Cheung, A. Y. Farra, N. Garcha, K. Chang, W. Y. Pasceri, P. Stanford, W. L. Ellis, J.2009OEOS lentiviral vector selection system for human induced pluripotent stem cells1828-44 Nat Protoc412 2009/12/17Animals Biological Markers/metabolism *Cell Culture Techniques Drug Resistance/genetics Fibroblasts/cytology/virology *Genetic Vectors Green Fluorescent Proteins/analysis/metabolism Humans Induced Pluripotent Stem Cells/*cytology/virology Lentivirus/*genetics Mice Transfection/methods!Generation of induced pluripotent stem (iPS) cells from patients has exciting applications for studying molecular mechanisms of diseases, screening drugs and ultimately for use in cell therapies. However, the low efficiency and heterogeneous nature of reprogramming is a major impediment to the generation of personalized iPS cell lines. We reported in Nature Methods (6, 370-376, 2009) the first selection system to enrich for reprogrammed human iPS cells. Using a lentiviral vector that specifically expresses the enhanced green fluorescence protein and puromycin resistance genes in pluripotent stem cells, it is now possible to mark and enrich for human iPS cell colonies expressing endogenous pluripotency markers. In this study, we describe a detailed protocol for the production of the pluripotent state-specific lentiviral vector and the selection system for the induction of healthy and disease-specific human iPS cells. Overall, preparation of the selection system takes 2 weeks, and the generation of human iPS cells takes approximately 2 months.+http://www.ncbi.nlm.nih.gov/pubmed/20010937Hotta, Akitsu Cheung, Aaron Y L Farra, Natalie Garcha, Kamal Chang, Wing Y Pasceri, Peter Stanford, William L Ellis, James IG1-94505/Canadian Institutes of Health Research/Canada MOP-186015/Canadian Institutes of Health Research/Canada MOP-81129/Canadian Institutes of Health Research/Canada RMF-92090/Canadian Institutes of Health Research/Canada Research Support, Non-U.S. Gov't England Nature protocols Nat Protoc. 2009;4(12):1828-44. Epub .*1750-2799 (Electronic) 1750-2799 (Linking)20010937PDevelopmental and Stem Cell Biology Program, SickKids, Toronto, Ontario, Canada.+nprot.2009.201 [pii] 10.1038/nprot.2009.201eng ||7xCKessner, D. Brezesinski, G. Funari, S. S. Dobner, B. Neubert, R. H.2010Impact of the long chain omega-acylceramides on the stratum corneum lipid nanostructure. Part 1: Thermotropic phase behaviour of CER[EOS] and CER[EOP] studied using X-ray powder diffraction and FT-Raman spectroscopy42-50Chem Phys Lipids1631 2009/11/11Ceramides/*chemistry Lipids/*chemistry Nanostructures/*chemistry Skin/*chemistry Spectrum Analysis, Raman Temperature X-Ray DiffractionJanThe stratum corneum (SC), the outermost layer of the mammalian skin, is the main skin barrier. Ceramides (CERs) as the major constituent of the SC lipid matrix are of particular interest. At the moment, 11 classes of CERs are identified, but the effect of each single ceramide species is still not known. Therefore in this article, the thermotropic behaviour of the long chain omega-acylceramides CER[EOS] and CER[EOP] was studied using X-ray powder diffraction and FT-Raman spectroscopy. It was found that the omega-acylceramides CER[EOS] and CER[EOP] do not show a pronounced polymorphism which is observed for shorter chain ceramides as a significant feature. The phase behaviour of both ceramides is strongly influenced by the extremely long acyl-chain residue. The latter has a much stronger influence compared with the structure of the polar head group, which is discussed as extremely important for the appearance of a rich polymorphism. Despite the strong influence of the long chain, the additional OH-group of the phyto-sphingosine type CER[EOP] influences the lamellar repeat distance and the chain packing. The less polar sphingosine type CER[EOS] is stronger influenced by the long acyl-chain residue. Hydration is necessary for the formation of an extended hydrogen-bonding network between the polar head groups leading to the appearance of a long-periodicity phase (LPP). In contrast, the more polar CER[EOP] forms the LPP with densely packed alkyl chains already in the dry state.+http://www.ncbi.nlm.nih.gov/pubmed/19900430Kessner, Doreen Brezesinski, Gerald Funari, Sergio S Dobner, Bodo Neubert, Reinhard H H Research Support, Non-U.S. Gov't Ireland Chemistry and physics of lipids Chem Phys Lipids. 2010 Jan;163(1):42-50. Epub .*1873-2941 (Electronic) 0009-3084 (Linking)19900430eInstitute of Pharmacy, Martin-Luther-University, Wolfgang-Langenbeck-Strasse 4, 06120 Halle, Germany.=S0009-3084(09)00345-4 [pii] 10.1016/j.chemphyslip.2009.10.007eng ||7y-Ohl, X. Stanchina, C. Billuart, F. Skalli, W.2010iShoulder bony landmarks location using the EOS low-dose stereoradiography system: a reproducibility study153-8Surg Radiol Anat322 2009/10/07Adult Female Humans Imaging, Three-Dimensional/*instrumentation Male Observer Variation Radiography/instrumentation Reference Values Reproducibility of Results Shoulder Joint/*radiography Software Young AdultFeb9PURPOSE: To investigate the reproducibility of shoulder bony landmarks location using the EOS low-dose stereoradiography system, in order to validate this new tool for the study of gleno-humeral pseudo-kinematics. METHODS: An inter and intraobserver reproducibility study of shoulder bony landmarks location concerning 22 healthy volunteers. This study concerned the neutral position, arm at rest. Humerus and scapula were modeled with simple geometric shapes using specific software. Those shapes were positioned on A-P and lateral x-rays views. Images analysis of the 22 subjects was carried out three times (n(r) = 3), by two observers (n(o) = 2), for a total of n(tot) = 132 analyses. RESULTS: We obtained a very good reproducibility for the humeral head center and the diaphysis axis with 95% confidence interval (IC95%) inferior to 1.09 mm and 0.41 degrees, respectively. The uncertainty was higher for the lateral and medial epicondyles. Regarding the scapular bony landmarks, we observed a good reproducibility for the tip of the coracoid process, the inferior glenoid rim, and the axillar border with a 95% confidence interval lower than 2.13, 2.91 mm, and 3.67 degrees, respectively. The uncertainty was higher for the most postero-lateral point of the acromion and the superior glenoid rim. CONCLUSION: Our analysis of the x-rays obtained with the EOS low-dose stereoradiography system assessed the location reliability and reproducibility of specific scapular and humeral bony landmarks. This work opens the way to gleno-humeral pseudo-kinematics analysis using EOS imaging system.+http://www.ncbi.nlm.nih.gov/pubmed/19806289Ohl, Xavier Stanchina, Claire Billuart, Fabien Skalli, Wafa Validation Studies Germany Surgical and radiologic anatomy : SRA Surg Radiol Anat. 2010 Feb;32(2):153-8. Epub 2009 Oct 6.*1279-8517 (Electronic) 0930-1038 (Linking)19806289Ecole Nationale Superieure d'Arts et Metiers, Laboratoire de Biomecanique, 151 Boulevard de l'Hopital, 75013, Paris, France. xohl@hotmail.com10.1007/s00276-009-0566-zeng |t7zPan, F. Yu, H. Dang, E. V. Barbi, J. Pan, X. Grosso, J. F. Jinasena, D. Sharma, S. M. McCadden, E. M. Getnet, D. Drake, C. G. Liu, J. O. Ostrowski, M. C. Pardoll, D. M.2009FEos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells1142-6Science3255944 2009/08/22JAcetylation Alcohol Oxidoreductases/metabolism Animals Carrier Proteins/genetics/*metabolism Colitis/immunology DNA Methylation DNA-Binding Proteins/metabolism Forkhead Transcription Factors/*metabolism Gene Knockdown Techniques *Gene Silencing Histones/metabolism Humans Interleukin-2/biosynthesis/genetics Jurkat Cells Methylation Mice Mice, Inbred BALB C Mice, Inbred C57BL Nerve Tissue Proteins/genetics/*metabolism Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic RNA Interference T-Lymphocytes, Regulatory/immunology/*physiology Transduction, Genetic Zinc FingersAug 28CD4+ regulatory T cells (Tregs) maintain immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses. The core genetic program of Tregs and their ability to suppress pathologic immune responses depends on the transcription factor Foxp3. Despite progress in understanding mechanisms of Foxp3-dependent gene activation, the molecular mechanism of Foxp3-dependent gene repression remains largely unknown. We identified Eos, a zinc-finger transcription factor of the Ikaros family, as a critical mediator of Foxp3-dependent gene silencing in Tregs. Eos interacts directly with Foxp3 and induces chromatin modifications that result in gene silencing in Tregs. Silencing of Eos in Tregs abrogates their ability to suppress immune responses and endows them with partial effector function, thus demonstrating the critical role that Eos plays in Treg programming.+http://www.ncbi.nlm.nih.gov/pubmed/19696312Pan, Fan Yu, Hong Dang, Eric V Barbi, Joseph Pan, Xiaoyu Grosso, Joseph F Jinasena, Dinili Sharma, Sudarshana M McCadden, Erin M Getnet, Derese Drake, Charles G Liu, Jun O Ostrowski, Michael C Pardoll, Drew M R01 AI058156-05/AI/NIAID NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Science (New York, N.Y.) Science. 2009 Aug 28;325(5944):1142-6. Epub 2009 Aug 20.*1095-9203 (Electronic) 0036-8075 (Linking)285970319696312Immunology and Hematopoiesis Division, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.%1176077 [pii] 10.1126/science.1176077eng [|t7{JSchroter, A. Kessner, D. Kiselev, M. A. Hauss, T. Dante, S. Neubert, R. H.2009tBasic nanostructure of stratum corneum lipid matrices based on ceramides [EOS] and [AP]: a neutron diffraction study1104-14 Biophys J974 2009/08/19Animals Biomimetic Materials/*chemistry Ceramides/*chemistry Epidermis Humans Lipids/*chemistry *Membranes, Artificial Molecular Conformation Nanostructures/*chemistry/*ultrastructure Neutron DiffractionAug 19{The goal of this study was to investigate the nanostructure of SC lipid model membranes comprising the most relevant SC lipids such as the unique-structured omega-acylceramide [EOS] in a near natural ratio with neutron diffraction. In models proposed recently the presence of ceramide [EOS] and FFA are necessary for the formation of one of the two existent crystalline lamellar phases of the SC lipids, the long-periodicity phase as well as for the normal barrier function of the SC. The focus of this study was placed on the influence of the FFA BA on the membrane structure and its localization within the membrane based on the ceramides [EOS] and [AP]. The internal nanostructure of such membranes was obtained by Fourier synthesis from the experimental diffraction patterns. The resulting neutron scattering length density profiles showed that the exceptionally long ceramide [EOS] is arranged in a short-periodicity phase created by ceramide [AP] by spanning through the whole bilayer and extending even further into the adjacent bilayer. Specifically deuterated BA allowed us to determine the exact position of this FFA inside this SC lipid model membrane. Furthermore, hydration experiments showed that the presented SC mimic system shows an extremely small intermembrane hydration of approximately 1 A, consequently the headgroups of the neighboring leaflets are positioned close to each other.+http://www.ncbi.nlm.nih.gov/pubmed/19686658Schroter, Annett Kessner, Doreen Kiselev, Mikhail A Hauss, Thomas Dante, Silva Neubert, Reinhard H H Research Support, Non-U.S. Gov't United States Biophysical journal Biophys J. 2009 Aug 19;97(4):1104-14.*1542-0086 (Electronic) 0006-3495 (Linking)272632019686658Martin Luther Universitat Halle-Wittenberg, Institute of Pharmacy, Halle (Saale), Germany. annett.ruettinger@pharmazie.uni-halle.de5S0006-3495(09)01049-2 [pii] 10.1016/j.bpj.2009.05.041eng ||7|Hotta, A. Cheung, A. Y. Farra, N. Vijayaragavan, K. Seguin, C. A. Draper, J. S. Pasceri, P. Maksakova, I. A. Mager, D. L. Rossant, J. Bhatia, M. Ellis, J.2009TIsolation of human iPS cells using EOS lentiviral vectors to select for pluripotency370-6 Nat Methods65 2009/05/01mAnimals Cell Dedifferentiation/*genetics Cell Differentiation/drug effects Cell Separation/*methods DNA Transposable Elements/genetics Embryo, Mammalian/cytology Embryonic Stem Cells/cytology/metabolism Enhancer Elements, Genetic/genetics Fibroblasts/cytology/metabolism Genes, Reporter/*genetics Genetic Vectors/*genetics Green Fluorescent Proteins/genetics/metabolism Humans Lentivirus/*genetics Methyl-CpG-Binding Protein 2/genetics Mice Mice, Inbred NOD Mice, Mutant Strains Mice, SCID Pluripotent Stem Cells/*cytology/*metabolism Promoter Regions, Genetic/genetics Rett Syndrome/genetics/pathology Teratoma/pathologyMayInduced pluripotent stem (iPS) cells may be of use in regenerative medicine. However, the low efficiency of reprogramming is a major impediment to the generation of patient-specific iPS cell lines. Here we report the first selection system for the isolation of human iPS cells. We developed the EOS (Early Transposon promoter and Oct-4 (Pou5f1) and Sox2 enhancers) lentiviral vector to specifically express in mouse and human embryonic stem cells but not in primary fibroblasts. The bicistronic EOS vector marked emerging mouse and human iPS cell colonies with EGFP, and we used puromycin selection to aid the isolation of iPS cell lines that expressed endogenous pluripotency markers. These lines differentiated into cell types from all three germ layers. Reporter expression was extinguished upon differentiation and therefore monitored the residual pluripotent cells that form teratomas. Finally, we used EOS selection to establish Rett syndrome-specific mouse and human iPS cell lines with known mutations in MECP2.+http://www.ncbi.nlm.nih.gov/pubmed/194042549Hotta, Akitsu Cheung, Aaron Y L Farra, Natalie Vijayaragavan, Kausalia Seguin, Cheryle A Draper, Jonathan S Pasceri, Peter Maksakova, Irina A Mager, Dixie L Rossant, Janet Bhatia, Mickie Ellis, James Research Support, Non-U.S. Gov't United States Nature methods Nat Methods. 2009 May;6(5):370-6. Epub 2009 Apr 26.*1548-7105 (Electronic) 1548-7091 (Linking)19404254FDevelopmental and Stem Cell Biology Program, Toronto, Ontario, Canada.#nmeth.1325 [pii] 10.1038/nmeth.1325engy||7}8Dupuch, A. Magnan, P. Bertolo, A. Dill, L. M. Proulx, M.2009mDoes predation risk influence habitat use by northern redbelly dace Phoxinus eos at different spatial scales?1371-82 J Fish Biol747 2009/05/01MayThis study investigated the relationship between spatial variations in predation risk and abundance of northern redbelly dace Phoxinus eos at both macroscale (littoral v. pelagic zones) and microscale (structured v. open water habitats in the littoral zone) of Canadian Shield lakes. Minnow traps were placed in both structured and open water habitats in the littoral zone of 13 Canadian Shield lakes, and estimates of the relative predation risk of P. eos in both the pelagic and the littoral zones were obtained from tethering experiments. Results showed that (1) the mean abundance of P. eos in the littoral zone was positively correlated with the relative predation risk in the pelagic zone, (2) P. eos preferentially used structured over open water habitats in the littoral zone and (3) this preference was not related to the relative predation risk in the littoral zone but decreased as the relative predation risk increased in the pelagic zone. At the lake level, these results support the hypothesis that P. eos enter the littoral zone to avoid pelagic piscivores. At the littoral zone level, the results do not necessarily contradict the widely accepted view that P. eos preferentially use structured over open habitats to reduce their predation risk, but suggest that flexibility in antipredator tactics (e.g. shelter use v. shoaling) could explain the spatial distribution of P. eos between structured and open water habitats.+http://www.ncbi.nlm.nih.gov/pubmed/20735640Dupuch, A Magnan, P Bertolo, A Dill, L M Proulx, M Research Support, Non-U.S. Gov't England Journal of fish biology J Fish Biol. 2009 May;74(7):1371-82.*1095-8649 (Electronic) 0022-1112 (Linking)20735640Groupe de Recherche sur les Ecosystemes Aquatiques, Departement de chimie-biologie, Universite du Quebec a Trois-Rivieres, C.P. 500, Trois-Rivieres (Quebec), G9A 5H7 Canada..JFB2183 [pii] 10.1111/j.1095-8649.2009.02183.xeng||7~JSchlatterer, B. Suedhoff, I. Bonnet, X. Catonne, Y. Maestro, M. Skalli, W.2009kSkeletal landmarks for TKR implantations: evaluation of their accuracy using EOS imaging acquisition system2-11Orthop Traumatol Surg Res951 2009/03/03MArthroplasty, Replacement, Knee/*methods Biomechanics Femur/anatomy & histology Humans Knee Joint/anatomy & histology/*radiography Male Observer Variation Radiographic Image Interpretation, Computer-Assisted/*instrumentation/methods Stereotaxic Techniques/instrumentation Surgery, Computer-Assisted/*methods Tibia/anatomy & histologyFeb?INTRODUCTION: Lower extremity alignment remains one essential objective during total knee replacement. Implants positioning analysis requires selecting reliable skeletal landmarks. Our objective was to in vivo evaluate the precision of the implemented skeletal landmarks. This evaluation was based on multiple three-dimensional (3D) computer reconstructions of the lower extremity derived from an EOS biplanar low-dose X-ray system acquisition. A 3D angle measurement protocol was used. HYPOTHESIS: Currently defined landmarks carry a tolerable uncertainty margin, which can still probably be further improved. MATERIAL AND METHODS: Nine lower extremity 3D computer reconstructions were obtained from an EOS protocol based on seven simultaneous A-P and lateral views performed in standing position. A database was established by four operators; finally, building up a total of 99 in vivo 3D reconstructions of these nine lower extremities. Specific algorithms were used for such 3D reconstructions of lower extremities based on bone points and pre-identified contours on X-ray. Four femoral landmarks and four tibial landmarks were thus defined. For each bone and each landmark studied, a mean landmark for the 11 consecutive series elements was established. The deviation from each constructed landmark to the corresponding mean landmark was calculated based on the anteroposterior (x), longitudinal (y) and mediolateral axes (z), in translation (Tx, Ty, Tz) and in rotation (Rx, Ry, Rz). Uncertainty was estimated by the 95% confidence interval (95% CI). RESULTS: The landmarks located at the middle of the segment joining the center of each posterior condyle and at the barycenter of the plateaux showed a greater reliability; these landmarks uncertainty (95% CI) of Tx, Ty, Tz was less than 1, 0.5, 1.5 mm for the femur and 1.5, 0.6, 0.6 mm for the tibia, respectively. The femoral landmarks using the center or posterior edge of the posterior condyles to define the mediolateral axis were retained; for rotations Rx, Ry, and Rz, uncertainty remained less than 0.3, 4, and 0.5 degrees. All of the tibial landmarks had a comparable reliability in rotation, 95% of the Rx and Rz deviations were under 0.5 and 1.3 degrees, respectively, with a mean error less than 1 degrees . For the tibial rotation Ry, the mean error was greater (4 degrees), with uncertainty (95% CI) at 11.2 degrees. All tibial translations showed a mean error of 1 mm. The 3D implantation angles were measured on two patients using preoperative 3D skeletal reconstructions and 3D geometric models of the implants repositioned on postoperative EOS knee X-rays. DISCUSSION: The posterior condyles are rarely involved in the arthritic wear process, making them an anatomic landmark of choice in the analysis of the femoral component positioning. The femoral landmarks using the posterior condyles were sufficiently reliable for clinical use. However, the posterior contours of the tibial plateaux were less precise. The knees should be staggered from an anteroposterior perspective on the EOS lateral images so that they can be visualized separately. The anatomic zones on which the skeletal landmarks are based are usually removed by the bone cuts, making it preferable to save the preoperative computer reconstructions to analyze the postimplantation 3D reconstruction. CONCLUSION: The lower extremity skeletal landmarks precision relates to the quality of the corresponding 3D reconstructions. Except for tibial rotation, all the translation and rotation parameters were estimated within a mean error margin inferior to 1.2 mm and 1.3 degrees, respectively. Making the reconstruction algorithms more robust would render certain anatomic zones even more precise. Biplanar low-dose EOS X-ray system is a tool of the future to generate 3D knee X-rays that can improve the evaluation and follow-up of total knee arthroplasty patients.+http://www.ncbi.nlm.nih.gov/pubmed/19251231Schlatterer, B Suedhoff, I Bonnet, X Catonne, Y Maestro, M Skalli, W Evaluation Studies France Orthopaedics & traumatology, surgery & research : OTSR Orthop Traumatol Surg Res. 2009 Feb;95(1):2-11. Epub 2009 Feb 3.1877-0568 (Electronic)19251231wMonaco Sportsmedicine and Surgery Institute, 11, avenue d'Ostende, 98000 Monaco, Monaco. bernard.schlatterer@wanadoo.fr6S1877-0568(08)00010-8 [pii] 10.1016/j.otsr.2008.05.001eng .||7GSapin, E. Briot, K. Kolta, S. Gravel, P. Skalli, W. Roux, C. Mitton, D.2008XBone mineral density assessment using the EOS low-dose X-ray device: a feasibility study1263-71Proc Inst Mech Eng H2228 2009/01/16Absorptiometry, Photon/*instrumentation Bone Density/*physiology Equipment Design *Equipment Failure Analysis Feasibility Studies Humans Radiation Dosage Reproducibility of Results Sensitivity and Specificity Spine/*physiology/*radiographyNovTo predict bone strength in the case of osteoporosis, it could be a real benefit to assess the three-dimensional (3D) geometry and the bone mineral density (BMD) with a single low-dose X-ray device, such as the EOS system (Biospace Med, Paris, France). EOS 3D reconstructions of the spine have already been validated. Thus, this study aims at evaluating the accuracy of this low-dose system as a densitometer first ex vivo. The European Spine Phantom (ESP) (number 129) was scanned ten times using both the EOS and a Hologic device (Hologic, Inc., Massachusetts, USA). Accuracy was given by the sum of the systematic error (difference between BMDs assessed and true values given by the phantom manufacturer) and the random error (coefficient of variation). EOS BMDs and Hologic BMDs of 41 ex-vivo vertebrae were calculated and compared. The reproducibility of the method evaluating the EOS BMD was assessed giving the coefficient of variation of three measurements of the 41 vertebrae. The accuracy of the EOS system is below 5.2 per cent, versus 7.2 per cent for the Hologic system in the same conditions. EOS BMDs are significantly higher than Hologic BMDs, but they are strongly correlated. The reproducibility of the method of assessment is equal to 0.95 per cent. The EOS system is accurate for ex-vivo BMD assessments, which is promising regarding the use of this new system to predict vertebral strength.+http://www.ncbi.nlm.nih.gov/pubmed/19143419Sapin, E Briot, K Kolta, S Gravel, P Skalli, W Roux, C Mitton, D Evaluation Studies England Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine Proc Inst Mech Eng H. 2008 Nov;222(8):1263-71.%0954-4119 (Print) 0954-4119 (Linking)19143419gLaboratoire de Biomecanique, LBM, Arts et Metier ParisTech, CNRS, Paris, France. emilie.sapin@gmail.comeng||7#Presser, V. Heiss, M. Nickel, K. G.2008>EOS calculations for hydrothermal diamond anvil cell operation085104Rev Sci Instrum798 2008/12/03AugpThe hydrothermal diamond anvil cell (HDAC) is an excellent tool for high-temperature, high-pressure (hydrothermal) experiments. For an accurate determination of pressure induced by a certain temperature in an isochoric sample chamber volume, an equation of state (EOS) of water can be used instead of direct measurement. This paper reviews the theoretic background and provides all needed equations for the application of EOS of water to HDAC experiments summarizing state-of-the-art knowledge and incorporating up-to-date thermodynamic data. The p-T conditions determined using the IAPWS-95 formulation for the thermodynamic properties of ordinary water are in agreement with values obtained from direct methods or other established EOS formulations. In particular, (1) the calculation of density through the (a) melting point or (b) homogenization method along with determining (2) pressure as a function of density and temperature or (3) density as a function of pressure and temperature is explained. As a new aspect in the context of HDAC operations, the critical influence of nucleation and a strategy to overcome this problem are discussed. Furthermore, we have derived new polynomial equations, which allow the direct calculation of the fluid phase's density from the melting temperature. These are implemented in a spreadsheet program, which is freely available for interested users.+http://www.ncbi.nlm.nih.gov/pubmed/19044377Presser, Volker Heiss, Martin Nickel, Klaus G United States The Review of scientific instruments Rev Sci Instrum. 2008 Aug;79(8):085104.*1089-7623 (Electronic) 0034-6748 (Linking)19044377Institute for Geoscience, Applied Mineralogy, Eberhard-Karls-Universitat Tubingen, D-72074 Tubingen, Germany. volker.presser@uni-tuebingen.de10.1063/1.2965210engd||7GDubousset, J. Charpak, G. Skalli, W. de Guise, J. Kalifa, G. Wicart, P.2008-[Skeletal and spinal imaging with EOS system]665-6 Arch Pediatr155 2008/06/28Child Funnel Chest/radiography/*surgery Humans Retrospective Studies Surgical Procedures, Minimally Invasive/*methods Treatment OutcomeJun+http://www.ncbi.nlm.nih.gov/pubmed/18582707Dubousset, J Charpak, G Skalli, W de Guise, J Kalifa, G Wicart, P France Archives de pediatrie : organe officiel de la Societe francaise de pediatrie Arch Pediatr. 2008 Jun;15(5):665-6.%0929-693X (Print) 0929-693X (Linking)18582707;Modelisation vertebrale et squelettique par le systeme EOS.{Academie Nationale de Medecine, 16 rue Bonaparte, Paris 75272 cedex 06. jeandubousset@wanadoo.fr 9S0929-693X(08)71868-2 [pii] 10.1016/S0929-693X(08)71868-2fre ||7Fiedler, J. L. Chuko, T.2008ZThe cost of Child Health Days: a case study of Ethiopia's Enhanced Outreach Strategy (EOS)222-33Health Policy Plan234 2008/06/20Anthelmintics/supply & distribution Bedding and Linens/supply & distribution Child Child Health Services/*economics Cost Allocation Ethiopia Health Care Costs/*statistics & numerical data Health Priorities Health Status Indicators Humans Immunization Programs/economics Measles/economics/prevention & control Organizational Case Studies Preventive Health Services/*economics Program Evaluation Quality-Adjusted Life Years Regional Health Planning/*economics Value of Life/economics Vitamin A/supply & distributionJulChild Health Days (CHDs) are twice-annual campaign-style events designed to increase the coverage of vitamin A and one or more other child health services. Although more than two dozen countries have had a CHD, little has been published about them. This paper presents an activity-based costing study of Ethiopia's version of CHDs, the Enhanced Outreach Strategy (EOS). The December 2006 round reached more than 10 million beneficiaries at an average cost per beneficiary of US$0.56. When measles is added, the cost of the package doubles. Given the way the distribution day delivery system and the service package are structured, there are economies of scope. Because most of the costs are determined by the number of delivery sites and are independent of the number of beneficiaries, other things equal, increasing the beneficiaries would reduce the average cost per beneficiary. Taking into account only the mortality impact of vitamin A, EOS saved 20,200 lives and averted 230,000 DALYs of children 6-59 months. The average cost per life saved was US$228 and the cost per DALY averted was equivalent to 6% of per capita GDP (US$9), making the EOS cost-effective, according to WHO criteria. While CHDs are generally construed as a temporary strategy for improving coverage of supply-constrained systems, inadequate attention has been paid to demand-side considerations that suggest CHDs have an important role to play in changing care-seeking behaviour, in increasing community organization and participation, and in promoting district autonomy and capacity. Recognition of these effects suggests the need for decisions about where and when to introduce, and when to end, a CHD to take into account more than 'just' health sector considerations: they are more broadly about community development. UNICEF played a key role in initiating the EOS and finances 68% of costs, raising concern about the programme's long-term sustainability.+http://www.ncbi.nlm.nih.gov/pubmed/18562457Fiedler, John L Chuko, Tesfaye Evaluation Studies Research Support, Non-U.S. Gov't England Health policy and planning Health Policy Plan. 2008 Jul;23(4):222-33.%0268-1080 (Print) 0268-1080 (Linking)18562457ISocial Sectors Development Strategies, Boston, MA, USA. jfiedler@ssds.net"czn015 [pii] 10.1093/heapol/czn015eng ||7RKessner, D. Kiselev, M. Dante, S. Hauss, T. Lersch, P. Wartewig, S. Neubert, R. H.2008zArrangement of ceramide [EOS] in a stratum corneum lipid model matrix: new aspects revealed by neutron diffraction studies989-99 Eur Biophys J376 2008/04/23Animals Ceramides/*chemistry Humans Lipid Bilayers/*chemistry Lipids/*chemistry Molecular Conformation Neutron Diffraction/*methods Skin/*chemistryJul^The lipid matrix in stratum corneum (SC) plays a key role in the barrier function of the mammalian skin. The major lipids are ceramides (CER), cholesterol (CHOL) and free fatty acids (FFA). Especially the unique-structured omega-acylceramide CER[EOS] is regarded to be essential for skin barrier properties by inducing the formation of a long-periodicity phase of 130 angstroms (LPP). In the present study, the arrangement of CER[EOS], either mixed with CER[AP] and CHOL or with CER[AP], CHOL and palmitic acid (PA), inside a SC lipid model membrane has been studied for the first time by neutron diffraction. For a mixed CER[EOS]/CER[AP]/CHOL membrane in a partly dehydrated state, the internal membrane nanostructure, i.e. the neutron scattering length density profile in the direction normal to the surface, was obtained by Fourier synthesis from the experimental diffraction patterns. The membrane repeat distance is equal to that of the formerly used SC lipid model system composed of CER[AP]/CHOL/PA/ChS. By comparing both the neutron scattering length density profiles, a possible arrangement of synthetic long-chain CER[EOS] molecules inside a SC lipid model matrix is suggested. The analysis of the internal membrane nanostructure implies that one CER[EOS] molecule penetrates from one membrane layer into an adjacent layer. A 130 angstroms periodicity phase could not be observed under experimental conditions, either in CER/CHOL mixtures or in CER/CHOL/FFA mixture. CER[EOS] can be arranged inside a phase with a repeat unit of 45.2 angstroms which is predominately formed by short-chain CER[AP] with distinct polarity.+http://www.ncbi.nlm.nih.gov/pubmed/18427800Kessner, Doreen Kiselev, Mikhail Dante, Silvia Hauss, Thomas Lersch, Peter Wartewig, Siegfried Neubert, Reinhard H H Research Support, Non-U.S. Gov't Germany European biophysics journal : EBJ Eur Biophys J. 2008 Jul;37(6):989-99. Epub 2008 Apr 22.%0175-7571 (Print) 0175-7571 (Linking)18427800|Institute of Pharmacy, Martin Luther University Halle/Wittenberg, Wolfgang-Langenbeck-Strabe 4, 06120, Halle Saale, Germany.10.1007/s00249-008-0328-6eng||7?Dubousset, J. Charpak, G. Skalli, W. Kalifa, G. Lazennec, J. Y.2007}[EOS stereo-radiography system: whole-body simultaneous anteroposterior and lateral radiographs with very low radiation dose]141-3%Rev Chir Orthop Reparatrice Appar Mot936 Suppl 2007/12/06Humans Imaging, Three-Dimensional/*instrumentation Musculoskeletal Diseases/diagnosis/*radiography Musculoskeletal System/*radiography Posture Radiation Dosage Reproducibility of ResultsOct+http://www.ncbi.nlm.nih.gov/pubmed/18033112Dubousset, J Charpak, G Skalli, W Kalifa, G Lazennec, J-Y Congresses France Revue de chirurgie orthopedique et reparatrice de l'appareil moteur Rev Chir Orthop Reparatrice Appar Mot. 2007 Oct;93(6 Suppl):141-3.%0035-1040 (Print) 0035-1040 (Linking)18033112nSysteme EOS: la radiographie de la tete aux pieds face et profil simultanes a tres basses doses de radiations.RHopital Saint-Vincent-de-Paul, 74, Avenue Denfert-Rochereau, 75014, Paris, France.7MDOI-RCO-10-2007-93-S6-0035-1040-101019-200520011 [pii]fre ||7JRousseau, M. A. Laporte, S. Chavary-Bernier, E. Lazennec, J. Y. Skalli, W.2007Reproducibility of measuring the shape and three-dimensional position of cervical vertebrae in upright position using the EOS stereoradiography system2569-72Spine (Phila Pa 1976)3223 2007/11/06Adult Cervical Vertebrae/anatomy & histology/*radiography Humans Imaging, Three-Dimensional/*instrumentation Male Observer Variation Posture Radiography/instrumentation Reference Values Reproducibility of ResultsNov 1STUDY DESIGN: An interobserver and intraobserver reproducibility study of the use of EOS stereoradiography system at the cervical spine. OBJECTIVE: To investigate reproducibility of the determination of the vertebral shape, position, and orientation of C3-C7 vertebrae in vivo using the EOS stereoradiography system. SUMMARY OF BACKGROUND DATA: Since CT and MRI 3-dimensional (3D) analysis of the spinal architecture are done in supine position, measurements of the relative position of the cervical vertebrae in vivo in standing position requires stereoradiography. The innovative EOS system is an accurate and promising tool for stereoradiography. Its reproducibility at the cervical spine had to be assessed. METHODS: Twenty volunteers had biplanar radiographs of the cervical spine. C3-C7 were reconstructed by 2 observers, 2 times each. Each reconstruction was compared with the corresponding average object in term of shape (point-to-surface distance) and position (Tx, Ty, Tz, Rx, Ry, Rz in a local screw-frame). RESULTS: The 95% confidence interval of the error in shape was 1.83 mm. It was 0.84 mm, 1.42 mm, 0.58 mm, 2.53 degrees, 2.34 degrees, and 3.24 degrees for the position in Tx, Ty, Tz, Rx, Ry, and Rz. Intraobserver differences were not significant. Interobserver differences were significant for the shape and in Tx, Rx, and Ry (0.9 mm, 0.54 mm, 0.33 degrees, and 0.28 degrees). CONCLUSION: Overall reproducibility favorably compared with other imaging methods, whereas significant interobserver disagreements were narrow and partial.+http://www.ncbi.nlm.nih.gov/pubmed/17978655Rousseau, Marc-Antoine Laporte, Sebastien Chavary-Bernier, Estelle Lazennec, Jean-Yves Skalli, W Evaluation Studies United States Spine Spine (Phila Pa 1976). 2007 Nov 1;32(23):2569-72.*1528-1159 (Electronic) 0362-2436 (Linking)17978655oBiomechanics Lab-Ecole Nationale Superieure d'Arts et Metiers, Paris, France. marc-antoine.rousseau@psl.aphp.fr;10.1097/BRS.0b013e318158cba2 00007632-200711010-00009 [pii]eng 1||7Angers, B. Schlosser, I. J.20075The origin of Phoxinus eos-neogaeus unisexual hybrids4562-71Mol Ecol1621 2007/09/26Animals Cyprinidae/*classification/genetics/physiology DNA, Mitochondrial/chemistry Haplotypes *Hybridization, Genetic Microsatellite Repeats Minnesota Montana Nebraska Parthenogenesis *Phylogeny Quebec Sequence Analysis, DNANovPhoxinus eos-neogaeus unisexual hybrids (Cyprinidae, Pisces) are among the few vertebrate taxa known to reproduce clonally by gynogenesis. These taxa have a broad distribution in North America, mostly located in regions previously covered by the last Pleistocene ice sheet. To assess whether asexual hybrids dispersed from glacial refuges at the end of the Pleistocene or they originated from current hybridization events, genetic diversity of mitochondrial DNA (mtDNA) sequences and microsatellite loci was determined in populations from 16 different sites in the Mississippi-Missouri River (Nebraska and Montana), Rainy River-Hudson Bay (Minnesota), and St Lawrence River (Quebec) drainages. The maternal species (P. neogaeus) occurred in Minnesota and Nebraska but was absent from Montana sites and was restricted to only two of 11 lakes sampled in Quebec, although hybrids were present at all sites. The genetic survey revealed a total of 49 clones, originating from 14 hybridization events. Several of the lineages were characterized by mtDNA haplotypes not detected in the maternal ancestor. Lineages as well as clones frequently displayed a large geographical distribution at a regional scale. Dating of hybridization events suggested a relatively recent origin (<50,000 years ago) from the Mississippi glacial refuge, even in regions not covered by the last Pleistocene glacier. Altogether, these results indicate P. eos-neogaeus hybrids are not the result of current hybridization events, but display a pattern predicted by postglacial dispersal. Our findings have considerable implications for the nature of selection processes affecting the diversity of these asexual taxa and their coexistence with sexual ancestors.+http://www.ncbi.nlm.nih.gov/pubmed/17892466Angers, Bernard Schlosser, Isaac J Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England Molecular ecology Mol Ecol. 2007 Nov;16(21):4562-71. Epub 2007 Sep 24.%0962-1083 (Print) 0962-1083 (Linking)17892466Department of Biological Sciences, Universite de Montreal, C.P. 6128, succ. Centre-ville, Montreal, Quebec, Canada H3C 3J7. bernard.angers@umontreal.ca.MEC3511 [pii] 10.1111/j.1365-294X.2007.03511.xeng||7'Saddichha, S. Manjunatha, N. Akhtar, S.2007.Diagnostic confusion - EOS or frontal dementia77-8, author reply 78Acta Psychiatr Scand1161 2007/06/15Adolescent Age Factors Child Cognition Disorders/diagnosis Dementia/*diagnosis/epidemiology/*physiopathology Diagnosis, Differential Frontal Lobe/*physiopathology Humans Schizophrenia/diagnosis/epidemiologyJul+http://www.ncbi.nlm.nih.gov/pubmed/17559606Saddichha, Sahoo Manjunatha, N Akhtar, Sayeed Comment Letter Denmark Acta psychiatrica Scandinavica Acta Psychiatr Scand. 2007 Jul;116(1):77-8, author reply 78.%0001-690X (Print) 0001-690X (Linking)17559606.ACP1039 [pii] 10.1111/j.1600-0447.2007.01039.xeng |t7KHu, R. Sharma, S. M. Bronisz, A. Srinivasan, R. Sankar, U. Ostrowski, M. C.2007fEos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors4018-27 Mol Cell Biol2711 2007/04/04Acid Phosphatase/genetics/metabolism Animals Carrier Proteins/genetics/*metabolism Cathepsin K Cathepsins/genetics/metabolism Cell Differentiation/physiology *Gene Expression Regulation, Developmental Humans Isoenzymes/genetics/metabolism Mice Microphthalmia-Associated Transcription Factor/genetics/*metabolism Myeloid Progenitor Cells/cytology/*physiology NIH 3T3 Cells Nerve Tissue Proteins/genetics/*metabolism Osteoclasts/*physiology Promoter Regions, Genetic Proto-Oncogene Proteins/genetics/*metabolism RANK Ligand/genetics/metabolism RNA, Small Interfering/metabolism Repressor Proteins/genetics/metabolism Signal Transduction/physiology Trans-Activators/genetics/*metabolism Zinc FingersJun`Transcription factors MITF and PU.1 collaborate to increase expression of target genes like cathepsin K (Ctsk) and acid phosphatase 5 (Acp5) during osteoclast differentiation. We show that these factors can also repress transcription of target genes in committed myeloid precursors capable of forming either macrophages or osteoclasts. The direct interaction of MITF and PU.1 with the zinc finger protein Eos, an Ikaros family member, was necessary for repression of Ctsk and Acp5. Eos formed a complex with MITF and PU.1 at target gene promoters and suppressed transcription through recruitment of corepressors CtBP (C-terminal binding protein) and Sin3A, but during osteoclast differentiation, Eos association with Ctsk and Acp5 promoters was significantly decreased. Subsequently, MITF and PU.1 recruited coactivators to these target genes, resulting in robust expression of target genes. Overexpression of Eos in bone marrow-derived precursors disrupted osteoclast differentiation and selectively repressed transcription of MITF/PU.1 targets, while small interfering RNA knockdown of Eos resulted in increased basal expression of Ctsk and Acp5. This work provides a mechanism to account for the modulation of MITF and PU.1 activity in committed myeloid progenitors prior to the initiation of osteoclast differentiation in response to the appropriate extracellular signals.+http://www.ncbi.nlm.nih.gov/pubmed/17403896Hu, Rong Sharma, Sudarshana M Bronisz, Agnieszka Srinivasan, Ruchika Sankar, Uma Ostrowski, Michael C R01 AR 0447129/AR/NIAMS NIH HHS/United States Research Support, N.I.H., Extramural United States Molecular and cellular biology Mol Cell Biol. 2007 Jun;27(11):4018-27. Epub 2007 Apr 2.%0270-7306 (Print) 0270-7306 (Linking)190002717403896Department of Molecular and Cellular Biochemistry and Comprehensive Cancer Center, 370A Tzagournis Medical Research Facility, Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA.'MCB.01839-06 [pii] 10.1128/MCB.01839-06eng ~t7 Weiss, H. R.2006Clinical improvement and radiological progression in a girl with early onset scoliosis (EOS) treated conservatively--a case report13 Scoliosis1 2006/07/29 BACKGROUND: Cheneau-Brace treatment of a certain standard reduces the rate of surgery, prevents progression and in a certain patient population leads to marked improvement of Cobb angle and cosmetic appearance. During the last two years a patient refusing surgery with a double major curvature of initially 60 degrees showed a clear cosmetic improvement and a clear radiological progression at the same time. The findings of this patient have been reviewed in order to find out how cosmetic appearance and Cobb angle can develop differently. METHODS: The patient entered conservative treatment at the age of 13 years, premenarchial with Tanner II and a Cobb angle of 60 degrees thoracic and 59 degrees lumbar. The angle of trunk rotation (ATR; Scoliometer) was 13 degrees thoracic and 13 degrees lumbar. We have documented the findings of this patient (Surface topography, ATR, Cobb angles and angles of vertebral rotation (according to Raimondi) during the treatment period (27 Month) until 2 years after the onset of menarche. RESULTS: After a treatment time of 27 Month the Cobb angle increased to 74 degrees thoracic and 65 degrees lumbar. The angles of vertebral rotation according to Raimondi increased slightly from 26 degrees thoracic and 28 degrees lumbar to 30 degrees thoracic and 28 degrees lumbar. The ATR improved to 12 degrees thoracic and 5 degrees lumbar while Lateral deviation improved from 22.4 mm to 4.6 mm and average surface rotation improved from 10.6 degrees to 6 degrees. In the X-rays a reduction of decompensation was visible. The patient felt comfortable with the cosmetic result. CONCLUSION: Conservative treatment may improve cosmetic appearance while the curve progresses radiologically. This could be explained by assuming that (1) the Rigo Cheneau brace is able to improve cosmetic appearance by changing the shape of the thorax when the curve itself is too stiff to be corrected by a brace, that (2) reduction of decompensation leads to significant cosmetical improvements or (3) that the patient gained weight and therefore the deformation is masked. However, the weight the patient gained cannot explain the cosmetical improvement in this case. Conservative treatment with a certain standard of quality seems a viable alternative for patients with Cobb angles of > 60 degrees when surgical treatment is refused. Specialists in scoliosis management should be aware of the fact that curve progression can occur even if the clinical measurements show an improvement.+http://www.ncbi.nlm.nih.gov/pubmed/16872503AWeiss, Hans-Rudolf England Scoliosis Scoliosis. 2006 Jul 26;1:13.1748-7161 (Electronic)155964016872503uAsklepios Katharina Schroth Spinal Deformities Rehabilitation Centre, Bad Sobernheim, Germany. hr.weiss@asklepios.com+1748-7161-1-13 [pii] 10.1186/1748-7161-1-13eng,||7,Zamperetti, N. Bellomo, R. Dan, M. Ronco, C.2006PEthical, political, and social aspects of high-technology medicine: Eos and care830-5Intensive Care Med326 2006/04/15TBiotechnology/*economics/*ethics Humans Intensive Care Units *Politics Terminal CareJunPOBJECTIVE: We discuss biosocial aspects of high-technology medicine (HTM) to provide a global view of the current model of medicine in the developed world and its consequences. METHODS: We analyze changes in the concept of death and in the use and cost of HTM. The consequences of HTM on the delivery of basic medical care within and among countries are discussed. Concepts derived from Greek mythology are used to illustrate the problems associated with HTM. RESULTS: HTM can be extremely effective in individual cases, but it poses important bioethical and biosocial problems. A major problem is related to the possibility of manipulating the process of dying and the consequent alteration in the social concept of death, which, if not carefully regulated, risks transforming medicine into an expensive way of pursuing pointless dreams of immortality (myth of Eos). Another problem is related to the extraordinary amount of resources necessary for HTM. This model of medicine (which is practiced daily) has limited sustainability, can work only in highly developed countries, may contribute to unequal access to health care, and has negligible positive impact on global health and survival. CONCLUSIONS: HTM poses very important biosocial questions that need to be addressed in a wider and transparent debate, in the best interest of society and HTM as well.+http://www.ncbi.nlm.nih.gov/pubmed/16614809Zamperetti, Nereo Bellomo, Rinaldo Dan, Maurizio Ronco, Claudio United States Intensive care medicine Intensive Care Med. 2006 Jun;32(6):830-5. Epub 2006 Apr 14.%0342-4642 (Print) 0342-4642 (Linking)16614809San Bortolo Hospital, Department of Anesthesia and Intensive Care Medicine, Via Rodolfi 37, 36100 Vicenza, Italy. zamperetti.n@medicivi.org10.1007/s00134-006-0155-0eng||7=Aparicio, S. Garcia, B. Alcalde, R. Davila, M. J. Leal, J. M.2006`PVTx measurements of the N-methylpyrrolidone/methanol mixed solvent: cubic and SAFT EOS analyses6933-42 J Phys Chem B11013 2006/03/31Apr 6sThe PVTx behavior for the x N-methylpyrrolidone (NMP) + (1 - x) methanol compressed liquid solvent is reported over the full composition range and within wide pressure and temperature ranges. The derived excess properties were analyzed in terms of structural effects and intermolecular interactions and revealed strong H-bonding heteroassociations between the two components. The cubic equations of state by Soave (SRK), Peng-Robinson (PR), Patel-Teja (PT), and Sako-Wu-Prausnitz (SWP), and the statistical associating fluid theory (SAFT) equation of state, combined with a number of selected mixing rules, were used to correlate and predict the behavior of both the pure components and mixed solvent. While the classical cubic equations of state were not successful in describing the properties of this system, the SWP equation of state and the SAFT yielded reasonably good results.+http://www.ncbi.nlm.nih.gov/pubmed/16571005Aparicio, Santiago Garcia, Begona Alcalde, Rafael Davila, Maria J Leal, Jose M United States The journal of physical chemistry. B J Phys Chem B. 2006 Apr 6;110(13):6933-42.%1520-6106 (Print) 1520-5207 (Linking)16571005DUniversidad de Burgos, Departamento de Quimica, 09001 Burgos, Spain.10.1021/jp060143teng||7+Ferrucci, L. Mahallati, A. Simonsick, E. M.2006"Frailty and the foolishness of Eos260-1J Gerontol A Biol Sci Med Sci613 2006/03/29Aged Aged, 80 and over Aging/physiology/psychology Attitude of Health Personnel Female *Frail Elderly *Geriatrics Humans Phenotype Terminology as TopicMar+http://www.ncbi.nlm.nih.gov/pubmed/16567374Ferrucci, Luigi Mahallati, Ahmad Simonsick, Eleanor M Comment Editorial United States The journals of gerontology. Series A, Biological sciences and medical sciences J Gerontol A Biol Sci Med Sci. 2006 Mar;61(3):260-1.%1079-5006 (Print) 1079-5006 (Linking)1656737461/3/260 [pii]eng||7\Dubousset, J. Charpak, G. Dorion, I. Skalli, W. Lavaste, F. Deguise, J. Kalifa, G. Ferey, S.2005[A new 2D and 3D imaging approach to musculoskeletal physiology and pathology with low-dose radiation and the standing position: the EOS system]287-97; discussion 297-300Bull Acad Natl Med1892 2005/08/24}Humans Musculoskeletal Diseases/*radiography Posture Radiation Dosage Radiographic Image Enhancement/*instrumentation/methodsFeb8Close collaboration between multidisciplinary specialists (physicists, biomecanical engineers, medical radiologists and pediatric orthopedic surgeons) has led to the development of a new low-dose radiation device named EOS. EOS has three main advantages: The use of a gaseous X-ray detector, invented by Georges Charpak (Nobel Prizewinner 1992), the dose necessary to obtain a 2D image of the skeletal system has been reduced by 8 to 10 times, while that required to obtain a 3D reconstruction from CT slices has fallen by a factor of 800 to 1000. The accuracy of the 3D reconstruction obtained with EOS is as good as that obtained with CT. The patient is examined in the standing (or seated) position, and is scanned simultaneously from head to feet, both frontally and laterally. This is a major advantage over conventional CT which requires the patient to be placed horizontally. -The 3D reconstructions of each element of the osteo-articular system are as precise as those obtained by conventional CT. EOS is also rapid, taking only 15 to 30 minutes to image the entire spine.+http://www.ncbi.nlm.nih.gov/pubmed/16114859 Dubousset, Jean Charpak, Georges Dorion, Irene Skalli, Wafa Lavaste, Francois Deguise, Jacques Kalifa, Gabriel Ferey, Solene English Abstract Review Netherlands Bulletin de l'Academie nationale de medecine Bull Acad Natl Med. 2005 Feb;189(2):287-97; discussion 297-300.%0001-4079 (Print) 0001-4079 (Linking)16114859VUne nouvelle imagerie osteo-articulaire basse dose en position debout: le systeme EOS.>Hopital St Vincent de Paul, Service de Chirurgie Orthopedique.fre||7\Dubey, J. P. Parnell, P. G. Sreekumar, C. Vianna, M. C. De Young, R. W. Dahl, E. Lehmann, T.2004Biologic and molecular characteristics of Toxoplasma gondii isolates from striped skunk (Mephitis mephitis), Canada goose (Branta canadensis), black-winged lory (Eos cyanogenia), and cats (Felis catus)1171-4 J Parasitol905 2004/11/26Animals Animals, Wild Antibodies, Protozoan/blood Biological Assay/veterinary Bird Diseases/epidemiology/*parasitology Brain/parasitology Cat Diseases/epidemiology/*parasitology Cats Female Geese/*parasitology Genotype Liver/parasitology Lung/parasitology Mephitidae/*parasitology Mice Mississippi/epidemiology Muscles/parasitology Parrots/*parasitology Prevalence South Carolina/epidemiology Toxoplasma/*classification/genetics/immunology Toxoplasmosis, Animal/epidemiology/*parasitologyOctToxoplasma gondii isolates can be grouped into 3 genetic lineages. Type I isolates are considered virulent to outbred mice, whereas Type II and III isolates are not. In the present report, viable T. gondii was isolated for the first time from striped skunk (Mephitis mephitis), Canada goose (Branta canadensis), and black-winged lory (Eos cyanogenia). For the isolation of T. gondii, tissues were bioassayed in mice, and genotyping was based on the SAG2 locus. Toxoplasma gondii was isolated from 3 of 6 skunks, 1 of 4 Canada geese, and 2 of 2 feral cats (Felis catus) from Mississippi. All donor animals were asymptomatic. Viable T. gondii was also isolated from 5 of 5 lories that had died of acute toxoplasmosis in an aviary in South Carolina. Genotypes of T. gondii isolates were Type III (all skunks, lories, and the goose) and Type II (both cats). All 5 Type III isolates from birds and 2 of the 3 isolates from skunks were mouse virulent.+http://www.ncbi.nlm.nih.gov/pubmed/15562622Dubey, J P Parnell, P G Sreekumar, C Vianna, M C B De Young, R W Dahl, E Lehmann, T United States The Journal of parasitology J Parasitol. 2004 Oct;90(5):1171-4.%0022-3395 (Print) 0022-3395 (Linking)15562622United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, Maryland 20705-2350, USA. jdubey@anri.barc.usda.goveng ||7gBao, J. Lin, H. Ouyang, Y. Lei, D. Osman, A. Kim, T. W. Mei, L. Dai, P. Ohlemiller, K. K. Ambron, R. T.2004MActivity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos1250-8 Nat Neurosci711 2004/10/21 Acoustic Stimulation/methods Animals Carrier Proteins/*physiology Cell Line Cochlea/cytology/physiology/radiation effects DNA-Binding Proteins/physiology Electrophoretic Mobility Shift Assay/methods Extracellular Space/metabolism/radiation effects Gene Expression Regulation/radiation effects Genes, Reporter/physiology Humans Ikaros Transcription Factor Immunohistochemistry/methods Immunoprecipitation/methods Intracellular Signaling Peptides and Proteins Membrane Proteins Mice Mutagenesis Nerve Tissue Proteins/genetics/*metabolism/*physiology Neuregulin-1/*physiology Neuronal Plasticity/physiology/radiation effects Neurons/cytology/*physiology/radiation effects Oligonucleotide Array Sequence Analysis/methods Potassium Chloride/pharmacology Promoter Regions, Genetic/physiology RNA, Messenger/biosynthesis Reverse Transcriptase Polymerase Chain Reaction/methods Signal Transduction/physiology Subcellular Fractions/metabolism Time Factors Transcription Factors/physiology Transcription, Genetic/*physiology Transfection/methodsNovNeuregulin-1 (Nrg-1) contains an intracellular domain (Nrg-ICD) that translocates into the nucleus, where it may regulate gene expression upon neuronal depolarization. However, the identity of its target promoters and the mechanisms by which it regulates transcription have been elusive. Here we report that, in the mouse cochlea, synaptic activity increases the level of nuclear Nrg-ICD and upregulates postsynaptic density protein-95 (PSD-95), a scaffolding protein that is enriched in post-synaptic structures. Nrg-ICD enhances the transcriptional activity of the PSD-95 promoter by binding to a zinc-finger transcription factor, Eos. The Nrg-ICD-Eos complex induces endogenous PSD-95 expression in vivo through a signaling pathway that is mostly independent of gamma-secretase regulation. This upregulation of PSD-95 expression by the Nrg-ICD-Eos complex provides a molecular basis for activity-dependent synaptic plasticity.+http://www.ncbi.nlm.nih.gov/pubmed/15494726cBao, Jianxin Lin, Hana Ouyang, Yannan Lei, Debin Osman, Abdullah Kim, Tae-Wan Mei, Lin Dai, Penggao Ohlemiller, Kevin K Ambron, Richard T AG01016/AG/NIA NIH HHS/United States AG05681/AG/NIA NIH HHS/United States Comparative Study Research Support, U.S. Gov't, P.H.S. United States Nature neuroscience Nat Neurosci. 2004 Nov;7(11):1250-8. Epub 2004 Oct 24.%1097-6256 (Print) 1097-6256 (Linking)15494726cDepartment of Otolaryngology, Washington University, St. Louis, Missouri 63110, USA. jbao@wustl.edunn1342 [pii] 10.1038/nn1342eng 1||7EWestman, B. J. Perdomo, J. Matthews, J. M. Crossley, M. Mackay, J. P.2004Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers13318-27 Biochemistry4342 2004/10/20Amino Acid Sequence Animals Binding Sites/genetics Carrier Proteins/*chemistry/genetics DNA-Binding Proteins/*chemistry/genetics Humans Ikaros Transcription Factor Mice Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Nerve Tissue Proteins/*chemistry/genetics Nuclear Magnetic Resonance, Biomolecular Peptide Fragments/*chemistry/genetics Protein Binding/genetics Protein Conformation Protein Folding Protein Isoforms/chemistry/genetics Protein Structure, Tertiary/genetics Static Electricity Structural Homology, Protein Transcription Factors/*chemistry/genetics Xenopus Proteins/chemistry/genetics Zinc/chemistry *Zinc Fingers/geneticsOct 26The oligomerization domain that is present at the C terminus of Ikaros-family proteins and the protein Trps-1 is important for the proper regulation of developmental processes such as hematopoiesis. Remarkably, this domain is predicted to contain two classical zinc fingers (ZnFs), domains normally associated with the recognition of nucleic acids. The preference for protein binding by these predicted ZnFs is not well-understood. We have used a range of methods to gain insight into the structure of this domain. Circular dichroism, UV-vis, and NMR experiments carried out on the C-terminal domain of Eos (EosC) revealed that the two putative ZnFs (C1 and C2) are separable, i.e., capable of folding independently in the presence of Zn(II). We next determined the structure of EosC2 using NMR spectroscopy, revealing that, although the overall fold of EosC2 is similar to other classical ZnFs, a number of differences exist. For example, the conformation of the C terminus of EosC2 appears to be flexible and may result in a major rearrangement of the zinc ligands. Finally, alanine-scanning mutagenesis was used to identify the residues that are involved in the homo- and hetero-oligomerization of Eos, and these results are discussed in the context of the structure of EosC. These studies provide the first structural insights into how EosC mediates protein-protein interactions and contributes to our understanding of why it does not exhibit high-affinity DNA binding.+http://www.ncbi.nlm.nih.gov/pubmed/15491138Westman, Belinda J Perdomo, Jose Matthews, Jacqueline M Crossley, Merlin Mackay, Joel P Comparative Study Research Support, Non-U.S. Gov't United States Biochemistry Biochemistry. 2004 Oct 26;43(42):13318-27.%0006-2960 (Print) 0006-2960 (Linking)15491138mSchool of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia.10.1021/bi049506aeng ||7@Doeringsfeld, M. R. Schlosser, I. J. Elder, J. F. Evenson, D. P.2004Phenotypic consequences of genetic variation in a gynogenetic complex of Phoxinus eos-neogaeus clonal fish (Pisces: Cyprinidae) inhabiting a heterogeneous environment1261-73 Evolution586 2004/07/236Animals Body Weights and Measures Cyprinidae/anatomy & histology/*genetics DNA/isolation & purification Demography *Environment Erythrocytes/chemistry Flow Cytometry Fresh Water *Genetic Variation Hybridization, Genetic/genetics Minnesota Multivariate Analysis *Phenotype *Ploidies Principal Component AnalysisJunWe examined the genetic composition, habitat use, and morphological variation of a Phoxinus eos-neogaeus unisexual hybrid complex and its sexually reproducing progenitor species inhabiting beaver-modified drainages of Voyageurs National Park, Minnesota. In addition to the single diploid P. eos-neogaeus gynogenetic clone, triploid and diploid-triploid mosaic biotypes were present at our study sites. Both P. eos and P. neogaeus, and all three hybrid biotypes were ubiquitous throughout one intensively surveyed drainage, but abundances and relative frequencies of the parental species and hybrids varied considerably within and among successional environments. Data from a large number of additional sites indicated that the proportion of polyploid hybrids within an environment was negatively related to hybrid relative frequency, implying that the genomic constitution of hybrids is an important determinant of clonal fitness among successional environments. Statistical comparisons of variation along size-free multivariate body shape axes indicated that despite its genetic uniformity, the P. eos-neogaeus clone is no less variable than its sexual progenitors, suggesting that a single genotype may actually respond to environmental variation with as much phenotypic variation as a genetically variable sexual population. The incorporation and expression of a third genome in triploid and diploid-triploid mosaic biotypes derived from the gynogenetic clone significantly expanded phenotypic variation of the clone. This additional variation results in greater similarities in habitat use and morphological overlap with the parental species, primarily P. eos, the predominant sperm donor for gynogenetic hybrid females in this complex. Polyploid augmentation of a diploid gynogenetic clone appears to be typical in the P. eos-neogaeus complex, and the additional genetic and phenotypic variation that it generates has potentially significant ecological and evolutionary consequences for the success and persistence of a single genotype in highly variable environments.+http://www.ncbi.nlm.nih.gov/pubmed/15266975 Doeringsfeld, Matthew R Schlosser, Isaac J Elder, John F Evenson, Donald P Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. United States Evolution; international journal of organic evolution Evolution. 2004 Jun;58(6):1261-73.%0014-3820 (Print) 0014-3820 (Linking)15266975Department of Biology, University of North Dakota, Grand Forks, North Dakota 58202-9019, USA. matthew_doeringsfeld@und.nodak.edueng ||7?Westman, B. J. Perdomo, J. Sunde, M. Crossley, M. Mackay, J. P.2003CThe C-terminal domain of Eos forms a high order complex in solution42419-26 J Biol Chem27843 2003/08/15DAmino Acid Sequence Animals Carrier Proteins/*metabolism/physiology Consensus Sequence *DNA-Binding Proteins Dimerization Ikaros Transcription Factor Nerve Tissue Proteins/*metabolism/physiology Protein Binding Protein Structure, Tertiary/physiology Sequence Alignment Solutions Transcription Factors Zinc Fingers/physiologyOct 24Ikaros family transcription factors play important roles in the control of hematopoiesis. Family members are predicted to contain up to six classic zinc fingers that are arranged into N- and C-terminal domains. The N-terminal domain is responsible for site-specific DNA binding, whereas the C-terminal domain primarily mediates the homo- and hetero-oligomerization between family members. Although the mechanisms of action of these proteins are not completely understood, the zinc finger domains are known to play a central role. In the current study, we have sought to understand the physical and functional properties of these domains, in particular the C-terminal domain. We show that the N-terminal domain from Eos, and not its C-terminal region, is required to recognize GGGA consensus sequences. Surprisingly, in contrast to the behavior exhibited by Ikaros, the C-terminal domain of Eos inhibits the DNA-binding activity of the full-length protein. In addition, we have used a range of biophysical techniques to demonstrate that the C-terminal domain of Eos mediates the formation of complexes that consist of nine or ten molecules. These results constitute the first direct demonstration that Ikaros family proteins can form higher order complexes in solution, and we discuss this unexpected result in the context of what is currently known about the family members and their possible mechanism of action.+http://www.ncbi.nlm.nih.gov/pubmed/12917396Westman, Belinda J Perdomo, Jose Sunde, Margaret Crossley, Merlin Mackay, Joel P Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2003 Oct 24;278(43):42419-26. Epub 2003 Aug 12.%0021-9258 (Print) 0021-9258 (Linking)12917396eSchool of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia.'10.1074/jbc.M306817200 M306817200 [pii]eng ||7NWard, M. P. Ramer, J. C. Proudfoot, J. Garner, M. M. Juan-Salles, C. Wu, C. C.2003pOutbreak of salmonellosis in a zoologic collection of lorikeets and lories (Trichoglossus, Lorius, and Eos spp.)493-8 Avian Dis472 2003/07/31mAnimals Animals, Zoo/*microbiology Anti-Infective Agents/therapeutic use Disease Outbreaks/*veterinary *Fluoroquinolones Infection Control Liver/microbiology Lung/microbiology Parrots/*microbiology Quinolones/therapeutic use Salmonella Infections, Animal/drug therapy/*epidemiology/prevention & control Salmonella typhimurium Snakes/microbiology Spleen/microbiologyApr-JunDuring August 2001, a syndrome characterized by acute lethargy and dyspnea was observed in a population of 45 lorikeets and lories in an open-air zoologic exhibit. The first death occurred on August 10, and within the next 12 days, nine more birds died (22% mortality rate). Hepatomegaly, reddening and congestion of the lungs, and injection of the serosal surface of the intestines were the common gross findings. Histologic changes, including fibrinonecrotic hepatitis and splenitis, bacterial emboli (liver, spleen, lung, kidney, proventriculus), pulmonary congestion and hemorrhage, and enteritis, were indicative of an acute, overwhelming bacterial septicemia. Salmonella typhimurium, with the same antibiogram, was isolated from four birds. Several birds had attacked and killed a snake on July 24, and Salmonella serogroup B (untypeable) was isolated from intestine and kidney samples of a garter snake caught in the open-air exhibit on August 28. Salmonella was also isolated from environmental samples of the exhibit but not from food preparation areas. After antimicrobial therapy, Salmonella spp. was not isolated from the surviving birds. The source of Salmonella in this outbreak remains unknown, but infection either directly or indirectly from snakes in the exhibit is possible. Contact between captive psittacine populations and reptiles should be avoided to prevent the risk of salmonellosis.+http://www.ncbi.nlm.nih.gov/pubmed/12887213Ward, M P Ramer, J C Proudfoot, J Garner, M M Juan-Salles, C Wu, C C United States Avian diseases Avian Dis. 2003 Apr-Jun;47(2):493-8.%0005-2086 (Print) 0005-2086 (Linking)12887213Epidemiology Section, Department of Veterinary Pathobiology, Purdue University School of Veterinary Medicine, West Lafayette, IN 47907-2070, USA.eng||7Perdomo, J. Crossley, M.2002UThe Ikaros family protein Eos associates with C-terminal-binding protein corepressors5885-92 Eur J Biochem26923 2002/11/26(3T3 Cells Animals COS Cells Carrier Proteins/*metabolism DNA-Binding Proteins/metabolism Mice *Neoplasm Proteins Nerve Tissue Proteins/*metabolism Nuclear Proteins/metabolism Protein Binding Repressor Proteins/chemistry/*metabolism Transcription Factors Two-Hybrid System Techniques *Zinc FingersDecEos is a zinc finger transcription factor of the Ikaros family. It binds typical GGGAA Ikaros recognition sites in DNA and functions as a transcriptional repressor. Here we show that Eos associates with the corepressor C-terminal-binding protein (CtBP). CtBP has previously been shown to bind Pro-X-Asp-Leu-Ser (PXDLS) motifs in several DNA-binding proteins. We note that Eos contains a related motif PEDLA, and we demonstrate that CtBP can bind this site weakly but that it also contacts additional regions of Eos. Consistent with this finding, mutation of the PEDLA motif does not negate CtBP binding or CtBP-mediated repression by Eos. CtBP has previously been shown to bind to a PXDLS-type motif in Ikaros, and we show that another Ikaros-related protein TRPS1 also contains a PXDLS CtBP contact motif within its repression domain. We conclude that several Ikaros family proteins utilize CtBP corepressors to inhibit gene expression.+http://www.ncbi.nlm.nih.gov/pubmed/12444977Perdomo, Jose Crossley, Merlin Research Support, Non-U.S. Gov't Germany European journal of biochemistry / FEBS Eur J Biochem. 2002 Dec;269(23):5885-92.%0014-2956 (Print) 0014-2956 (Linking)12444977FDepartment of Biochemistry, G08, University of Sydney, NSW, Australia. 3313 [pii]eng||7TScope, A. Schwendenwein, I. Enders, F. Gabler, C. Seidl, E. Filip, T. Soklaridis, U.2000LHematologic and clinical chemistry reference values in red lories (Eos spp.)885-90 Avian Dis444 2001/02/243Animals Female Male Parrots/*blood Reference ValuesOct-DecZWe established reference ranges for three hematologic and 15 clinical chemistry parameters of 40 clinically healthy birds of the genus Eos. The following species were included to the study: Eos histrio (n = 19), Eos squamata (n = 8), Eos bomea (n = 5), Eos reticulata (n = 4), Eos cyanogenia (n = 4). Detailed information concerning methodology, which is often missing in papers dealing with reference values, is included. As far as possible, data are compared with literature, and some thoughts on obvious deviations are given. The problem of establishing reference values in rare species is reviewed.+http://www.ncbi.nlm.nih.gov/pubmed/11195643Scope, A Schwendenwein, I Enders, F Gabler, C Seidl, E Filip, T Soklaridis, U United States Avian diseases Avian Dis. 2000 Oct-Dec;44(4):885-90.%0005-2086 (Print) 0005-2086 (Linking)11195643IClinic for Poultry and Pet Birds, Veterinary University, Vienna, Austria.eng +||7-Perdomo, J. Holmes, M. Chong, B. Crossley, M.2000bEos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities38347-54 J Biol Chem27549 2000/09/093T3 Cells Amino Acid Sequence Animals Carrier Proteins/genetics/*metabolism Cell Line Cloning, Molecular DNA-Binding Proteins/chemistry/genetics/*metabolism Dimerization Humans Ikaros Transcription Factor Mice Molecular Sequence Data Nerve Tissue Proteins/genetics/*metabolism Protein Conformation Recombinant Proteins/metabolism Saccharomyces cerevisiae Sequence Alignment Sequence Homology, Amino Acid Transcription Factors/chemistry/genetics/*metabolism Transfection Zinc FingersDec 8Members of the Ikaros family of transcription factors, Ikaros, Aiolos, and Helios, are expressed in lymphocytes and have been implicated in controlling lymphoid development. These proteins contain two characteristic clusters of zinc fingers, an N-terminal domain important for DNA recognition, and a C-terminal domain that mediates homo- and heterotypic associations between family members. The conservation of these domains is such that all three proteins recognize related DNA sequences, and all are capable of dimerizing with other family members. Here we describe two additional Ikaros family proteins, Eos and Pegasus. Eos is most highly related to Helios and shares its DNA binding and protein association properties. Pegasus is related to other Ikaros proteins in its C-terminal dimerization domain but contains a divergent N-terminal zinc finger domain. Pegasus self-associates and binds to other family members but recognizes distinct DNA-binding sites. Eos and Pegasus repress the expression of reporter genes containing their recognition elements. Our results suggest that these proteins may associate with previously described Ikaros family proteins in lymphoid cells and play additional roles in other tissues.+http://www.ncbi.nlm.nih.gov/pubmed/10978333Perdomo, J Holmes, M Chong, B Crossley, M Research Support, Non-U.S. Gov't United states The Journal of biological chemistry J Biol Chem. 2000 Dec 8;275(49):38347-54.%0021-9258 (Print) 0021-9258 (Linking)10978333_Department of Biochemistry, G08, University of Sydney, Sydney, New South Wales 2006, Australia.'10.1074/jbc.M005457200 M005457200 [pii]eng z||7bLetting, D. L. Fecteau, D. A. Haws, T. F. Reed, S. L. Hopkins, R. O. Coleman, R. D. Goddard, K. A.1999{Unexpected ratio of allozyme expression in diploid and triploid individuals of the clonal hybrid fish Phoxinus eos-neogaeus663-74 J Exp Zool2846 1999/10/262Animals Cell Separation Cloning, Organism Cyprinidae/*metabolism DNA/genetics *Diploidy Electrophoresis, Cellulose Acetate Female Flow Cytometry Glucose-6-Phosphate Isomerase/genetics/*metabolism Hybridization, Genetic Isoenzymes/genetics/metabolism Male Phosphoglucomutase/genetics/*metabolism *PolyploidyNov 1HPhoxinus eos-neogaeus, a North American freshwater fish, was formed by hybridization between P. neogaeus and P. eos. Individuals of P. eos-neogaeus express one allozyme of P. eos and one allozyme of P. neogaeus for enzymes for which the parental allozymes are distinctive. We performed densitometry on phosphoglucomutase (PGM) and one glucose-6-phosphate isomerase locus (GPI-A) separated by cellulose acetate electrophoresis to determine if the parental species' allozymes are expressed in proportion to the number of genomes present in diploid and triploid individuals, and if these enzymes are regulated separately in different tissues. In diploids, activity of the P. eos allozyme was greater than the P. neogaeus allozyme in eye, liver, and muscle but not in heart (one sample t-test, P = 0.05) for PGM. The activity of the P. eos GPI-A allozyme was significantly greater than the P. neogaeus allozyme in heart, eye and muscle but not in liver (one sample t-test, P = 0.05). The expected ratio of eos:neogaeus expression in triploid P. eos-neogaeus x eos individuals is 2:1. For PGM, the observed ratio of eos:neogaeus expression was not significantly different from 2:1 in all four tissues. The P. eos allozyme for GPI was expressed less than expected in all four tissues (one-sample t-test, P = 0.05). Thus, greater than expected expression of the P. eos allozyme was not observed in triploid individuals as it was in the diploids. These data show that PGM and GPI are regulated separately, and that regulation differs by tissue, and in fish of distinct ploidy levels. J. Exp. Zool. 284:663-674, 1999.+http://www.ncbi.nlm.nih.gov/pubmed/10531553Letting, D L Fecteau, D A Haws, T F Reed, S L Hopkins, R O Coleman, R D Goddard, K A Research Support, Non-U.S. Gov't United states The Journal of experimental zoology J Exp Zool. 1999 Nov 1;284(6):663-74.%0022-104X (Print) 0022-104X (Linking)10531553NDepartment of Biology, Ursinus College, Collegeville, Pennsylvania 19426, USA.E10.1002/(SICI)1097-010X(19991101)284:6<663::AID-JEZ8>3.0.CO;2-N [pii]engV||7Honma, Y. Kiyosawa, H. Mori, T. Oguri, A. Nikaido, T. Kanazawa, K. Tojo, M. Takeda, J. Tanno, Y. Yokoya, S. Kawabata, I. Ikeda, H. Wanaka, A.1999fEos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system76-80 FEBS Lett4471 1999/04/28Amino Acid Sequence Animals Astrocytes/cytology Carrier Proteins/*genetics/isolation & purification Central Nervous System/chemistry *DNA-Binding Proteins Ikaros Transcription Factor In Situ Hybridization Mice Mice, Inbred ICR Molecular Sequence Data *Multigene Family Nerve Tissue Proteins/*genetics/isolation & purification Peripheral Nervous System/chemistry Protein Binding RNA, Messenger/isolation & purification Sequence Homology, Amino Acid Tissue Distribution Transcription Factors/genetics/metabolism Zinc Fingers/*geneticsMar 19We identified a novel member of the Ikaros gene family, which has critical roles in the development of lymphoid lineages. This gene, which we named Eos, was expressed predominantly in the developing central and peripheral nervous system. Eos protein could interact with itself and Ikaros protein through its C-terminal portion in the yeast two hybrid assay. These findings suggested that Eos may have important roles in neural development similarly to the Ikaros family in the development of hemolymphoid tissue.+http://www.ncbi.nlm.nih.gov/pubmed/10218586Honma, Y Kiyosawa, H Mori, T Oguri, A Nikaido, T Kanazawa, K Tojo, M Takeda, J Tanno, Y Yokoya, S Kawabata, I Ikeda, H Wanaka, A Comparative Study Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 1999 Mar 19;447(1):76-80.%0014-5793 (Print) 0014-5793 (Linking)10218586Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima City, Japan.S0014579399002653 [pii]eng||7Yasunaga, T. Wakabayashi, T.1996Extensible and object-oriented system Eos supplies a new environment for image analysis of electron micrographs of macromolecules155-60 J Struct Biol1161 1996/01/01Actins/chemistry/*ultrastructure Computer Graphics *Computer Simulation Databases, Factual *Microscopy, Electron *Models, Structural Protein Structure, SecondaryJan-FebTo study macromolecular structure by electron microscopy, a highly extensible and object-oriented system has been developed for image analysis. This system is named "Eos" (Extensible and object-oriented system). The system described here supplies an environment with four types of supports: (i) a group of small tools for image analysis, (ii) tools for integration of small tools, such as "Display2," (iii) tools for development, such as "maketool," and (iv) object-oriented libraries for development of new tools. Using Eos, electron micrographs can be analyzed by small tools and integration tools. In addition, Eos can be used to develop new tools based on new ideas because development tool and object-oriented libraries are provided. The examples of implemented small tools for image analysis include three-dimensional reconstruction of objects with helical symmetry, cluster analysis, and contour expression.*http://www.ncbi.nlm.nih.gov/pubmed/8742738Yasunaga, T Wakabayashi, T Research Support, Non-U.S. Gov't United states Journal of structural biology J Struct Biol. 1996 Jan-Feb;116(1):155-60.%1047-8477 (Print) 1047-8477 (Linking)87427382Department of Physics, University of Tokyo, Japan.2S1047-8477(96)90025-8 [pii] 10.1006/jsbi.1996.0025eng ||7Toline, C. A. Baker, A. J.1995iMitochondrial DNA variation and population genetic structure of the northern redbelly dace (Phoxinus eos)745-53Mol Ecol46 1995/12/01Animals Base Sequence Cyprinidae/*genetics DNA Primers/genetics DNA, Mitochondrial/*genetics Ecosystem Founder Effect *Genetic Variation Genetics, Population Molecular Sequence Data NADH Dehydrogenase/genetics Ontario Polymerase Chain Reaction Polymorphism, Restriction Fragment LengthDecTwo sections of the control region and the genes coding for NADH dehydrogenase subunits 5 and 6 (ND-5/6) of mitochondrial DNA (mtDNA) were amplified from Phoxinus eos with the polymerase chain reaction. Both sections of the control region were sequenced directly while the ND-5/6 fragment was sequenced in from each end only. Additionally, the entire ND-5/6 fragment was examined for sequence variation using RFLP analysis. No sequence variation was detected in the control region among 70 individuals sampled from 18 populations across three Ontario regions (Spanish River, Madawaska R. and Cataraqui R.). To examine ND-5/6 variation, a total of 75 individuals were sampled from five populations representing two of the three regions (Madawaska River and Cataraqui R.). Six haplotypes were detected by direct sequencing and four by RFLP analysis. Estimates of population subdivision from RFLP data, sequence analysis, and the two data sets combined for the ND-5/6 fragment, suggest that gene flow is restricted within and between regions. However, estimates of sequence divergence for both sequence and RFLP analysis of this fragment suggested that populations were either founded by already differentiated populations or that populations were founded by a single stock and divergence between regions occurred prior to isolation of populations within regions. These estimates of population structure are much greater than those obtained from allozyme analysis. Additionally, high levels of heterozygosity in nuclear DNA, but low mtDNA diversity suggests that populations have experienced reductions in population size sufficient to reduce only mtDNA variation. Random lineage extinction and limited time for the accumulation of new mutations are likely responsible for low levels of mtDNA variation in ND-5/6 and the control region, while functional constraints may limit variation more than expected in the control region in dace and other fishes.*http://www.ncbi.nlm.nih.gov/pubmed/8564012qToline, C A Baker, A J Research Support, Non-U.S. Gov't England Molecular ecology Mol Ecol. 1995 Dec;4(6):745-53.%0962-1083 (Print) 0962-1083 (Linking)8564012>Department of Zoology, University of Toronto, Ontario, Canada.eng||7Gilkes, M. L. Choi, Y. Elliott, J. B. Hauger, J. A. Hirsch, A. S. Hjort, E. L. Porile, N. T. Scharenberg, R. Srivastava, B. K. Tincknell, M. Warren, P.1995-Gilkes et al. reply for the EOS Collaboration768 Phys Rev Lett754 1995/07/24Jul 24+http://www.ncbi.nlm.nih.gov/pubmed/10060110MJournal article Physical review letters Phys Rev Lett. 1995 Jul 24;75(4):768.*1079-7114 (Electronic) 0031-9007 (Linking)10060110EngS|t7"Elder, J. F., Jr. Schlosser, I. J.1995Extreme clonal uniformity of Phoxinus eos/neogaeus gynogens (pisces: Cyprinidae) among variable habitats in northern Minnesota beaver ponds5001-5Proc Natl Acad Sci U S A9211 1995/05/23Animals Base Sequence Cyprinidae/*genetics/physiology DNA Fingerprinting Demography Fresh Water *Genetic Variation Minnesota Molecular Sequence Data Mosaicism Oligonucleotide Probes Parthenogenesis Ploidies Population Density Species SpecificityMay 23Genetic surveys of parthenogenetic vertebrate populations have demonstrated a common pattern of relatively high degrees of clonal variation and the coexistence of numerous clones. In striking contrast, the Phoxinus eos/Phoxinus neogaeus/hybrid gynogen complex of cyprinid fishes exhibits no clonal variation within a northern Minnesota drainage characterized by successional beaver ponds. Gynogens were sampled from three habitats in each of four different pond types in a single drainage in Voyageurs National Park, Minnesota. The abundance of gynogens relative to sexual dace varied with pond type, being least common in deep upland ponds and most common in shallow, collapsed, lowland ponds (13.4% and 48.6%, respectively). Simple-sequence multilocus DNA fingerprinting of 464 individual gynogens detected one, and only one, clone. DNA fingerprints, generated sequentially by using three oligonucleotide probes, (CAC)5, (GACA)4, and the Jeffreys' 33.15 probe, all revealed the same unprecedented lack of variation. The extreme lack of clonal diversity in these gynogens across a range of habitat types does not fit the general pattern of high clonal diversity found within populations of other vertebrate parthenogens.*http://www.ncbi.nlm.nih.gov/pubmed/7761438Elder, J F Jr Schlosser, I J Comparative Study Research Support, U.S. Gov't, Non-P.H.S. United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1995 May 23;92(11):5001-5.%0027-8424 (Print) 0027-8424 (Linking)418357761438-Department of Biology, Grand Forks, ND 58202.eng,||7 Eicke, C.1994[New diagnostic technics in orthodontics. A report on the 70th Congress of the European Orthodontic Society (EOS) of 8-11 June 1994 in Graz]1136-7, 1168-9Schweiz Monatsschr Zahnmed1049 1994/01/01MEurope Humans Malocclusion/*diagnosis Orthodontics/*methods Societies, Dental*http://www.ncbi.nlm.nih.gov/pubmed/7939553Eicke, C Congresses Switzerland Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia / SSO Schweiz Monatsschr Zahnmed. 1994;104(9):1136-7, 1168-9.1011-4203 (Print)7939553Neue diagnostische Verfahren in der Kieferorthopadie. Bericht uber den siebzigsten Kongress der "European Orthodontic Society (EOS)" vom 8.-11. Juni 1994 in Graz.fre ger3||72O'Toole, D. Mills, K. Ellis, R. Farr, R. Davis, M.19930Clostridial enteritis in red lories (Eos bornea)111-3J Vet Diagn Invest51 1993/01/01Animals *Bird Diseases Birds Clostridium Infections/pathology/*veterinary *Clostridium perfringens Enteritis/microbiology/pathology/*veterinary Female Gastric Mucosa/pathology Gram-Positive Bacteria/isolation & purification Male NecrosisJan*http://www.ncbi.nlm.nih.gov/pubmed/8466969O'Toole, D Mills, K Ellis, R Farr, R Davis, M United states Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc J Vet Diagn Invest. 1993 Jan;5(1):111-3.%1040-6387 (Print) 1040-6387 (Linking)84669693Wyoming State Veterinary Laboratory, Laramie 82070.engP||71992$Academy Weighs in on EOS Data System611Science2565057 1992/05/01May 1+http://www.ncbi.nlm.nih.gov/pubmed/17843481IUnited States Science (New York, N.Y.) Science. 1992 May 1;256(5057):611.%0036-8075 (Print) 0036-8075 (Linking)17843481/256/5057/611 [pii] 10.1126/science.256.5057.611engi||7 Marshall, E.1992Accountants Fret Over EOS Data1206Science2555049 1992/03/06Mar 6+http://www.ncbi.nlm.nih.gov/pubmed/17816813VMarshall, E United States Science (New York, N.Y.) Science. 1992 Mar 6;255(5049):1206.%0036-8075 (Print) 0036-8075 (Linking)178168131255/5049/1206 [pii] 10.1126/science.255.5049.1206eng||74Howerth, E. W. Rich, G. Dubey, J. P. Yogasundram, K.1991.Fatal toxoplasmosis in a red lory (Eos bornea)642-6 Avian Dis353 1991/07/01Animals Bird Diseases/*pathology Hepatomegaly/veterinary Liver/pathology Lung/pathology Myocardium/pathology Necrosis *Psittaciformes Toxoplasmosis, Animal/*pathologyJul-Sep"Toxoplasmosis was diagnosed in a 3-week-old red lory (Eos bornea). Grossly, there was hepatomegaly and pulmonary consolidation. The salient microscopic lesions were multifocal necrotizing mycocarditis, interstitial pneumonia with multifocal necrosis and vasculitis, and multifocal necrotizing hepatitis with periacinar hepatocellular necrosis. Toxoplasma gondii-like organisms were observed in lung, heart, and liver by light and electron microscopy. The organisms in tissues stained with anti-T. gondii serum using an immunohistochemical method.*http://www.ncbi.nlm.nih.gov/pubmed/1953590}Howerth, E W Rich, G Dubey, J P Yogasundram, K Case Reports United states Avian diseases Avian Dis. 1991 Jul-Sep;35(3):642-6.%0005-2086 (Print) 0005-2086 (Linking)1953590Louisiana Veterinary Medical Diagnostic Laboratory, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.engS||71990%A Round of Applause (Sort of) for EOS983Science2494972 1990/08/31Aug 31+http://www.ncbi.nlm.nih.gov/pubmed/17789605JUnited States Science (New York, N.Y.) Science. 1990 Aug 31;249(4972):983.%0036-8075 (Print) 0036-8075 (Linking)17789605/249/4972/983 [pii] 10.1126/science.249.4972.983eng||7Belvedere, P. C.1990j[A metal-free single sitting fibre-reinforced composite bridge for tooth replacement using the EOS-System]7-18 Swiss Dent116 1990/06/01*Composite Resins *Dental Bonding Dental Models Denture Design/*methods *Denture, Partial, Fixed *Denture, Partial, Immediate Humans Time FactorsJun$This paper intends to introduce a technique for a one sitting fixed resin bridge with excellent aesthetics and longevity. Techniques using denture teeth or a crown portion of the patient's own teeth have already been presented by many authors. But they all have been unpredictable and their longevity could not be assured. The addition of resin fibre filament to create a flexible reinforcement at the pontic-abutment interface gives added strength to the acid etch bond between pontic and abutment. Reinforcing systems such as metal wires, woven screen, metal bars with retentive holes, glass fibres, silk and resin fibres have been used with varying results. The original composite reinforced bridge using resin fibres was done by the author with Kevlar 49 in February of 1981, replacing both upper central incisors using only the lateral incisors on a 22 year-old female. This four-unit-bridge is still in function (end of 1989) and has never been replaced or repaired. Since then improvements have been made and the following technique has evolved. 360 fibre reinforced "Belvedere bridges" have been placed to date with a success rate of 98%. One of the improvements is the use of another fibre, which has extremely high tensile strength: it is a polyethylene fibre, colourless and six times stronger than steel.*http://www.ncbi.nlm.nih.gov/pubmed/2120805WBelvedere, P C English Abstract Switzerland Swiss dent Swiss Dent. 1990 Jun;11(6):7-18.%0251-1657 (Print) 0251-1657 (Linking)2120805Vom Zahnarzt ausserhalb des Mundes gefertigte metallfreie, lichtgehartete Composite-Faser-Brucken. Eine neuartige Technik mit neuen Materialien.ger||7>Bjornson, B. H. Pincus, S. H. DiNapoli, A. M. Desforges, J. F.19847Inhibition of CFU-NM and CFU-EOS by mature granulocytes376-9Blood632 1984/02/01Colony-Forming Units Assay Culture Media Eosinophils/immunology Feedback Female Granulocytes/*immunology Growth Inhibitors Hematopoietic Stem Cells/*immunology Humans Male Monocytes/immunology Neutrophils/immunology Staining and LabelingFebApproximately half of the colony-forming units-culture (CFU-C) from normal peripheral blood are eosinophilic. The purpose of our study was to determine: (1) whether progenitor cells committed to eosinophil or neutrophil maturation would be differentially affected by feedback inhibition, and (2) whether mature eosinophils added to the feeder layers of the culture would inhibit the proliferation of CFU-C in a manner similar to that described for neutrophils. Concentrated eosinophils and neutrophils, obtained by separation on a metrizamide gradient, were added to feeder layers containing either 10(6) autologous whole mononuclear cells (WMNC) or 0.1 ml of leukocyte conditioned media (LCM). The average number of colonies was 123/10(6) nonadherent cells (NAC) cultured. When neutrophils or eosinophils were added to the WMNC feeder layer, the percent inhibition of growth was 40.2% +/- 1.6% (mean +/- SEM) and 42.3% +/- 5.4%, respectively, but the ratio of neutrophil to eosinophil colonies remained constant. No effect was seen when neutrophils or eosinophils were added to an LCM feeder layer. Thus, it appears that the differential control of neutrophil versus eosinophil production in vitro is not regulated through feedback inhibition by mature granulocytes. In addition, these studies suggest that eosinophils, as well as neutrophils, cause inhibition of CFU-C growth when intact cells are the source of colony-stimulating factor (CSF).*http://www.ncbi.nlm.nih.gov/pubmed/61980130Bjornson, B H Pincus, S H DiNapoli, A M Desforges, J F AI 16432/AI/NIAID NIH HHS/United States HL 07437-04/HL/NHLBI NIH HHS/United States HL 15157-10/HL/NHLBI NIH HHS/United States etc. Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United states Blood Blood. 1984 Feb;63(2):376-9.%0006-4971 (Print) 0006-4971 (Linking)6198013engs}|7Timofeeva, T. E.1983OS-22 echoophthalmoscope]48-9Med Tekh6 1983/11/012*Ophthalmoscopes Ussr Ultrasonics/*instrumentationNov-Dec*http://www.ncbi.nlm.nih.gov/pubmed/6664274KTimofeeva, T E Ussr Meditsinskaia tekhnika Med Tekh. 1983 Nov-Dec;(6):48-9.%0025-8075 (Print) 0025-8075 (Linking)6664274Ekhooftal'moskop EOS-22.rus ||7Nobrega, J. N. Coscina, D. V.1983Central injections of the GABA-transaminase inhibitor ethanolamine-O-sulfate (EOS): effects on brain [14C]2-deoxy-D-glucose uptake and behavior in rats243-52 Brain Res2622 1983/03/074-Aminobutyrate Transaminase/*antagonists & inhibitors Animals Autoradiography Blood Glucose/*metabolism Brain/*drug effects/enzymology Deoxyglucose/metabolism Dose-Response Relationship, Drug Eating/drug effects Ethanolamines/*pharmacology Male Motor Activity/drug effects Motor Skills/drug effects Orientation/drug effects Postural Balance/drug effects Rats Rats, Inbred Strains Reflex/drug effects Transaminases/*antagonists & inhibitors gamma-Aminobutyric Acid/metabolismMar 7Brain glucose utilization was examined 24 h after single intracisternal injections of the GABA-transaminase inhibitor ethanolamine-O-sulfate (EOS) in rats. Qualitative autoradiography indicated a pronounced and homogeneous depression in [14C]2-deoxy-D-glucose ([14C]2DG) uptake throughout the brains of rats treated with 200 or 400 micrograms EOS. Quantitative scintillation counting of 14C in 9 brain areas of other rats confirmed the marked, generalized decrease in label uptake 24 h after EOS. Food intake measurements confirmed previous reports of dose-dependent anorexia after EOS. Rats treated with the 200 micrograms dose showed decreased open-field activity 24 h after injection but no other deficits in various tests of sensorimotor function or in tail-pinch-induced feeding. Rats treated with the 400 micrograms dose also showed deficits in open-field activity, plus deficits in orientation to touch stimuli, longer latencies than controls in catalepsy tests, and faster habituation of startle responses to sound. This group showed normal feeding responses to tail-pinch stimulation in the presence of solid food but not in the presence of liquid food. It was concluded that sensorimotor deficits may play some role in the anorexigenic effects of EOS but are probably not their primary cause. The discrepancy between the apparent degree of depression of brain glucose utilization and the comparatively mild behavioral deficits observed would suggest the possibility that metabolic fuels other than glucose may be mobilized following central EOS treatment.*http://www.ncbi.nlm.nih.gov/pubmed/6839155YNobrega, J N Coscina, D V Netherlands Brain research Brain Res. 1983 Mar 7;262(2):243-52.%0006-8993 (Print) 0006-8993 (Linking)6839155eng||7Nobrega, J. N. Coscina, D. V.1982Inhibition of acute feeding responses to systemic 2-deoxyglucose or insulin in rats pretreated with the GABA-transaminase blocker ethanolamine-O-sulfate (EOS)1145-8Pharmacol Biochem Behav176 1982/12/01M4-Aminobutyrate Transaminase/*antagonists & inhibitors Animals Blood Glucose/metabolism Brain/drug effects Deoxy Sugars/*pharmacology Deoxyglucose/*pharmacology Eating/*drug effects Ethanolamines/*pharmacology Female Injections, Intraventricular Insulin/*pharmacology Rats Rats, Inbred Strains Transaminases/*antagonists & inhibitorsDec6Acute feeding responses to 2-deoxyglucose (750 mg/kg) or insulin (12 U/kg) were examined 24 hr after intracisternal injection of the GABA-transaminase inhibitor ethanolamine-O-sulfate (EOS, 400 micrograms) in female rats. EOS pretreatment completely abolished acute feeding responses to both challenges. These findings complement recent research showing that central EOS can reverse chronic overeating in several experimental preparations. The present results are consistent with previous indications that EOS treatment may induce a metabolic shift away from brain glucose utilization, thus making glucoprivation irrelevant as a metabolic challenge. An alternative possibility is that EOS-induced increases of brain GABA may offset specific neural mechanisms through which these glucoprivic agents normally induce feeding.*http://www.ncbi.nlm.nih.gov/pubmed/6761711Nobrega, J N Coscina, D V Research Support, Non-U.S. Gov't United states Pharmacology, biochemistry, and behavior Pharmacol Biochem Behav. 1982 Dec;17(6):1145-8.%0091-3057 (Print) 0091-3057 (Linking)6761711eng||7NBjornson, B. H. Harley, J. B. Andre-Schwartz, J. Fauci, A. S. Desforges, J. F.1982Peripheral blood myeloid progenitor cell cultures in patients with hypereosinophilic syndrome (CFU-eos in hypereosinophilic syndrome)721-6Blood603 1982/09/019Adolescent Adult Aged Cell Differentiation Cells, Cultured *Colony-Forming Units Assay Colony-Stimulating Factors/biosynthesis Eosinophilia/*blood Eosinophils/ultrastructure Female Granulocytes/*cytology Hematopoietic Stem Cells/*cytology Humans Macrophages/cytology Male Middle Aged Neutrophils/cytology SyndromeSep Myeloid progenitor cell cultures (CFU-C) were established in a double-layer agar system with peripheral blood mononuclear cells from 13 patients with the hypereosinophilic syndrome (HES). Normal controls produced 49% +/- 3.5% eosinophil colonies; results in 7 of the 13 HES patients were within the normal range, while in 5, the proportion of eosinophil colonies was greater than 3 standard deviations above the normal mean, and in 1 patient there was a low proportion of eosinophil colonies. The production of an increased proportion of eosinophil colonies correlated with more aggressive disease. Experiments in which normal progenitor cells were cultured over feeder layers of mononuclear cells demonstrated that cells of 3 of the 5 patients had an excess production of eosinophil colony-stimulating activity. When HES patients progenitor cells were cultured over normal feeder layers, 2 of the 5 patient samples continued to produce an increased proportion of eosinophil colonies, suggesting that these patients have an excess proportion of progenitor cells committed to eosinophil differentiation. Thus, the results demonstrated heterogeneity of growth characteristics for the HES patients. None, however, had the colony growth characteristic of acute or chronic myelogenous leukemia.*http://www.ncbi.nlm.nih.gov/pubmed/6980678Bjornson, B H Harley, J B Andre-Schwartz, J Fauci, A S Desforges, J F HL07437-04/HL/NHLBI NIH HHS/United States HL15157/HL/NHLBI NIH HHS/United States Research Support, U.S. Gov't, P.H.S. United states Blood Blood. 1982 Sep;60(3):721-6.%0006-4971 (Print) 0006-4971 (Linking)6980678eng||7Dalgaard, O. Z.1980;[The Eos syndrome. Comments to the commission for the aged]793-4 Ugeskr Laeger14212 1980/03/17OAged Demography Denmark Geriatrics/*trends *Health Services for the Aged HumansMar 17*http://www.ncbi.nlm.nih.gov/pubmed/7368365TDalgaard, O Z Denmark Ugeskrift for laeger Ugeskr Laeger. 1980 Mar 17;142(12):793-4.%0041-5782 (Print) 0041-5782 (Linking)73683650Eos-syndromet. Kommentar til aeldrekommissionen.dan||7*Bilsen, F. A. Frietman, E. E. W. Eillems W1980JElectroacoustic obstacle simulator (EOS) for the training of blind persons553-7Int J Rehabil Res34 1980/01/01zAcoustic Stimulation/*instrumentation Auditory Perception Blindness/*rehabilitation Humans *Orientation Sound Localization*http://www.ncbi.nlm.nih.gov/pubmed/7203758Bilsen, F A Frietman, E E WEillems, W Germany, west International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation Int J Rehabil Res. 1980;3(4):553-7.%0342-5282 (Print) 0342-5282 (Linking)7203758eng ~|7Wilkie, J. S. Lloyd, G. E.1978@The Arabic version of Galen's De sectis ad eos qui introducuntur167-9 J Hell Stud98 1978/01/01nGreek World History, Ancient History, Early Modern 1451-1600 History, Medieval History, Modern 1601- *Medicine+http://www.ncbi.nlm.nih.gov/pubmed/11639007Wilkie, J S Lloyd, G E Biography Historical Article England The Journal of Hellenic studies / the Society for the Promotion of Hellenic Studies J Hell Stud. 1978;98:167-9.%0075-4269 (Print) 0075-4269 (Linking)11639007engd|t7&Koob, G. del Fiacco, M. Iversen, S. D.1976\The behavioural effects of EOS-induced changes in substantia nigra GABA levels [proceedings]454PBr J Pharmacol583 1976/11/01Aminobutyric Acids/*metabolism Animals Behavior, Animal/*drug effects Ethanolamines/*pharmacology Rats Substantia Nigra/drug effects/*metabolism gamma-Aminobutyric Acid/*metabolismNov)http://www.ncbi.nlm.nih.gov/pubmed/990632oKoob, G del Fiacco, M Iversen, S D England British journal of pharmacology Br J Pharmacol. 1976 Nov;58(3):454P.%0007-1188 (Print) 0007-1188 (Linking)1667580990632engQ||72007^Recommended practices for reducing radiological exposure in the perioperative practice setting989-90, 992-1002AORN J855 2007/05/31Humans Occupational Exposure/*prevention & control Occupational Health Perioperative Nursing/methods/*standards Radiation Monitoring/methods/standards Radiation Protection/methods/*standardsMay+http://www.ncbi.nlm.nih.gov/pubmed/17533678{AORN Recommended Practices Committee Practice Guideline United States AORN journal AORN J. 2007 May;85(5):989-90, 992-1002.%0001-2092 (Print) 0001-2092 (Linking)17533678engx||72001PRecommended practices for reducing radiological exposure in the practice setting220, 223-6, 229-30AORN J731 2001/02/24Humans Occupational Exposure/analysis/*prevention & control *Occupational Health Operating Room Nursing/methods/*standards *Patient Advocacy Radiation Monitoring/methods/standards Radiation Protection/methods/*standardsJan+http://www.ncbi.nlm.nih.gov/pubmed/11201550Association of Perioperative Registered Nurses Guideline Practice Guideline United States AORN journal AORN J. 2001 Jan;73(1):220, 223-6, 229-30.%0001-2092 (Print) 0001-2092 (Linking)11201550eng)||71993Proposed recommended practices. Reducing radiological exposure in the practice setting. Association of Operating Room Nurses, Inc599-608AORN J583 1993/09/01Humans Occupational Exposure/*prevention & control Operating Room Nursing/*standards Radiation Dosage Radiation Monitoring Radiation Protection/methods/*standardsSep*http://www.ncbi.nlm.nih.gov/pubmed/8215318WGuideline Practice Guideline United states AORN journal AORN J. 1993 Sep;58(3):599-608.%0001-2092 (Print) 0001-2092 (Linking)8215318eng ent of Orthopaedics, Polyclinic of the Hospitaller Brothers of St. John of God in Budapest, Budapest, Hungary. sz0798@freemail.huA10.1097/01.brs.0000250183.97746.51 00007632-200612150-00016 [pii]eng ted specimens. On the basis of our results, the implants can already be used in clinical practice.*http://www.ncbi.nlm.nih.gov/pubmed/9408284Csernatony, Z Gaspar, L Benko, K Fekete, Z Soos, P Nyulasi, T Szepesi, K Jonas, Z Hungary Acta chirurgica Hungarica Acta Chir Hung. 1997;36(1-4):51-3.%0231-4614 (Print) 0231-4614 (Linking)9408284BDepartment of Orthopaedics, University Medical School of Debrecen.eng 0 Jul;130(7):813-8. Epub 2010 Feb 18.*1434-3916 (Electronic) 0936-8051 (Linking)20165860WDepartment of Orthopaedics, University of Szeged, Hungary. tothk@orto.szote.u-szeged.hu10.1007/s00402-010-1063-xeng rt="35" />5Csernátony, Z. Gáspár, L. Jónás, Z. Szepesi, K.20020Modified unit rod technique in scoliosis surgery481-2Acta Orthop Scand734 w patológia a gerincferdülés kialakulásában69-76*First Hungarian Conference on BiomechanicsPécs Jun 11-12  Egy új típusú implantátum a háti gerincszakasz görbületének korrekciójára77-84*First Hungarian Conference on BiomechanicsPécs Jun 11-12 zrection of the dorsal part of the scoliotic spine77-84*First Hungarian Conference on BiomechanicsPécs Jun 11-12 { erimental bone replacement.177-182*Third Hungarian Conference on BiomechanicsBudapestJul 4-5978 963 06 4307 8 2*ne substitution151-158 Biomech HungIII1 4( a cranioplasticában15-20 Biomech Hung11 Vtion analysis system for biomedical applications23-30Acta Biol DebrXLIII23 txlubricity examination ||76Papp, M. Csernatony, Z. Kazai, S. Karolyi, Z. Rode, L.2007dThe patella and tibial condyle position after combined and after closing wedge high tibial osteotomy769-80#Knee Surg Sports Traumatol Arthrosc156 2007/02/07Adult Aged Female Follow-Up Studies Humans Male Middle Aged Osteoarthritis, Knee/surgery Osteotomy/adverse effects/*methods Patella/*radiography Tibia/*radiography/*surgeryJun= High tibial osteotomy changes the patella and tibial condyle position, which makes the subsequent total knee replacement technically demanding. From 1 January 1993 to 31 December 2000, combined osteotomy [After the first osteotomy made 2 cm distally to the joint line, a bone wedge is removed based laterally. Its tip ends at the center of the tibial condyle (half bone wedge). The distal part of the tibia is placed into the valgus position and the half bone wedge is placed into the gap opened medially.] was performed on 103 knees and closing wedge osteotomy was performed on 47 consecutive knees. Eighty combined (group A) and 41 closing wedge (group B) osteotomy were studied. All knees were assessed radiologically before surgery, in the 10th postoperative week, in the 12th postoperative month and at the time of the final follow-up (in group A-66.15 months, in group B-66.61 months). We examined the change of the femorotibial angle, of the patellar height according to the method of Insall and Salvati, of the tibial slope angle according to the method of Bonnin, of the tibial condylar offset according to the method of Yoshida and of the distance between the lateral tibial plateau and the top of the fibular head. In group A and B, the recurrence of the varus deformity was not noted and valgus alignment did not increase in any case. In group-A, the Insall-Salvati ratio remained unchanged in 65% of knees. The tibial slope angle decreased in both groups. There was correlation between the change of the tibial condylar offset and the angle of the correction in both groups. There was correlation between the change of the distance between the lateral tibial plateau and the top of the fibular head. After combined osteotomy, the transposition of the tibial condyle and the decrease of the distance between the lateral tibial plateau and the top of the fibular head was less than after closing wedge osteotomy, although the average angle of correction was more after combined osteotomy (11.835 degrees ), than after closing wedge osteotomy (9.465 degrees ). Theoretically, the recurrence of the varus deformity, the increase of the valgus alignment and (in majority of cases) the shortening of the patellar tendon do not compromise the likelihood of successful conversion to the subsequent total knee replacement, either after combined or after closing wedge osteotomy. The combined osteotomy does not lead to considerable transposition of the tibial condyle and to considerable lateral tibial bone loss; therefore, theoretically, the combined osteotomy does not impair the subsequent total knee replacement.+http://www.ncbi.nlm.nih.gov/pubmed/17279426Papp, Miklos Csernatony, Zoltan Kazai, Sandor Karolyi, Zoltan Rode, Laszlo Comparative Study Germany Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA Knee Surg Sports Traumatol Arthrosc. 2007 Jun;15(6):769-80. Epub 2007 Feb 6.%0942-2056 (Print) 0942-2056 (Linking)17279426Department of Orthopaedic Surgery, Borsod County Hospital, 72-76 Szentpeteri kapu str., Miskolc 3501, Hungary. drpapp.miklos@hotmail.com10.1007/s00167-006-0271-yeng . c ||7.Molnár, S. Manó, S. Kiss, L. Csernátony, Z.2006[Ex vivo and in vitro determination of the axial rotational axis of the human thoracic spineE984-91Spine3126 2006/12/19Aged Biomechanics Cadaver Female Humans Magnetic Resonance Imaging Male Models, Biological *Rotation Thoracic Vertebrae/*anatomy & histology/*physiology Tomography, X-Ray ComputedDec 15STUDY DESIGN: Different geometrical and biomechanical evaluations were performed to determine the axial rotational axis of the thoracic spine. OBJECTIVE: Our research group has been dealing with the determination of the axial rotational axis of the thoracic spine. Here, we would like to present the geometrical and experimental results of our trials. With our experiments, we are trying to evaluate the contradictions of the related literature. SUMMARY OF BACKGROUND DATA: In the present state, we know quite a lot about the biomechanics of healthy and pathologic spines. Nevertheless, for a seemingly simple question like the position of the axial rotation of the thoracic spine, the literature gives contradicting results. During correction of a scoliotic deformity, when trying to correct the pathologic rotation, not knowing the physiologic rotation can be hazardous. METHODS: We wanted to clarify this question, so we examined the thoracic spine in many different ways. First, we examined the problem from a geometrical point of view then we modeled the different rotational axes by studying the change in volume of the spinal canal. Finally, we used cadaver spines that we rotated and examined with radiographs and digital pictures. RESULTS: Based on the results, we made the following establishments: most of the center points fell on the anterior half of the vertebral body or into the spinal canal, basically on the midsagittal axis of the vertebra. The rib cage has a significant effect on the place of the axis. After removing the ribs, the axis of axial rotation moved forward. CONCLUSIONS: After evaluating the results, we determined that the most likely place for the rotational axis is on the median-sagittal plane, in the anterior portion of the spinal canal.+http://www.ncbi.nlm.nih.gov/pubmed/17172989Molnar, Szabolcs Mano, Sandor Kiss, Laszlo Csernatony, Zoltan Research Support, Non-U.S. Gov't United States Spine Spine (Phila Pa 1976). 2006 Dec 15;31(26):E984-91.*1528-1159 (Electronic) 0362-2436 (Linking)17172989Departm}||7^Szepesi, K. Posan, E. Harsfalvi, J. Ajzner, E. Szucs, G. Gaspar, L. Csernatony, Z. Udvardy, M.2004aThe most severe forms of Perthes' disease associated with the homozygous Factor V Leiden mutation426-9J Bone Joint Surg Br863 2004/05/06Activated Protein C Resistance/complications Adolescent Adult Child Child, Preschool Factor V/*genetics Female Hip Joint/radiography Homozygote Humans Legg-Perthes Disease/complications/*genetics/radiography Male Point Mutation/genetics Retrospective Studies Severity of Illness IndexAprIt has recently been postulated that thrombophilia may have a role in the aetiology of Perthes' disease. The published reports, however, remain conflicting. In this study a retrospective analysis of the coagulation parameters was made in 47 patients with Perthes' disease and the results compared with the clinical data. Five patients with Factor V Leiden mutation were found (10.6%) and surprisingly four of them had a homozygous pattern. These four patients showed the most severe form of the disease, Catterall group IV, with flattening of the entire epiphysis, involvement of the metaphysis, shortening and broadening of the femoral neck, trochanteric overgrowth and developed mushroom-shaped aspherical laterally displaced femoral heads in dysplastic acetabula. We would like to suggest that the homozygous form of Factor V Leiden mutation has some role in the clinical course of Perthes' disease and particularly its most severe form.+http://www.ncbi.nlm.nih.gov/pubmed/15125132Szepesi, K Posan, E Harsfalvi, J Ajzner, E Szucs, G Gaspar, L Csernatony, Z Udvardy, M England The Journal of bone and joint surgery. British volume J Bone Joint Surg Br. 2004 Apr;86(3):426-9.%0301-620X (Print) 0021-9355 (Linking)15125132pDepartment of Orthopaedic Surgery, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary.eng ||7FFarkas, C. Hargitai, Z. Gaspar, L. Kuki, A. Csernatony, Z. Szepesi, K.2004;Histological changes in the symptomatic mediopatellar plica103-8Knee112 2004/04/07Adolescent Adult Female Humans Immunohistochemistry Knee Joint/*pathology Male Middle Aged Neurofilament Proteins/analysis Pain/etiology/*pathology Synovial Membrane/chemistry/*pathologyAprOne of the causes of anterior knee pain may be symptomatic mediopatellar plica. The pain is usually attributed to the mechanical damage caused by the plica inside the joint, or, more precisely, to the synovitis induced as a result. Recent observations seem to suggest, however, that the pain is, in addition, likely to be engendered by an increased number of nerve-elements present in the substance of the plica. The present study used up-to-date histochemical methods to reveal in the symptomatic mediopatellar plicae nerve-elements that may be made responsible for the pain. Semi-quantitative methods were used to establish the number of nerve-elements in the tissue samples obtained from 21 symptomatic mediopatellar plicae (Group 'A'), exposing them to view with the aid of synaptophysin and neurofilament serum, coupled with routine light microscope as well as polarising microscope examinations following H&E and van Gieson staining. Tissue samples taken from the asymptomatic mediopatellar plica of 11 patients served as control (Group 'B'). A significantly larger number of nerve-elements were found in the substance of the plicae of Group 'A' 6.9 (S.D.+/-2.9) than in Group 'B' 3 (S.D.+/-1.2). Within Group 'A', more nerve-elements were revealed in trauma-related case histories than in those with no recollections of trauma (an average of 9.6 vs. 5.2, respectively). Similarly, the reduction of pain achieved by surgery was greater in the trauma-related group than in the non-traumatic one (3.0 vs. 1.8, respectively). Relying on our observations, we claim that the painfulness of the knee joint plicae is in all probability also attributable to the fact that their tissue substance contains an increased number of nerve-elements. A major trauma in a particular case history contributes, in all likelihood, to an increase in the number of nerve-elements, but further examinations are required to clarify the pathomechanism involved.+http://www.ncbi.nlm.nih.gov/pubmed/15066619Farkas, Csaba Hargitai, Zoltan Gaspar, Levente Kuki, Attila Csernatony, Zoltan Szepesi, Kalman Research Support, Non-U.S. Gov't England The Knee Knee. 2004 Apr;11(2):103-8.%0968-0160 (Print) 0968-0160 (Linking)15066619Department of Orthopaedics, University of Debrecen, Medical and Health Science Centre, Nagyerdei krt. 98. H 4012 Debrecen, Hungary. farkas@josa.szabinet.hu510.1016/S0968-0160(02)00143-6 S0968016002001436 [pii]eng||7RGaspar, L. Dezso, B. Csernatony, Z. Szabo, J. Szekanecz, Z. Szepesi, K. Matesz, K.2004zCapsular neuronal elements and their relation to pain reduction and functional improvement following total hip replacement142-5International Orthopaedics283 2004/02/06*Arthroplasty, Replacement, Hip Health Status Indicators Humans Immunohistochemistry Joint Capsule/*innervation/metabolism Nerve Fibers/*metabolism Osteoarthritis/*physiopathology/*surgery Pain Measurement Treatment OutcomeJunWe studied changes of pain intensity and functional impairment in 22 patients with osteoarthrosis undergoing total hip replacement. Using a visual analogue scale, the mean scores for pain and disability before surgery were 71.7 and 70.9 respectively. Both scores showed gradual improvement during a 1-year follow-up period, with more than 90% of the total improvement occurring within the first 3 months. After 1 year, the scores for pain and disability were 11.9 and 4.1 respectively. The hip joint capsule was studied using immunohistochemistry to detect neurofilaments. Neurofilament immunoreactivity was observed in 16/22 cases and was correlated with pain and disability scores. However, there were no correlations between pre- and postoperative pain scores, the score changes, and the quantity of capsular neurofilaments. Thus, other factors than capsular neurofilaments influence the scores of pain and disability in osteoarthritis.+http://www.ncbi.nlm.nih.gov/pubmed/14762693Gaspar, Levente Dezso, Balazs Csernatony, Zoltan Gaspar, Lilla Szabo, Janos Szekanecz, Zoltan Szepesi, Kalman Matesz, Klara Research Support, Non-U.S. Gov't Germany International orthopaedics Int Orthop. 2004 Jun;28(3):142-5. Epub 2004 Feb 5.%0341-2695 (Print) 0341-2695 (Linking)14762693Department of Orthopaedic Surgery, Medical Health and Science Center, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary. lgaspar@jaguar.dote.hu10.1007/s00264-004-0539-0eng ||7]Posan, E. Szepesi, K. Gaspar, L. Csernatony, Z. Harsfalvi, J. Ajzner, E. Toth, A. Udvardy, M.2003OThrombotic and fibrinolytic alterations in the aseptic necrosis of femoral head243-8Blood Coagul Fibrinolysis143 2003/04/16KAdolescent Adult Aged Aged, 80 and over Biological Markers/blood Blood Coagulation/*physiology Case-Control Studies Child Child, Preschool Factor V/physiology Female Femur Head Necrosis/*blood/etiology Fibrinolysis/*physiology Hemostasis/*physiology Humans Legg-Perthes Disease/blood/etiology Male Middle Aged Retrospective StudiesAprZRecent reports seem to support the role of the thrombophilia and decreased fibrinolysis in the aetiopathogenesis of aseptic necrosis of bone. In the present study, haemostatic disturbances were analysed in adults (n = 49) and patients in childhood (Perthes disease) (n = 47) with aseptic necrosis of the femoral head. Fibrinolytic parameters (in vitro clot lysis, plasminogen, plasmatic plasminogen activator inhibitor-1 activity, D-dimer) along with lipoprotein (a) [Lp(a)] and fibrinogen were measured. von Willebrand factor, platelet activation and some thrombophilic factors (activated protein C resistance and factor V Leiden mutation, protein C, protein S activity) were also determined. Impaired fibrinolysis, an increased Lp(a) level along with slow clot lysis and increased platelet activation were found in adult cases. We detected five cases of factor V Leiden mutations (one heterozygotic and four homozygotic) among patients with Perthes disease. The clinical course of the heterozygous case was similar to the usual form of Perthes disease. The most severe form of Perthes disease has been observed in homozygous factor V Leiden mutation cases. The mutation of factor V Leiden per se probably does not induce the development of aseptic necrosis of bone tissue in childhood, but it does play a role in its acceleration. Homozygous factor V Leiden mutation definitely runs a more severe course. On the other hand, in adult cases, the disturbances of haemostasis, impaired fibrinolysis, elevated Lp(a) level, increased platelet activation and slight elevation of fibrinogen might have clinical relevance. Further studies should focus on proving the role of the haemostatic alterations in the pathogenesis of severe forms of aseptic bone necrosis. The use of antithrombotic drugs in order to slow the process of aseptic necrosis also has to be addressed in future surveys.+http://www.ncbi.nlm.nih.gov/pubmed/12695746,Posan, Emoke Szepesi, Kalman Gaspar, Levente Csernatony, Zoltan Harsfalvi, Jolan Ajzner, Eva Toth, Aniko Udvardy, Miklos Research Support, Non-U.S. Gov't England Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Blood Coagul Fibrinolysis. 2003 Apr;14(3):243-8.%0957-5235 (Print) 0957-5235 (Linking)126957462nd Department of Medicine, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, 4012 Debrecen, Hungary. eposan@jaguar.dote.hu"10.1097/01.mbc.0000061299.28953.34eng||77Csernatony, Z. Kiss, L. Mano, S. Gaspar, L. Szepesi, K.2003KMultilevel callus distraction: a novel idea to shorten the lengthening time494-7Med Hypotheses604 2003/03/05Bone Lengthening/*instrumentation/*methods Bony Callus Humans Ilizarov Technique Leg Length Inequality Models, Theoretical Time FactorsAprLower extremity inequality is a common problem in everyday orthopaedic practice. The leg discrepancy can lead to variety of other problems, i.e., spinal problems. Surgical intervention is very demanding and requires patient compliance. Wagner's and Ilizarov's elongation technique are most commonly used worldwide, but it gives satisfactory results only in a long period of time and as we know there could be several inconvenient outcomes. Our idea aims at shortening this time period, and avoiding some of the inconvenient outcomes. Unfortunately we do not have the opportunity to go further in our investigations, but we hope that someone interested in this field will have an idea which would make continuation possible.+http://www.ncbi.nlm.nih.gov/pubmed/12615506tCsernatony, Z Kiss, L Mano, S Gaspar, L Szepesi, K Scotland Medical hypotheses Med Hypotheses. 2003 Apr;60(4):494-7.%0306-9877 (Print) 0306-9877 (Linking)12615506rLaboratory of Biomechanics, Medical Health and Science Center, University of Debrecen, Hungary. csz@jaguar.dote.huS0306987702004322 [pii]engR||7IGaspar, L. Szekanecz, Z. Dezso, B. Szegedi, G. Csernatony, Z. Szepesi, K.2003WTechnique of synovial biopsy of metacarpophalangeal joints using the needle arthroscope50-2#Knee Surg Sports Traumatol Arthrosc111 2003/01/28Adult Arthritis, Rheumatoid/*pathology *Arthroscopes Arthroscopy/methods Biopsy, Needle Female Humans Metacarpophalangeal Joint/*pathology Middle Aged Synovial Fluid/*cytologyJanyWe demonstrate the technique, advantages, and disadvantages of metacarpophalangeal joint examination with needle arthroscope. We evaluated our experience from biopsies of 10 metacarpophalangeal joints of eight rheumatoid women aged 41-45 years. The procedures were performed using a 1-mm needle arthroscope. The synovium biopsy was taken with a microforceps. The procedure was performed under local anesthesia. The tight tension of the joint and traction of the finger is necessary for good visualization, but despite this visibility can be difficult. Needle biopsy is a useful method for the early diagnosis of rheumatoid arthritis.+http://www.ncbi.nlm.nih.gov/pubmed/12548452Gaspar, Levente Szekanecz, Zoltan Dezso, Balazs Szegedi, Gyula Csernatony, Zoltan Szepesi, Kalman Germany Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA Knee Surg Sports Traumatol Arthrosc. 2003 Jan;11(1):50-2. Epub 2002 Dec 10.%0942-2056 (Print) 0942-2056 (Linking)12548452Department of Orthopedics, Medical Health and Science CenterUniversity of Debrecen, Nagyerdei krt. 98, 4012, Debrecen, Hungary. lgaspar@jaguar.dote.hu10.1007/s00167-002-0329-4eng||7/Csernatony, Z. Gaspar, L. Jonas, Z. Szepesi, K.2002?Modified unit rod technique in scoliosis surgery--a case report481-2Acta Orthop Scand734 2002/10/03QChild Female Humans Scoliosis/radiography/*surgery Spinal Fusion/*instrumentationAug+http://www.ncbi.nlm.nih.gov/pubmed/12358127Csernatony, Zoltan Gaspar, Levente Jonas, Zoltan Szepesi, Kalman Case Reports Norway Acta orthopaedica Scandinavica Acta Orthop Scand. 2002 Aug;73(4):481-2.%0001-6470 (Print) 0001-6470 (Linking)12358127xDepartment of Orthopaedic Surgery, University of Debrecen, Medical and Health Science Center, Hungary. csz@jaguar.dote.h10.1080/00016470216325eng||7.Csernatony, Z. Szepesi, K. Gaspar, L. Kiss, L.2002HContradictions of derotation in scoliosis surgery using the CD principle498-502Med Hypotheses586 2002/09/278Humans Orthopedic Procedures/*methods Scoliosis/*surgeryJunCurrent literature has increasingly emphasized the problem of derotation in scoliotic deformities. The Cotrel-Dubousset (CD) principle as a means of correcting rotation has been questioned by various authors. This paper aims to draw attention, using algebraic methods, to the importance of the remaining rotational deformities, and to suggest the introduction of the notion 'rotational balance'.+http://www.ncbi.nlm.nih.gov/pubmed/12323117nCsernatony, Z Szepesi, K Gaspar, L Kiss, L Scotland Medical hypotheses Med Hypotheses. 2002 Jun;58(6):498-502.%0306-9877 (Print) 0306-9877 (Linking)12323117|Department of Orthopaedics, Medical Health and Science Center, University of Debrecen, Debrecen, Hungary. csz@jaguar.dote.huS0306987701914707 [pii]eng ||7MCseri, J. Szappanos, H. Szigeti, G. P. Csernatony, Z. Kovacs, L. Csernoch, L.2002VA purinergic signal transduction pathway in mammalian skeletal muscle cells in culture731-8 Pflugers Arch4435-6 2002/03/13)Adenosine Triphosphate/*analogs & derivatives/pharmacology Anesthetics, Local/pharmacology Animals Antineoplastic Agents/pharmacology Calcium/metabolism Calcium Channel Blockers/pharmacology Cells, Cultured Dose-Response Relationship, Drug Humans Mammals Mice Muscle Fibers, Skeletal/cytology/*physiology Muscle, Skeletal/*cytology/growth & development Nicotinic Antagonists/pharmacology Receptors, Purinergic P2/agonists/*physiology Signal Transduction/drug effects/*physiology Tetrodotoxin/pharmacology Tubocurarine/pharmacology Verapamil/pharmacologyMarThe effects of adenosine 5'-triphosphate (ATP) on human and mouse skeletal muscle fibres in primary culture were investigated. ATP-evoked changes in intracellular calcium concentration ([Ca(2+)](i)) were measured and compared with those induced by agonists of the nicotinic acetylcholine (Ach)- and P2X purinoreceptors. While ATP was effective on both myoblasts and multi-nucleated myotubes in the micromolar range, Ach failed to induce any change in [Ca(2+)](i) at early stages of development. In contrast, myofibres with peripheral nuclei showed little response to ATP but responded to Ach with a large change in [Ca(2+)](i). The responsiveness of the myotubes to Ach paralleled that to potassium. The removal of external calcium abolished the response to ATP. P2X receptor agonists mimicked the response to ATP with the order of potency being ATP>2',3'- O-(4-benzoyl)-benzoyl-ATP>beta,gamma-methylene-ATP>alpha,beta-methylene-AT P. Under voltage-clamp conditions ATP induced an inward current that showed little inactivation. These results are consistent with the existence of P2X receptor-mediated signal transduction pathway in cultured mammalian skeletal muscle cells.+http://www.ncbi.nlm.nih.gov/pubmed/11889570Cseri, Julianna Szappanos, Henrietta Szigeti, Gyula Peter Csernatony, Zoltan Kovacs, Laszlo Csernoch, Laszlo Research Support, Non-U.S. Gov't Germany Pflugers Archiv : European journal of physiology Pflugers Arch. 2002 Mar;443(5-6):731-8. Epub 2001 Dec 4.%0031-6768 (Print) 0031-6768 (Linking)11889570xDepartment of Physiology, Medical and Health Science Centre, University of Debrecen, Debrecen, P.O.Box 22, 4012 Hungary.10.1007/s00424-001-0757-xeng||79Csernatony, Z. Szepesi, K. Gaspar, L. Dezso, Z. Jonas, Z.2000The 'rotational preconstraint'203-6Med Hypotheses542 2000/05/03Humans Models, Biological Muscle, Skeletal/physiopathology Scoliosis/*etiology/*physiopathology Spine/*physiopathology Stress, MechanicalFebfThis model provides a novel view of the etiology of some scolioses and can answer some of the biomechanical questions regarding pathogenesis of dorsal curves. According to our findings, paravertebral muscular imbalance is likely to favour such a pathological condition which, with the interference of the postural reflexes and the body weight-related vertical loading, might lead to the formation of a true scoliotic curve. Review of earlier research studies in the light of our findings reveals controversy in some authors' reported results and their own interpretations and seems to generally support our theory.+http://www.ncbi.nlm.nih.gov/pubmed/10790753vCsernatony, Z Szepesi, K Gaspar, L Dezso, Z Jonas, Z Scotland Medical hypotheses Med Hypotheses. 2000 Feb;54(2):203-6.%0306-9877 (Print) 0306-9877 (Linking)10790753fRoyal National Orthopaedic Hospital, Institute of Orthopaedics, Stanmore, Middlesex, UK. cszuk@aol.com210.1054/mehy.1999.0019 S0306-9877(99)90019-1 [pii]eng||7@Abd-el Wahab, M. Szepesi, K. Szucs, G. Farkas, C. Csernatony, Z.1998MFunctional improvement after knee arthroplasty without resurfacing of patella59-66Acta Chir Hung371-2 1999/04/10Adult Aged Aged, 80 and over Arthritis/surgery Arthritis, Rheumatoid/surgery *Arthroplasty, Replacement, Knee/adverse effects Female Femur/pathology Follow-Up Studies Humans Incidence Knee Injuries/complications/surgery Knee Joint/*physiology/surgery Locomotion/physiology Male Middle Aged Osteoarthritis, Knee/surgery Patella/*pathology/surgery Range of Motion, Articular/physiology Treatment Outcome Weight-Bearing/physiologyTThere has been no universal agreement so far regarding the necessity of patellar resurfacing in total knee arthroplasty. As resurfacing has been reported to be associated with high incidence of complications, this practice has been avoided in our Department. A report is given on the analysis of the functional outcome of 60 knee arthroplasties without patellar resurfacing in 53 patients (7 bilateral) followed up for twelve to thirty months, with special regard to the functions closely related to patelloformal articulation. The underlying diagnosis was osteoarthritis in 78.3%, rheumatoid arthritis in 13.3%, and posttraumatic arthritis in 8.3% of the patients. Graded according to the modified knee-rating system of the Hospital for Special Surgery, excellent or good results were obtained in the case of 55 knees (91.6%) and the mean score improved from 53.6 points preoperatively to 82.6 points following arthroplasty. Subjective and objective functional assessment of stair climbing and transfer activities have shown no functional deficit attributed to the patellofemoral joint of the replaced knee.+http://www.ncbi.nlm.nih.gov/pubmed/10196612Abd-el Wahab, M Szepesi, K Szucs, G Farkas, C Csernatony, Z Hungary Acta chirurgica Hungarica Acta Chir Hung. 1998;37(1-2):59-66.%0231-4614 (Print) 0231-4614 (Linking)10196612IDepartment of Orthopaedics, University Medical School, Debrecen, Hungary.eng;||70Gaspar, L. Farkas, C. Szepesi, K. Csernatony, Z.1997RTherapeutic value of continuous passive motion after anterior cruciate replacement104-5Acta Chir Hung361-4 1997/01/01Adult Anterior Cruciate Ligament/injuries/*surgery Arthroscopy Endoscopy Evaluation Studies as Topic Exercise Therapy Female Follow-Up Studies Humans Joint Instability/rehabilitation/surgery Knee Injuries/rehabilitation/*surgery Male *Motion Therapy, Continuous Passive/methods Muscle Contraction Patient Discharge Patient Satisfaction Postoperative Complications Range of Motion, ArticularThe aim of this study is the evaluation of the therapeutic value of continuous passive motion after ACL replacement. After 41 ACL reconstruction in 13 cases only active motion, in 28 cases active motion and CPM were used postoperatively. Stability, the range of motion and complications were evaluated at the time of discharge, 3 and 6 months after the operation. The flexion-extension in the CPM group was significantly greater at the time of discharge, but this difference was practically eliminated in 6 months after the operation. There were not any other significant difference between the two groups. The CPM gives only a little advantage in the rehabilitation after the ACL replacement.*http://www.ncbi.nlm.nih.gov/pubmed/9408304rGaspar, L Farkas, C Szepesi, K Csernatony, Z Hungary Acta chirurgica Hungarica Acta Chir Hung. 1997;36(1-4):104-5.%0231-4614 (Print) 0231-4614 (Linking)9408304RDepartment of Orthopaedic Surgery, University Medical School of Debrecen, Hungary.eng||7$Gaspar, L. Farkas, C. Csernatony, Z.1997Acute arthroscopy100-3Acta Chir Hung361-4 1997/01/01Adolescent Adult Anterior Cruciate Ligament/injuries/surgery *Arthroscopy Athletic Injuries/diagnosis/surgery Dislocations/diagnosis/surgery *Endoscopy Evaluation Studies as Topic Female Femur/injuries/surgery Humans Knee Injuries/diagnosis/*surgery Male Medial Collateral Ligament, Knee/injuries/surgery Menisci, Tibial/injuries/surgery Middle Aged Occupational Diseases/diagnosis/surgery Patellar Ligament/transplantation Posterior Cruciate Ligament/injuries/surgery Rupture Tendons/transplantationThe role and significance of acute arthroscopy have been evaluated in the treatment of knee joint injuries on the basis of findings during 59 arthroscopic operations which were conducted within two weeks after the accident. The injuries developed isolated in more than half of the cases (65%) whereas they appeared in a combination of two or more in 26% and in 9%, respectively. Injuries requiring operation were found in 91.5%, most of which were ruptures of the ACL (33 cases) and menisci (23 cases). In the case of ACL rupture, in the acute phase on sportsmen and physical workers primary arthroscopically assisted transligamental replacement was performed with patellar graft while in the case of proximal rupture of the ACL reinsertion and augmentation were carried out with semitendinosus tendon. The ruptures of dislocated eminentia were refixed in each case. In the case of the rupture of meniscus the refixation of the meniscus of resection of the ruptured part was attempted. By means of acute arthroscopy the lesion of the intraarticular structures or that of their combinations can be exactly diagnosed. Depending on the findings of arthroscopy the injuries can be treated immediately or operated on at a later time, thus preventing the joint from further deterioration.*http://www.ncbi.nlm.nih.gov/pubmed/9408303gGaspar, L Farkas, C Csernatony, Z Hungary Acta chirurgica Hungarica Acta Chir Hung. 1997;36(1-4):100-3.%0231-4614 (Print) 0231-4614 (Linking)9408303RDepartment of Orthopaedic Surgery, University Medical School of Debrecen, Hungary.eng||7YCsernatony, Z. Gaspar, L. Benko, K. Fekete, Z. Soos, P. Nyulasi, T. Szepesi, K. Jonas, Z.1997YExperimental studies for the surgical correction and fixation of dorsal spine deformities51-3Acta Chir Hung361-4 1997/01/01 Cadaver Dissection Equipment Design Humans Internal Fixators Kyphosis/surgery *Orthopedic Fixation Devices/adverse effects Osteoporosis/complications Rotation Scoliosis/radiography/*surgery Spinal Fractures/etiology Spine/radiography/*surgery Stress, Mechanical Tomography, X-Ray ComputedOne of the specific features of the scoliosis operations with a posterior approach is that both the correction of the deformity and then the maintaining of the corrected situation are carried out with the help of the implants. With the currently applied systems based on the CD principle it is still difficult to control the rotational component of the scoliotic curve. To complement the systems based on the CD principle, we have developed an implant family whose application makes the correction of the dorsal deformity generally simplier and derotation more effective. Our method is based on the application of such hooks which, linked to the longitudinal rods and hooked on both transverse processes of the instrumented vertebrae, transmit the concerted forces exerting their influence in the direction of the correction. Depending on their symmetrical relations, the hooks are capable of tilting in the frontal plane and derotating in the horizontal plane simultaneously, in the direction of our choice. The stability and applicability of the hooks were tested in implants into cadavers, and then the intimate relations of the implants were examined by means of radiological tests and dissection on instrumented specimens. On the basis of our results, the implants can already be used in clinical practice.*http://www.ncbi.nlm.nih.gov/pubmed/9408284Csernatony, Z Gaspar, L Benko, K Fekete, Z Soos, P Nyulasi, T Szepesi, K Jonas, Z Hungary Acta chirurgica Hungarica Acta Chir Hung. 1997;36(1-4):51-3.%0231-4614 (Print) 0231-4614 (Linking)9408284BDepartment of Orthopaedics, University Medical School of Debrecen.eng|~7#Szepesi, K. Rigo, J. Csernatony, Z.1993l[Experience with the implantation of porous coated hip endoprostheses and primary stability of implantation]253-9*Magy Traumatol Ortop Kezseb Plasztikai Seb363 1993/01/01Adult Female Femoral Neck Fractures/complications/surgery Femur Head Necrosis/etiology/surgery Hip Dislocation, Congenital/*complications/surgery Hip Prosthesis/*methods Humans Joint Instability/rehabilitation Male Middle Aged Osteoarthritis, Hip/etiology/*surgery Prosthesis DesignNThe use of porous coated cementless prosthesis, shows a worldwide spread in consequence of the advantages given by the "live" connection between the implant and the bone. Based on 40 implantations of prostheses of this type (Duraloc 1200 acetabulum, AML shaft) authors report on the technique of the implantation and the primary stability reached. In consequence of the formation, the variety of size and the properly usable instruments for implantation, the prostheses could be used for every kind of deformed, dysplastic hips and good primary stability was reached in every case operated.*http://www.ncbi.nlm.nih.gov/pubmed/8364660Szepesi, K Rigo, J Csernatony, Z English Abstract Hungary Magyar traumatologia, ortopedia, kezsebeszet, plasztikai sebeszet Magy Traumatol Ortop Kezseb Plasztikai Seb. 1993;36(3):253-9.8364660mTapaztalataink porosus bevonatu csipoprothesis beultetesi technikajaval es a beultetes primer stabilitasaval.DDebreceni Orvostudomanyi Egyetem Ortopediai Klinikajanak kozlemenye.hun||7$Csernatony, Z. Gaspar, L. Morocz, I.1991+[Synovial chondromatosis of the knee joint]53-6&Magy Traumatol Orthop Helyreallito Seb341 1991/01/01Adolescent Chondromatosis, Synovial/etiology/radiography/*surgery Female Humans Knee Injuries/*complications Knee Joint/radiography/surgeryAuthors removed more than hundred free bodies from the knee joint of a young female patient. In connection with their case the criteria of the synovial chondromatosis, the theories concerning the pathogenesis and the therapy to be chosen are described, based on literary data.*http://www.ncbi.nlm.nih.gov/pubmed/1672718Csernatony, Z Gaspar, L Morocz, I Case Reports English Abstract Review Hungary Magyar traumatologia, orthopaedia es helyreallito sebeszet Magy Traumatol Orthop Helyreallito Seb. 1991;34(1):53-6.%0025-0317 (Print) 0025-0317 (Linking)1672718&Terdizuleti synovialis chondromatosis.DDebreceni Orvostudomanyi Egyetem Ortopediai Klinikajanak kozlemenye.hun||7$Mandi, A. Csernatony, Z. Szepesi, K.1989Z[Results in Miacalcic therapy in the analgesic treatment of patients with bone metastases]145-50&Magy Traumatol Orthop Helyreallito Seb322 1989/01/01Analgesics/therapeutic use Bone Neoplasms/*drug therapy/surgery Calcitonin/*therapeutic use Humans Pain, Intractable/*drug therapy Palliative Care Postoperative CareAuthors have administered between 1984--87 in 30 patients with bone metastasis weekly 3 X 100 iu Miacalcic injections to relieve pain. The literature dealing with the pain relieving effect of calcitonin is summarized and their own results are assessed from more viewpoints. The use of Miacalcic injection is suggested as it was found a modern and very effective palliative medicine for pain relieving.*http://www.ncbi.nlm.nih.gov/pubmed/2476638Mandi, A Csernatony, Z Szepesi, K English Abstract Hungary Magyar traumatologia, orthopaedia es helyreallito sebeszet Magy Traumatol Orthop Helyreallito Seb. 1989;32(2):145-50.%0025-0317 (Print) 0025-0317 (Linking)2476638\Miacalcic kezelessel elert eredmenyeink a csontmetastasisos betegek fajdalomcsillapitasaban.hun<||7PTolan, L. Barna, V. Szigeti, I. Tecsa, D. Gavris, C. Csernatony, O. Buchwald, I.19694[The use of bilberry powder in dyspepsia in infants]375-9Pediatria (Bucur)184 1969/07/018Dyspepsia/*drug therapy Humans Infant *Plants, MedicinalJul-Aug*http://www.ncbi.nlm.nih.gov/pubmed/5355704Tolan, L Barna, V Szigeti, I Tecsa, D Gavris, C Csernatony, O Buchwald, I Romania Pediatria Pediatria (Bucur). 1969 Jul-Aug;18(4):375-9.%0031-3904 (Print) 0031-3904 (Linking)53557046Utilizarea prafului de afine in dispepsille sugarului.rum"@?Csernátony, Z.2005,A mozgásszervek biomechanikai vonatkozásaiOrvosi biofizikaDamjanovich, S. Mátyus, L.Medicina @?6Szántó, J. Csernátony, Z. Dezső, B. Horváth, Á. 2005+Rosszindulatú támasztószöveti daganatok"Klinikai onkológia a gyakorlatban Szántó, J.k @?Csernátony, Z.2006$A csontok felépítése, fejlődése Ortopédia Szendrői, M. Semw @?Csernátony, Z.2006$Konzervatív gyógyító eljárások Ortopédia Szendrői, M.  @?qCsernátony, Z.2006Alagútszindrómák OrtopédiaSzendrői, M. Se @?QCsernátony, Z.2006@Az inak, ínhüvelyek, bursák, fasciák és szalagok betegsége OrtopédiaSzendrői, M. S  melweis 963 9214 65 5  melweis978 963 9656 93 2 emmelweis978 963 9656 93 2 mmelweis978 963 9656 93 2  melweis978 963 9656 93 2  melweis978 963 9656 93 2 Semmelweis978 963 9656 93 2/ @?Csernátony, Z.2006ASudeck-szindróma (felső vagy alsó végtag reflexdystrophiája) Ortopédia Szendrői, M. Sem @?qCsernátony, Z.2008"Structure and development of bones Orthopedics Szendrői, M. Sem @?`Csernátony, Z.2008!Conservative treatment procedures Orthopedics Szendrői, M. S @?`Csernátony, Z.2008Tunnel syndromes Orthopedics Szendrői, M. Se D@?`Csernátony, Z.2008CDisorders of tendons, tendon sheaths, bursae, fasciae and ligaments Orthopedics Szendrői, M. Sem p@?@Csernátony, Z.2008SDiseases of joints/The structure of the joints. The biomechanical aspects of joints Orthopedics Szendrői, M. Semk @?Csernátony, Z.2008&Reflex dystrophy (Sudeck’s syndrome) Orthopedics Szendrői, M. ?'Mándi, A. Csernátony, Z. Szepesi, K.1989bMiacalcic kezeléssel elért eredményeink a csontmetastasisos betegek fájdalomcsillapításában145-50Magyar Traumat Ortop32?(Csernátony, Z. Gáspár, L. Mórocz, I.1991(Térdízületi synovialis chondromatosis53-6Magyar Traumat Ortop34?'Szepesi, K. Rigó, J. Csernátony, Z. 1993yTapasztalataink porosus bevonatú csípőprothesis beültetési technikájával és a beültetés primer stabilitásával253-9Magyar Traumat Ortop36 m hhe objective IKDC final scores showed statistically significantly more "normal knees" in the DB group than in Bto movement275-281*First Hungarian Conference on Biomechanics`?#/Molnár, Sz. Manó, S. Kiss, L. Csernátony, Z.2004IIn vitro determination of the axial rotational axis of the thoracic spine290-294*First Hungarian Conference on Biomechanics?$@Pálinkás, J. Daróczi, L. Pék, Gy. Manó, S. Csernátony, Z.2004HElectronic device for the training and control of partial weight bearing342-347*First Hungarian Conference on Biomechanics?%b2Hajdú, A. Manó, S. Zörgő, Z. Csernátony, Z.20042The “spiral cut” technique for leg lengthening151-160*First Hungarian Conference on Biomechanics L?&BCsernátony, Z. Fekete, Zs. Soós, P. Nyulasi, T. Gáspár, L.1999yA háti szakasz scoliosisának módosított instrumentálása. Első klinikai tapasztalatok a CAB horgok alkalmazásával42-46Magyar Traumat Ortop42?*Gáspár, L. Farkas, Cs. Csernátony, Z.1999Menisectomia után kialakuló radiológiai elváltozások és ezek összefüggése a térdfunkció romlásával. Késői eredmények5-12Magyar Traumat Ortop42z?Jónás, Z. Csernátony, Z.1999OMalignus primer csonttumoros betegeink késői eredményei 15 éves anyagunkban55-60Magyar Traumat Ortop42q?3Póti, L. Csernátony, Z. Soltész, I. Kiss, Á.1999hA csípőízületre frontális síkban ható erők biomechanikai analízise avascularis necrosis esetén34-41Magyar Traumat Ortop42?y)Csernátony, Z. Horváth, R. Szepesi, K.1999&Biomechanika: a felzárkózás kezdete10-2Gép10?BCsernátony, Z. Szepesi, K. Gáspár, L. Dezső, Zs. Jónás, Z.2000q"The Rotational Preconstraint". A kinetic model of a possible new mechanism in the ethiopathogenesis of scoliosis203-6Medical Hypotheses542$? [Csernátony, Z. Goodship, A. Szepesi, K. Jónás, Z. Gáspár, L. Benkő, K. Lawes, T.2001iA complementary thoracic implant for the surgical correction of the scoliotic curve. A preliminary report85-9Eur J Orthop Traumatol11 m pe screws reinforced with a staple on the femur. The same rehabilitation protocol was adopted. Outcome assessment was performed by a blinded, independent observer using the visual analog scale (VAS) score, the new International Knee Documentation Committee (IKDC) form, the Knee Injury and Osteoarthritis Outcome Score (KOOS), and KT-1000 arthrometer evaluation. Results: All the patients reached a minimum follow-up of 2 years. No differences between the 2 groups were observed in terms of KOOS and IKDC subjective score. A statistically significant difference in favor of the DB group was found with the VAS (P < .03). T)3 ?PCseri, J. Szappanos, H. Szigeti, GP. Csernátony, Z. Kovács, L. Csernoch, L.2002VA purinergic signal transduction pathway on mammalian skeletal muscle cells in culture731-8Pflügers Arch Eur J of Physiol443?8Csernátony, Z. Gáspár, L. Mándi, B. Székely, Gy.2002kElektrofiziológiai és MRI vizsgálattal igazolt és sikeresen operált piriformis alagútszindróma esete319-21Magyar Traumat Ortop45?&PGáspár, L. Szekanecz, Z. Dezső, B. Szegedi, G. Csernátony, Z. Szepesi, K.2003TTechnique of synovial biopsy of metacarpophalangeal joints with needle arthroscope. 50-2"Knee Surg Sports Traumatol Artrosc111 iomechanics  mint lehetséges etio iomechanics iomechanics iomechanics iomechanics  New nanostructured  lmaterials for exp Medicina 963 242 973 7:@W?Csernátony, Z.2006 BiomechanikaOrvosi biofizika'Damjanovich, S. Fidy, J. Szöllősi, J.Medicina2 963 226 024 4  melweis 963 9214 65 5 Semmelweis 963 9214 65 5 mmelweis 963 9214 65 5 emmelweis 963 9214 65 5@?Csernátony, Z.2006aAz ízületek betegségei/Az ízületek fejlődése, felépítése. Az ízületek biomechanikája Ortopédia Szendrői, M. Semmelweis 963 9214 65 5  start="29" />Csernatony, Z.2008 BiomechanikBiophysik für mediziner&Damjanovich, S Fidy, J. Szöllősi, J.Medicina978 963 226 140 9@?Csernátony, Z.2009 BiomechanicsMedical Biophysics'Damjanovich, S. Fidy, J. Szöllősi, J.Medicina978 963 226 127 0 @? Csernátony, Z.2010A gerinc elváltozásaiRehabilitációs orvoslásVekerdy-Nagy, Zs.Medicina978 963 226 276 5 @?!Csernátony, Z.2010A gerinc elváltozásaiRehabilitációs orvoslásVekerdy-Nagy, Zs.Medicina978 963 226 276 5 ?".(Manó, S. Molnár, Sz. Csernátony, Z.2004WThe volumetric examination of the thoracic spinal canal changes in relation  $?Csernátony, Z.2004hA Debreceni Egyetem Biomechanikai Kutatólaboratóriumának bemutatása: története és tevékenységei64-68*First Hungarian Conference on B?KFooladi, S. Szabó, S. Szűcs, G. Daróczi, L. Deák, Gy. Csernátony, Z.2004jA vérrel való szennyeződés hatása a csontcement ultrastruktúrájára és mechanikai tulajdonságaira128-134*First Hungarian Conference on Biomechanics |?&Manó, S. Molnár, Sz. Csernátony, Z.2004dA háti gerinccsatorna térfogat mozgásokkal összefüggő változásainak volumetriás vizsgálata275-281*First Hungarian Conference on BO @?5Csernátony, Z. Gáspár, L. Molnár, Sz. Fooladi, S.2004jA „rotációs előfeszítettség”,  ߘ?1Molnár, Sz. Manó, S. Kiss, L. Csernátony, Z.2004LA háti csigolyák axiális rotációs tengelyének in vitro meghatározása290-294*First Hungarian Conference on B ߴ?@Pálinkás, J. Daróczi, L. Pék, Gy. Manó, S. Csernátony, Z.2004]Elektronikus járósarok az alsóvégtagi tehermentesítés betanítására és kontrolljára342-347*First Hungarian Conference on B?50Hajdú, A. Manó, S. Zörgő, Z. Csernátony, Z.2004GA hosszú csövescsontok hosszabbításának „Spiral Cut” módszere151-160*First Hungarian Conference on Biomechanicsd 0?})Csernátony, Z. Manó, S. Pálinkás, J.2004XCAB: `?5Csernátony, Z. Manó, S. Pálinkás, J. Kovács, Á.2004YA Spine Knows Better műtéti technikájának kidolgozásával eddig elért eredményeink85-89*First Hungarian Conference on B`?"Manó, S. Nagy, N. Csernátony, Z.2004(Gerincsebészeti műtőasztal tervezése282-289*First Hungarian Conference on Biomechanics?#0Szabó, J. Szűcs, G. Szabó, S. Csernátony, Z.2004UA totál endoprotézisek korai lazulásának balesetszerű oka: reológiai tanulmány423-431*First Hungarian Conference on Biomechanics@?C/Kiss, L. Manó, S. Molnár, Sz. Csernátony, Z.2004zSikertelen felső ugróízületi protézisműtét salvage technikája: az Ankle Ball Spacer - biomechanikai előtanulmány198-204*First Hungarian Conference on Biomechanics?/'Szakál, Z. Zsoldos, I. Csernátony, Z.2004IGyors prototípus gyártás alkalmazása a humángyógyászat területén432-437*First Hungarian Conference on Biomechanics ) .-34#American Journal of Sports Medicine381knee acl reconstruction double-bundle technique single-bundle technique posterolateral fiber-bundles femoral tunnel placement anatomic double-bundle acl reconstruction biomechanical analysis semitendinosus tendon hamstring tendons knee graft attachmentJanBackground: Double-bundle ACL reconstruction popularity is increasing with the aim to reproduce native ACL anatomy and improve ACL reconstruction outcome. However, to date, only a few randomized clinical studies have been published. Purpos 1 start="0" /> Szeverényi, Cs. Csernátony, Z.2006;Kümmel-Verneuil szindróma áttekintése egy eset kapcsán106-109Magyar Reumatológia47 Vions. The double-bundle construct was significantly better in limiting anterior translation of the lateral compartment compared with the single-bundle reconstruction during a pivot-shift maneuver (2.0 +/- 5.7 mm vs 7.8 +/- 1.8 mm, P<.001) and was not significantly different than the intact anterior cruciate ligament condition (2.7 mm +/- 4.7 mm, P>.05). Discussion: Although double-bundle and single-bundle, center-center anterior cruciate ligament reconstructions appear equally effective in controlling anterior translation during a Lachman examination, analysis of pivot-shift kinematics reveals significant differences between these surgical reconstructions. An altered rotational axis resulted in significantly greater translation of the lateral compartment in the single-bundle compared with double-bundle reconstruction. Clinical Relevance: A double-bundle anterior cruciate ligament reconstruction may be a favorable construct for restoration of knee kinematics in the at-risk knee with associated meniscal injuries and/or significant pivot shift on preoperative examination.://000281419800006-644ZD Times Cited:0 Cited References Count:25 0363-5465ISI:000281419800006{Pearle, AD 535 E 70th St, New York, NY 10021 USA Hosp Special Surg, Sports Med & Shoulder Surg Serv, New York, NY 10021 USADoi 10.1177/0363546510369303English - H|70GAglietti, P. Giron, F. Losco, M. Cuomo, P. Ciardullo, A. Mondanelli, N.2010Comparison Between Single- and Double-Bundle Anterior Cruciate Ligament Reconstruction A Prospective, Randomized, Single-Blinded Clinical Trial25 ecord>8Horváth, R. Bodnár, I. Manó, S. Dajkó, G. Zolnai, L.2008$Műanyagok mesterséges öregítése37-9Gép 598?,4Rybaltovszki, H. Muraközy, K. Manó, S. Fekete, K.2008yKanülált combnyakcsavar behasítása és rotáció gátló lemez alkalmazásának hatása a rögzítés stabilitására365-9Magyar Traumat Ortop514?-"Csernátony, Z. Kiss, L. Manó, S.2008DA new technique of wedge osteotomy to diminish undesirable fractures485-488Eur J Orthop Surg Traumatol 18?.STiba, Zs. Husi, G. Manó, S. Kiss, L. Jónás, Z. Nádházi, L. Csernátony, Z.2009/An easy to use device for lubricity examination27-30Biomechanica HungaricaII2 O 1|7/MBedi, A. Musahl, V. O'Loughlin, P. Maak, T. Citak, M. Dixon, P. Pearle, A. D.2010A Comparison of the Effect of Central Anatomical Single-Bundle Anterior Cruciate Ligament Reconstruction and Double-Bundle Anterior Cruciate Ligament Reconstruction on Pivot-Shift Kinematics 1788-1794#American Journal of Sports Medicine389anterior cruciate ligament (acl) central single bundle double bundle pivot shift femoral tunnel placement acl reconstruction intraoperative evaluation biomechanical analysis navigation system insufficiency reliability laxitySepl Backg?<Csernátony, Z. Novák, L. Bognár, L. Ruszthi, P. Manó, S.2007rSzámítógépes tervezésű cranioplastica. Első hazai eredmények a térbeli nyomtatás orvosi alkalmazásával238-43Magyar Traumat Ortop503!?DJónás, Z. Kiss, L. ifj. Noviczki, M. Noviczki, M. Csernátony, Z. 2007Totál térdízületi endoprotézis késői szeptikus szövődményének megoldása az implantátumok megtartásával - Esetismertetés366-70Magyar Traumat Ortop504  " />)Csernátony, Z. Manó, S. Pálinkás, J.2004OCAB: a new implant for the cor ?'5Csernátony, Z. Manó, S. Pálinkás, J. Kovács, Á.2004GOur results so far with the “Spine Knows Better” surgical technique85-89*First Hungarian Conference on Biomechanics?("Manó, S. Nagy, N. Csernátony, Z.2004JOperating table design for the „Spine knows better” surgical technique282-289*First Hungarian Conference on Biomechanics ?)2Kiss, L. Manó, S. Molnár, Sz. Csernátony, Z.2004The salvage technique of unsuccessful total ankle replacement: the ankle ball spacer – prliminary in vitro biomechanical experimentation198-204*First Hungarian Conference on Biomechanics ?*#Manó, S. Pálinkás, J. Kiss, L.2008WThe design of a moving device to aid the postoperative rehabilitation of the knee joint195-204*Third Hungarian Conference on Biomechanics7 |?+`7Bazsó, A. Csernátony, Z. Szekanecz, Z. Maródi, L.2005$Krónikus multifocalis osteomyelitis182-186Gyermekgyógyászat5628?jCsernátony, Z.2005zA scoliosis-csapda – tévedések, tévhitek és tévutak. Biomechanika, terápia, prognosztika és egy kis pszichológia641-648.Gyermekgyógyászat566j? Szeverényi, Cs. Csernátony, Z.2006;Kümmel-Verneuil szindróma áttekintése egy eset kapcsán106-109Magyar Reumatológia478?F>Szabó, J. Szabó, S. Jónás, Z. Kiss, L. Csernátony, Z. 2006pModellkísérlet a csípőízületi endoprotézisfejek lehetséges intraoperatív sérülésének vizsgálatára147-52Magyar Traumat Ortop492  @e: The aim of this study was to prospectively compare the clinical results of single- and double-bundle ACL reconstruction. Study Design: Randomized controlled clinical trial; Level of evidence, 1. Methods: Seventy patients with a chronic unilateral ACL rupture who underwent arthroscopically assisted ACL reconstruction using a hamstring graft were randomized to receive a single- (SB) or double-bundle (DB) reconstruction. Both groups were comparable with regard to preoperative data. A double-incision surgical technique was adopted in both groups. The graft was fixed by looping the hamstring tendons around a bony (DB) or a metallic (SB) bridge on the tibial side and with interferenc  _round: Biomechanical differences between anatomical double-bundle and central single-bundle anterior cruciate ligament reconstruction using the same graft tissue have not been defined. Purpose: The purpose of this study was to compare these reconstructions in their ability to restore native knee kinematics during a reproducible Lachman and pivot-shift examination. Study Design: Controlled laboratory study. Methods: Using a computer-assisted navigation system, 10 paired knees were subjected to biomechanical testing with a standardized Lachman and mechanized pivot-shift examination. The navigation system recorded the 3D motion path of a tracked point at the center of the tibia, center of the medial tibial plateau, and center of the lateral tibial plateau with e? +Csernátony, Z. Dezső, Zs. Gáspár, L. 2007mCsípőprotézisek rotációs stabilitása a femur proximalis metaphysisében. Biomechanikai modellkísérlet107-16Magyar Traumat Ortop502| ? >Lázár, I. Kiss, L. Manó, S. Fábián, I. Csernátony, Z.2008?s? X? 'Manó, S. Novák, L. Csernátony, Z. 2008EA 3D nyomtatás technológiájának alkalmazása? 3Csernátony, Z. Hunya, Zs. Sikula, J. Kollár, J.2008EA thoracalis gerinc processus transversusainak geometriai vizsgálata57-62Biomechanica Hungarica11I? Csernátony, Z.2008"Az orvosi biomechanika története63-75Biomechanica HungaricaI1(?y#Csernátony, Z. Kiss, L. Manó, S.2008DA new technique of wedge osteotomy to diminish undesirable fractures485-488Eur J Orthop Surg Traumatol18?G2Csernátony, Z. Kiss, L. Füleki, M. Jónás, Z.2009VThe useful-harmful collar in cemented THR – Do we really do what we are going to do?47-49Biomechanica HungaricaII1 ?NPálinkás, J. Szabó, I. Harasztosi, L. Vass, Sz. Soha, F. Csernátony, Z.2009Különböző egyensúlyvizsgáló rendszerek összehasonlítása – Előtanulmány a lovasterápia egyensúlyfejlesztő hatásának vizsgálatára51-58 Biomech HungII1]?Csernátony, Z.2009OA hátsó feltárásból végzett scoliosis műtétek a kezdetektől napjainkig59-79Biomechanica HungaricaII1:??Gáspár, L. Jónás, Z. Kiss, L. Vereb, Gy. Csernátony, Z.2009Coccygectomy has a favorable effect on the intensity, manifestation, and characteristics of pain caused by coccygodynia: a retrospective evaluation of 34 patients followed for 3–18 years403-407Eur J Orthop Surg Traumatol19?NSzűcs, G. Szabó, S. Seyawash, F. Deák, Gy. Daróczi, L. Csernátony, Z.2009]Műtétekből származó, vérrel kevert csontcement szerkezeti és mechanikai tulajdonságai253-57Magyar Traumat Ortop523 ?jCsernátony, Z.2009OTraumatizált ortopédia. Szerelemházasság? Névházasság? Érdekházasság?282-85Magyar Traumat Ortop523B?6Bazsó, T. Kiss, L. Szeverényi, Cs. Csernátony, Z.20091Kristálycukor helye és szerepe a sebkezelésben5-14Sebkezelés-sebgyógyulásXII2) ?MCSoha, F. Szabó, I. Harasztosi, L. Pálinkás, J. Csernátony, Z.2009XDevelopment of an accelerometer based mo ?STiba, Zs. Husi, G. Manó, S. Kiss, L. Jónás, Z. Nádházi, L. Csernátony, Z.2009/An easy to use device for Z?"Csernátony, Z. Manó, S. Kiss, L.2009"The geometry of the proximal femur31-36Biomechanica HungaricaII2 ) (ach maneuver. The testing protocol consisted of evaluation in the intact state, after complete anterior cruciate ligament transection, after medial and lateral meniscectomy, and after anterior cruciate ligament reconstruction with (1) a single-bundle center-center or (2) anatomical double-bundle technique. Repeated-measures analysis of variance with a post hoc Tukey test was used to compare the measured translations with each test condition. Results: A significant difference in anterior translation was seen with Lachman examination between the anterior cruciate ligament- and medial and lateral meniscus-deficient condition compared with both the double-bundle and single-bundle center-center anterior cruciate ligament reconstruction (P<.001); no significant difference was observed between reconstruct?1Csernátony, Z. Kiss, L. Szücs, G. Jónás, Z.2010wStrukturális, szegmentális, proximalis, femoralis allograft alkalmazása kiterjedt periprotetikus csonthiány esetén67-71Magyar Traumat Ortop531i7 ?KLázár, I. Manó, S. Jónás, Z. Kiss, L. Fábián, I. Csernátony, Z. 2010QMesoporous silica-calcium phosphate composites for experimental bo  the SB group (P = .03). There was 1 stability failure in the DB group and 3 in the SB group. The KT-1000 arthrometer data showed a statistically significant decrease in the average anterior tibial translation in the DB group (1.2 mm DB vs 2.1 mm SB; P < .03). The incidence of a residual pivot-shift glide was 14% in DB and 26% in SB (P = .08). Conclusion: In the 2-year minimum follow-up, DB ACL reconstructions showed better VAS, anterior knee laxity, and final objective IKDC scores than SB. However, longer follow-up and accurate instrumented in vivo rotational stability assessment are needed.://000273293300002-539XT Times Cited:2 Cited References Count:47 0363-5465ISI:000273293300002Giron, F Univ Florence, Orthopaed Clin 1, Largo Pietro Palagi 1, I-50139 Florence, Italy Univ Florence, Orthopaed Clin 1, I-50139 Florence, ItalyDoi 10.1177/0363546509347096English |71(Kim, S. J. Jo, S. B. Kumar, P. Oh, K. S.2009yComparison of Single- and Double-Bundle Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon-Bone Autografts70-77;Arthroscopy-the Journal of Arthroscopic and Related Surgery251anterior cruciate ligament double-bundle reconstruction functional outcomes knee stability quadriceps tendon-bone autograft multistranded hamstring tendons anatomic reconstruction femoral fixation joint laxity grafts knee socket trialJanwPurpose: The purpose of this study was to evaluate and compare postoperative knee stability and functional scores between single- and double-bundle anterior cruciate ligament (ACL) reconstruction with the use of quadriceps tendon-bone auto-rafts at a 2-year follow-up. Methods: The records of 59 patients who had ACL reconstruction between January 2005 and April 2006 were analyzed retrospectively. Twenty-eight patients had single-bundle reconstruction (group S) and 31 received double-bundle reconstruction (group D). Ligament stability was assessed with the Lachman and pivot-shift tests and a KT-2000 arthrometer. International Knee Documentation Committee (IKDC) and Lysholm scores were employed to evaluate the functional outcomes. Results: The postoperative mean side-to-side difference for group S was 2.64 mm and 1.79 mm for group D, a difference that was found to be statistically significant (P = .020). Regarding the pivot-shift test, 3 patients had grade 1+ and 1 patient had grade 2+ pivot-shift in group S, while no patients had abnormal pivot-shift in group D (P = .093). The patients who reported grade A or B on IKDC scores were 24 and 28 in group S and D, respectively (P >.1). On the questionnaire of the twisting activity, although statistical difference was not found between the groups, there was a trend toward more restriction in twisting activity in group S (P = .096). We found significant correlation between the twisting activity and instability questionnaire of the Lysholm score (Spearman coefficient, 0.737; P < .001). Conclusions: Double-bundle ACL reconstruction using quadriceps tendon-bone autografts provide less laxity (1.79 mm) than single-bundle ACL reconstruction (2.64 mm) as measured by the KT-2000. However, we could not find any significant differences in the functional measurements between the 2 groups. Level of Evidence: Level M, retrospective comparative study.://000262858200013-400HI Times Cited:2 Cited References Count:27 0749-8063ISI:000262858200013Oh, Ks Yonsei Univ, Coll Med, Dept Orthopaed Surg, CPO Box 8044,134 Shinchon Dong, Seoul 120752, South Korea Yonsei Univ, Coll Med, Dept Orthopaed Surg, Seoul 120752, South Korea Lisie Hosp, Dept Orthopaed, Kochi, India DOI 10.1016/j.arthro.2008.09.004English |72jSasaki, S. U. Albuquerque, R. F. D. M. E. Pereira, C. A. M. Gouveia, G. S. Vilela, J. C. R. Alcaras, F. D.2008An in vitro biomechanical comparison of anterior cruciate ligament reconstruction: Single bundle versus anatomical double bundle techniques71-76Clinics631_anterior cruciate ligament knee anatomy comparative study surgery tendon fixation grafts socketFeb)INTRODUCTION: Anterior cruciate ligament ruptures are frequent, especially in sports. Surgical reconstruction with autologous grafts is widely employed in the international literature. Controversies remain with respect to technique variations as continuous research for improvement takes place. One of these variations is the anatomical double bundle technique, which is performed instead of the conventional single bundle technique. More recently, there has been a tendency towards positioning the two bundles through double bone tunnels in the femur and tibia (anatomical reconstruction). OBJECTIVES: To compare, through biomechanical tests, the practice of anatomical double bundle anterior cruciate ligament reconstruction with a patellar graft to conventional single bundle reconstruction with the same amount of patellar graft in a paired experimental cadaver study. METHODS: Nine pairs of male cadaver knees ranging in age from 44 to 63 years were randomized into two groups: group A (single bundle) and group B (anatomical reconstruction). Each knee was biomechanically tested under three conditions: intact anterior cruciate ligament, reconstructed anterior cruciate ligament, and injured anterior cruciate ligament. Maximum anterior dislocation, rigidity, and passive internal tibia rotation were recorded with knees submitted to a 100 N horizontal anterior dislocation force applied to the tibia with the knees at 30, 60 and 90 degrees of flexion. RESULTS: There were no differences between the two techniques for any of the measurements by ANOVA tests. CONCLUSION: The technique of anatomical double bundle reconstruction of the anterior cruciate ligament with bone-patellar tendon-bone graft has a similar biomechanical behavior with regard to anterior tibial dislocation, rigidity, and passive internal tibial rotation.://000254321700013-278YH Times Cited:7 Cited References Count:21 1807-5932ISI:000254321700013Sasaki, SU Univ Sao Paulo, Fac Med, Hosp Clin, Inst Ortopedia & Traumatol, Sao Paulo, Brazil Univ Sao Paulo, Fac Med, Hosp Clin, Inst Ortopedia & Traumatol, Sao Paulo, BrazilEnglish I|73!Siebold, R. Dehler, C. Ellert, T.2008qProspective randomized comparison of double-bundle versus single-bundle anterior cruciate ligament reconstruction137-145;Arthroscopy-the Journal of Arthroscopic and Related Surgery242anterior cruciate ligament reconstruction anteromedial bundle double bundle posterolateral bundle quadruple hamstring graft hamstring tendon grafts in-situ forces semitendinosus tendon anatomic reconstruction patellar tendon tibial tunnel 2-bundle loadsFeb Purpose: Biomechanical studies show increased anterior and rotational stability with double-bundle (DB) compared to single-bundle (SB) anterior cruciate ligament (ACL) reconstruction. The aim of this study was to evaluate the clinical results of four-tunnel DB ACL reconstruction. Methods: Seventy patients undergoing arthroscopic hamstring ACL reconstruction were prospectively randomized to DB (n = 35) or SB (n = 35) groups. Each bundle fixation was by means of a femoral EndoButton CL and a tibial biodegradable interference screw. Demographic data were comparable between groups, and the average age of all patients was 29 years. The average follow-up was 19 months for both groups and included a history, clinical evaluation with knee scores, and radiographs. Results: The subjective results were similar in groups. The subjective International Knee Documentation Committee (IKDC) 2000 score was 88 P for DB versus 90 P for SB; the Lysholm score was 90 P for DB versus 93 P for SB; and the Cincinnati knee score was 91 P for DB versus 92 P for SB. The objective IKDC was significantly higher for DB: 78% "A" (P < .000) and 19% "B" compared to 24% "A" and 68% "B" for SB. The average KT-1000 side-to-side difference was 1.0 mm for DB and 1.6 mm for SB (P = .054) and the pivot shift test was negative in 97% for DB (P = .01) and 71% for SB. The range of motion was comparable for both groups. Conclusions: Our study shows a significant advantage in anterior and rotational stability as well as objective IKDC for four-tunnel DB ACL reconstruction compared to SB ACL reconstruction. The subjective Cincinnati knee score, the Lysholm score, and the subjective IKDC 2000 did not show any statistical difference for one or the other technique. Level of Evidence: Level I, randomized controlled trial.://000253049600004.260ZT Times Cited:54 Cited References Count:36 0749-8063ISI:000253049600004Siebold, R ARCUS Sportsclin, Dept Orthopaed, Rastatter Str 17-19, D-75179 Pforzheim, Germany ARCUS Sportsclin, Dept Orthopaed, D-75179 Pforzheim, Germany DOI 10.1016/j.arthro.2007.11.013English=<744Eggers, J. Fontelos, M. A. Josserand, C. Zaleski, S.2010BDrop dynamics after impact on a solid wall: Theory and simulations-Physics of Fluids226=water drops liquid-drop surface solidification model film airJunWe study the impact of a fluid drop onto a planar solid surface at high speed so that at impact, kinetic energy dominates over surface energy and inertia dominates over viscous effects. As the drop spreads, it deforms into a thin film, whose thickness is limited by the growth of a viscous boundary layer near the solid wall. Owing to surface tension, the edge of the film retracts relative to the flow in the film and fluid collects into a toroidal rim bounding the film. Using mass and momentum conservation, we construct a model for the radius of the deposit as a function of time. At each stage, we perform detailed comparisons between theory and numerical simulations of the Navier-Stokes equation. (C) 2010 American Institute of Physics. [doi:10.1063/1.3432498]://000280143100012-628SX Times Cited:1 Cited References Count:36 1070-6631 Phys FluidsISI:000280143100012Eggers, J Univ Bristol, Sch Math, Univ Walk, Bristol BS8 1TW, Avon, England Univ Bristol, Sch Math, Univ Walk, Bristol BS8 1TW, Avon, England Univ Bristol, Sch Math, Bristol BS8 1TW, Avon, England Inst Ciencias Matemat ICMAT, CSIC UAM UC3M UCM, Madrid 28006, Spain CNRS, Inst Jean Le Rond Alembert, UMR 7190, F-75005 Paris, France Univ Paris 06, Inst Jean Le Rond Alembert, UMR 7190, F-75005 Paris, France!Artn 062101 Doi 10.1063/1.3432498English<75Wiercigroch, M. Pavlovskaia, E.2003BNonlinear dynamics of vibro-impact systems: Theory and experiments513-5200Modern Practice in Stress and Vibration Analysis440-4Qdrift friction impact oscillator nonlinear dynamics dry friction model oscillatorDynamics of a vibro-impact ground moling system is considered. Due to its structural complexity the dynamic response of an idealised impact oscillator is investigated in the first instance. The model is comprised of an harmonically excited mass simulating the penetrating part of the mole and a visco-elastic slider, which represents the soil resistance. Comparison between experimental and theoretical results shows that the considered model reflects well the dynamics of the vibro-impact system and also the soil resistance curves. A typical nonlinear dynamic analysis has revealed complex behaviour ranging from periodic to chaotic motion. It was found out that the maximum progression is achieved when system responds periodically with the period of external excitation.://000188594100063EBy26p Times Cited:2 Cited References Count:23 Materials Science Forum 0255-5476Mater Sci ForumISI:000188594100063.Wiercigroch, M Univ Aberdeen, Kings Coll, Sch Engn & Phys Sci, Ctr Appl Dynam Res, Aberdeen AB24 3UE, Scotland Univ Aberdeen, Kings Coll, Sch Engn & Phys Sci, Ctr Appl Dynam Res, Aberdeen AB24 3UE, Scotland Univ Aberdeen, Kings Coll, Sch Engn & Phys Sci, Ctr Appl Dynam Res, Aberdeen AB24 3UE, ScotlandEnglish'<76!Haug, E. J. Wu, S. C. Yang, S. M.1986rDynamics of Mechanical Systems with Coulomb-Friction, Stiction, Impact and Constraint Addition Deletion .1. Theory401-406Mechanism and Machine Theory215://A1986E844700005-E8447 Times Cited:71 Cited References Count:7 0094-114XMech Mach TheoryISI:A1986E844700005Haug, Ej Univ Iowa,Coll Engn,Ctr Comp Aided Design,Iowa City,Ia 52242 Univ Iowa,Coll Engn,Ctr Comp Aided Design,Iowa City,Ia 52242 Univ Iowa,Coll Engn,Dept Mech Engn,Iowa City,Ia 52242Englishb<77Andrianov, A. A.1975IDynamics of Impact Parameter in Quantum-Theory for Large-Angle Scattering198-205&Soviet Journal of Nuclear Physics-Ussr222://A1975BV89900023-Bv899 Times Cited:1 Cited References Count:10 0038-5506Sov J Nucl Phys+ISI:A1975BV89900023#Leningrad State Univ,Leningrad,UssrEnglishh<78Bernstein, R. B.1975<Molecular Reaction Dynamics - Impact of Theory on Experiment79-88Israel Journal of Chemistry14://A1975BG49400008.Bg494 Times Cited:1 Cited References Count:118 0021-2148 Israel J ChemISI:A1975BG49400008IUniv Texas,Chem Dept,Austin,Tx 78712 Univ Texas,Phys Dept,Austin,Tx 78712English[<79'Bundzel, M. Kasanicky, T. Frankovic, B.2006VBuilding support vector machine alternative using algorithms of computational geometry955-961-Advances in Neural Networks - Isnn 2006, Pt 13971#The task of pattern recognition is a task of division of a feature space into regions separating the training examples belonging to different classes. Support Vector Machines (SVM) identify the most borderline examples called support vectors and use them to determine discrimination hyperplanes (hyper-curves). In this paper a pattern recognition method is proposed which represents an alternative to SVM algorithm. Support vectors are identified using selected methods of computational geometry in the original space of features i.e. not in the transformed space determined partially by the kernel function of SVM. The proposed algorithm enables usage of kernel functions. The separation task is reduced to a search for an optimal separating hyperplane or a Winner Takes All (WTA) principle is applied.://000238112000140UPart 1 Bem20 Times Cited:0 Cited References Count:9 Lecture Notes in Computer Science 0302-9743Lect Notes Comput ScISI:000238112000140Bundzel, M Tech Univ Kosice, Fac Elect Engn & Informat, Dept Cybernet & Artificial Intelligence, Letna 9, Kosice 04001, Slovakia Tech Univ Kosice, Fac Elect Engn & Informat, Dept Cybernet & Artificial Intelligence, Letna 9, Kosice 04001, Slovakia Tech Univ Kosice, Fac Elect Engn & Informat, Dept Cybernet & Artificial Intelligence, Kosice 04001, Slovakia Slovak Acad Sci, Inst Informat, Bratislava 84507 45, SlovakiaEnglish<7:OMikulecky, M. Hantak, I. Dedik, L. Valentin, M. Kratochvilova, H. Kasanicky, V.1986XNew Approach to the Mathematical-Modeling of Liver Blood-Flow and Hepatobiliary Function S193-S193Digestive Diseases and Sciences3110Oct://A1986E2170007635Suppl. S E2170 Times Cited:0 Cited References Count:0 0163-2116Digest Dis SciISI:A1986E217000763;Comenius Univ,Med Clin 1,Cs-81369 Bratislava,CzechoslovakiaEnglish||7;.Murin, J. Kasanicky, V. Valentin, M. Pisut, V.1982?[Ultrasound diagnosis of cholecystolithiasis (author's transl)]333-8Bratisl Lek Listy773 1982/03/011Cholelithiasis/*diagnosis Humans *UltrasonographyMar*http://www.ncbi.nlm.nih.gov/pubmed/7074375Murin, J Kasanicky, V Valentin, M Pisut, V English Abstract Czechoslovakia Bratislavske lekarske listy Bratisl Lek Listy. 1982 Mar;77(3):333-8.%0006-9248 (Print) 0006-9248 (Linking)7074375+Ultrazvukova diagnostika cholecystolitiazy.slo;||7<?Vajcik, J. Kasanicky, V. Vida, S. Mikulecky, M. Balazovjech, I.1975[Clinical and roentgenographic picture of circulatory insufficiency of the lungs in acute myocardial infarction (author's transl)]652-60Bratisl Lek Listy645 1975/11/01Adult Aged Female Heart Diseases/physiopathology Humans Lung Diseases/*etiology/physiopathology/radiography Male Middle Aged Myocardial Infarction/*complications/radiography *Pulmonary CirculationNov*http://www.ncbi.nlm.nih.gov/pubmed/1192218Vajcik, J Kasanicky, V Vida, S Mikulecky, M Balazovjech, I English Abstract Czechoslovakia Bratislavske lekarske listy Bratisl Lek Listy. 1975 Nov;64(5):652-60.%0006-9248 (Print) 0006-9248 (Linking)1192218WKlinicky o rontgenovy obraz obehovej slabosti na pl'ucach pri akutnom infarkte myokarduslo<7=Punjwani, N. Kumaravel, M.2010Anteromedial or Posterolateral: Comprehensive Review of Functional Anatomy, MRI Appearance, and Surgical Reconstruction of Normal and Injured Double-bundle Anterior Cruciate Ligament-!American Journal of Roentgenology1945May://000276931000683:Suppl. S 586RV E441 Times Cited:0 Cited References Count:0 0361-803XAm J RoentgenolISI:000276931000683&Univ Texas Houston, Sugar Land, TX USAEnglish<7>>Bicer, E. K. Lustig, S. Servien, E. Selmi, T. A. S. Neyret, P.2010HCurrent knowledge in the anatomy of the human anterior cruciate ligament 1075-1084,Knee Surgery Sports Traumatology Arthroscopy188-anterior cruciate ligament anteromedial bundle posterolateral bundle double-bundle anatomy anterolateral rotatory instability iliotibial-band transfer bone tunnel placement human knee-joint in-situ forces posterolateral bundles acl reconstruction functional-anatomy patellar ligament tibial attachmentAugThe anterior cruciate ligament (ACL) is one of the most frequently studied structures of the musculoskeletal system and continues to stimulate debate and challenges among researchers and surgeons. The ultimate goal of anatomic reconstruction surgery is to restore the native anatomy as much as possible. However, this requires thorough knowledge of its anatomy. The aim of this article is to review the current knowledge of the anatomy of ACL along with its macrostructural and ultrastructural properties.://000280137100009-628RA Times Cited:0 Cited References Count:65 0942-2056Knee Surg Sport Tr AISI:000280137100009%Bicer, EK Ege Univ, Dept Orthopaed & Traumatol, Fac Med, TR-35100 Izmir, Turkey Ege Univ, Dept Orthopaed & Traumatol, Fac Med, TR-35100 Izmir, Turkey Ege Univ, Dept Orthopaed & Traumatol, Fac Med, TR-35100 Izmir, Turkey Hosp Civils Lyon, Grp Hosp Nord, Ctr Albert Trillat, F-69300 Lyon, FranceDOI 10.1007/s00167-009-0993-8English <7?DHara, K. Mochizuki, T. Sekiya, I. Yamaguchi, K. Akita, K. Muneta, T.2009aAnatomy of Normal Human Anterior Cruciate Ligament Attachments Evaluated by Divided Small Bundles 2386-2391#American Journal of Sports Medicine3712%normal anatomy anterior cruciate ligament anterior cruciate ligament attachments double-bundle anterior cruciate ligament reconstruction posterolateral bundles semitendinosus tendon functional-anatomy femoral attachment tibial insertions tunnel placement single-bundle reconstruction landmarksDecBackground: Double-bundle anterior cruciate ligament (ACL) reconstruction has several potential advantages over single-bundle reconstruction with hamstring tendons. However, there are still controversies regarding tunnel placement in tibial and femoral attachments. Hypothesis: The macroscopically normal ACL consists of small bundles about 1 mm in diameter. Detailed observation of the divided smaller bundles will achieve better understanding of the tunnel placement in anatomic ACL reconstruction. Study Design: Descriptive laboratory study. Methods: This study used 20 cadaveric knees. The ACL was divided into anteromedial and posterolateral bundles, then separated into 10 small bundles of 2-mm diameters, with preservation of their attachment sites marked with color markers. The positional relationship between the femoral and tibial attachments of each small bundle was investigated. Results: A layered positional correlation of small bundles was found between the tibial and femoral attachments. Small bundles aligned in the anterior-posterior direction in the tibia corresponded to the bundles aligned in a high-low direction in the femur in flexion. The femoral attachment pattern was relatively similar in each specimen; however, the tibial attachment showed 2 patterns: an oblique type (12 of 20) and a transverse type (8 of 20). The posterior portion of the posterolateral bundle was separately attached to the medial and lateral portions of the tibial attachment. There was no fibrous insertion in the center of the posterior portion of the ACL tibial attachment in any specimen. In this bare area, there was fat tissue and vascular bundles. Conclusion: Small bundles constituting the ACL showed a relatively layered arrangement between 2 attachments. The tibial attachment showed 2 patterns of oblique and transverse types, and the vascular bundles were located in the center of the posterolateral bundle. Clinical Relevance: The results of this study of the normal ACL will provide insights for surgeons when placing grafts during anatomic ACL reconstruction.://000272180500013-524YO Times Cited:1 Cited References Count:24 0363-5465Am J Sport MedISI:000272180500013Muneta, T Tokyo Med & Dent Univ, Grad Sch, Sect Orthoped Surg, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Grad Sch, Sect Orthoped Surg, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Grad Sch, Sect Orthoped Surg, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Hosp, Sch Med, Dept Orthopaed Surg, Tokyo, Japan Tokyo Med & Dent Univ, Grad Sch, Sect Cartilage Regenerat, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Grad Sch, Sect Clin Anat, Tokyo 1138519, JapanDoi 10.1177/0363546509340404EnglishQ<7@Shen, W. Fu, F. H.20081Anterior cruciate ligament insertion site anatomy 850-851 168;Arthroscopy-the Journal of Arthroscopic and Related Surgery247(posterolateral fiber-bundles attachmentsJul://000257715000018,327FM Times Cited:2 Cited References Count:4 0749-8063 ArthroscopyISI:000257715000018Shen, W Univ Pittsburgh, Dept Orthoped Surg, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Orthoped Surg, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Orthoped Surg, Pittsburgh, PA 15260 USA DOI 10.1016/j.arthro.2008.04.069Englishs<7A Siebold, R.20089Anterior cruciate ligament insertion site anatomy - Reply 851-852 168;Arthroscopy-the Journal of Arthroscopic and Related Surgery247attachments bundlesJul://000257715000019,327FM Times Cited:0 Cited References Count:5 0749-8063 ArthroscopyISI:000257715000019Siebold, R Ctr Knee Surg Foot Surg & Sports Traumatol, ATOS Clin Ctr, Heidelberg, Germany Ctr Knee Surg Foot Surg & Sports Traumatol, ATOS Clin Ctr, Heidelberg, Germany Ctr Knee Surg Foot Surg & Sports Traumatol, ATOS Clin Ctr, Heidelberg, Germany DOI 10.1016/j.arthro.2008.04.068English <7BLSteckel, H. Starman, J. S. Baums, M. H. Klinger, H. M. Schultz, W. Fu, F. H.2007[Anatomy of the anterior cruciate ligament double bundle structure: a macroscopic evaluation387-3924Scandinavian Journal of Medicine & Science in Sports174anterior cruciate ligament anteromedial bundle posterolateral bundle anatomy reconstruction patellar tendon autograft femoral tunnel placement in-situ forces posterolateral bundles semitendinosus tendon functional-anatomy knee-joint reconstruction loads aclAugSIntroduction: Traditional anterior cruciate ligament (ACL) surgery has demonstrated good results, but there is still a subset of unsatisfactory outcomes. Trends in reconstruction technique have changed from bone-patella-tendon-bone to hamstring refixation, and the next step appears to be the double bundle concept. Methods: We examined six fresh-frozen cadaver knees to evaluate the double bundle structure, dynamic motion characteristics and the relationship of knee flexion and relative position of the femoral insertion sites of the ACL. Results: In all knees, we identified an anteromedial (AM) and posterolateral (PL) bundle. The motion pattern demonstrated that the AM and PL bundles are oriented near parallel with the knee extended, and twist around each other as the knee is flexed. The visualization of the femoral footprint anatomy differs with knee flexion. Discussion: The double bundle model facilitates restoration of the original footprint anatomy and biomechanics more easily than the concept of the ACL as a one-bundle structure and the use of the o'clock position. It is essential to be aware of the degree of knee flexion when drilling the femoral tunnels. Perspective: Anatomic ACL reconstruction is a concept, not a technique, and allows a more refined surgical approach to ACL reconstruction including revision cases and partial ACL tears.://000248481300013-196KW Times Cited:7 Cited References Count:40 0905-7188Scand J Med Sci SporISI:000248481300013Steckel, H Robert Koch Str 40, D-37075 Gottingen, Germany Robert Koch Str 40, D-37075 Gottingen, Germany Univ Pittsburgh, Dept Orthopaed Surg, Pittsburgh, PA 15260 USA Univ Gottingen, Dept Orthopaed Surg, D-3400 Gottingen, Germany$DOI 10.1111/j.1600-0838.2006.00579.xEnglish<7CPetersen, W. Zantop, T.2007HAnatomy of the anterior cruciate ligament with regard to its two bundles35-47*Clinical Orthopaedics and Related Research454intercondylar notch stenosis in-situ forces patellar tendon knee-joint functional-anatomy femoral attachment hamstring tendons tunnel placement acl grafts reconstructionJanRThe anterior cruciate ligament (ACL) consists of two major fiber bundles, namely the anteromedial and posterolateral bundle. When the knee is extended, the posterolateral bundle (PL) is tight and the anteromedial (AM) bundle is moderately lax. As the knee is flexed, the femoral attachment of the ACL becomes a more horizontal orientation; causing the AM bundle to tighten and the PL bundle to relax. There is some degree of variability for the femoral origin of the anteromedial and posterolateral bundle. The anteromedial bundle is located proximal and anterior in the femoral ACL origin (high and deep in the notch when the knee is flexed at 90 degrees); the posterolateral bundle starts in the distal and posterior aspect of the femoral ACL origin (shallow and low when the knee is flexed at 90 degrees). In the frontal plane the anteromedial bundle origin is in the 10:30 clock position and the posterolateral bundle origin in the 9:30 clock position. At the tibial insertion the ACL fans out to form the foot region. The anteromedial bundle insertion is in the anterior part of the tibial ACL footprint, the posterolateral bundle in the posterior part. While the anteromedial bundle is the primary restraint against anterior tibial translation, the posterolateral bundle tends to stabilize the knee near full extension, particularly against rotatory loads.://000243272300009.123BW Times Cited:50 Cited References Count:67 0009-921XClin Orthop Relat RISI:000243272300009 Zantop, T Univ Munster, Dept Trauma Hand & Reconstruct Surg, Waldeyer Str 1, D-48149 Munster, Germany Univ Munster, Dept Trauma Hand & Reconstruct Surg, Waldeyer Str 1, D-48149 Munster, Germany Univ Munster, Dept Trauma Hand & Reconstruct Surg, D-48149 Munster, Germany Doi 10.1097/Blo.0b013e31802b4a59English<7D*Steckel, H. Vadala, G. Davis, D. Fu, F. H.2006q2D and 3D 3-tesla magnetic resonance imaging of the double bundle structure in anterior cruciate ligament anatomy 1151-1158,Knee Surgery Sports Traumatology Arthroscopy1411anterior cruciate ligament anteromedial bundle posterolateral bundle anatomy magnetic resonance imaging partial tears functional-anatomy axial images knee-joint diagnosis reconstruction signs insertions injuries ruptureNovFor anterior cruciate ligament (ACL) surgery using the anatomic approach of the double bundle concept it is helpful to describe the anteromedial (AM) and posterolateral (PL) bundle using Magnetic Resonance Imaging (MRI), since this is the most important preoperative parameter next to the physical examination. The aim of this study was to distinguish both bundles in MRI. In a prospective study we evaluated the double bundle structure in ACL anatomy with a 3-T ultra-high-field strength MR imaging of cadaver knees, which allows faster imaging times, increased resolution and increased signal-to-noise ratio. Using oblique sagittal and oblique coronal planes, we were able to distinguish the double bundle structure in each knee. The following arthroscopic evaluation of the knees confirmed our MRI findings. Our study demonstrates the possibility of distinguishing the two bundles in the native ACL with 3T MRI. Following examinations must study the value for clinical application by describing different rupture patterns of the bundles and correlating this to arthroscopy. It would be advantageous to know the rupture pattern in advance. Presurgical planning could be improved by reconstructing only the torn and preserving the intact bundle.://000241796700017.102FP Times Cited:10 Cited References Count:45 0942-2056Knee Surg Sport Tr AISI:000241796700017nSteckel, H 3471 5th Ave,Suite 1011, Pittsburgh, PA 15213 USA 3471 5th Ave,Suite 1011, Pittsburgh, PA 15213 USA Univ Gottingen, Dept Orthopaed Surg, D-37075 Gottingen, Germany Campus Biomed Univ, Dept Orthopaed Surg, I-00155 Rome, Italy Univ Pittsburgh, Magnet Resonance Res Ctr, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Orthopaed Surg, Pittsburgh, PA 15213 USADOI 10.1007/s00167-006-0185-8English <7E:Zantop, T. Petersen, W. Sekiya, J. K. Musahl, V. Fu, F. H.2006UAnterior cruciate ligament anatomy and function relating to anatomical reconstruction982-992,Knee Surgery Sports Traumatology Arthroscopy1410knee anterior cruciate ligament reconstruction posterolateral bundle anatomy double bundle tibial tunnel placement in-situ forces double-bundle intercondylar notch patellar tendon knee-joint acl reconstruction hamstring tendons grafts motionOctRecently, the interest in surgical techniques that reconstruct the anteromedial (AM) and the posterolateral (PL) bundles of the anterior cruciate ligament (ACL) has risen. This review focuses on the structural as well as the mechanical properties of the ACL and the anatomical details of the femoral origin, midsubstance, and tibial insertion of AM and PL bundles of the ACL. The terminology of AM and PL bundles is chosen according to the tibial insertion and determined by their functional tensioning pattern throughout knee flexion. Close to extension the AM is moderately loose and the PL is tight. As the knee is flexed, the femoral attachment of the ACL becomes more horizontally oriented, causing the AM bundle to tighten and the PM bundle to loosen up. The ACL has been described to be restraint to anterior tibial displacement and internal tibial rotation. The rotational component might be represented by the PL bundle. The femoral origin has an oval shape with the center of the AM close to over-the-top position and the center of the PL close to the anterior and inferior cartilage margin. Tibial and femoral insertions of the ACL are over 3.5 times larger when compared to the midsubstance and tunnel placement is more challenging because of the limited size of potential grafts selection of tunnel site placement. For reconstruction, both bone-patellar tendon-bone (BPTB) and quadrupled hamstring grafts are used. Structural properties of a 10 mm wide BPTB or quadrupled hamstring graft have been reported to be comparable with those of the native ACL.://000240913000012.089WQ Times Cited:43 Cited References Count:69 0942-2056Knee Surg Sport Tr AISI:000240913000012FZantop, T Univ Munster, Dept Trauma Hand & Reconstruct Surg, Waldeyer Str 1, D-48149 Munster, Germany Univ Munster, Dept Trauma Hand & Reconstruct Surg, Waldeyer Str 1, D-48149 Munster, Germany Univ Munster, Dept Trauma Hand & Reconstruct Surg, D-48149 Munster, Germany Univ Pittsburgh, Dept Orthopaed Surg, Pittsburgh, PA USADOI 10.1007/s00167-006-0076-zEnglish<7FLDuthon, V. B. Barea, C. Abrassart, S. Fasel, J. H. Fritschy, D. Menetrey, J.2006)Anatomy of the anterior cruciate ligament204-213,Knee Surgery Sports Traumatology Arthroscopy143anterior cruciate ligament anteromedial bundle posterolateral bundle in-situ forces human knee patellar tendon mechanoreceptors joint injuries collagen acl reconstruction fibrocartilageMarThe anterior cruciate ligament (ACL) is a band of dense connective tissue which courses from the femur to the tibia. The ACL is a key structure in the knee joint, as it resists anterior tibial translation and rotational loads. When the knee is extended, the ACL has a mean length of 32 mm and a width of 7-12 mm. There are two components of the ACL, the anteromedial bundle (AMB) and the posterolateral bundle (PLB). They are not isometric with the main change being lengthening of the AMB and shortening of the PLB during flexion. The ACL has a microstructure of collagen bundles of multiple types (mostly type I) and a matrix made of a network of proteins, glycoproteins, elastic systems, and glycosaminoglycans with multiple functional interactions. The complex ultrastructural organization and abundant elastic system of the ACL allow it to withstand multiaxial stresses and varying tensile strains. The ACL is innervated by posterior articular branches of the tibial nerve and is vascularized by branches of the middle genicular artery.://000235756700002.018IC Times Cited:33 Cited References Count:57 0942-2056Knee Surg Sport Tr AISI:000235756700002VDuthon, VB Hop Univ Geneve, Serv Chirurg Orthoped & Traumatol Appareil Moteur, Unite Orthopedie & Traumatol Sport, 24 Rue Micheli du Crest, CH-1211 Geneva 14, Switzerland Hop Univ Geneve, Serv Chirurg Orthoped & Traumatol Appareil Moteur, Unite Orthopedie & Traumatol Sport, 24 Rue Micheli du Crest, CH-1211 Geneva 14, Switzerland Hop Univ Geneve, Serv Chirurg Orthoped & Traumatol Appareil Moteur, Unite Orthopedie & Traumatol Sport, CH-1211 Geneva 14, Switzerland Univ Geneva, Dept Morphol, Div Anat, Geneva, Switzerland Univ Hosp Geneva, Dept Orthopaed Surg, Sports Med Unit, Geneva, SwitzerlandDOI 10.1007/s00167-005-0679-9English <7GJMusahl, V. Burkart, A. Debski, R. E. Van Scyoc, A. Fu, F. H. Woo, S. L. Y.2003Anterior cruciate ligament tunnel placement: Comparison of insertion site anatomy with the guidelines of a computer-assisted surgical system154-160;Arthroscopy-the Journal of Arthroscopic and Related Surgery192wcomputer assisted orthopaedic surgery acl planning station tunnel placement insertion site tibial tunnel reconstructionFebPurpose: With the development of computer-assisted surgery (CAS) systems, the surgeon's ability to operate a CAS planning station will become essential. For example, default parameters in computed tomographic (CT) data are being used to place tunnels in anterior cruciate ligament (ACL) reconstruction. The goal of this study was to compare the location of the insertion sites in ACL reconstruction anatomically, via roentgenographic images and via CT scan data and to validate these tunnel placement parameters. Type of Study: Cadaveric analysis. Methods: Eight human cadaveric knees were marked with 6 copper wires 1 mm in diameter around the circumference of the insertions of the ACL. Using lateral roentgenograms and CT scans that were subsequently transferred to the CAS planning station, the tunnel locations were determined. These were based on a distance from the back of the condyle (location A) and from the roof of the notch (location 13) on the femur and on a distance posterior from the tuberosity to the posterior margin along the tibial plateau, which is set as the CAS planning station's default. Locations according to roentgenograms and CT scans were then compared and the accuracy of the CAS planning station was assessed. Results: Comparison of roentgenograms and CT revealed a femoral insertion at 27.5% +/- 3.2% and 26.9% +/- 3.5% (roentgenograms) and 26.6% +/- 1.9% and 26.3% +/- 2.4% (CT), respectively. The CAS planning station provided a tunnel location that was 1.3 +/- 1.0 mm (0.3 to 2.5 mm) away from the actual femoral ACL insertion. The tibial tunnel was placed according to the copper wire markers and was found to be at 46.2% +/- 2.8% (roentgenograms) and 45.4% +/- 2.1% (CT). No statistical differences between position in CT and roentgenograms could be detected (P > .05). Conclusions: The compared methodologies showed similar locations of the ACL insertions, assuring accurate preoperative planning with the CAS system. However, the CAS system requires adjustment to each individual knee anatomy.://000180971800005.645JE Times Cited:18 Cited References Count:31 0749-8063 ArthroscopyISI:000180971800005Fu, Fh Mcclure Musculoskeletal Res Ctr, Dept Orthopaed Surg, E 1641 BST,210 Lothrop St,POB 71199, Pittsburgh, PA 15213 USA Mcclure Musculoskeletal Res Ctr, Dept Orthopaed Surg, E 1641 BST,210 Lothrop St,POB 71199, Pittsburgh, PA 15213 USA Mcclure Musculoskeletal Res Ctr, Dept Orthopaed Surg, Pittsburgh, PA 15213 USA Tech Univ Munich, Dept Orthopaed Sports Med, D-8000 Munich, GermanyDOI 10.1053/jars.2003.50001English<7H$Dienst, M. Burks, R. T. Greis, P. E.2002:Anatomy and biomechanics of the anterior cruciate ligament605-+#Orthopedic Clinics of North America334intercondylar notch width tibial tunnel placement in-situ forces magnetic-resonance patellar tendon strain behavior knee motion injuries reconstruction loadsOctThis article reviews the literature on embryology, anatomy, function, and biomechanics to define the properties of the native ACL. The discussion focuses on the ligamentous architecture and gross anatomy of the ACL including its femoral and tibial insertions as well as its midsubstance passing through the intercondylar fossa. Biomechanical modeling, mechanical and structural properties, and function of the ACL as a primary and secondary stabilizer under non-weightbearing and weightbearing conditions are described.://000179343600002.617CX Times Cited:22 Cited References Count:82 0030-5898Orthop Clin N AmISI:000179343600002Greis, PE Univ Utah Hosp, Dept Orthoped Surg, Salt Lake City, UT 84132 USA Univ Utah Hosp, Dept Orthoped Surg, Salt Lake City, UT 84132 USA Univ Utah Hosp, Dept Orthoped Surg, Salt Lake City, UT 84132 USAPii S0030-5898(02)00010-XEnglish <7IPetersen, W. Tillmann, B.20026Anatomy and function of the anterior cruciate ligament710-+ Orthopade318xinsertion structure vascular supply fibrocartilage supporting structures knee-joint reconstruction reflex injuries nerveAug0 The anterior cruciate ligament originates at the medial wall of the lateral femoral condyle and inserts into the middle of the intercondylar area. It contributes significantly to the stabilization and kinematics of the knee joint. The femoral origin is oval and is located in the posterior aspect of the lateral femoral condyle. Therefore, it is difficult to visualize the femoral origin arthroscopically. This might be one reason for anterior malpositioning of the femoral bone tunnel during anterior cruciate ligament reconstruction. The position of the femoral origin is behind the center of rotation of the knee joint; therefore, it becomes tense when the knee is extended. The tibial insertion is oval and its center is nearly in the middle of the tibial plateau. Definite landmarks for tibial tunnel placement in anterior cruciate ligament reconstruction are the distance between the central insertion point at the intercondylar floor and the posterior cruciate ligament (7-8 mm) and the anterior horn of the lateral meniscus. The anterior cruciate ligament consists of multiple small fiber bundles. From a functional point of view, one can differentiate the anteromedial and posterolateral fiber bundles. The anteromedial fibers are tense during a greater range of motion than the posterolateral fibers. The main part of the anterior cruciate ligament consists of type I collagen-positive dense connective tissue. The longitudinal fibrils of type I collagen are divided into small bundles by thin type III collagen-positive fibrils. In the distal third, the structure of the tissue varies from the typical structure of a ligament. In this region, the structure of the tissue resembles fibrocartilage. Oval-shaped cells surrounded by a metachromatic extracellular matrix lie between the longitudinal collagen fibrils. The femoral origin and the tibial insertion have the structure of a chondral apophyseal enthesis. Near the anchoring region at the femur and tibia,there should be various mechanoreceptors, which might have an important function for the kinematics of the knee joint. The blood supply of the anterior cruciate ligament arises from the middle geniculate artery. The ligament is covered by a synovial fold where the terminal branches of the middle and the inferior geniculate artery form a periligamentous network. From the synovial sheath,the blood vessels penetrate the ligament in a horizontal direction and anastomose with a longitudinally orientated intra ligamentous network. The distribution of blood vessels within the anterior cruciate ligament is not homogeneous. We detected three avascular areas within the ligament: Both fibrocartilaginous entheses of the anterior cruciate ligament are devoid of blood vessels. A third avascular zone is located in the distal zone of fibrocartilage adjacent to the roof of the intercondylar fossa.://000177751900003.589HC Times Cited:22 Cited References Count:62 0085-4530 OrthopadeISI:000177751900003Petersen, W Univ Kiel, Orthopad Klin, Michaelisstr 1, D-24105 Kiel, Germany Univ Kiel, Orthopad Klin, Michaelisstr 1, D-24105 Kiel, Germany Univ Kiel, Orthopad Klin, D-24105 Kiel, GermanyDOI 10.1007/s00132-002-0330-0German<7J'Yu, B. Kirkendall, D. T. Garrett, W. E.2002^Anterior cruciate ligament injuries in female athletes: Anatomy, physiology, and motor control58-68&Sports Medicine and Arthroscopy Review101anterior cruciate ligament injury injury prevention biomechanics motor control female athletes intercondylar notch knee-joint tibial translation quadriceps femoris menstrual-cycle team handball acl injury women basketball estrogenAnterior cruciate ligament (ACL) injuries are common in sports. Most ACL injuries are noncontact in nature and frequently occur in certain athletic tasks. In sports such as soccer, basketball and volleyball, female athletes have higher risk for ACL injuries than their male counterparts. Previous studies on the proposed risk factors for noncontact ACL injuries focused mainly on non-modifiable static factors that are remote from the injury events, without consideration of movements. Little convincing evidence, theoretical or experimental, has demonstrated the association between these static factors and the risk of noncontact ACL injuries. Female athletes have altered knee motion patterns in athletic tasks that place the ACL at risk. These altered motion patterns by female athletes tend to increase the load on the ACL, and may be a major contributor to the elevated frequency of ACL injuries in female athletes.://000174045600009.525AT Times Cited:16 Cited References Count:82 1062-8592Sports Med ArthroscISI:000174045600009Yu, B Univ N Carolina, Sch Med, Div Phys Therapy, Ctr Human Movement Sci, CB 7135 Med Sch Wing E, Chapel Hill, NC 27599 USA Univ N Carolina, Sch Med, Div Phys Therapy, Ctr Human Movement Sci, CB 7135 Med Sch Wing E, Chapel Hill, NC 27599 USA Univ N Carolina, Sch Med, Div Phys Therapy, Ctr Human Movement Sci, Chapel Hill, NC 27599 USA Univ N Carolina, Sch Med, Dept Orthoped Surg, Chapel Hill, NC USAEnglish <7K0Staeubli, H. U. Adam, O. Becker, W. Burgkart, R.1999Anterior cruciate ligament and intercondylar notch in the coronal oblique plane: Anatomy complemented by magnetic resonance imaging in cruciate ligament-intact knees349-359;Arthroscopy-the Journal of Arthroscopic and Related Surgery154anatomy anterior cruciate ligament posterior cruciate ligament femoral intercondylar notch magnetic resonance imaging knee, coronal oblique imaging plane gender injuries width stenosis tearsMay-JunA We assessed the anatomy of the anterior cruciate ligament (ACL) and femoral intercondylar notch on cryosections from one cadaveric knee specimen in the coronal oblique plane oriented parallel to the intercondylar roof. We determined the course of the ACL, the widths of the cruciate ligaments at intersection, and the intercondylar notch configuration on coronal oblique plane magnetic resonance images in 51 adult cruciate ligament-intact knees (25 women, 26 men; age range, 16 to 47 years). The intercondylar notch widths were measured at the notch entrance, at the intersection of the ACL and posterior cruciate ligament (PCL), and at the notch outlet. In the coronal oblique plane, the ACL exhibited a diagonal course from the central and medial part of the anterior intercondylar area of the tibia distally, across the lateral third of the intercondylar notch, to the intercondylar surface of the lateral femoral condyle proximally. At the cruciate ligament intersection, the absolute widths of the ACLs measured on average 6.1 +/- 1.1 mm in men and 5.2 +/- 1.0 mm in women representing 31.9% and 31.1% of the ACL/central intercondylar notch width ratios, The absolute widths of the PCLs measured on average 9.6 +/- 1.3 mm in men and 8.5 +/- 1.3 mm in women representing 50.4% and 51.4% of PCL/central intercondylar notch width ratios. On average for both groups, men and women, the absolute widths of the PCLs were significantly larger than the absolute widths of the ACLs. However, the relative widths of the cruciate ligaments with respect to corresponding intercondylar notch widths were not significantly different. In the coronal oblique plane, the intercondylar notch widths showed on average a significant decrease from posterior to intersection and from intersection to anterior. At notch outlet, the mean notch width measured 21.4 mm in men and 18.5 mm in women. At intersection, the mean notch width measured 19.1 mm in men and 16.6 mm in women. At notch entrance, the notch width measured 14.6 +/- 1.8 mm in men and 12.7 +/- 2.1 mm in women. We recommend magnetic resonance tomography of the knee in the coronal oblique plane oriented parallel to the intercondylar roof as the imaging modality of choice to visualize accurately the anatomic diagonal course of the ACL and its relation to the intercondylar notch and posterior cruciate ligament complex.://000080296700001.196EU Times Cited:17 Cited References Count:31 0749-8063 ArthroscopyISI:000080296700001-Staeubli, HU Tiefenauspital, Surg Clin, Tiefenaustr 112, CH-3004 Bern, Switzerland Tiefenauspital, Surg Clin, Tiefenaustr 112, CH-3004 Bern, Switzerland Tiefenauspital, Surg Clin, CH-3004 Bern, Switzerland Tiefenauspital, Dept Radiol, CH-3004 Bern, Switzerland Tech Univ Munich, D-8000 Munich, GermanyEnglish|<7L9Seitz, H. Hausner, T. Schlenz, I. Lang, S. Eschberger, J.1997mVascular anatomy of the ovine anterior cruciate ligament - A macroscopic, histological and radiographic study19-21*Archives of Orthopaedic and Trauma Surgery1161-2rabbit knee reconstructionJanSheep are being extensively utilized in animal models for orthopaedic research, but the vascular anatomy of their anterior cruciate ligament (ACL) has not yet been thoroughly described. This study demonstrates the blood supply to the ACL. Vascular injection with plastogen G, lead oxide and India ink was performed in 12 back limbs of Styrian mountain sheep, and gross observations, microradiography and routine histology were done. The large vessel and the microvascular anatomy are similar to those described for humans. The middle genicular artery and the descending genicular artery contribute vessels that supply the ACL. Epiligamentous vascular plexuses give off capillaries which penetrate the ligament substance and supply numerous, longitudinally oriented intraligamentous vessels. These findings make the Styrian mountain sheep a potential animal model for biologic investigations of ACL pathology.://A1997VZ64800005-Vz648 Times Cited:3 Cited References Count:24 0936-8051Arch Orthop Traum SuISI:A1997VZ648000055Seitz, H Univ Vienna,Unfallchirurg Klin,Waehringer Guertel 18-20,a-1090 Vienna,Austria Univ Vienna,Unfallchirurg Klin,Waehringer Guertel 18-20,a-1090 Vienna,Austria Univ Vienna,Inst Anat 3,a-1010 Vienna,Austria Univ Vienna,Klin Inst Klin Pathol,a-1010 Vienna,Austria Ludwig Botzmann Inst Osteol,Vienna,AustriaEnglishr<7MIRoychowdhury, S. Fitzgerald, S. W. Sonin, A. H. Miller, F. H. Hoff, F. L.1996]Normal and abnormal anatomy of the anterior cruciate ligament at axial MR imaging of the knee 1633-1633 Radiology201Nov://A1996VP843016805Suppl. S Vp843 Times Cited:0 Cited References Count:0 0033-8419 RadiologyISI:A1996VP84301680Englishp<7NDodds, J. A. Arnoczky, S. P.1994UAnatomy of the Anterior Cruciate Ligament - a Blueprint for Repair and Reconstruction132-139 Arthroscopy102Tanterior cruciate ligament anatomy blood supply mechanoreceptors tissues matrix kneeAprYThe anterior cruciate ligament of the knee joint is a complex structure whose orientation, construct, and biology are directly related to its function as a constraint of knee joint motion. While the complexity of its design allows the ligament to function through the normal range of motion as a static stabilizer of the knee, it also makes the exact duplication of this structure very difficult. A fundamental knowledge of the functional anatomy of the anterior cruciate ligament provides the orthopaedic surgeon with an essential blueprint on which to base techniques of repair and reconstruction.://A1994NE03800003.Ne038 Times Cited:28 Cited References Count:39 0749-8063 ArthroscopyISI:A1994NE03800003Michigan State Univ,Coll Vet Med,Comaprat Orthopaed Res Lab,E Lansing,Mi 48824 Michigan State Univ,Dept Surg,E Lansing,Mi 48824English<7O@Goertzen, M. Gruber, J. Dellmann, A. Clahsen, H. Schulitz, K. P.1993PNeurovascular Anatomy after Anterior Cruciate Ligament Allograft Transplantation420-4240Zeitschrift Fur Orthopadie Und Ihre Grenzgebiete1315Sep-OctQA multiplicity of surgical operations have been developed in an attempt to achieve satisfactory function after ACL repair. None of these procedures have been able to duplicate the fiber organization, attachment site anatomy, vascularity, or function of the ACL. 18 foxhounds received a deep frozen bone-ACL-bone allograft and a ligament augmentation device (LAD). Neurohistological changes were evaluated 3, 6, and 12 months following implantation. Modified silver impregnation method and gold chloride technique were used to examine the presence of nerve endings and axons. Two morphological distinct mechanoreceptors were identified, and then were catogorized as follows: free nerve-endings golgi-like tendon receptors. Fine nerve endings were frequently ramified freely into ligament collagen bundles. Nerves and blood vessels were commonly associated. Like in normal ACL's both neuroreceptors were mostly located near the surface of the allografts and at both bony attachments. This study demonstrated the first histological evidence of viable mechanoreceptors and free nerve-endings in transplantated ACL-allografts, not previously reported in other ACL-substitutes using for ACL-reconstruction. Particurely important for post-op. rehabilitation, this technique may allow to reconstruct the proprioreceptive functions of normal anterior cruciate ligaments.://A1993ME17800006,Me178 Times Cited:5 Cited References Count:0 0044-3220Z Orthop GrenzgebISI:A1993ME17800006Goertzen, M Univ Dusseldorf,Orthopad Klin & Poliklin,Moorenstr 5,D-40225 Dusseldorf,Germany Univ Dusseldorf,Orthopad Klin & Poliklin,Moorenstr 5,D-40225 Dusseldorf,GermanyGerman <7PAmis, A. A. Dawkins, G. P. C.1991yFunctional-Anatomy of the Anterior Cruciate Ligament - Fiber Bundle Actions Related to Ligament Replacements and Injuries260-2670Journal of Bone and Joint Surgery-British Volume732length patterns knee flexionMarThis work studied the fibre bundle anatomy of the anterior cruciate ligament. Three functional bundles - anteromedial, intermediate, and posterolateral - were identified in cadaver knees. Their contributions to resisting anterior subluxation in flexion and extension were found by repeated tests after sequential bundle transection. Changes of length in flexion and extension and in tibial rotation were measured. None of the fibres were isometric. The posterolateral bundle was stretched in extension and the anteromedial in flexion, which correlated with increased contributions to knee stability and the likelihood of partial ruptures in these positions. Tibial rotation had no significant effect. The fibre length changes suggested that the 'isometric point' aimed at by some ligament replacements lay anterior and superior to the femoral origin of the intermediate fibre bundle, and towards the roof of the intercondylar notch.://A1991FD09300018/Fd093 Times Cited:178 Cited References Count:33 0301-620XJ Bone Joint Surg BrISI:A1991FD09300018Amis, Aa Imperial Coll Sci Technol & Med,Biomech Sect,Exhibition Rd,London Sw7 2bx,England Imperial Coll Sci Technol & Med,Biomech Sect,Exhibition Rd,London Sw7 2bx,EnglandEnglish<7QDye, S. F. Cannon, W. D.1988:Anatomy and Biomechanics of the Anterior Cruciate Ligament715-725Clinics in Sports Medicine74Oct://A1988Q412200003-Q4122 Times Cited:13 Cited References Count:0 0278-5919Clin Sport MedISI:A1988Q412200003Dye, Sf Ralph K Davies Med Ctr,45 Castro St,Suite 117,San Francisco,Ca 94114 Ralph K Davies Med Ctr,45 Castro St,Suite 117,San Francisco,Ca 94114EnglishC<7R9Schutte, M. J. Dabezies, E. J. Zimny, M. L. Happel, L. T.19876Neural Anatomy of the Human Anterior Cruciate Ligament243-2471Journal of Bone and Joint Surgery-American Volume69A2Feb://A1987G083000011/G0830 Times Cited:185 Cited References Count:20 0021-9355J Bone Joint Surg AmISI:A1987G083000011Louisiana State Univ,Med Ctr,Sch Med,Dept Orthoped Surg,New Orleans,La 70112 Louisiana State Univ,Med Ctr,Sch Med,Dept Anat,New Orleans,La 70112 Louisiana State Univ,Med Ctr,Sch Med,Dept Neurol,New Orleans,La 70112EnglishO<7S Buck, W. R.1985PA Detailed Re-Examination of the Gross-Anatomy of the Anterior Cruciate LigamentA28-A28Anatomical Record2113://A1985AFC3200133,Afc32 Times Cited:2 Cited References Count:0 0003-276XAnat RecISI:A1985AFC3200133+Ohio State Univ,Dept Anat,Columbus,Oh 43210English&<7TOdensten, M. Gillquist, J.1985WFunctional-Anatomy of the Anterior Cruciate Ligament and a Rationale for Reconstruction257-2621Journal of Bone and Joint Surgery-American Volume67A2://A1985ACB9500012/Acb95 Times Cited:202 Cited References Count:27 0021-9355J Bone Joint Surg AmISI:A1985ACB9500012Odensten, M Linkoping Univ Hosp,Dept Orthopaed Surg,Sports & Trauma Res Grp,S-58185 Linkoping,Sweden Linkoping Univ Hosp,Dept Orthopaed Surg,Sports & Trauma Res Grp,S-58185 Linkoping,SwedenEnglish<7UEllison, A. E. Berg, E. E.1985CEmbryology, Anatomy, and Function of the Anterior Cruciate Ligament3-14#Orthopedic Clinics of North America161://A1985ABZ0400003.Abz04 Times Cited:16 Cited References Count:14 0030-5898Orthop Clin N AmISI:A1985ABZ0400003Ellison, Ae Orthoped Associates Williamstown,Doctors Pk,Adams Rd,Williamstown,Ma 01267 Orthoped Associates Williamstown,Doctors Pk,Adams Rd,Williamstown,Ma 01267 Union Univ Albany Med Coll,Orthoped,Albany,Ny 12208English<7VArnoczky, S. P.1983)Anatomy of the Anterior Cruciate Ligament19-25*Clinical Orthopaedics and Related Research172://A1983QB46900006/Qb469 Times Cited:100 Cited References Count:11 0009-921XClin Orthop Relat RISI:A1983QB46900006Arnoczky, Sp Hosp Special Surg,Comparat Orthoped & Sports Med Res Lab,New York,Ny 10021 Hosp Special Surg,Comparat Orthoped & Sports Med Res Lab,New York,Ny 10021 Cornell Univ,Med Ctr,New York Hosp,Coll Med,New York,Ny 10021Englishu<7WHorne, J. G. Parsons, C. J.1977KAnterior Cruciate Ligament - Its Anatomy and a New Method of Reconstruction214-220Canadian Journal of Surgery203://A1977DG60600007.Dg606 Times Cited:16 Cited References Count:13 0008-428X Can J SurgISI:A1977DG606000079St Josephs Hosp,Dept Orthoped Surg,Toronto,Ontario,CanadaEnglish<7XLDuthon, V. B. Barea, C. Abrassart, S. Fasel, J. H. Fritschy, D. Menetrey, J.2006)Anatomy of the anterior cruciate ligament204-213,Knee Surgery Sports Traumatology Arthroscopy143anterior cruciate ligament anteromedial bundle posterolateral bundle in-situ forces human knee patellar tendon mechanoreceptors joint injuries collagen acl reconstruction fibrocartilageMarThe anterior cruciate ligament (ACL) is a band of dense connective tissue which courses from the femur to the tibia. The ACL is a key structure in the knee joint, as it resists anterior tibial translation and rotational loads. When the knee is extended, the ACL has a mean length of 32 mm and a width of 7-12 mm. There are two components of the ACL, the anteromedial bundle (AMB) and the posterolateral bundle (PLB). They are not isometric with the main change being lengthening of the AMB and shortening of the PLB during flexion. The ACL has a microstructure of collagen bundles of multiple types (mostly type I) and a matrix made of a network of proteins, glycoproteins, elastic systems, and glycosaminoglycans with multiple functional interactions. The complex ultrastructural organization and abundant elastic system of the ACL allow it to withstand multiaxial stresses and varying tensile strains. The ACL is innervated by posterior articular branches of the tibial nerve and is vascularized by branches of the middle genicular artery.://000235756700002.018IC Times Cited:33 Cited References Count:57 0942-2056Knee Surg Sport Tr AISI:000235756700002VDuthon, VB Hop Univ Geneve, Serv Chirurg Orthoped & Traumatol Appareil Moteur, Unite Orthopedie & Traumatol Sport, 24 Rue Micheli du Crest, CH-1211 Geneva 14, Switzerland Hop Univ Geneve, Serv Chirurg Orthoped & Traumatol Appareil Moteur, Unite Orthopedie & Traumatol Sport, 24 Rue Micheli du Crest, CH-1211 Geneva 14, Switzerland Hop Univ Geneve, Serv Chirurg Orthoped & Traumatol Appareil Moteur, Unite Orthopedie & Traumatol Sport, CH-1211 Geneva 14, Switzerland Univ Geneva, Dept Morphol, Div Anat, Geneva, Switzerland Univ Hosp Geneva, Dept Orthopaed Surg, Sports Med Unit, Geneva, SwitzerlandDOI 10.1007/s00167-005-0679-9English<7YMOrishimo, K. F. Kremenic, I. J. Mullaney, M. J. McHugh, M. P. Nicholas, S. J.2010^Adaptations in single-leg hop biomechanics following anterior cruciate ligament reconstruction 1587-1593,Knee Surgery Sports Traumatology Arthroscopy1811knee ankle hip landing takeoff compensations tests knee performance rehabilitation predictors strength jump patterns kinetics ruptureNovWhen a patient performs a clinically normal hop test based on distance, it cannot be assumed that the biomechanics are similar between limbs. The objective was to compare takeoff and landing biomechanics between legs in patients who have undergone anterior cruciate ligament reconstruction. Kinematics and ground reaction forces were recorded as 13 patients performed the single-leg hop on each leg. Distance hopped, joint range of motion, peak joint kinetics and the peak total extensor moment were compared between legs during both takeoff and landing. Average hop distance ratio (involved/noninvolved) was 93 +/- A 4%. Compared to the noninvolved side, knee motion during takeoff on the involved side was significantly reduced (P = 0.008). Peak moments and powers on the involved side were lower at the knee and higher at the ankle and hip compared with the noninvolved side (Side by Joint P = 0.011; P = 0.003, respectively). The peak total extensor moment was not different between legs (P = 0.305) despite a decrease in knee moment and increases in ankle and hip moments (Side by Joint P = 0.015). During landing, knee motion was reduced (P = 0.043), and peak power absorbed was decreased at the knee and hip and increased at the ankle on the involved side compared to the noninvolved side (P = 0.003). The compensations by other joints may indicate protective adaptations to avoid overloading the reconstructed knee.://000283257300026-668GT Times Cited:0 Cited References Count:25 0942-2056Knee Surg Sport Tr AISI:000283257300026Orishimo, KF Nicholas Inst Sports Med & Athlet Trauma, 130 E 77th St,10th Floor, New York, NY 10075 USA Nicholas Inst Sports Med & Athlet Trauma, 130 E 77th St,10th Floor, New York, NY 10075 USA Nicholas Inst Sports Med & Athlet Trauma, New York, NY 10075 USADOI 10.1007/s00167-010-1185-2English W<7Z8Hayes, D. A. Watts, M. C. Tevelen, G. A. Crawford, R. W.2005~Central versus peripheral tibial screw placement in hamstring anterior cruciate ligament reconstruction: In vitro biomechanics703-706;Arthroscopy-the Journal of Arthroscopic and Related Surgery216_acl reconstruction tibial fixation peripheral fixation central fixation fixation tendons graftsJunoPurpose: To determine whether a cone-shaped interference screw positioned centrally during tibial fixation in hamstring anterior cruciate ligament (ACL) reconstruction was equal to or better than a peripheral position in terms of stiffness, yield load, ultimate load, and mode of failure. Type of Study: Randomized matched-pair biomechanical pullout study. Methods: One of each of 7 matched pairs of human cadaveric tendon in porcine tibia with titanium cone-shaped screws were randomly allocated to either the peripheral or central group. Bone tunnels were drilled 45 degrees to the long axis of the tibia, akin to standard ACL reconstruction. Tunnel diameter was matched to tendon diameter and a screw 1 mm larger than tunnel diameter was inserted. A Universal Materials Testing Machine (Hounsfield Testing Equipment, Horsham, PA) was used to pull in the line of the tendon. Tendons were inspected after construct disassembly. Results: The central screw configuration showed significantly higher stiffness (P = .0085), yield load (P = .0135), and ultimate load (P = .0075). The mode of failure in the peripheral screw position was slippage at the screw-tendon interface in all cases. In the central group, 87.5% of cases had a breakage in the tendon and 12.5% had slippage at the tendon-bone interface. Conclusions: Central interference screw fixation of soft-tissue ACL reconstruction offers superior fixation strength and stiffness in single pullout mode when compared with peripheral interference screw fixation. Failure in the central group was mostly by tendon breakage, suggesting that a larger difference may be exhibited by the central over the peripheral fixation than demonstrated in this study. Clinical Relevance: Central interference screw fixation compared with peripheral fixation may allow greater confidence in early rehabilitation and reduced clinical failure rates in the long term.://000229857100010-936LI Times Cited:6 Cited References Count:11 0749-8063 ArthroscopyISI:000229857100010Hayes, DA Brisbane Private Hosp, Brisbane Orthopaed & Sports Med Ctr, Arnold Janssen Ctr, Level 5,259 Wickham Tce, Brisbane, Qld 4000, Australia Brisbane Private Hosp, Brisbane Orthopaed & Sports Med Ctr, Arnold Janssen Ctr, Level 5,259 Wickham Tce, Brisbane, Qld 4000, Australia Queensland Univ Technol, Brisbane Orthopaed & Sports Med Ctr, Brisbane, Qld, Australia Queensland Univ Technol, Sch Engn Syst, Brisbane, Qld, AustraliaDOI 10.1016/j.artho.2005.03.004English<7[,Brand, J. C. Caborn, D. N. M. Johnson, D. L.2003eBiomechanics of soft-tissue interference screw fixation for anterior cruciate ligament reconstruction432-439 Orthopedics264xhamstring tendon graft bone-mineral density patellar tendon femoral tunnel autograft strength semitendinosus tibia womenApr://000182346000021-669HN Times Cited:3 Cited References Count:43 0147-7447 OrthopedicsISI:000182346000021Brand, JC 1500 Irving, Alexandria, MN 56308 USA 1500 Irving, Alexandria, MN 56308 USA Alexandria Orthopaed & Sports Med, Alexandria, MN USA Univ Kentucky, Sch Med, Lexington, KY 40536 USAEnglish<7\KFerretti, A. Conteduca, F. Morelli, F. Monteleone, L. Nanni, F. Valente, M.2003aBiomechanics of anterior cruciate ligament reconstruction using twisted doubled hamstring tendons22-25International Orthopaedics271dpatellar tendon mechanical-properties gracilis tendons in-vivo graft semitendinosus behavior tensionJanaWe studied the biomechanical properties of a twisted doubled semitendinosus and gracilis graft. We applied an un-axial load in order to reproduce the kinematics of a reconstructed anterior cruciate ligament (ACL). A modified cryo-jaw clamp system was used to minimize soft tissue slippage. The lower grip, after fixation of the free ends of the tendons, was rotated 45degrees, translated 1 cm, and bent 40degrees, simulating a knee sprain. The graft was tested to failure using a servohydraulic machine. The specimen from one knee of seven unembalmed cadavers was assigned to the untwisted (parallel) bundles group, while its pair was assigned to the twisted group. For the parallel bundles group, the mean maximum load was 1709.3+/-581.9 N, for the twisted group 2428.3+/-475.4 N (P<0.05). The mean stiffness was respectively 213.6+/-72.4 N/mm and 310.3+/-97.3 N/mm (P=0.08). Although caution should be used in extrapolating the results to clinical estimates of the strength of hamstring grafts, the results of the present study could justify the use of twisted semitendinosus and gracilis bundles in ACL reconstruction.://000181594000005-656DR Times Cited:2 Cited References Count:26 0341-2695 Int OrthopISI:000181594000005Ferretti, A Univ Roma La Sapienza, Hosp S Andrea, Dept Orthopaed Surg, Via Lidia 73, I-00179 Rome, Italy Univ Roma La Sapienza, Hosp S Andrea, Dept Orthopaed Surg, Via Lidia 73, I-00179 Rome, Italy Univ Roma La Sapienza, Hosp S Andrea, Dept Orthopaed Surg, I-00179 Rome, Italy Univ Roma La Sapienza, Dept Mech & Aeronaut, Rome, Italy Univ Roma La Sapienza, Dept Chem & Mat Engn, Rome, ItalyDOI 10.1007/s00264-002-0395-8Englishf<7]IBrown, C. H. Ferretti, A. Conteduca, F. Morelli, F. Hecker, A. Wilson, D.2001XBiomechanics of the swing-bridge technique for anterior cruciate ligament reconstruction69-73<European Journal of Sports Traumatology and Related Research232Obiomechanics hamstrings semitendinosus acl semitendinosus fixation tendon graftJunPSecure graft fixation (high failure load and stiffness) is one of the important factors to be considered during an ACL reconstruction. The goal of graft fixation is to prevent slippage or failure at graft fixation sites and thereby to permit early motion without loss of stability. in the first part of the study, we compared biomechanical properties of a new femoral fixation device (swing-bridge) with endobutton/continuous loop which has proved to be the strongest of six fixation devices tested in our laboratory in a previous study, In the second part of the study, we investigate whether twisting the four bundles of a gracilis and semitendinosus graft modifies its biomechanical properties. The swing-bridge device was significantly stiffer than the endobutton/continuous loop (mean stiffness: 218 N/mm for the swing-bridge, 118 N/mm. for the endobutton), but could not be found significant difference between the failure load of the two fixation devices (mean failure load: 1181 N for the swing-bridge, 1226 N for the endobutton). Twisting the tendons significantly reduces the failure load of the DGST graft (mean failure load: 3334 N for the untwisted grafts, 2259 N for the twisted grafts), but it doesn't affect stiffness significantly (mean stiffness: 759 N/mm for the untwisted grafts, 698 N/mm for the twisted grafts). (C) 2001. Editrice Kurtis.://000174589800001-534MH Times Cited:6 Cited References Count:14 1592-3894Eur J Sport Trauma RISI:000174589800001Ferretti, A Via Lidia 73, I-00179 Rome, Italy Via Lidia 73, I-00179 Rome, Italy Beth Israel Deaconess Med Ctr, Orthopaed Biomech Lab, Dept Orthopaed Surg, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA USA Univ Roma La Sapienza, Dept Orthopaed Surg, S Andrea Hosp, Rome, ItalyEnglish<7^1Fu, F. H. Bennett, C. H. Lattermann, C. Ma, C. B.1999nCurrent trends in anterior cruciate ligament reconstruction part 1: Biology and biomechanics of reconstruction821-830#American Journal of Sports Medicine276patellar tendon graft medial collateral ligament autogenous semitendinosus tendon accelerated rehabilitation interference screws in-vivo functional-analysis autograft fixation hamstring tendons gracilis tendonsNov-DecWith today's increasing emphasis on sporting activities, the incidence of anterior cruciate ligament injuries has also increased. Epidemiologic studies estimate that the prevalence of anterior cruciate ligament injuries is about 1 per 3000 Americans. Management of these injuries has evolved from nonoperative treatment to extracapsular augmentation and primary ligament repair to anterior cruciate ligament reconstruction. Treatment of these injuries has significantly improved over the last few decades with the application of knowledge gained from both basic science and clinical research. This article is composed of two parts. The first part reviews the biology and biomechanics of the injured anterior cruciate ligament and the basic science of reconstruction. In the second part, to be published later, current operative concepts of reconstruction, as well-as clinical correlations, are reviewed. Summarizing the latest information on basic scientific as well as clinical studies regarding the anterior cruciate ligament, this article intends to demonstrate the correlation between the application of basic science knowledge and improvement of clinical outcomes.://0000837193000240256HF Times Cited:119 Cited References Count:118 0363-5465Am J Sport MedISI:000083719300024Fu, Fh Dept Orthopaed Surg, 1010 Kaufman Bldg,3471 5th Ave, Pittsburgh, PA 15213 USA Dept Orthopaed Surg, 1010 Kaufman Bldg,3471 5th Ave, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Orthopaed, Pittsburgh, PA 15260 USAEnglish A<7_%DeVita, P. Hortobagyi, T. Barrier, J.1998oGait biomechanics are not normal after anterior cruciate ligament reconstruction and accelerated rehabilitation 1481-1488+Medicine and Science in Sports and Exercise3010acl injury knee walking reconstruction surgery biomechanics functional knee brace patellar tendon graft muscle strength follow-up stability joint patterns surgery coactivation walkingOct!Purpose: Accelerated rehabilitation for anterior cruciate ligament (ACL) injury and reconstruction surgery is designed to return injured people to athletic activities in approximately 6 months. The small amount of empirical data on this population suggests, however, that the torque at the knee joint may nor return until 22 months after surgery during walking and even longer during running. Although the rehabilitation has ended and individuals have returned to preinjury activities, gait mechanics appear to be abnormal at the end of accelerated programs. The purpose of this study was to compare lower extremity joint kinematics, kinetics, and energetics between individuals having undergone ACL reconstruction and accelerated rehabilitation and healthy individuals. Methods: Eight ACL-injured and 22 healthy subjects were tested. Injured subjects were tested 3 wk and 6 months (the end of rehabilitation) after surgery. Ground reaction force and kinematic data were combined with inverse dynamics to predict sagittal plane joint torques and powers from which angular impulse and work were derived. Results: The difference in all kinematic variables between the two tests for the ACL group averaged 38% (all P < 0.05). The kinematics were not different between the ACL group after rehabilitation and healthy subjects. Angular impulses and work averaged 100% difference for all joints (all P < 0.05) between tests for the ACL group. After rehabilitation, the differences between injured and healthy groups in angular impulse and work at both the hip and knee remained large and averaged 52% (all P < 0.05). Conclusions: Results indicated that after reconstruction surgery and accelerated rehabilitation for ACL injury, humans walk with normal kinematic patterns but continue to use altered joint torque and power patterns.://000076365600003.127TA Times Cited:70 Cited References Count:43 0195-9131Med Sci Sport ExerISI:000076365600003DeVita, P E Carolina Univ, Dept Exercise & Sport Sci, Greenville, NC 27858 USA E Carolina Univ, Dept Exercise & Sport Sci, Greenville, NC 27858 USA E Carolina Univ, Dept Exercise & Sport Sci, Greenville, NC 27858 USAEnglish<7`>Ng, G. Y. Oakes, B. W. Deacon, O. W. Mclean, I. D. Lampard, D.1995yBiomechanics of Patellar Tendon Autograft for Reconstruction of the Anterior Cruciate Ligament in the Goat - 3-Year Study602-608Journal of Orthopaedic Research134jmedial collateral ligament mechanical-properties rabbit knee transplantation replacement fascia injury dogJul~This study examined the biomechanics of anterior cruciate ligament-patellar tendon autografts for as long as 3 years after surgery. Twenty-seven adult female goats were tested; four served as controls and the others received an autograft to the right knee with each left knee serving as an additional control. The animals with grafts were tested at 0 week (n = 4), 6 weeks (n = 4), 12 weeks (n = 4), 24 weeks (n = 3), 1 year (n = 5), and 3 years (n = 3) after surgery. The anteroposterior laxity of the knee joint, load-relaxation, and structural and material properties of the graft were tested. The anteroposterior laxity was significantly greater than that of the controls for all groups except at 3 years. Load-relaxation was greater than that of the control anterior cruciate ligaments but in the 1 and 3-year grafts load-relaxation was less than that of the patellar tendons with 5 minutes of sustained loading. Between 12 and 52 weeks, the stiffness and modulus of the grafts increased 3-fold, but the improvement was slow afterward. At 3 years, the strength and stiffness of the grafts were 44 and 49% those of the control ligaments, respectively; the modulus was 37 and 46% that of the control anterior cruciate ligaments and patellar tendons, respectively. The persistent inferior mechanical performance at 3 years suggests that anterior cruciate ligament grafts may never attain normal strength.://A1995RT62500015.Rt625 Times Cited:47 Cited References Count:28 0736-0266J Orthopaed ResISI:A1995RT62500015xMonash Univ,Fac Med,Dept Anat,Clayton,Vic 3168,Australia Monash Univ,Fac Engn,Dept Elect Engn,Clayton,Vic 3168,AustraliaEnglish<7aAmis, A. A. Scammell, B. E.1993bBiomechanics of Intraarticular and Extraarticular Reconstruction of the Anterior Cruciate Ligament812-8170Journal of Bone and Joint Surgery-British Volume755knee tenodesisSepfMany methods of reconstruction for ACL deficiency have been described, but little is known about their biomechanical properties. We examined extra-articular (EA), intra-articular (IA) and combined (EA + IA) reconstructions in ten cadaver knees after the ACL had been ruptured by the performance of a rapid anterior drawer movement. Stability at each stage before and after rupture and reconstruction was tested by anterior drawer, Lachman, varus-valgus and tibial rotation tests. Both IA and IA + EA reconstructions restored normal stability, while EA reconstructions improved stability but did not restore it to normal. The addition of an EA procedure to an IA procedure made no difference to knee stability. We conclude that in cases of isolated ACL deficiency there is no biomechanical basis for EA reconstruction, either alone or in addition to an IA reconstruction.://A1993LW75600031.Lw756 Times Cited:25 Cited References Count:23 0301-620XJ Bone Joint Surg BrISI:A1993LW75600031Amis, Aa Univ London Imperial Coll Sci Technol & Med,Dept Mech Engn,Biomech Sect,London Sw7 2bx,England Univ London Imperial Coll Sci Technol & Med,Dept Mech Engn,Biomech Sect,London Sw7 2bx,EnglandEnglishm<7bYasuda, K. Sasaki, T.1987Muscle Exercise after Anterior Cruciate Ligament Reconstruction - Biomechanics of the Simultaneous Isometric Contraction Method of the Quadriceps and the Hamstrings266-274*Clinical Orthopaedics and Related Research220Jul://A1987J083000037.J0830 Times Cited:30 Cited References Count:13 0009-921XClin Orthop Relat RISI:A1987J083000037Yasuda, K Hokkaido Univ,Sch Med,Dept Orthopaed Surg,Kita 15 Nishi 7,Kita Ku,Sapporo,Hokkaido 060,Japan Hokkaido Univ,Sch Med,Dept Orthopaed Surg,Kita 15 Nishi 7,Kita Ku,Sapporo,Hokkaido 060,JapanEnglish<7c0Hill, J. A. Lew, W. D. Lewis, J. L. Yongnian, L.1984VBiomechanics of Anterior Cruciate Ligament Surgical Reconstruction - Preliminary-Study537-539Surgical Forum35://A1984TW53800225,Tw538 Times Cited:0 Cited References Count:3 0071-8041 Surg ForumISI:A1984TW53800225Hill, Ja Northwestern Univ,Sch Med,Dept Orthopaed Surg,Chicago,Il 60611 Northwestern Univ,Sch Med,Dept Orthopaed Surg,Chicago,Il 60611English<7dPArms, S. W. Pope, M. H. Johnson, R. J. Fischer, R. A. Arvidsson, I. Eriksson, E.1984PThe Biomechanics of Anterior Cruciate Ligament Rehabilitation and Reconstruction8-18#American Journal of Sports Medicine121://A1984SB47800002.Sb478 Times Cited:225 Cited References Count:0 0363-5465Am J Sport MedISI:A1984SB47800002AUniv Vermont,Sch Med,Dept Orthopaed & Rehabil,Burlington,Vt 05405English9~t7e3Woo, S. L. Wu, C. Dede, O. Vercillo, F. Noorani, S.2006:Biomechanics and anterior cruciate ligament reconstruction2J Orthop Surg Res1 2006/12/08For years, bioengineers and orthopaedic surgeons have applied the principles of mechanics to gain valuable information about the complex function of the anterior cruciate ligament (ACL). The results of these investigations have provided scientific data for surgeons to improve methods of ACL reconstruction and postoperative rehabilitation. This review paper will present specific examples of how the field of biomechanics has impacted the evolution of ACL research. The anatomy and biomechanics of the ACL as well as the discovery of new tools in ACL-related biomechanical study are first introduced. Some important factors affecting the surgical outcome of ACL reconstruction, including graft selection, tunnel placement, initial graft tension, graft fixation, graft tunnel motion and healing, are then discussed. The scientific basis for the new surgical procedure, i.e., anatomic double bundle ACL reconstruction, designed to regain rotatory stability of the knee, is presented. To conclude, the future role of biomechanics in gaining valuable in-vivo data that can further advance the understanding of the ACL and ACL graft function in order to improve the patient outcome following ACL reconstruction is suggested.+http://www.ncbi.nlm.nih.gov/pubmed/17150122Woo, Savio L-Y Wu, Changfu Dede, Ozgur Vercillo, Fabio Noorani, Sabrina England Journal of orthopaedic surgery and research J Orthop Surg Res. 2006 Sep 25;1:2.*1749-799X (Electronic) 1749-799X (Linking)163500517150122}Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, Pennsylvania, USA. ddecenzo@pitt.edu)1749-799X-1-2 [pii] 10.1186/1749-799X-1-2eng||7f Woo, S. L. Karaoglu, S. Dede, O.2006K[Contribution of biomechanics to anterior cruciate ligament reconstruction]94-100Acta Orthop Traumatol Turc401 2006/05/02lAnterior Cruciate Ligament/*injuries/*surgery Biomechanics Humans Reconstructive Surgical Procedures/methodsFor years, bioengineers and orthopedic surgeons have applied the principles of biomechanics to gain valuable information about the complex function of the anterior cruciate ligament (ACL), as well as to improve the design of replacement grafts for ACL reconstruction. New experimental tools, such as robotic testing systems and mathematical models have been used to measure the multiple degree-of-freedom (DOF) knee kinematics, in situ forces, and biomechanical properties of the ACL. This manuscript will review specific examples of how biomechanics has impacted surgical reconstruction of the ACL by improving technical factors such as graft selection, tunnel placement, initial graft tension, graft fixation, and graft tunnel healing. Evolution of the single-bundle ACL reconstruction to the more anatomical double-bundle reconstruction will be featured. Finally, the future role of biomechanics to facilitate in vivo data for further improvement of ACL reconstruction will be discussed.+http://www.ncbi.nlm.nih.gov/pubmed/16648686Woo, Savio L-Y Karaoglu, Sinan Dede, Ozgur English Abstract Review Turkey Acta orthopaedica et traumatologica turcica Acta Orthop Traumatol Turc. 2006;40(1):94-100.%1017-995X (Print) 1017-995X (Linking)166486869Biyomekanigin on capraz bag rekonstruksiyonuna katkilari.{Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, Pittsburgh, USA. ddecenzo@pitt.edutur ||7gNHarner, C. D. Janaushek, M. A. Ma, C. B. Kanamori, A. Vogrin, T. M. Woo, S. L.2000The effect of knee flexion angle and application of an anterior tibial load at the time of graft fixation on the biomechanics of a posterior cruciate ligament-reconstructed knee460-5Am J Sports Med284 2000/08/02Adult Aged Anterior Cruciate Ligament/*injuries/*surgery Biomechanics Cadaver Female Graft Survival Humans Knee Injuries/pathology/surgery Knee Joint/physiology Male Middle Aged Range of Motion, Articular *Reconstructive Surgical Procedures Tibia/*physiology Weight-BearingJul-AugTen knees were studied using a robotic testing system under a 134-N posterior tibial load at five flexion angles. Three knee positions were used to study the effect of flexion angle at the time of graft fixation (full extension, 60 degrees, and 90 degrees) and two were used to study the effect of anterior tibial load (60 degrees and 90 degrees). Knee kinematics and in situ forces were determined for the intact ligament and the graft for each reconstruction. Graft fixation at full extension significantly decreased posterior tibial translation compared with the intact knee by up to 2.9 +/- 2.9 mm at 30 degrees, while in situ forces in the graft were up to 18 +/- 35 N greater than for the intact ligament. Conversely, posterior tibial translation for graft fixation at 90 degrees was significantly greater than that of the intact knee by up to 2.2 +/- 1.1 mm at all flexion angles; in situ forces decreased as much as 33 +/- 30 N. When an anterior tibial load was applied before graft fixation at 90 degrees of flexion, posterior tibial translation did not differ from the intact knee from 30 degrees to 120 degrees, while the in situ force in the graft did not differ from the intact ligament at full extension, 60 degrees, and 120 degrees of flexion. These data suggest that graft fixation at full extension may overconstrain the knee and elevate in situ graft forces. Conversely, fixation with the knee in flexion and an anterior tibial load best restored intact knee biomechanics.+http://www.ncbi.nlm.nih.gov/pubmed/10921635Harner, C D Janaushek, M A Ma, C B Kanamori, A Vogrin, T M Woo, S L Research Support, Non-U.S. Gov't United states The American journal of sports medicine Am J Sports Med. 2000 Jul-Aug;28(4):460-5.%0363-5465 (Print) 0363-5465 (Linking)10921635vMusculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania 15213, USA.eng||7h&Smith, B. A. Livesay, G. A. Woo, S. L.1993:Biology and biomechanics of the anterior cruciate ligament637-70Clin Sports Med124 1993/10/01Animals *Anterior Cruciate Ligament/anatomy & histology/injuries/physiology/surgery Biomechanics Elasticity Humans Knee Injuries/pathology/physiopathology Tensile StrengthOctWith detailed information concerning the role of the anterior cruciate ligament in the overall kinematic response of the knee during external loading, current clinical management of the orthopedic injuries to this joint may be improved upon and refined. Among the largest challenges to be met will be elucidation of the effects of various levels and types of muscular stabilization concurrent with a precise determination of the roles of passive knee restraints.*http://www.ncbi.nlm.nih.gov/pubmed/8261518Smith, B A Livesay, G A Woo, S L AR39683/AR/NIAMS NIH HHS/United States Research Support, U.S. Gov't, P.H.S. Review United states Clinics in sports medicine Clin Sports Med. 1993 Oct;12(4):637-70.%0278-5919 (Print) 0278-5919 (Linking)8261518JDepartment of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania.eng||7i#Woo, S. L. Livesay, G. A. Engle, C.1992aBiomechanics of the human anterior cruciate ligament. Muscle stabilization and ACL reconstruction935-41 Orthop Rev218 1992/08/01EAnterior Cruciate Ligament/*injuries Biomechanics Evaluation Studies as Topic Humans Orthopedics/*methods Range of Motion, Articular Tendons/transplantation Tensile Strength Transplantation, Autologous/methods/standards Transplantation, Homologous/methods/standards Wounds and Injuries/physiopathology/rehabilitation/*surgeryAugSeveral topics of debate surround the surgical reconstruction of the anterior cruciate ligament (ACL), including graft selection, reconstructive technique, and postoperative rehabilitation. The tensile properties of the human ACL and the role of this ligament in the normal kinematics of the knee have been addressed in the first part of this two-part review. This portion of the review will focus on the effects of reconstruction technique, initial graft tension, and muscular stabilization on knee kinematics.*http://www.ncbi.nlm.nih.gov/pubmed/1523008Woo, S L Livesay, G A Engle, C AR-39683/AR/NIAMS NIH HHS/United States Research Support, U.S. Gov't, P.H.S. Review United states Orthopaedic review Orthop Rev. 1992 Aug;21(8):935-41.%0094-6591 (Print) 0094-6591 (Linking)1523008JDepartment of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania.eng||7j#Woo, S. L. Livesay, G. A. Engle, C.1992[Biomechanics of the human anterior cruciate ligament. ACL structure and role in knee motion835-42 Orthop Rev217 1992/07/01Adult Aged Aged, 80 and over Aging/physiology Anterior Cruciate Ligament/anatomy & histology/*physiology Biomechanics Humans Knee Joint/*physiology Middle Aged Range of Motion, ArticularJulSurgical reconstruction of the anterior cruciate ligament (ACL) to restore knee stability has introduced many subjects of debate, including graft selection, reconstructive technique, and postoperative rehabilitation. In the first part of this two-part review, the tensile properties of the human ACL and the role of the ACL in knee kinematics are discussed. Reconstructive techniques for ACL replacement with regard to the biomechanics of the ACL in normal and ACL-deficient knees will be addressed in Part II.*http://www.ncbi.nlm.nih.gov/pubmed/1501921Woo, S L Livesay, G A Engle, C AR-39683/AR/NIAMS NIH HHS/United States Research Support, U.S. Gov't, P.H.S. Review United states Orthopaedic review Orthop Rev. 1992 Jul;21(7):835-42.%0094-6591 (Print) 0094-6591 (Linking)1501921JDepartment of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania.engK @?k Wolff, J.1989The law of bone remodelling)Das Gesetz der Transformation der KnochenBerlinSpringerMaquet, P. Furlong, R.i# ||7l!Bauer, G. Arand, M. M Futschler, W.1991JPost-traumatic radioulnar synostosis after forearm fracture osteosynthesis142-5Arch Orthop Trauma Surg1103 1991/01/01Adolescent Adult Aged Female *Fracture Fixation, Internal/adverse effects/methods Humans Male Middle Aged Radius Fractures/*complications/surgery Synostosis/*etiology/radiography Ulna Fractures/*complications/surgeryoOne hundred sixty-seven forearm fractures treated with plate osteosynthesis were analyzed for synostosis occurring between the radius and the ulna. Eleven cases (6.6%) were found, in 7 of which both bones of the forearm had been fractured, while the other 4 were cases of isolated radial or ulnar fracture. Overall there were 89 cases of fracture of both bones; of the 65 cases treated utilizing the two-incision approach, cross-union was seen in only 1, while in a comparable group (12 cases) in which the fractures were stabilized using the Boyd approach, there were 5 synostoses. In 38 cases of isolated ulna fracture, only 2 synostoses were seen one associated with severe soft-tissue trauma and the other arising after treatment with a modified Boyd approach. Among 40 isolated radial fractures, 2 radioulnar synostoses occurred, one in an open fracture and the other after fixation via the Boyd approach. These results emphasize the importance of using two approaches for fractures of both forearm bones. The highest risk of post-osteosynthetic synostosis appears to be in fractures of the proximal third of both radius and ulna.*http://www.ncbi.nlm.nih.gov/pubmed/2059537}Bauer, G Arand, M Mutschler, W Germany Archives of orthopaedic and trauma surgery Arch Orthop Trauma Surg. 1991;110(3):142-5.%0936-8051 (Print) 0936-8051 (Linking)2059537xAbteilung fur Unfall-, Hand-, Plastische- und Wiederherstellungschirurgie, Universitat Ulm, Federal Republic of Germany.engC<7mAsscheman, H. T'Sjoen, G. Lemaire, A. Mas, M. Meriggiola, C. Mueller, A. Buffat, J. Kuhn, A. Dhejne, C. Journel, N. M. Gooren, L.2010Risk of venous thromboembolism (VTE) in estrogen-treated male-to-female transsexuals: Review of literature and observations from 9 European centers for gender dysphoria449-449Journal of Sexual Medicine7Dec://0002840715002185Suppl. 6 678KC Times Cited:0 Cited References Count:0 1743-6095 J Sex MedISI:000284071500218>HAJAP, Amsterdam, Netherlands Univ Hosp Ghent, Ghent, Belgium Univ La Laguna, Tenerife, Spain Univ Bologna, I-40126 Bologna, Italy Univ Hosp Erlangen, Erlangen, Germany Univ Hosp Bern, Frauenklin, CH-3010 Bern, Switzerland Karolinska Univ, Stockholm, Sweden Univ Lyon Sud, Lyon, France AndroConsult, Changmai, ThailandEnglish[<7n!Murphy, W. G. Tong, E. Murphy, C.2010Women Have Lower Circulating Red Cell Counts than Men Because of More Efficient Red Cell Delivery to the Capillaries: Observations from Paired Capillary and Venous Blood Samples in a Large Cohort of Blood Donors E225-E2250Arteriosclerosis Thrombosis and Vascular Biology3011Nov://000283234800194,667YS Times Cited:0 Cited References Count:0 1079-5642Arterioscl Throm VasISI:000283234800194kUniv Coll Dublin, Dublin 2, Ireland Univ Dublin, Dublin, Ireland Irish Blood Transfus Serv, Dublin, IrelandEnglish<7oNPedrosa, I. Ngo, L. Wei, J. Schuster, M. Mahallati, H. Smith, M. Rofsky, N. M.2009oDynamic half-Fourier single-shot turbo spin echo for assessment of deep venous thrombosis: initial observations617-624Magnetic Resonance Imaging275magnetic resonance imaging deep venous thrombosis venography mr venography central veins ultrasonography angiography diagnosis disease usJunSObjective: The objective of this study was to retrospectively analyze the value of dynamic half-Fourier single-shot turbo spin echo (HASTE) imaging in patients with Suspected deep venous thrombosis (DVT). Materials and Methods: Fifty-five veins in 24 patients were interrogated using a HASTE sequence with the patients relaxed and ill various degrees of Valsalva. Veins were analyzed for changes in caliber (+CAL) and signal intensity (+SI) or in their absence (-CAL and -SI, respectively) and compared with the presence of thrombus oil gadolinium-enhanced magnetic resonance imaging. Results: There was no thrombus in veins with the +CAL, +SI pattern (n=40) (P<.01). Five of seven veins (71.4%) with the -CAL, -SI pattern had thrombus (P<.01). A qualitative change in CAL had a sensitivity of 100% and a specificity of 91% for the presence of thrombus. An increase of 1.5 mm in CAL had a sensitivity of 100% and a specificity of 93% for this diagnosis. Conclusion: Dynamic HASTE imaging offers a physiological method to evaluate veins for deep venous thrombosis. (C) 2009 Elsevier Inc. All rights reserved.://000266799600005-455WS Times Cited:1 Cited References Count:32 0730-725XMagn Reson ImagingISI:000266799600005vPedrosa, I Beth Israel Deaconess Med Ctr, Dept Radiol, 330 Brookline Ave, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr, Dept Radiol, 330 Brookline Ave, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr, Dept Med, Brookline, MA 02446 USA Foothills Prov Gen Hosp, Dept Radiol, Calgary, AB T2N 2T9, CanadaDOI 10.1016/j.mri.2008.10.002English <7pShorr, A. F. Williams, M. D.2009`Venous thromboembolism in critically ill patients Observations from a randomized trial in sepsis139-144Thrombosis and Haemostasis1011deep-vein thrombosis heparin prevention pulmonary embolism sepsis acute coronary syndromes critical-care prophylaxis prevention thrombosis heparinJanVenous thromboembolism (VTE) is a central concern in the intensive care unit (ICU). However, little is known about both current practices for VTE prevention in the ICU and the risk for VTE in persons with severe sepsis and septic shock. XPRESS was a randomized, double-blind, placebo-controlled trial of prophylactic heparin in patients with severe sepsis and higher disease severity who were treated with drotrecogin alfa (activated) (DAA). Subjects were randomized to unfractionated heparin, low-molecular-weight heparin, or placebo during the DAA infusion period. All patients underwent ultrasonography between days 4-6 to screen for VTE. We assessed baseline utilization of VTE prophylaxis along with application of these methods after completion of the DAA infusion. The study included 1,935 subjects and, prior to enrollment approximately half were given no form of prophylaxis. By day 6, 5% of subjects developed a VTE, and the rate of VTE did not vary based on type of heparin administered. The vast majority of VTE detected by day 6 were clinically silent. Of factors analyzed, history of VTE was the only variable independently associated with development of a VTE (odds ratio, 3.66, 95% confidence interval 1.77-7.56, p=0.005). Strikingly, patients who were initially receiving heparin prophylaxis prior to enrollment but who then had this discontinued because of randomization to placebo suffered more VTE that persons continuing on some form of heparin. Despite multiple guidelines, physicians do not uniformly prescribe VTE prophylaxis. Nonetheless, early VTE occurs even in persons given DAA. Most VTE in critically ill patients are clinically silent.://000262626700023-396XZ Times Cited:1 Cited References Count:13 0340-6245Thromb HaemostasisISI:0002626267000239Shorr, AF Washington Hosp Ctr, Pulm & Crit Care Dept, Room 2A-38D,110 Irving St NW, Washington, DC 20010 USA Washington Hosp Ctr, Pulm & Crit Care Dept, Room 2A-38D,110 Irving St NW, Washington, DC 20010 USA Washington Hosp Ctr, Pulm & Crit Care Dept, Washington, DC 20010 USA Lilly Res Labs, Indianapolis, IN USADoi 10.1160/Th08-07-0468English %<7q8Harenberg, J. Jorg, I. Vukojevic, Y. Mikus, G. Weiss, C.2008Anticoagulant effects of Idraparinux after termination of therapy for prevention of recurrent venous thromboembolism: observations from the van Gogh trials555-563)European Journal of Clinical Pharmacology646anticoagulants anticoagulation idraparinux pharmacodynamics thrombosis venous thromboembolism molecular weight heparin intensity warfarin therapy secondary prevention long-term pentasaccharide antithrombin fraction diseaseJunAim To gather information on anticoagulant effects after the termination of long- term therapy with idraparinux. Methods The anticoagulant effects of idraparinux, a synthetic polymethylated analogue of its pentasaccharide, were analysed in 23 patients after termination of a 6- or 12-month therapy period for the prevention of recurrent venous thromboembolism ( VTE). Plasma samples of patients initially randomized to 2.5 mg idraparinux ( normal creatinine clearance) or 1.5 mg idraparinux ( creatinine clearance < 30 ml/ min) were investigated in the van Gogh trials. At 3-month intervals for up to 15 months following the termination of the therapy, the factor Xa- specific S2222 chromogenic substrate ( aXa) assay and Heptest were used to determine various pharmacokinetic parameters and prothrombin- induced clotting time ( PiCT), activated partial thromboplastin time ( aPTT) and prothrombin time ( PT) were determined. Results Based on the aXa assay and Heptest, the half lives ( t1/ 2) were 60.2 days and 107.7 days ( p< 0.0001), maximum drug concentrations ( Cmax) were 0.30 and 0.39 mu g/ l ( p= 0.0016), areas under the activity time curve ( AUC) were 33.7 and 38.0 mu g/ l per day ( p= 0.0002), plasma clearances were 0.09 and 0.06 ml/ min ( p< 0.0001), mean residence times ( MRT) were 75.4 and 121.9 ( p< 0.0001) and volumes of distribution ( Vdiss) were 7.4 and 8.6 l ( p= 0.1336), respectively. After 12 months of treatment ( n= 18), the S2222 and Heptest results showed significantly higher Cmax and AUC, lower Vdiss and clearance and unchanged t1/ 2 and MRT values compared to 6 months of treatment ( n= 5). The PiCT was prolonged for a period of 9 months. Coagulation times of aPTT and PT were not influenced. The results of these parameters did not differ between 12 and 6 months of treatment. Conclusion The data support reports on a non- ionic binding of idraparinux to antithrombin and other proteins. We suggest that these findings may explain some of the findings of the van Gogh Extension trial.://000255254800001.292GP Times Cited:10 Cited References Count:29 0031-6970Eur J Clin PharmacolISI:000255254800001uHarenberg, J Univ Hosp Mannheim, Dept Med 4, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany Univ Hosp Mannheim, Dept Med 4, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany Univ Hosp Mannheim, Dept Med 4, D-68167 Mannheim, Germany Univ Heidelberg, Dept Clin Pharmacol & Pharmacoepidemiol, Heidelberg, Germany Univ Hosp Mannheim, Inst Biometr & Stat, Mannheim, GermanyDOI 10.1007/s00228-008-0463-0English<7rBHarenberg, J. Joerg, I. Hagedorn, A. Giese, C. Weiss, C. Mikus, G.2007Pharmacodynamic analysis of the anticoagulant effects of Idraparinuxparinux after termination of 6 and 12 months therapy for prevention of recurrent venous thromboembolism: Observations after the vanGogh trials. 557a-558aBlood11011Nov 16://0002511008024058Part 1 233OS 1883 Times Cited:0 Cited References Count:0 0006-4971BloodISI:000251100802405Univ Hosp Mannheim, Dept Med 4, Mannheim, Germany Univ Hosp Mannheim, Inst Biometr & Stat, Mannheim, Germany Univ Hosp Mannheim, Dept Clin Pharmacol & Pharmacoepidemiol, Mannheim, GermanyEnglish <7s(Christie, B. A. Baumann, K. Kurth, M. H.2006Retrospective comparative examination of the long term effects of venous access devices on upper extremity limb measurement in children with haemophilia: pilot observations from a single haemophilia treatment centre526-530 Haemophilia125>haemophilia upper extremity measurements venous access devicesSepBackground: Venous access devices (VADs) have been used in some individuals with haemophilia to facilitate infusions of factor concentrates. Studies have reported complications of infection and thrombosis with VADs but there have been no studies looking at the potential effect that VADs may have on growth of the upper extremities in children with haemophilia. We hypothesize that there could be potential growth discrepancies in upper extremities in children with VADs related to changes in blood flow to the extremity caused by the VADs. Methods: This study was a cohort descriptive comparative study to determine if VAD use correlated to discrepancies in upper extremity limb measurement data. A multivariate analysis compared limb measurements with VAD use, bleeding, clotting, infections, surgeries, chest wall collateral patterns and magnetic resonance venogram results. Results: A total of 59 children with haemophilia participated (36 subjects with VADs, 23 subjects without). Overall, in subjects with VADs the non-VAD side was found to be shorter and measured less in girth than the VAD side. These differences did not reach statistical significance except bicep/tricep girth in the 11-15 age group. There was no correlation found between duration of VAD placement and subject age vs. length and girth measurements. When comparing subjects with VADs to those without VADs, no differences in measurements were seen. Differences in girth were measured between dominant hand and non-dominant hand in all subjects indicating that the dominant hand arm was larger. Reproducibility of this data may be hampered by limitations of sample size, subject homogeneity and variability in bleeding history between subject groups.://000239779600010-073YU Times Cited:2 Cited References Count:13 1351-8216 HaemophiliaISI:000239779600010Christie, BA Univ Minnesota, Med Ctr, Ctr Thrombosis & Hemostasis, MMC 713,B-549 Mayo,420 Delaware St SE, Minneapolis, MN 55455 USA Univ Minnesota, Med Ctr, Ctr Thrombosis & Hemostasis, MMC 713,B-549 Mayo,420 Delaware St SE, Minneapolis, MN 55455 USA Univ Minnesota, Med Ctr, Ctr Thrombosis & Hemostasis, Minneapolis, MN 55455 USA Childrens Hosp & Clin, Dept Pediat Haemotol & Oncol, Minneapolis, MN USA$DOI 10.1111/j.1365-2516.2006.01316.xEnglish<7t&Belcaro, G. Cesarone, M. R. Dugall, M.2004Microcirculatory efficacy of topical treatment with Aescin plus essential phospholipids gel in venous insufficiency and hypertension: New clinical observationsS1-S5 Angiology55^essaven gel diabetic microangiopathy standardized application microvascular changes ulcerationMay-Jun1Aescin + essential phospholipids (AEPL) topical gels are used for local treatment of venous and microcirculatory alterations (varicose veins, chronic venous insufficiency). Bruises, swelling, thrombophlebitis, and contusions are effectively treated with AEPL. Active ingredients are escinate and essential phospholipids (EPL). The aim of this new study was the evaluation of the efficacy of the effects of AEPL gel on the microcirculation in subjects with chronic venous insufficiency, venous hypertension (CVH), and venous microangiopathy. Patients were assessed measuring skin flux with laser-Doppler flowmetry (LDF). After 2 weeks of local treatment, all individual values (100%) were significantly decreased (p<0.05), indicating an improvement in the microcirculation. In all treated patients, flux decreased at least 30% (indicating a decrease in the level of venous microangiopathy) (p<0.05). Considering these observations, topical treatment with AEPL in areas of venous microangiopathy is beneficial, can prevent ulceration, and improves the skin healing processes.://0002216399000016Suppl. 1 823UW Times Cited:0 Cited References Count:33 0003-3197 AngiologyISI:000221639900001Belcaro, G Via Vespucci 65, I-65100 Pescara, Italy Via Vespucci 65, I-65100 Pescara, Italy Univ G DAnnunzio, Dept Biomed Sci, Irvine Vasc Lab 2, Chieti, ItalyEnglish <7u2Grenard, A. S. Mahe, I. Tourde, V. Bergmann, J. F.2003qAn aetiological survey of venous thromboembolic disease - What examinations for which patients ? 104 observations 1310-1316Presse Medicale3228hdeep-vein thrombosis pulmonary-embolism occult cancer population risk predictors malignancy cohort ratesSep 6S Objective The objective of the study was to determine, depending on the risk profile of the patients and characteristics of the venous thromboembolic disease (VTED), the interest of an aetiological control in the search for a neoplasia or abnormality in haemostasis among a cohort of patients hospitalised for deep-vein thrombosis (DVT) and/or pulmonary embolism (PE). Method This was a single centre, retrospective study of 104 files of patients hospitalised over a period of 3 years for DVT and/or PE in a department of internal medicine, in an intensive care unit. The patients included must have been diagnosed with DVT and/or PE, confirmed by respectively venous Doppler, pulmonary scintigraphy and pulmonary angiography or spiralled tomodensitometry. The thromboembolic risk factors and the supplementary examinations conducted for etiological research were analysed. Results In our population, with a mean age of 71.4 years, 98 patients exhibited at least one thromboembolic risk factor The thromboembolic episode was considered as idiopathic in 33 patients, i.e. in 31.7%. An abnormality in haemostasis was discovered in 10 patients, with a mean age of 57.5 years and 7 exhibited personal or familial past history of venous thromboembolic disease. Nine neoplasia were discovered, 4 of which were at metastatic stage. There was no significant difference in discovery of a neoplasia with regard to age, but it was more frequent in cases of seemingly idiopathic thrombosis. Anamnesis and the clinical examination suggested its existence in 6 patients. Abdominal-pelvic sonography was sufficient to orient the etiological research in 7 cases. The other examinations without clinical orientation (endoscopy, tumour markers) provided no further contribution. Conclusion We feel that systemic exhaustive survey in search of the etiology of a DVT/PE in all patients is not warranted. Simple explorations - including interrogation, complete clinical examination, current biological examinations (blood count, sedimentation rate), pulmonary x-ray and abdominal-pelvic sonography - were evocative in our series. Haemostasis tests should be reserved for young patients or for those in whom thromboembolic events occur repeatedly. The more specific examinations should be set-aside for patients in whom this first assessment has not suggested an underlying carcinoma. (C) 2003, Masson, Paris.://000185288800004-720XW Times Cited:1 Cited References Count:27 0755-4982 Presse MedISI:000185288800004Mahe, I Hop Lariboisiere, Serv Med A, 2 Rue Ambroise Pare, F-75010 Paris, France Hop Lariboisiere, Serv Med A, 2 Rue Ambroise Pare, F-75010 Paris, France Hop Lariboisiere, Serv Med Interne A, F-75475 Paris, FranceFrench/<7vEJolicoeur, M. E. Berube, C. Bernier, M. Soulieres, D. Miron, M. J. F.2002Use of D-dimer in the management of suspected deep venous thrombosis and pulmonary embolism in the emergency room: Prospective observations over 1 year. 277a-277aBlood10011Nov 16://0001791847010628Part 1 614JK 1062 Times Cited:0 Cited References Count:0 0006-4971BloodISI:000179184701062CHUM HND, Dept Med, Montreal, PQ, Canada CHUM HND, Dept Hematol, Montreal, PQ, Canada CHUM HND, Blood Bank, Montreal, PQ, CanadaEnglish<7w Stein, P. D.2001&Observations in venous thromboembolism69-70American Journal of Medicine1101pulmonary-embolismJan://000166373800014,391UH Times Cited:1 Cited References Count:9 0002-9343Am J MedISI:000166373800014Stein, PD St Joseph Mercy Hosp, 44555 Woodward Ave,Suite 107, Pontiac, MI 48341 USA St Joseph Mercy Hosp, 44555 Woodward Ave,Suite 107, Pontiac, MI 48341 USA St Joseph Mercy Hosp, Pontiac, MI 48341 USAEnglish<7x#Bonacker, M. Kroger, S. Krupski, G.2000eTwo unusual observations of collateral arterial and venous formations by the ligamentum teres hepatis856-857SRofo-Fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren17210Oct://000165281000015,373GQ Times Cited:0 Cited References Count:0 1438-9029Rofo-Fortschr RontgISI:000165281000015German<7yOBen-Haim, M. Rosenthal, R. J. Martz, J. Gurland, B. Mandeli, J. Friedman, R. L.1999The impact of inferior vena cava obstruction (IVCO) on central venous pressure (CVP) and intracranial pressure (ICP) during acute elevation of intraabdominal pressure (IAP) with CO2 pneumoperitoneum (PNP): Large animal model observations A1299-A1299Gastroenterology1164Apr://0000797784056319Part 2 187GJ S0023 Times Cited:0 Cited References Count:0 0016-5085GastroenterologyISI:000079778405631eMt Sinai Med Ctr, Mt Sinai Sch Med, New York, NY 10029 USA Albert Einstein Coll Med, New York, NY USAEnglish<7z"Said, S. A. M. Geeraedts, L. M. G.1997aVentriculo-venous communications in adults: ventriculographic observations in two female patients161-165#International Journal of Cardiology622ventriculo-venous fistulas hypertrophic obstructive cardiomyopathy degenerative valvular aortic stenosis contrast ventriculography left-to-right shunt fistulaNov 20ZVentriculo-venous communications (VVC) were angiographically demonstrated in two adult female patients clinically presented with effort angina. During oxymetric studies there were minor to moderate left-to-right shunts. Concomitant, mild valvular aortic stenosis (AS) was present in one patient and hypertrophic obstructive cardiomyopathy (HOCM) in the other. It is believed that ventriculo-venous communications have contributed to the symptomatology in both patients. Symptoms were controlled medically in combination with dual (DDD) cardiac pacing with short AV-delay in one patient and only medically in the other patient. From the differential diagnostic point of view, superselective contrast injection into an 'inert' myocardial sinusoid or intramural contrast staining has been considered but could be excluded. (C) 1997 Elsevier Science Ireland Ltd.://000071030500007-Ym119 Times Cited:0 Cited References Count:14 0167-5273 Int J CardiolISI:000071030500007ySaid, SAM Hosp Streekziekenhuis Midden Twente, Dept Cardiol, Geerdinksweg 141, NL-7555 DL Hengelo Ov, Netherlands Hosp Streekziekenhuis Midden Twente, Dept Cardiol, Geerdinksweg 141, NL-7555 DL Hengelo Ov, Netherlands Hosp Streekziekenhuis Midden Twente, Dept Cardiol, NL-7555 DL Hengelo Ov, Netherlands Univ Nijmegen Hosp, Dept Anat & Embryol, NL-6500 HB Nijmegen, NetherlandsEnglish<7{]Yoshimitsu, K. Honda, H. Kaneko, K. Kuroiwa, T. Irie, H. Chijiiwa, K. Takenaka, K. Masuda, K.1997Anatomy and clinical importance of cholecystic venous drainage: Helical CT observations during injection of contrast medium into the cholecystic artery505-510!American Journal of Roentgenology1692pseudolesion liverAugOBJECTIVE. The purpose of this study was to use helical CT to elucidate the anatomy and clinical importance of cholecystic venous drainage. SUBJECTS AND METHODS. We performed helical CT of the upper abdomen during injection of contrast medium through a superselectively catheterized cholecystic artery (cholecystic artery CT) in 28 patients, all of whom were surgical candidates for suspected hepatobiliary abnormality. In nine of these patients, CT during arterial portography (CTAP) was also performed. RESULTS. Cholecystic venous blood most frequently entered peripheral portal branches of hepatic segment V (27 of 28 patients, 96%) and segment IV (26 of 28, 93%). In order of decreasing frequency, cholecystic venous blood also drained to segments I, VI, VIII, III, and VII. Cholecystic venous blood subsequently drained into the middle hepatic vein (21 of 28, 75%) or right hepatic vein (20 of 28, 71%), In two patients with adenocarcinoma involving the gallbladder associated with multiple liver metastases, cholecystic venous drainage was seen around each metastatic focus, In the nine patients in whom both cholecystic artery CT and CTAP were performed, nontumorous portal perfusion defects were attributable to cholecystic venous drainage. CONCLUSION. Recognition of cholecystic venous drainage as a possible pathway for spread of disease from the gallbladder to the liver and also as one of the causes of nontumorous portal perfusion defects seen on CTAP is important.://A1997XM75800042.Xm758 Times Cited:35 Cited References Count:13 0361-803XAm J RoentgenolISI:A1997XM75800042Yoshimitsu, K Kyushu Univ Hosp,Dept Radiol,Higashi Ku,3-1-1 Maidashi,Fukuoka 81282,Japan Kyushu Univ Hosp,Dept Radiol,Higashi Ku,3-1-1 Maidashi,Fukuoka 81282,Japan Kyushu Univ Hosp,Dept Surg 1,Higashi Ku,Fukuoka 81282,Japan Kyushu Univ Hosp,Dept Surg 2,Higashi Ku,Fukuoka 81282,JapanEnglish<7|0Greenberg, M. Movahed, H. Peterson, B. Bejar, R.1995|Clinical and Laboratory Observations - Placement of Umbilical Venous Catheters with Use of Bedside Real-Time Ultrasonography633-635Journal of Pediatrics1264AprReal-time ultrasonography was used to assess the position of umbilical venous catheters tips in 79 newborn infants (birth weight range, 400 to 4200 gm). The position of the umbilical venous catheters determined by ultrasonography was compared with the projection of the catheter tip on the closest vertebral body shown on a standard chest radiograph. Of the catheters initially placed with radiographic guidance, 56% were repositioned because of unsatisfactory location. Ultrasonography is more precise than radiography because it allows direct visualization of the catheter tips in relation to internal vascular structures. When ultrasonography is unavailable, placement at the ninth thoracic vertebral body ensures safe positioning.://A1995QR21200023-Qr212 Times Cited:20 Cited References Count:5 0022-3476 J PediatrISI:A1995QR21200023iUniv Calif San Diego,Dept Neonatol,San Diego,Ca 92103 Univ Calif San Diego,Dept Pediat,San Diego,Ca 92103English %<7}^Vanleeuwen, M. S. Noordzij, J. Fernandez, M. A. Hennipman, A. Feldberg, M. A. M. Dillon, E. H.1994uPortal Venous and Segmental Anatomy of the Right Hemiliver - Observations Based on 3-Dimensional Spiral Ct Renderings 1395-1404!American Journal of Roentgenology1636jhepatic neoplasms arterial portography surgical anatomy liver localization utility nomenclature metastasesDec OBJECTIVE. The purpose of this study was to evaluate the segmental anatomy of the right hemiliver and to assess whether the right hepatic vein and right portal trunk are accurate indicators of the position of the right and transverse scissurae, respectively. SUBJECTS AND METHODS. We examined 26 patients with spiral Ct using 5-mm slices, reconstructed at 2-mm intervals. Three-dimensional renderings of the portal and hepatic venous structures were created. The portal ramification pattern and relationship between the hepatic veins and portal system were evaluated. RESULTS. In the right hemiliver, an anterosuperior sector and a posteroinferior sector were present in all patients. In addition, in nine patients, a total of 15 accessory portal sectors were present, each arising directly from the portal bifurcation or the right portal trunk. Further subdivision of the portal sectors showed marked individual variability, with no prevailing branching pattern. The scissura between the anterosuperior and posteroinferior sectors showed an angled orientation-its cranial part was tilted posteriorly (average, 58.4 degrees) and its caudal part was tilted anteriorly (average, 2.8 degrees)-relative to the coronal plane. In 24 patients, portal branches crossed the plane of the right hepatic vein. No transverse scissura could be seen in the anterosuperior or posteroinferior sector. CONCLUSION. The right hemiliver could be divided into anterosuperior and posteroinferior sectors in all patients studied; Many patients have accessory sectors. Further subdivision into portal segments can be described only after the individual portal branching pattern has been studied. The right hepatic vein is an inaccurate indicator of the position of the right scissura. No clear transverse scissura can be seen in the right hemiliver.://A1994PX33700023.Px337 Times Cited:31 Cited References Count:31 0361-803XAm J RoentgenolISI:A1994PX33700023Vanleeuwen, Ms Univ Utrecht Hosp,Dept Radiol,Heidelberglaan 100,3584 Cx Utrecht,Netherlands Univ Utrecht Hosp,Dept Radiol,Heidelberglaan 100,3584 Cx Utrecht,Netherlands Univ Utrecht Hosp,Dept Surg,Utrecht,NetherlandsEnglishl<7~Johnson, J. A. Didlake, R. H.1994VPeripherally-Placed Central Venous Access Ports - Clinical and Laboratory Observations915-919American Surgeon6012-cancer-patients catheter complications systemDecThe P.A.S. Port(TM) system is a totally implantable central venous access device consisting of a miniature titanium portal and a 5.8 French catheter that is specifically designed for implantation in the forearm. The configuration of this system combined with its unique placement technology provides a simplified alternative to conventional chest-placed systems. Our group has placed a total of 61 P.A.S. Port(TM) devices in 56 patients whose ages ranged from 9 months to 85 years and who were followed for a median of 672 days. Over this period of follow-up, these devices have demonstrated a low overall complication rate (13.1%), an infection rate of 6.6%, median event-free patency of 278 days, and exceptional patient acceptance. Placement of the P.A.S. Port(TM) system is easily performed as an outpatient procedure under local anesthesia and requires neither fluoroscopy nor a conventional operating room setting. In vitro measurement of infusion pressure across a P.A.S. Port(TM) and a conventional catheter system revealed much higher resistance in the peripherally placed device, but this was found to be of no clinical significance because infusion pressures generated by flow rates up to 750 mL/hr were well within the limits of clinically available infusion pumps. We recommend the P.A.S. Port(TM) system as a safe, durable, and effective alternative for patients in whom a chest-placed device is inappropriate or undesired.://A1994PX34400003-Px344 Times Cited:7 Cited References Count:16 0003-1348 Am SurgeonISI:A1994PX34400003RUniv Mississippi,Med Ctr,Dept Surg,Exptl Surg Lab,2500 N State St,Jackson,Ms 39216English<7HMcnally, P. G. Bolia, A. Absalom, S. R. Falconersmith, J. Howlett, T. A.1993Preliminary-Observations Using Endocrine Markers of Pituitary Venous Dilution during Bilateral Simultaneous Inferior Petrosal Sinus Catheterization in Cushings-Syndrome - Is Combined Crf and Trh Stimulation of Value681-686Clinical Endocrinology396;differential-diagnosis disease acth microadenomas gland prlDecOBJECTIVE We determined whether the measurement of hormones in pituitary blood permits correction for dilution by non-pituitary blood during bilateral simultaneous inferior petrosal sinus blood sampling in Cushing's syndrome. DESIGN Bilateral simultaneous inferior petrosal sinus blood sampling was performed after combined hCRF and TRH stimulation. Peak ACTH concentrations were corrected for the TSH and PRL inter-sinus ratio, assuming uniform secretion of both hormones into each inferior petrosal sinus. PATIENTS Eight patients with clinical and biochemical features of Cushing's syndrome. MEASUREMENTS Basal and stimulated ACTH, TSH and PRL concentrations were measured after bilateral simultaneous inferior petrosal sinus blood sampling and simultaneously from a peripheral forearm vein. RESULTS Basal central:peripheral ACTH ratio misdiagnosed four of eight patients as having non-pituitary disease. Peak uncorrected ACTH central:peripheral ratio erroneously suggested two of eight patients had non-pituitary disease. ACTH central:peripheral ratio corrected by TSH and PRL correctly predicted pituitary-dependent disease in all eight cases and provided correct lateralization data in four of five patients with a unilateral pituitary microadenoma. CONCLUSION This study suggests that measuring other hormones in pituitary blood after TRH stimulation can offer a simple and reliable method for correcting for dilution by non-pituitary blood during bilateral simultaneous inferior petrosal sinus blood sampling in Cushing's syndrome.://A1993MM22400009.Mm224 Times Cited:22 Cited References Count:21 0300-0664Clin EndocrinolISI:A1993MM22400009Leicester Royal Infirm,Dept Endocrinol,Leicester Lb1 5ww,England Leicester Royal Infirm,Dept Radiol,Leicester,England Leicester Royal Infirm,Dept Chem Pathol,Leicester,EnglandEnglishg<7?Lenoble, E. Foucher, G. Voisin, M. C. Maurel, A. Goutallier, D.19936Observations on Experimental Flow-through Venous Flaps378-383"British Journal of Plastic Surgery465;island flaps arterial inflow skin flaps vein survival graftJulWThe aim of this work was to compare the survival of an arteriovenous island flap with the survival of an island flap with a flow-through venous supply. Our experimental studies were performed on 95 Wistar rats randomised into six groups: Group 1: Indian ink injection of flow-through venous flaps with capillary network; Group 2: control group deprived of vascularisation; Group 3: control group with arteriovenous supply; Group 4: flow-through venous flaps of group 1 ; Group 5: epigastric flow-through venous flaps with a main venous trunk; Group 6: histological examination of flow-through venous flaps. The survival of flaps was monitored by direct examination, histological examination, capillaroscopy, and laser Doppler. Three out of 50 flow-through venous flaps survived. There was a statistically significant difference in the delay of clinical necrosis between the composite non vascularised free grafts (2.8 +/- 1.2 days) and the flow-through venous flaps (4.1 +/- 1.3 to 4.9 +/- 1.1 days depending on the type of flap). A 20% decreased venous blood flow was observed in the flow-through venous flaps.://A1993LP07900005.Lp079 Times Cited:11 Cited References Count:13 0007-1226Brit J Plast SurgISI:A1993LP07900005pLenoble, E Hop Henri Mondor,Dept Chirurg Orthoped & Traumatol,51 Av Ml Delattre Detassigny,F-94010 Creteil,France Hop Henri Mondor,Dept Chirurg Orthoped & Traumatol,51 Av Ml Delattre Detassigny,F-94010 Creteil,France Lab Microchirurg,F-75005 Paris,France Hop Henri Mondor,Rech Chirurg Lab,F-94010 Creteil,France Hop Henri Mondor,Dept Anat Pathol,F-94010 Creteil,FranceEnglish <79Raju, S. Fredericks, R. Lishman, P. Neglen, P. Morano, J.1993VObservations on the Calf Venous Pump Mechanism - Determinants of Postexercise Pressure459-469Journal of Vascular Surgery173 insufficiencyMar?Purpose: We investigated the factors determining postexercise pressure and the relationship of venous valve closure and venous column segmentation to ambulatory venous pressure changes. Methods: Valve closure and venous segmentation were observed during dynamic ascending phlebography in 40 nonrefluxive limbs and by duplex imaging in 25 normal limbs in healthy volunteers. Simultaneous volume (air plethysmography) and pressure studies during calf exercise were also carried out. Some studies used a simple mechanical model comprised of a collapsible latex tube (''calf pump'') and a graduated ''popliteal'' valve. Results: The femoropopliteal venous column above the popliteal valve remains unsegmented and continuous during ambulatory venous pressure changes in response to calf muscle contraction. Therefore ambulatory venous pressure changes cannot be explained purely on the basis of hydrostatic column pressure changes. Postexercise pressure appears to be determined by a complex set of factors: (1) physical segmentation of the venous column below the popliteal valve (i.e., tibial valve closure); (2) tube collapse below the closed valve, which further aids in the breakup of the hydrostatic column pressure and dampens the effect of any reflux through or around the closed valve; (3) ejection fraction, which influences the degree of tube collapse; and (4) the interaction of the resultant pressure forces with the wall properties of the venous pump. Conclusions: The mechanism of ambulatory venous pressure reduction is complex and multifactorial. The importance of venous wall characteristics as a determinant of postexercise pressure has not been previously appreciated. Changes in venous wall property after a thrombotic process, for example, could conceivably influence ambulatory venous pressure and recovery time in the absence of reflux.://A1993KR85100001.Kr851 Times Cited:22 Cited References Count:23 0741-5214 J Vasc SurgISI:A1993KR85100001Raju, S Univ Mississippi,Med Ctr,Dept Surg,2500 N State St,Jackson,Ms 39216 Univ Mississippi,Med Ctr,Dept Surg,2500 N State St,Jackson,Ms 39216 Univ Mississippi,Med Ctr,Dept Radiol,Jackson,Ms 39216English<7 Bondil, P.19938Venous Leaks - Anatomical and Physiological Observations379-380Journal of Urology1492Feb://A1993KK26400056,Kk264 Times Cited:0 Cited References Count:5 0022-5347 J UrologyISI:A1993KK26400056yBondil, P Gen Hosp,Dept Urol,Pl Dr Chiron,F-73011 Chambery,France Gen Hosp,Dept Urol,Pl Dr Chiron,F-73011 Chambery,FranceEnglishC<75Shabsigh, R. Fishman, I. J. Toombs, B. D. Skolkin, M.1993@Venous Leaks - Anatomical and Physiological Observations - Reply380-380Journal of Urology1492Feb://A1993KK26400057,Kk264 Times Cited:0 Cited References Count:0 0022-5347 J UrologyISI:A1993KK26400057English <75Shabsigh, R. Fishman, I. J. Toombs, B. D. Skolkin, M.19918Venous Leaks - Anatomical and Physiological Observations 1260-1265Journal of Urology1465xpenile erection impotence veins venous insufficiency erectile impotence penile erection cavernosography hemodynamics menNovA total of 50 patients with impotence underwent cavernosometry and cavernosography with intracavernous injection of vasoactive drugs. Several hemodynamic parameters were analyzed, including the pressure response curve after injection of vasoactive drugs and infusion of saline, the volume required to achieve erection, venous outflow resistance, erection maintenance infusion rate, rate of pressure decrease after discontinuation of infusion and post-infusion steady state pressure. On the basis of cavernosometric findings, venous leakage was ruled out in 4 patients. In the remaining 46 patients leak sites visualized during cavernosography included superficial dorsal vein in 1 (2.2%), deep dorsal vein in all 46 (100%), cavernous veins in 32 (69.6%), glans in 19 (41.3%) and corpus spongiosum in 14 (30.4%). Aberrant veins were documented in 7 patients (15.2%) communicating with the saphenous vein in 4 (8.9%), scrotal veins in 2 (4.4%) and femoral veins in 1 (2.2%). Eight patients (17.4%) had leakage through the deep dorsal vein as the only venous site, 17 (36.9%) had leakage through 2 venous sites, 14 (30.4%) had leakage through 3 venous sites and 7 (15.2%) had leakage through 4 venous sites. Correlations among hemodynamic and radiographic observations allowed the identification of 4 different types of cavernosometric findings. While type I represented normal penile vascular findings, types III and IV represented venous leakage. Type II could represent no leak, a mild leak or an undetected arterial problem. Accuracy of interpretation of a study may be improved by taking more than 1 parameter into consideration, including erection maintenance infusion rate, intracavernous pressure decrease within the first 5 seconds after discontinuation of infusion and the final steady state intracavernous pressure. The majority of patients have more than 1 leak site (82.6%). The most commonly combined sites of leakage are the deep dorsal and cavernous veins.://A1991GM83100015.Gm831 Times Cited:10 Cited References Count:18 0022-5347 J UrologyISI:A1991GM83100015St Lukes Episcopal Hosp,Scott Dept Urol,Houston,Tx 77030 St Lukes Episcopal Hosp,Urol Serv,Houston,Tx 77030 St Lukes Episcopal Hosp,Radiol Serv,Houston,Tx 77030English<75Braedel, H. U. Steffens, J. Ziegler, M. Polsky, M. S.1991Observations on the Development of the Secondary Venous System in the Abdomen with Special Reference to Idiopathic Left-Sided Varicoceles11-19UFortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Neuen Bildgebenden Verfahren1551ontogeny of abdominal venous system persistent vena-cardinalis posterior sinistra pathogenesis of varicocele pressure measurements phlebography hemodynamics veinJul:Based on 1.778 radiologic investigations of vena cava inferior, left renal vein and left spermatic vein the anomalies due to incorrect transformations from the first to the second abdominal venous system are presented. A persistent vena cardinalis posterior could be demonstrated in two cases. Varicoceles were seen with and without insufficient valves of the spermatic vein and venous outflow obstruction of the renal vein, respectively. Based on the demonstrated phlebographies disorders of ontogenesis seem to be the cause of the idiopathic left-sided varicoceles.://A1991FZ23600003-Fz236 Times Cited:8 Cited References Count:31 0936-6652Rofo Fortschr RontgISI:A1991FZ23600003Braedel, Hu Univ Homburg,Urol Rontgenabt,W-6650 Homburg,Germany Univ Homburg,Urol Rontgenabt,W-6650 Homburg,Germany Univ Homburg,Hno Klin,W-6650 Homburg,Germany Univ Homburg,Urol Klin,W-6650 Homburg,GermanyGerman<78Marn, C. S. Glazer, G. M. Williams, D. M. Francis, I. R.1990oCt-Angiographic Correlation of Collateral Venous Pathways in Isolated Splenic Vein Occlusion - New Observations375-380 Radiology1752May://A1990CZ49100016.Cz491 Times Cited:30 Cited References Count:19 0033-8419 RadiologyISI:A1990CZ49100016Marn, Cs Univ Michigan Hosp,Dept Radiol,1500 E Med Ctr Dr,Ann Arbor,Mi 48109 Univ Michigan Hosp,Dept Radiol,1500 E Med Ctr Dr,Ann Arbor,Mi 48109English<7jPark, P. K. Jarrell, B. E. Williams, S. K. Carter, T. L. Rose, D. G. Martinezhernandez, A. Carabasi, R. A.1990Thrombus-Free, Human Endothelial Surface in the Midregion of a Dacron Vascular Graft in the Splanchnic Venous Circuit - Observations after 9 Months of Implantation468-475Journal of Vascular Surgery113Mar://A1990CU51600015.Cu516 Times Cited:39 Cited References Count:27 0741-5214 J Vasc SurgISI:A1990CU51600015Park, Pk Thomas Jefferson Univ,Jefferson Med Coll,Dept Surg,1025 Walnut St,Philadelphia,Pa 19107 Thomas Jefferson Univ,Jefferson Med Coll,Dept Surg,1025 Walnut St,Philadelphia,Pa 19107 Thomas Jefferson Univ,Jefferson Med Coll,Dept Pathol,Philadelphia,Pa 19107English<7-Peachey, T. Eason, J. Potter, D. Ginsburg, R.1989YObservations on Abdominal Venous Pressures during Orthotopic Liver-Transplantation in Man 3526-3527Transplantation Proceedings213Jun://A1989AC67700048-Ac677 Times Cited:13 Cited References Count:0 0041-1345 Transplant PISI:A1989AC67700048Peachey, T Univ London Kings Coll Hosp,Dept Anaesthet & Intens Care,London Se5 9rs,England Univ London Kings Coll Hosp,Dept Anaesthet & Intens Care,London Se5 9rs,EnglandEnglish,<7_Eulry, F. Chazerain, P. Magnin, J. Demazieres, A. Clement, R. Chanudet, X. Pattin, S. Doury, P.1989nAlgodystrophy and Venous Thrombosis in the Lower-Limbs - Difficulties in Diagnosis - Concerning 5 Observations403-407Revue Du Rhumatisme565Apr://A1989U135600007-U1356 Times Cited:9 Cited References Count:20 1169-8446Rev RhumISI:A1989U135600007Hop Instruct Armees Begin,Serv Rheumatol,69 Av Paris,F-94160 St Mande,France Hop Instruct Armees Begin,Serv Pathol Vasc,F-94160 St Mande,FranceFrench/<79Francis, C. W. Ricotta, J. J. Evarts, C. M. Marder, V. J.1988Long-Term Clinical Observations and Venous Functional Abnormalities after Asymptomatic Venous Thrombosis Following Total Hip or Knee Arthroplasty271-278*Clinical Orthopaedics and Related Research232Jul://A1988P023100034.P0231 Times Cited:18 Cited References Count:22 0009-921XClin Orthop Relat RISI:A1988P023100034tUniv Rochester,Sch Med & Dent,Dept Surg,Rochester,Ny 14642 Penn State Univ,Milton S Hershey Med Ctr,Hershey,Pa 17033English`<7,Kruithof, E. K. O. Nicolosa, G. Bachmann, F.1987Plasminogen-Activator Inhibitor-1 - Development of a Radioimmunoassay and Observations on Its Plasma-Concentration during Venous Occlusion and after Platelet-Aggregation 1645-1653Blood705Nov://A1987K780600061/K7806 Times Cited:184 Cited References Count:47 0006-4971BloodISI:A1987K780600061Kruithof, Eko Chu Vaudois,Univ Hosp Ctr,Dept Med Div Hematol,Cent Hematol Lab,Ch-1011 Lausanne,Switzerland Chu Vaudois,Univ Hosp Ctr,Dept Med Div Hematol,Cent Hematol Lab,Ch-1011 Lausanne,SwitzerlandEnglish<7Mcwhorter, J. H.19870Observations on the Venous Structure of a Breast957-958Archives of Surgery1228Aug://A1987J971200025,J9712 Times Cited:1 Cited References Count:2 0004-0010Arch Surg-ChicagoISI:A1987J971200025English<7;Planes, A. Vochelle, N. Ferru, J. Przyrowski, D. Fagola, M.1986Low-Molecular-Weight Heparin, Enoxaparine (Pk-10-169), Its Use in the Prevention of Deep Venous Thrombosis (Tvp) after Total Hip-Prosthesis (Pth) and Repeated Total Hip-Prosthesis (Rpth), Based on 228 Successive Observations135-135 Journal Des Maladies Vasculaires11://A1986D1846000725Suppl. C D1846 Times Cited:0 Cited References Count:0 0398-0499 J Mal VasculISI:A1986D184600072French<7TCamblin, J. Rihani, R. Cornaert, P. Puppinck, P. Lepoutre, B. Dutoit, A. Croccel, L.1986cMultiple Thrombotic Manifestations (Venous and Arterial) during Heparin Treatments - 2 Observations137-137 Journal Des Maladies Vasculaires11://A1986D1846000785Suppl. C D1846 Times Cited:0 Cited References Count:0 0398-0499 J Mal VasculISI:A1986D184600078TCh St Philibert,Serv Cardiol,F-59462 Lomme,France Fac Libre Med,F-59046 Lille,FranceFrench9<7IPachter, H. L. Spencer, F. C. Hofstetter, S. R. Liang, H. C. Coppa, G. F.1986nThe Management of Juxtahepatic Venous Injuries without an Atriocaval Shunt - Preliminary Clinical Observations569-575Surgery995May://A1986C190300008.C1903 Times Cited:57 Cited References Count:22 0039-6060SurgeryISI:A1986C190300008Pachter, Hl Nyu Med Ctr,Dept Surg,530 1st Ave,Suite 6c,New York,Ny 10016 Nyu Med Ctr,Dept Surg,530 1st Ave,Suite 6c,New York,Ny 10016 Bellevue Hosp Ctr,Trauma & Shock Unit,New York,Ny 10016English*<7'Holm, H. A. Kalvenes, S. Abildgaard, U.1985Changes in Plasma Antithrombin (Heparin-Cofactor Activity) during Intravenous Heparin-Therapy - Observations in 198 Patients with Deep Venous Thrombosis564-569#Scandinavian Journal of Haematology355Nov://A1985AYW4200017.Ayw42 Times Cited:15 Cited References Count:16 0036-553XScand J HaematolISI:A1985AYW4200017Holm, Ha Aker Univ Hosp,Dept Med,N-0514 Oslo 5,Norway Aker Univ Hosp,Dept Med,N-0514 Oslo 5,Norway Norwegian Comp Ctr,Oslo,NorwayEnglish<7@Manenti, A. Botticelli, A. Lagana, G. Buttazzi, A. Pollastri, C.1985OThe Acute Venous Congestion of the Liver - Experimental-Observations in the Dog355-357Lyon Chirurgical815://A1985ASL4300025,Asl43 Times Cited:1 Cited References Count:9 0024-7782 Lyon ChirISI:A1985ASL4300025Manenti, A Univ Modena,Inst Anat Pathol,Chair Surg Semiol,I-41100 Modena,Italy Univ Modena,Inst Anat Pathol,Chair Surg Semiol,I-41100 Modena,ItalyFrench<7Calne, R. Y. Brons, I. G. M.1985RObservations on Paratopic Segmental Pancreas Grafting with Splenic Venous Drainage340-341Transplantation Proceedings171://A1985ABP6600106-Abp66 Times Cited:17 Cited References Count:2 0041-1345 Transplant PISI:A1985ABP6600106Calne, Ry Addenbrookes Hosp,Dept Surg,Level 9,Hills Rd,Cambridge Cb2 2qq,England Addenbrookes Hosp,Dept Surg,Level 9,Hills Rd,Cambridge Cb2 2qq,England Univ Cambridge,Dept Surg,Cambridge,EnglandEnglish<7+Morettin, L. B. Olifant, D. M. Brown, R. W.1984Comparative-Evaluation of the Effects of an Ionic Vs a Nonionic Contrast-Medium on the Venous Endothelium - Preliminary Scanning Electron-Microscopic Observations593-596Investigative Radiology196://A1984TU11000020,Tu110 Times Cited:7 Cited References Count:8 0020-9996 Invest RadiolISI:A1984TU11000020^Morettin, Lb Univ Texas,Med Branch,Galveston,Tx 77550 Univ Texas,Med Branch,Galveston,Tx 77550English7<7 Langeron, P.1984\Blue Phlebitis and Venous Gangrene after Concealed Obstruction - 3 Observations - Discussion 3011-3011Semaine Des Hopitaux6042://A1984TU17500013,Tu175 Times Cited:0 Cited References Count:0 0037-1777 Sem Hop ParisISI:A1984TU17500013French<7:Besson, G. Mimassi, N. Person, H. Meyen, A. Buonaguidi, R.1984Treatment of Highly-Situated Aneurysms of the Internal Cervical Carotid Using a Direct Approach, Venous Bypass or Endoaneurysmography - 2 Observations193-193Neurochirurgie303://A1984SU88500032,Su885 Times Cited:0 Cited References Count:0 0028-3770NeurochirurgieISI:A1984SU88500032French<7Setchell, B. P.1982xThe Flow and Composition of Lymph from the Testes of Pigs with Some Observations on the Effect of Raised Venous-Pressure201-2054Comparative Biochemistry and Physiology a-Physiology732://A1982PL78000010-Pl780 Times Cited:9 Cited References Count:42 0300-9629Comp Biochem Phys AISI:A1982PL78000010Setchell, Bp Arc,Inst Anim Physiol,Dept Physiol,Cambridge Cb2 4at,England Arc,Inst Anim Physiol,Dept Physiol,Cambridge Cb2 4at,EnglandEnglishU<7*Henriksen, L. Paulson, O. B. Lauritzen, M.1982The Effects of Sodium-Nitroprusside on Cerebral Blood-Flow and Cerebral Venous-Blood Gases .1. Observations in Awake Man during and Following Moderate Blood-Pressure Reduction383-387*European Journal of Clinical Investigation125://A1982PL85800005.Pl858 Times Cited:15 Cited References Count:22 0014-2972Eur J Clin InvestISI:A1982PL85800005Henriksen, L Univ Copenhagen,Rigshosp,Dept Neurol,Dk-2100 Copenhagen O,Denmark Univ Copenhagen,Rigshosp,Dept Neurol,Dk-2100 Copenhagen O,DenmarkEnglish;<7Henriksen, L. Paulson, O. B.1982The Effects of Sodium-Nitroprusside on Cerebral Blood-Flow and Cerebral Venous-Blood Gases .2. Observations in Awake Man during Successive Blood-Pressure Reduction389-393*European Journal of Clinical Investigation125://A1982PL85800006.Pl858 Times Cited:19 Cited References Count:19 0014-2972Eur J Clin InvestISI:A1982PL85800006Henriksen, L Univ Copenhagen,Rigshosp,Dept Neurol,Dk-2100 Copenhagen O,Denmark Univ Copenhagen,Rigshosp,Dept Neurol,Dk-2100 Copenhagen O,DenmarkEnglish<7JSegall, H. D. Ahmadi, J. Mccomb, J. G. Zee, C. S. Becker, T. S. Han, J. S.1982Computed Tomographic Observations Pertinent to Intra-Cranical Venous Thrombotic and Occlusive Disease in Childhood - State of the Art, Some New Data, and Hypotheses441-449 Radiology1432://A1982NM65700026.Nm657 Times Cited:55 Cited References Count:24 0033-8419 RadiologyISI:A1982NM65700026"Segall, Hd Univ So Calif,Los Angeles Cty Med Ctr,Dept Radiol,Los Angeles,Ca 90033 Univ So Calif,Los Angeles Cty Med Ctr,Dept Radiol,Los Angeles,Ca 90033 Univ So Calif,Childrens Hosp,Sch Med,Dept Radiol,Neuroradiol Sect,Los Angeles,Ca 90027 Childrens Hosp,Dept Neurosurg,Los Angeles,Ca 90027English<70Macalpin, R. N. Bassenge, E. Holtz, J. Kolin, A.1982UObservations of Arterial and Venous Vasomotion with the Absolute Induction Angiometer88-108 Blood Vessels192://A1982NL50000004-Nl500 Times Cited:3 Cited References Count:11 0303-6847 Blood VesselsISI:A1982NL50000004Macalpin, Rn Univ Calif Los Angeles,Sch Med,Los Angeles,Ca 90024 Univ Calif Los Angeles,Sch Med,Los Angeles,Ca 90024 Univ Freiburg,Inst Appl Physiol,D-7800 Freiburg,Fed Rep GerEnglish<7/Vidic, B. Bartl, G. Fellinger, C. Schuhmann, G.1980BObservations of the Course of Branch and Central Venous Occlusions710-714*Klinische Monatsblatter Fur Augenheilkunde1776://A1980KX64500010-Kx645 Times Cited:1 Cited References Count:10 0023-2165Klin Monatsbl AugenhISI:A1980KX64500010ZVidic, B Univ Graz,Augen Klin,a-8036 Graz,Austria Univ Graz,Augen Klin,a-8036 Graz,AustriaGerman<7%Haim, M. Cahn, R. Sebire, A. Cahn, J.1980Preliminary-Observations on Behavior of Platelets in Venous Plasma from Brain in State of Focal or Multiple Ischemia - Study in Dog334-335Journal De Pharmacologie113://A1980KP57000034,Kp570 Times Cited:0 Cited References Count:0 0021-793XJ Pharmacol-ParisISI:A1980KP570000349Inst Therapeut Exptl & Rech Clin,F-92120 Montrouge,FranceFrench<7 Warren, R.19804Behavior of Venous Thrombi - Historical Observations 1151-1154Archives of Surgery11510://A1980KM73200001-Km732 Times Cited:4 Cited References Count:39 0004-0010Arch Surg-ChicagoISI:A1980KM73200001Warren, R Peter Bent Brigham Hosp,Dept Surg,Boston,Ma 02115 Peter Bent Brigham Hosp,Dept Surg,Boston,Ma 02115 Harvard Univ,Sch Med,Boston,Ma 02115English<7Rauschning, W.1980kReport on 16 Ruptures of Popliteal Cysts Mimicking Deep Venous Thrombosis (12 Observations during One Year)324-3300Zeitschrift Fur Orthopadie Und Ihre Grenzgebiete1183://A1980KA64500005-Ka645 Times Cited:1 Cited References Count:33 0044-3220Z Orthop GrenzgebISI:A1980KA64500005Rauschning, W Univ Uppsala Hosp,Akad Krankenhaus,Orthopad Klin,S-75014 Uppsala,Sweden Univ Uppsala Hosp,Akad Krankenhaus,Orthopad Klin,S-75014 Uppsala,SwedenGerman<7 Vitums, A.1979QSome Observations on the Development of the Venous Drainage from the Equine Brain711-711Anatomical Record1933://A1979GM18600682,Gm186 Times Cited:0 Cited References Count:0 0003-276XAnat RecISI:A1979GM18600682Washington State Univ,Dept Vet & Comparat Anat,Pullman,Wa 99163 Washington State Univ,Dept Pharmacol,Pullman,Wa 99163 Washington State Univ,Dept Physiol,Pullman,Wa 99163English<7 Hayashi, T.1978xTrans-Cutaneous Observations of the Internal Jugular Venous Flow in Atrial Septal-Defect by Ultrasonic Doppler Flowmeter1069-&,Japanese Circulation Journal-English Edition429://A1978GD68400008-Gd684 Times Cited:1 Cited References Count:24 0047-1828 Jpn Circ JISI:A1978GD68400008Hayashi, T Osaka Univ,Sch Med,Dept Med 1,Fukushima Ku,Osaka 553,Japan Osaka Univ,Sch Med,Dept Med 1,Fukushima Ku,Osaka 553,JapanJapanese<7-Rouault, F. Huguet, J. F. Aubert, J. Unal, D.1978}Cardiac-Catheterization by Percutaneous Femoral Venous Approach in Infants Weighing Less Than 5-Kg - Observations in 97 Cases193-196Pediatric Radiology74://A1978GA63200001,Ga632 Times Cited:2 Cited References Count:0 0301-0449Pediatr RadiolISI:A1978GA63200001Rouault, F City Hosp Univ,Timone,Dept Radiol,F-13385 Marseille 4,France City Hosp Univ,Timone,Dept Radiol,F-13385 Marseille 4,FranceEnglishl<7`Arnett, E. N. Bacos, J. M. Macher, A. M. Marsh, H. B. Savage, D. D. Fulmer, J. D. Roberts, W. C.1977Fibrosing Mediastinitis Causing Pulmonary Arterial-Hypertension without Pulmonary Venous Hypertension - Clinical and Necropsy Observations634-643American Journal of Medicine634://A1977DY19500018.Dy195 Times Cited:35 Cited References Count:31 0002-9343Am J MedISI:A1977DY19500018Nhlbi,Pathol Branch,Bethesda,Md 20014 Nhlbi,Cardiol Branch,Bethesda,Md 20014 Nhlbi,Polm Branch,Bethesda,Md 20014 Washington Hosp Ctr,Dept Med,Div Cardiol,Washington,Dc 20010English<7_Marco, J. D. Hahn, J. W. Barner, H. B. Jellinek, M. Blair, O. M. Standeven, J. W. Kaiser, G. C.1977cCoronary Venous Arterialization - Acute Hemodynamic, Metabolic, and Chronic Anatomical Observations449-454Annals of Thoracic Surgery235://A1977DE22600010-De226 Times Cited:8 Cited References Count:14 0003-4975Ann Thorac SurgISI:A1977DE226000101St Louis Univ,Sch Med,Dept Surg,St Louis,Mo 63104Englishv<72Twersky, J. Levin, D. C. Twersky, N. Gordon, D. H.1976.Further Observations on Pulmonary Venous Varix435-440!American Journal of Roentgenology1273://A1976CG74200014.Cg742 Times Cited:11 Cited References Count:14 0361-803XAm J RoentgenolISI:A1976CG742000144Suny,Downstate Med Ctr,Dept Radiol,Brooklyn,Ny 11203English<7 Serenyi, P. Magyar, Z. Szabo, G.1976Cervical Lymphato-Venous Shunt in Treatment of Ascites in Caval-Constricted Dogs and in Patients with Hepatic Cirrhosis - Experimental-Observations and 7 Years Clinical Experience53-61 Lymphology92://A1976CA06700003-Ca067 Times Cited:3 Cited References Count:23 0024-7766 LymphologyISI:A1976CA06700003+Natl Inst Traumatol,H-1430 Budapest,HungaryEnglish<7 Gaylis, H.1975eSome Observations on Peripheral Venous-Pressure Using a Non-Invasive Technique - a Preliminary Report259-263British Journal of Surgery624://A1975W315500002,W3155 Times Cited:7 Cited References Count:3 0007-1323 Brit J SurgISI:A1975W315500002ZUniv Witwatersrand,Dept Surg,Witwatersrand,South Africa Gen Hosp,Johannesburg,South AfricaEnglish<7&Krusejarres, J. D. Karpf, M. Quaas, L.1974Invivo Observations Concerning Relation between Metabolism, Regulation and Biochemical Oscillations in Glucose Concentrations of Venous-Blood530-5348Zeitschrift Fur Klinische Chemie Und Klinische Biochemie1212://A1974V254000003-V2540 Times Cited:1 Cited References Count:16 0044-2933Z Klin Chem Klin BioISI:A1974V254000003^Univ Freiburg,Chirurg Klin,Klin Chem & Exptl Lab,Hugstetter Str 55,D-7800 Freiburg,Fed Rep GerEnglish<7!Honda, Y. Miyamura, M. Nakano, E.1975]Serial Observations of Arterial and Mixed-Venous Blood-Gases after Step Change in Ventilation123-138.Pflugers Archiv-European Journal of Physiology3532://A1975V228800003-V2288 Times Cited:3 Cited References Count:27 0031-6768Pflug Arch Eur J PhyISI:A1975V2288000031Kanazawa Univ,Sch Med,Dept Physiol,Kanazawa,JapanEnglish6~? Compton, Boyd1952,Mao's China; party reform documents, 1942-44 lii, 278 p.-University of Washington publications on AsiaSeattle,University of Washington Press)Zhongguo gong chan dang. Communism China.51012273 Translation and introd. by Boyd Compton. map. 21 cm. Report of the Progaganda Bureau of the Central Committee on the Cheng Feng movement.--Reform in learning, the party, and literature, by Mao Tse-tung.--In opposition to party formalism, by Mao Tse-tung.--Second preface to "Village investigations," by Mao Tse-tung.--The reconstruction of our studies, by Mao Tse-tung.--Central Committee resolution on investigation and research.--Resolution of the Central Committee of the Chinese Communist Party on the Yenan Cadre School.--Resolution of the Central Committee of the Chinese Communist Party on the education of cadres in service.--How to be a Communist Party member, by Ch*en Yün.--Training of the Communist Party member, by Liu Shao-ch*i.--Central Committee resolution on strengthening the party spirit.--Central Committee resolution on the unification of leadership in the anti-Japanese war bases.--Resolution of the Central Committee of the Chinese Communist Party on methods of leadership.--In opposition to liberalism, by Mao Tse-tung.--On the intra-party struggle, by Liu Shao-ch*i.--In opposition to several incorrect tendencies within the party, by Mao Tse-tung.--Address to the Shen-Kan-Ning Border Region Assembly, by Mao Tse-tung.--Progaganda guide.--Liquidation of Menshevik though in the part, by Liu Shao-sh*i.--The Bolshevization of the party, by J. Stalin.--Remolding the party's style of work and improving its state of organization.4055534Jefferson or Adams Building Reading Rooms JQ1519.A5; M3573 Jefferson or Adams Building Reading Rooms - STORED OFFSITE JQ1519.A5; M3573k~? Hanna, Boyd1952,The story of the Nativity in wood engravings59 p.Mount Vernon, N.Y.,Peter Pauper Press<Jesus Christ Nativity Texts. [from old catalog] Jesus ChristR52043438 Bible. N.T. Gospels. English. Authorized. Selections. 1952? illus. 18 cm.6036441FJefferson or Adams Building Reading Rooms BT315; .H27 (Rare Bk. Coll.)~?Barrett, E. Boyd1952Life begins with love114 p. Milwaukee,Bruce Pub. Co.$Love Religious aspects Christianity.52003971 (Edward Boyd), 21 cm.79054876Jefferson or Adams Building Reading Rooms BV4639; .B34O~?%Boyd, Anne Morris Rips, Rae Elizabeth1949%United States Government publications xx, 627 p. New York,Wilson3dZGovernment publications United States. Government publications United States Bibliography.d55000694 by Rae Elizabeth Rips. [Reprinted with corrections] diagrs. 26 cm. Includes bibliographies.1220811~Jefferson or Adams Building Reading Rooms Z1223.Z7; B7 1952 Reference - Main Reading Room (Jefferson, LJ100) Z1223.Z7; B7 1952ń~?Boyd, Catherine E.1952OTithes and parishes in medieval Italy; the historical roots of a modern problem xi, 280 p. Ithaca, N.Y.,@Cornell University Press for the American Historical Association$Tithes Italy. Catholic Church Italy.|53005744 GB53-4541 (Catherine Evangeline), 24 cm. Bibliographical footnotes. "Literature of the private church": p. 252-254.69761517Jefferson or Adams Building Reading Rooms HJ2287.I8; B6~?Boyd, Elizabeth Orr1952)Cross-country walks in the West Highlands233 p. Edinburgh,Oliver and Boyd;Scotland Guidebooks. Walking Scotland Highlands Guidebooks.53018741 GB52-12289 19 cm.79138635Jefferson or Adams Building Reading Rooms DA870; .B77 ~? Boyd, Fiske1952[Baptistown barns]!1 print : woodcut ; 33.2 x 46 cm.graphic,2003654630 Rights status not evaluated. For general information see "Copyright and Other Restrictions..." (http://lcweb.loc.gov/rr/print/195_copr.html) Signed with monogram and dated on block; signed in pencil. Rubber stamp: Dec 3 1952. Title and other information from Beall. Purchase; Pennell fund.13076215iPrints and Photographs Division Prints & Photographs Reading Room (Madison, LM337) FP - XX - B761,; no. 7~? Boyd, Fiske1952 [Concept]#1 print : woodcut ; 30.6 x 23.3 cm.New York$Society of American Graphic Artists,graphic2003654636 Rights status not evaluated. For general information see "Copyright and Other Restrictions..." (http://lcweb.loc.gov/rr/print/195_copr.html) Signed with monogram and dated on block; signed in pencil. Title and other information from Beall. Purchase; Pennell fund.13076253iPrints and Photographs Division Prints & Photographs Reading Room (Madison, LM337) FP - XX - B761,; no. 9l~?Boyd, George Adams19520Elias Boudinot, patriot and statesman, 1740-1821 xiii, 321 p. Princeton,Princeton University PressLBoudinot, Elias, 1740-1821. United States Politics and government 1789-1815.A52008761 GB53-187 illus., ports., map. Bibliography: p.[297]-304.79060927Jefferson or Adams Building Reading Rooms E302.6.B7; B6~?Boyd, Gilbert W.1952General physical metallurgy161 p.s.l.s.n.Physical metallurgy.Z52023725 by Gilbert W. Boyd. (Ann Arbor : Edwards Brothers). ill. ; 28 cm. Includes index.65025335Jefferson or Adams Building Reading Rooms TN690; .B76~? Boyd, James1952Old pines, and other stories165 p. Chapel Hill"University of North Carolina Press52012702 21 cm.10248110IJefferson or Adams Building Reading Rooms - STORED OFFSITE PZ3.B69375; Ol7~?Boyd, James I. C.1952^Narrow gauge rails in mid-Wales; a historical survey of the narrow gauge railways in mid-Wales146 p.South Godstone, Surrey, Oakwood PressNarrow gauge railroads Wales.54039779 illus. 22 cm.74531485Jefferson or Adams Building Reading Rooms TF675; .B74~? Boyd, Martin1952The cardboard crown255 p.London, Cresset Press53015909 GB52-15979 19 cm.7445215JJefferson or Adams Building Reading Rooms - STORED OFFSITE PZ3.B69378; Care~? Boyd, Robin19526Australia's home; its origins, builders, and occupiers287 p.CarltonMelbourne University Press4Architecture, Domestic Australia. [from old catalog]52039322 illus. 22 cm.10250498|Jefferson or Adams Building Reading Rooms NA7469; .B6 Jefferson or Adams Building Reading Rooms - STORED OFFSITE NA7469; .B6O~? Boyd, William1952CAn introduction to medical science; an elementary text on pathology304 p. Philadelphia, Lea & Febiger4th Medicine.'52004144 illus. 24 cm. Medical science.69689869Jefferson or Adams Building Reading Rooms RC58; .B65 1952~?6Boyd, William Harland Kern County Historical Society.,1952rLand of Havilah, 1854-1874; the story of Keyesville, Kernville, and Havilah, in the Kern River country, California54 p.Bakersfield, Calif.,Kern County (Calif.) History.52035983 illus. 24 cm.9781996~Jefferson or Adams Building Reading Rooms F868.K3; B68 Jefferson or Adams Building Reading Rooms - STORED OFFSITE F868.K3; B68O~?(Burks, Martin Parks Boyd, Thomas Munford1952.Common law and statutory pleading and practice xc, 1108 p.Charlottesville, Va., Michie Co.4thRPleading Virginia. [from old catalog] Civil procedure Virginia. [from old catalog]Q52019531 Pleading and practice in actions at common law [from old catalog] 27 cm.7907091Law Library Reading Room (Madison, LM201) KFV2930; .B83 1952 Law Library Reading Room (Madison, LM201) - STORED OFFSITE KFV2930; .B83 1952O~?&Evans, Lawrence B. Fenwick, Charles G.1952$Cases on American constitutional law942 p.National case book seriesChicago, Callaghan6th'Constitutional law United States Cases. 52004090 (Lawrence Boyd), 26 cm.9310351Law Library Reading Room (Madison, LM201) KF4549; .E88 1952 Law Library Reading Room (Madison, LM201) - STORED OFFSITE KF4549; .E88 1952S||7(Boyd, E. M. Connell, M. L. McEwen, H. D.1952The lipid composition and water content of carcass, skeletal muscle, and testicle in the host component of the albino rat, Walker carcinoma 256 dual organism471-83 Can J Med Sci306 1952/12/01Y*Lipids Muscles/*metabolism *Neoplasms, Experimental Testis/*metabolism Water/*metabolismDec+http://www.ncbi.nlm.nih.gov/pubmed/13019643{Boyd, e m Connell, m l Mcewen, h d Not Available Canadian journal of medical sciences Can J Med Sci. 1952 Dec;30(6):471-83.%0316-4403 (Print) 0316-4403 (Linking)13019643eng||7 Josiukas, A. Roy, T. E. Boyd, G.1952nDevelopment of resistance by Mycobacterium tuberculosis to streptomycin, viomycin, and paraaminosalicylic acid747-8AMA Am J Dis Child846 1952/12/01(Mycobacterium tuberculosis/*drug effectsDec+http://www.ncbi.nlm.nih.gov/pubmed/12996007Josiukas, a Roy, t e Boyd, g Not Available A.M.A. American journal of diseases of children AMA Am J Dis Child. 1952 Dec;84(6):747-8.%0096-8994 (Print) 0096-8994 (Linking)12996007eng||7'Chase, H. F. Boyd, R. S. Andrews, P. M.1952bN-allylnormorphine in treatment of dihydromorphinone and methorphinan overdosage; report of a case1103-4J Am Med Assoc15011 1952/11/15FAnalgesics/*toxicity *Hydromorphone Morphine/*antagonists & inhibitorsNov 15+http://www.ncbi.nlm.nih.gov/pubmed/12990361Chase, h f Boyd, r s Andrews, p m Not Available Journal of the American Medical Association J Am Med Assoc. 1952 Nov 15;150(11):1103-4.%0002-9955 (Print) 0002-9955 (Linking)12990361eng||7Boyd, W. L. Lichstein, H. C.1952MEffects of nutrition on aspartic acid deaminase system of Bacterium cadaveris424-5Proc Soc Exp Biol Med812 1952/11/01*Amidohydrolases *BacteriaNov+http://www.ncbi.nlm.nih.gov/pubmed/13027327Boyd, w l Lichstein, h c Not Available Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Proc Soc Exp Biol Med. 1952 Nov;81(2):424-5.%0037-9727 (Print) 0037-9727 (Linking)13027327eng||7"Agnew, J. T. Lisan, P. Boyd, M. J.1952SThe use of infrared absorption techniques in the study of hypersensitivity diseases815-7 J Opt Soc Am4211 1952/11/01Hypersensitivity/*bloodNov+http://www.ncbi.nlm.nih.gov/pubmed/13011670zAgnew, j t Lisan, p Boyd, m j Not Available Journal of the Optical Society of America J Opt Soc Am. 1952 Nov;42(11):815-7.%0030-3941 (Print) 0030-3941 (Linking)13011670eng|~7Adams, H. D. Boyd, D. P.1952:[Surgical treatment of coarctation of the aorta in adults]646-9 Arch Med Cuba36 1952/11/01Aortic Coarctation/*surgeryNov+http://www.ncbi.nlm.nih.gov/pubmed/13008726_Adams, h d Boyd, d p Not Available Archivos medicos de Cuba Arch Med Cuba. 1952 Nov;3(6):646-9.13008726ATratamiento quirurgico de la coartacion de la aorta en el adulto.und||76Boyd, A. M. Catchpole, B. N. Jepson, R. P. Rose, S. S.1952BSome observations on venous pressure estimations in the lower limb599-607J Bone Joint Surg Br34-B4 1952/11/01!*Blood Pressure Leg/*blood supplyNov+http://www.ncbi.nlm.nih.gov/pubmed/12999949Boyd, a m Catchpole, b n Jepson, r p Rose, s s Not Available The Journal of bone and joint surgery. British volume J Bone Joint Surg Br. 1952 Nov;34-B(4):599-607.0301-620X (Print)12999949eng||7&Hare, H. F. Souders, C. R. Boyd, D. P.1952A new concept in the treatment of carcinoma of the lung; combined radical surgery and supervoltage radiation; a preliminary report34-5Lahey Clin Bull82 1952/10/01 *RadiationOct+http://www.ncbi.nlm.nih.gov/pubmed/13024004mHare, h f Souders, c r Boyd, d p Not Available The Lahey Clinic bulletin Lahey Clin Bull. 1952 Oct;8(2):34-5.%0099-815X (Print) 0099-815X (Linking)13024004eng|t7 Boyd, E. M.1952)Cough medication and antihistaminic drugs289-92Can Med Assoc J674 1952/10/013Cough/*therapy *Respiratory Physiological PhenomenaOct+http://www.ncbi.nlm.nih.gov/pubmed/13009543dBoyd, e m Not Available Canadian Medical Association journal Can Med Assoc J. 1952 Oct;67(4):289-92.%0008-4409 (Print) 0008-4409 (Linking)182260613009543eng||7Bradley, P. L. Boyd, J. S.1952ZReadsorption of phage produced in cultures of lysogenic strains of Salmonella typhi-murium891-2J Pathol Bacteriol644 1952/10/01 *SalmonellaOct+http://www.ncbi.nlm.nih.gov/pubmed/13000601zBradley, p l Boyd, j s k Not Available The Journal of pathology and bacteriology J Pathol Bacteriol. 1952 Oct;64(4):891-2.%0368-3494 (Print) 0368-3494 (Linking)13000601eng7|t7GMersheimer, W. L. Glass, G. B. Speer, F. D. Winfield, J. M. Boyd, L. J.1952zGastric mucin; a chemical and histologic study following bilateral vagectomy, gastric resection and the combined procedure668-79Ann Surg1364 1952/10/015*Gastric Mucins Stomach/*surgery Vagus Nerve/*surgeryOct+http://www.ncbi.nlm.nih.gov/pubmed/12986649Mersheimer, w l Glass, g b j Speer, f d Winfield, j m Boyd, l j Not Available Annals of surgery Ann Surg. 1952 Oct;136(4):668-79.%0003-4932 (Print) 0003-4932 (Linking)180305112986649eng[||7 Boyd, J. H.1952"Subclinical carcinoma of the ovary926-30Am J Obstet Gynecol644 1952/10/01Oct+http://www.ncbi.nlm.nih.gov/pubmed/12985729qBoyd, j h Not Available American journal of obstetrics and gynecology Am J Obstet Gynecol. 1952 Oct;64(4):926-30.%0002-9378 (Print) 0002-9378 (Linking)12985729eng||7Hepp, J. A. Boyd, E. F.1952DRepair of the large rectocele; a report on the Dannreuther technique921-2Am J Obstet Gynecol644 1952/10/01Oct+http://www.ncbi.nlm.nih.gov/pubmed/12985727zHepp, j a Boyd, e f Not Available American journal of obstetrics and gynecology Am J Obstet Gynecol. 1952 Oct;64(4):921-2.%0002-9378 (Print) 0002-9378 (Linking)12985727eng||7Jones, L. T. Boyden, G. L.19522New mucous membrane flap for dacryocystorhinostomy405-8AMA Arch Otolaryngol564 1952/10/01Lacrimal Apparatus/*surgeryOct+http://www.ncbi.nlm.nih.gov/pubmed/12984929rJones, l t Boyden, g l Not Available A.M.A. archives of otolaryngology AMA Arch Otolaryngol. 1952 Oct;56(4):405-8.%0096-6894 (Print) 0096-6894 (Linking)12984929engr|t7 Boyd, J. S.19521Bacteriophage-typing and epidemiological problems679-85Br Med J24786 1952/09/27*Bacteriophages *SalmonellaSep 27+http://www.ncbi.nlm.nih.gov/pubmed/12978286WBoyd, j s k Not Available British medical journal Br Med J. 1952 Sep 27;2(4786):679-85.%0007-1447 (Print) 0007-1447 (Linking)202157612978286engY||7Walker, G. Boyd, P. R.19525Tetraethyl lead poisoning; report of a non-fatal case467-9Lancet26732 1952/09/06Lead/*toxicitySep 6+http://www.ncbi.nlm.nih.gov/pubmed/14956045JWalker, g Boyd, p r Not Available Lancet Lancet. 1952 Sep 6;2(6732):467-9.%0140-6736 (Print) 0140-6736 (Linking)14956045eng||75Kandler, H. Behymer, A. F. Kegeles, S. S. Boyd, R. W.19529A study of nurse-patient interaction in a mental hospital1100-3 Am J Nurs529 1952/09/01 *Nursing CareSep+http://www.ncbi.nlm.nih.gov/pubmed/12985616~Kandler, h Behymer, a f Kegeles, s s Boyd, r w Not Available The American journal of nursing Am J Nurs. 1952 Sep;52(9):1100-3.%0002-936X (Print) 0002-936X (Linking)12985616eng||7Johnson, F. E. Boyden, E. A.1952MThe effect of double vagotomy on the motor activity of the human gall bladder591-601Surgery323 1952/09/01,Gallbladder/*physiology Vagus Nerve/*surgerySep+http://www.ncbi.nlm.nih.gov/pubmed/12984275OJohnson, f e Boyden, e a Not Available Surgery Surgery. 1952 Sep;32(3):591-601.%0039-6060 (Print) 0039-6060 (Linking)12984275eng||7(Zilversmit, D. B. Boyd, G. A. Brucer, M.1952WThe preparation and particle size measurement of monodisperse radioactive gold colloids261-6J Lab Clin Med402 1952/08/01*Gold RadioisotopesAug+http://www.ncbi.nlm.nih.gov/pubmed/14946463Zilversmit, d b Boyd, g a Brucer, m Not Available The Journal of laboratory and clinical medicine J Lab Clin Med. 1952 Aug;40(2):261-6.%0022-2143 (Print) 0022-2143 (Linking)14946463eng||7(Zilversmit, D. B. Boyd, G. A. Brucer, M.1952cThe effect of particle size on blood clearance and tissue distribution of radioactive gold colloids255-60J Lab Clin Med402 1952/08/01*Gold RadioisotopesAug+http://www.ncbi.nlm.nih.gov/pubmed/14946462Zilversmit, d b Boyd, g a Brucer, m Not Available The Journal of laboratory and clinical medicine J Lab Clin Med. 1952 Aug;40(2):255-60.%0022-2143 (Print) 0022-2143 (Linking)14946462eng~|7Boyd, R. I. Commons, R. R.1952=The nephrotic syndrome; pathogenesis, diagnosis and treatment921-39Med Clin North Am21 1952/07/01 *NephrosisJul+http://www.ncbi.nlm.nih.gov/pubmed/14947327pBoyd, r i Commons, r r Not Available The Medical clinics of North America Med Clin North Am. 1952 Jul;21:921-39.%0025-7125 (Print) 0025-7125 (Linking)14947327eng||7)Laughlin, V. C. Derian, G. H. Boyd, P. F.1952Incomplete frontal septum of bladder complicated by congenital urethral valves and complete reduplication of upper left urinary tract289-96J Urol681 1952/07/01Urinary Bladder/*abnormalitiesJul+http://www.ncbi.nlm.nih.gov/pubmed/14939461gLaughlin, v c Derian, g h Boyd, p f Not Available The Journal of urology J Urol. 1952 Jul;68(1):289-96.%0022-5347 (Print) 0022-5347 (Linking)14939461eng||7Boyd, H. B. Brindley, H. H.1952KNonunion of the neck of the femur; study of three hundred forty-seven cases169-80 AMA Arch Surg651 1952/07/01*Femoral Neck FracturesJul+http://www.ncbi.nlm.nih.gov/pubmed/14932610fBoyd, h b Brindley, h h Not Available A.M.A. archives of surgery AMA Arch Surg. 1952 Jul;65(1):169-80.%0096-6908 (Print) 0096-6908 (Linking)14932610engX||7Boyd, W.19527The pathology of the ground substance of the mesenchyme353-7 Hawaii Med J116 1952/07/01 *MesodermJul-Aug+http://www.ncbi.nlm.nih.gov/pubmed/12989751TBoyd, w Not Available Hawaii medical journal Hawaii Med J. 1952 Jul-Aug;11(6):353-7.%0017-8594 (Print) 0017-8594 (Linking)12989751eng||7Boyd, E. M. Mc, Ewen Hd1952The concentration and accumulation of lipids in the tumor component of a tumor-host organism; Walker carcinoma 256 in albino rats163-72 Can J Med Sci303 1952/06/01'*Lipid Metabolism Neoplasms/*metabolismJun+http://www.ncbi.nlm.nih.gov/pubmed/14945007nBoyd, e m McEWEN, H D Not Available Canadian journal of medical sciences Can J Med Sci. 1952 Jun;30(3):163-72.%0316-4403 (Print) 0316-4403 (Linking)14945007eng||7 Boyden, G. L.1952/Surgical treatment of chronic frontal sinusitis558-66Ann Otol Rhinol Laryngol612 1952/06/01 *SinusitisJun+http://www.ncbi.nlm.nih.gov/pubmed/14944154|Boyden, g l Not Available The Annals of otology, rhinology, and laryngology Ann Otol Rhinol Laryngol. 1952 Jun;61(2):558-66.%0003-4894 (Print) 0003-4894 (Linking)14944154engW|7 Boyd, D. P.19527The surgical management of peripheral arterial aneurysm955-60Surg Clin North Am 1952/06/01Jun+http://www.ncbi.nlm.nih.gov/pubmed/14942667bBoyd, d p Not Available The Surgical clinics of North America Surg Clin North Am. 1952 Jun:955-60.%0039-6109 (Print) 0039-6109 (Linking)14942667eng||7 Boyden, E. A.1952The distribution of bronchi in gross anomalies of the right upper lobe particularly lobes subdivided by the azygos vein and those containing pre-eparterial bronchi797-807 Radiology586 1952/06/01Lung/*abnormalitiesJun+http://www.ncbi.nlm.nih.gov/pubmed/14941980FBoyden, e a Not Available Radiology Radiology. 1952 Jun;58(6):797-807.%0033-8419 (Print) 0033-8419 (Linking)14941980engI||7 Boyd, S. A.1952Presidential address389-91 Manit Med Rev326 1952/06/01*Societies, MedicalJun-Jul+http://www.ncbi.nlm.nih.gov/pubmed/14940082YBoyd, s a Not Available Manitoba medical review Manit Med Rev. 1952 Jun-Jul;32(6):389-91.%0025-2255 (Print) 0025-2255 (Linking)14940082eng||7)Boyd, J. D. Cannon, J. J. Leighton, R. E.1952Epidemiologic studies in dental caries. V. Placement of fillings as a source of statistical error of estimate as to dental caries progression rates354-8 J Dent Res313 1952/06/018Dental Caries/*epidemiology/*statistics & numerical dataJun+http://www.ncbi.nlm.nih.gov/pubmed/14938490nBoyd, j d Cannon, j j Leighton, r e Not Available Journal of dental research J Dent Res. 1952 Jun;31(3):354-8.%0022-0345 (Print) 0022-0345 (Linking)14938490eng||76Boyd, A. M. Jepson, R. P. Ratcliffe, A. H. Rose, S. S.19523The logical management of chronic ulcers of the leg207-15 Angiology33 1952/06/01 *Leg UlcerJun+http://www.ncbi.nlm.nih.gov/pubmed/14933836gBoyd, a m Jepson, r p Ratcliffe, a h Rose, s s Not Available Angiology Angiology. 1952 Jun;3(3):207-15.%0003-3197 (Print) 0003-3197 (Linking)14933836engB||7 Boyd, W. H.1952Colonic diverticula110-6 Am J Proctol32 1952/06/01*Diverticulum, ColonJun+http://www.ncbi.nlm.nih.gov/pubmed/14933622YBoyd, w h Not Available American journal of proctology Am J Proctol. 1952 Jun;3(2):110-6.%0002-9521 (Print) 0002-9521 (Linking)14933622eng||7Boyd, A. S. Charlewood, G. P.1952=The treatment of radium burn fistulae into bladder and rectum400-1 S Afr Med J2619 1952/05/10May 10+http://www.ncbi.nlm.nih.gov/pubmed/14950395Boyd, a s Charlewood, g p Not Available South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde S Afr Med J. 1952 May 10;26(19):400-1.%0256-9574 (Print) 0256-9574 (Linking)14950395eng||7Boyden, S. V. Suter, W. E.1952xStimulating effect of tuberculin upon production of circulating antibodies in guinea pigs infected with tubercle bacilli577-89 J Immunol685 1952/05/01 *TuberculinMay+http://www.ncbi.nlm.nih.gov/pubmed/14946396tBoyden, s v Suter, w e Not Available Journal of immunology (Baltimore, Md. : 1950) J Immunol. 1952 May;68(5):577-89.%0022-1767 (Print) 0022-1767 (Linking)14946396eng||7Brown, R. B. Boyd, S. A.1952!Thoracostomy versus thoracentesis557-60U S Armed Forces Med J34 1952/04/01Hemothorax/*surgeryApr+http://www.ncbi.nlm.nih.gov/pubmed/14913793{Brown, r b Boyd, s a Not Available United States Armed Forces medical journal U S Armed Forces Med J. 1952 Apr;3(4):557-60.%0566-0777 (Print) 0566-0777 (Linking)14913793engn||7Boyd, W. C. London, I. D.1952Soviet Science318Science1152986 1952/03/21Mar 21+http://www.ncbi.nlm.nih.gov/pubmed/17733452`Boyd, W C London, I D United States Science (New York, N.Y.) Science. 1952 Mar 21;115(2986):318.%0036-8075 (Print) 0036-8075 (Linking)17733452/115/2986/318 [pii] 10.1126/science.115.2986.318eng||7Paff, G. H. Boyd, M. J.19529Effects of fluoride on developing bones in tissue culture518-20Proc Soc Exp Biol Med793 1952/03/01*Bone and BonesMar+http://www.ncbi.nlm.nih.gov/pubmed/14920480Paff, g h Boyd, m j Not Available Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Proc Soc Exp Biol Med. 1952 Mar;79(3):518-20.%0037-9727 (Print) 0037-9727 (Linking)14920480eng`||7Thomas, L. B. Boyden, E. A.19521Agenesis of the right lung; report of three cases429-35Surgery313 1952/03/01Lung/*abnormalitiesMar+http://www.ncbi.nlm.nih.gov/pubmed/14913458MThomas, l b Boyden, e a Not Available Surgery Surgery. 1952 Mar;31(3):429-35.%0039-6060 (Print) 0039-6060 (Linking)14913458engM||7Corbus, B. C., Jr. Boyd, A. D.1952Urological anesthesia139-40J Lancet723 1952/03/01 *AnesthesiaMar+http://www.ncbi.nlm.nih.gov/pubmed/14908322ZCORBUS, B C Jr Boyd, a d Not Available The Journal-lancet J Lancet. 1952 Mar;72(3):139-40.%0096-0233 (Print) 0096-0233 (Linking)14908322eng||7Glass, G. B. Boyd, L. J.1952Studies on the non-parietal component of gastric secretion in humans. II. Present concept of the "alkaline constituent" of the gastric juice442-57Gastroenterology203 1952/03/01*Gastric JuiceMar+http://www.ncbi.nlm.nih.gov/pubmed/14906640^Glass, g b j Boyd, l j Not Available Gastroenterology Gastroenterology. 1952 Mar;20(3):442-57.%0016-5085 (Print) 0016-5085 (Linking)14906640eng||73Glass, G. B. Boyd, L. J. Drekter, I. J. Heisler, A.1952Studies on the non-parietal component of gastric secretion in humans. I. Variations in electrolytes and dissolved mucin of the gastric juice following insulin stimulation430-41Gastroenterology203 1952/03/01*Gastric JuiceMar+http://www.ncbi.nlm.nih.gov/pubmed/14906639vGlass, g b j Boyd, l j Drekter, i j Heisler, a Not Available Gastroenterology Gastroenterology. 1952 Mar;20(3):430-41.%0016-5085 (Print) 0016-5085 (Linking)14906639eng||7&Innerfield, I. Angrist, A. Boyd, L. J.1952EThe plasma antithrombin titer in incipient and advanced liver failure417-29Gastroenterology203 1952/03/01*Liver DiseasesMar+http://www.ncbi.nlm.nih.gov/pubmed/14906638jInnerfield, i Angrist, a Boyd, l j Not Available Gastroenterology Gastroenterology. 1952 Mar;20(3):417-29.%0016-5085 (Print) 0016-5085 (Linking)14906638eng||7Irons, W. G. Boyd, E. F.1952?Arginase as an anti-carcinogenic agent in mice and human beings39-44Ariz Med93 1952/03/01)*Amidohydrolases *Neoplasms, ExperimentalMar+http://www.ncbi.nlm.nih.gov/pubmed/14904295RIrons, w g Boyd, e f Not Available Arizona medicine Ariz Med. 1952 Mar;9(3):39-44.%0004-1556 (Print) 0004-1556 (Linking)14904295engt||7Small, A. R. Boyd, L. J.1952,Rupture of the esophagus induced by vomiting73-9 Am J Dig Dis193 1952/03/01 *VomitingMar+http://www.ncbi.nlm.nih.gov/pubmed/14902752pSmall, a r Boyd, l j Not Available The American journal of digestive diseases Am J Dig Dis. 1952 Mar;19(3):73-9.%0002-9211 (Print) 0002-9211 (Linking)14902752eng||7Braceland, F. J. Boyd, D. A.1952-Secretary of the board: apologia pro vita sua708-12J Am Med Assoc1489 1952/03/01*Licensure, MedicalMar 1+http://www.ncbi.nlm.nih.gov/pubmed/14897630|Braceland, f j Boyd, d a Not Available Journal of the American Medical Association J Am Med Assoc. 1952 Mar 1;148(9):708-12.%0002-9955 (Print) 0002-9955 (Linking)14897630eng||7,Grabar, P. Boyden, S. Taquet, A. Borduas, A.1952Z[Demonstration of 2 different antibodies in tuberculous serum by passive hemagglutination]899-901C R Hebd Seances Acad Sci2348 1952/02/18Tuberculosis/*immunologyFeb 18+http://www.ncbi.nlm.nih.gov/pubmed/12979248Grabar, p Boyden, s Taquet, a Borduas, a Not Available Comptes rendus hebdomadaires des seances de l'Academie des sciences C R Hebd Seances Acad Sci. 1952 Feb 18;234(8):899-901.%0001-4036 (Print) 0001-4036 (Linking)12979248gMise en evidence de deux anticorps differents dans les serums tuberculeux par hemagglutination passive.und||7YCrawford, K. Heatley, N. G. Boyd, P. F. Hale, C. W. Kelley, B. K. Miller, G. A. Smith, N.19524Antibiotic production by a species of Cephalosporium47-59J Gen Microbiol61-2 1952/02/01"*Acremonium *Anti-Bacterial AgentsFeb+http://www.ncbi.nlm.nih.gov/pubmed/14927850Crawford, k Heatley, n g Boyd, p f Hale, c w Kelley, b k Miller, g a Smith, n Not Available Journal of general microbiology J Gen Microbiol. 1952 Feb;6(1-2):47-59.%0022-1287 (Print) 0022-1287 (Linking)14927850eng||7*Boyd, J. D. Wessels, K. E. Leighton, R. E.1952Epidemiologic studies in dental caries. IV. Variability of progression rates of dental cavities in the occlusal surfaces of second molar teeth124-8 J Dent Res311 1952/02/01*Dental CariesFeb+http://www.ncbi.nlm.nih.gov/pubmed/14917826oBoyd, j d Wessels, k e Leighton, r e Not Available Journal of dental research J Dent Res. 1952 Feb;31(1):124-8.%0022-0345 (Print) 0022-0345 (Linking)14917826eng||79Glass, G. B. Boyd, L. J. Rubinstein, M. A. Svigals, C. S.1952fRelationship of glandular mucoprotein from human gastric juice to Castle's intrinsic antianemic factor101-8Science1152979 1952/02/01"*Anemia, Pernicious *Gastric JuiceFeb 1+http://www.ncbi.nlm.nih.gov/pubmed/14913181Glass, g b j Boyd, l j Rubinstein, m a Svigals, c s Not Available Science (New York, N.Y.) Science. 1952 Feb 1;115(2979):101-8.%0036-8075 (Print) 0036-8075 (Linking)14913181eng||7Lichstein, H. C. Boyd, R. B.19525A cofactor for the formic hydrogenylase enzyme system308-11Proc Soc Exp Biol Med792 1952/02/01*Coenzymes *Lyases *Oleic AcidFeb+http://www.ncbi.nlm.nih.gov/pubmed/14912105Lichstein, h c Boyd, r b Not Available Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Proc Soc Exp Biol Med. 1952 Feb;79(2):308-11.%0037-9727 (Print) 0037-9727 (Linking)14912105eng||7Bidwell, S. M. Boyd, E. M.1952FDiphenhydramine hydrochloride, U.S.P. XIV, and respiratory tract fluid224-8J Pharmacol Exp Ther1042 1952/02/01#*Diphenhydramine Lung/*drug effectsFeb+http://www.ncbi.nlm.nih.gov/pubmed/14908889Bidwell, s m r Boyd, e m Not Available The Journal of pharmacology and experimental therapeutics J Pharmacol Exp Ther. 1952 Feb;104(2):224-8.%0022-3565 (Print) 0022-3565 (Linking)14908889engm||7 Boyd, H. L.19523Lymphomatous involvement of the genitourinary tract197-204N Y State J Med522 1952/01/15 *LymphomaJan 15+http://www.ncbi.nlm.nih.gov/pubmed/14890971fBoyd, h l Not Available New York state journal of medicine N Y State J Med. 1952 Jan 15;52(2):197-204.%0028-7628 (Print) 0028-7628 (Linking)14890971eng[||7Van Huysen, G. Boyd, T. M.1952%Cleaning effectiveness of dentifrices575-81 J Dent Res314 1952/01/01 *Dentifrices+http://www.ncbi.nlm.nih.gov/pubmed/14946300_Van huysen, g Boyd, t m Not Available Journal of dental research J Dent Res. 1952;31(4):575-81.%0022-0345 (Print) 0022-0345 (Linking)14946300eng|t7 Boyd, W. C.1952>Newer concepts of human races suggested by blood group studies1-6J Natl Med Assoc441 1952/01/01*Blood Group AntigensJan+http://www.ncbi.nlm.nih.gov/pubmed/14908567iBoyd, w c Not Available Journal of the National Medical Association J Natl Med Assoc. 1952 Jan;44(1):1-6.%0027-9684 (Print) 0027-9684 (Linking)261709114908567engs||7Boyd, W. H. Mac, Lennan Wd1952BGeneral anaesthetic technique in maxillary and mandibular injuries24-6 Anaesthesia71 1952/01/01 Jaw/*injuriesJan+http://www.ncbi.nlm.nih.gov/pubmed/14903554UBoyd, w h f MacLENNAN, W D Not Available Anaesthesia Anaesthesia. 1952 Jan;7(1):24-6.%0003-2409 (Print) 0003-2409 (Linking)14903554eng||7$Comar, C. L. Lotz, W. E. Boyd, G. A.1952jAutoradiographic studies of calcium, phosphorus and strontium distribution in the bones of the growing pig113-29 Am J Anat901 1952/01/011*Bone and Bones Calcium Radioisotopes/*metabolismJan+http://www.ncbi.nlm.nih.gov/pubmed/14902690nComar, c l Lotz, w e Boyd, g a Not Available The American journal of anatomy Am J Anat. 1952 Jan;90(1):113-29.%0002-9106 (Print) 0002-9106 (Linking)1490269010.1002/aja.1000900105eng ~|7Jones, L. T. Boyden, G. L.19524A new mucous membrane flap for dacryocystorhinostomy137-41; discussion, 141-5+Trans Pac Coast Otoophthalmol Soc Annu Meet33 1952/01/01Lacrimal Apparatus/*surgery+http://www.ncbi.nlm.nih.gov/pubmed/13136401Jones, l t Boyden, g l Not Available Transactions of the Pacific Coast Oto-Ophthalmological Society annual meeting Trans Pac Coast Otoophthalmol Soc Annu Meet. 1952;33:137-41; discussion, 141-5.%0097-0093 (Print) 0097-0093 (Linking)13136401eng~~7Goldbloom, A. A. Boyd, L. J.1952Clinical studies in blood lipid metabolism. VII. Serial serum lipid partitions during the first and sixth week periods in patients with acute myocardial infarction103-20Bulletin NY Med Coll15 1952/01/011*Blood Lipids/*blood Myocardial Infarction/*blood+http://www.ncbi.nlm.nih.gov/pubmed/13042496oGoldbloom, a a Boyd, l j Not Available Bulletin. New York Medical College Bulletin NY Med Coll. 1952;15:103-20.13042496eng~~7#Lange, K. Langan, W. B. Boyd, L. J.1952mThe effect of acetyl beta methyl choline (mecholyl) on the absorption and efficacy of a hyperkinemic ointment94-102Bulletin NY Med Coll15 1952/01/01(*Ointments *Skin Physiological Phenomena+http://www.ncbi.nlm.nih.gov/pubmed/13042495uLange, k Langan, w b Boyd, l j Not Available Bulletin. New York Medical College Bulletin NY Med Coll. 1952;15:94-102.13042495eng~~7*Boyd, L. J. Lombardi, A. A. Svigals, C. S.19528The use of hexa-nitro-mesoinositol in renal hypertension59-78Bulletin NY Med Coll15 1952/01/01-*Hypertension Inositol/*analogs & derivatives+http://www.ncbi.nlm.nih.gov/pubmed/13042492zBoyd, l j Lombardi, a a Svigals, c s Not Available Bulletin. New York Medical College Bulletin NY Med Coll. 1952;15:59-78.13042492eng~~7'Glass, G. B. Lillick, L. C. Boyd, L. J.1952+Metabolic interrelations between gastric intrinsic hematopoietic factor and vitamin B12. I. E. coli mutant assay of vitamin B12 in blood and urines of 3 patients with pernicious anemia following administration of vitamin B12 alone or in combination with mucinous materials extracted from hog stomach17-41Bulletin NY Med Coll15 1952/01/01DAnemia, Pernicious/*therapy *Blood *Urine Vitamin B 12/*blood/*urine+http://www.ncbi.nlm.nih.gov/pubmed/13042489yGlass, g b j Lillick, l c Boyd, l j Not Available Bulletin. New York Medical College Bulletin NY Med Coll. 1952;15:17-41.13042489eng||7 Boyden, G. L.1952/Surgical treatment of chronic frontal sinusitis121-31!Trans Am Laryngol Rhinol Otol Soc1 73rd Meeting 1952/01/01+http://www.ncbi.nlm.nih.gov/pubmed/13005594Boyden, g l Not Available Transactions of the American Laryngological, Rhinological and Otological Society, Inc Trans Am Laryngol Rhinol Otol Soc. 1952;1(73rd Meeting):121-31.0065-9037 (Print)13005594engM<75Qui, Y. C. Quijano, R. C. Wang, S. K. Hwang, N. H. C.1995&Fluid-Dynamics of Venous Valve Closure750-759 Annals of Biomedical Engineering236wvenous prosthesis reflux flow at valve closure opening area closed p-q loop laser doppler anemometer vein valve diseaseNov-Dec;In vitro experiment was performed on a stented bovine jugular vein valve (VV, 14 mm I.D. x 2 cm long) and a stentless bovine jugular vein valve conduit (10 mm I.D. x 6 cm long) in a hydraulic flow loop with a downstream oscillatory pressure source to mimic respiratory changes. Simultaneous measurements were made on the valve opening area, conduit and sinus diameter changes using a specially designed laser optic system. Visualization of flow fields both proximal and distal to the venous valve, and the valve opening area were simultaneously recorded by using two video cameras. Laser Doppler anemometer surveys were made at three cross sections: the valve inlet, the valve exist, and 2 cm downstream of the venous valve to quantity flow reflux at valve closure. The experiment confirmed that the VV is a pressure-operated rather than a flow-driven device and that little or no reflux is needed to close the valve completely, The experiment further demonstrated that the VV sinus expands rapidly against back pressure, a critical character to consider in venous prosthesis design.://A1995TE84100005-Te841 Times Cited:9 Cited References Count:10 0090-6964Ann Biomed EngISI:A1995TE84100005RUniv Miami,Dept Biomed Engn,Coral Gables,Fl 33124 Baxter Edwards Cvs Div,Irvine,CaEnglish |t7Buxton, G. A. Clarke, N.20068Computational phlebology: the simulation of a vein valve507-21 J Biol Phys326 2006/12/01DecWe present a three-dimensional computer simulation of the dynamics of a vein valve. In particular, we couple the solid mechanics of the vein wall and valve leaflets with the fluid dynamics of the blood flow in the valve. Our model captures the unidirectional nature of blood flow in vein valves; blood is allowed to flow proximally back to the heart, while retrograde blood flow is prohibited through the occlusion of the vein by the valve cusps. Furthermore, we investigate the dynamics of the valve opening area and the blood flow rate through the valve, gaining new insights into the physics of vein valve operation. It is anticipated that through computer simulations we can help raise our understanding of venous hemodynamics and various forms of venous dysfunction.+http://www.ncbi.nlm.nih.gov/pubmed/19669438}Buxton, Gavin A Clarke, Nigel Netherlands Journal of biological physics J Biol Phys. 2006 Dec;32(6):507-21. Epub 2007 Feb 13.%0092-0606 (Print) 0092-0606 (Linking)265154419669438[Department of Chemistry, University of Durham, Durham, DH1 3LE, UK. g.a.buxton@durham.ac.uk10.1007/s10867-007-9033-4eng<7Buxton, G. A. Clarke, N.20068Computational phlebology: The simulation of a vein valve507-521Journal of Biological Physics326vein valves phlebology venous simulation lattice spring modei lattice boltzmann lattice boltzmann-equation mechanical-properties venous valves closure flow microcapsules dynamics modelWe present a three-dimensional computer simulation of the dynamics of a vein valve. In particular, we couple the solid mechanics of the vein wall and valve leaflets with the fluid dynamics of the blood flow in the valve. Our model captures the unidirectional nature of blood flow in vein valves; blood is allowed to flow proximally back to the heart, while retrograde blood flow is prohibited through the occlusion of the vein by the valve cusps. Furthermore, we investigate the dynamics of the valve opening area and the blood flow rate through the valve, gaining new insights into the physics of vein valve operation. It is anticipated that through computer simulations we can help raise our understanding of venous hemodynamics and various forms of venous dysfunction.://000247311900004-179TB Times Cited:4 Cited References Count:34 0092-0606 J Biol PhysISI:000247311900004Buxton, GA Univ Durham, Dept Chem, Durham DH1 3LE, England Univ Durham, Dept Chem, Durham DH1 3LE, England Univ Durham, Dept Chem, Durham DH1 3LE, EnglandDOI 10.1007/s10867-007-9033-4English <76Ivancic, P. C. Beauchman, N. N. Mo, F. Lawrence, B. D.2009OBiomechanics of Halo-Vest and Dens Screw Fixation for Type II Odontoid Fracture484-490Spine345cervical spine biomechanics halo-vest odontoid screw type ii dens fracture restricting cervical motion elderly-patients spine injuries death sentence c1-c2 fusion immobilization management orthoses axisMar 1Study Design. An in vitro biomechanical study of halo-vest and odontoid screw fixation of Type II dens fracture. Objective. The objective were to determine upper cervical spine instability due to simulated dens fracture and investigate stability provided by the halo-vest and odontoid screw, applied individually and combined. Summary of Background Data. Previous studies have evaluated posterior fixation techniques for stabilizing dens fracture. No previous biomechanical study has investigated the halo-vest and odontoid screw for stabilizing dens fracture. Methods. A biofidelic skull-neck-thorax model was used with 5 osteoligamentous whole cervical spine specimens. Three-dimensional flexibility tests were performed on the specimens while intact, following simulated dens fracture, and following application of the halo-vest alone, odontoid screw alone, and halo-vest and screw combined. Average total neutral zone and total ranges of motion at C0/1 and C1/2 were computed for each experimental condition and statistically compared with physiologic motion limits, obtained from the intact flexibility test. Significance was set at P < 0.05 with a trend toward significance at P < 0.1. Results. Type II dens fracture caused trends toward increased sagittal neutral zone and lateral bending range of motion at C1/2. Spinal motions with the dens screw alone could not be differentiated from physiologic limits. Significant reductions in motion were observed at C0/1 and C1/2 in flexion-extension and axial rotation due to the halo-vest, applied individually or combined with the dens screw. At C1/2, the halo-vest combined with the dens screw generally allowed the smallest average percentages of intact motion: 3% in axial rotation, 17% in flexion-extension, and 18% in lateral bending. Conclusion. The present reduction in C1/2 motion observed, due to the halo-vest and dens screw combined is similar to previously reported immobilization provided by the polyaxial screw/rod system and transarticular screw fixation combined with wiring. The present biomechanical data may be useful to clinicians when choosing an appropriate treatment for those with Type II dens fracture.://000265673900010-440BT Times Cited:2 Cited References Count:61 0362-2436SpineISI:000265673900010BIvancic, PC Yale Univ, Sch Med, Biomech Res Lab, Dept Orthopaed & Rehabil, 333 Cedar St,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Biomech Res Lab, Dept Orthopaed & Rehabil, 333 Cedar St,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Biomech Res Lab, Dept Orthopaed & Rehabil, New Haven, CT 06520 USA Doi 10.1097/Brs.0b013e318195a65bEnglish N<7;McConnell, A. Zdero, R. Syed, K. Peskun, C. Schetnitsch, E.2008}The biomechanics of ipsilateral intertrochanteric and femoral shaft fractures: A comparison of 5 fracture fixation techniques517-524Journal of Orthopaedic Trauma228fracture fixation femur intertrochanteric ipsilateral biomechanics sliding hip screw intramedullary nails proximal femur internal-fixation neck fractures implant plate design longSepbObjectives: The aim of the present study was to examine biomechanically 5 different construct combinations for fixation of ipsilateral intertrochanteric and femoral shaft fractures. Methods: Twenty-five fresh-frozen adult human femora (age range = 58-91 years, average age = 75.4 years) were tested in physiological bending and in torsion to characterize initial bending and torsional stiffness and stiffness following fixation of combined intertrochanteric and femoral shaft fractures. Five fracture fixation device constructs were assessed-construct A: long dynamic hip screw (long DHS); construct B: reconstruction nail; construct C: DHS plus low-contact dynamic compression plate; construct D: DHS plus retrograde intramedullary nail; and construct E: long intramedullary hip screw. Axial stiffness, torsional stiffness, and axial load-to-failure were the main measurements recorded. Results: There were no differences between constructs in terms of axial stiffness (P = 0.41), external rotation stiffness (P = 0.13), and axial load-to-failure (P = 0.16). However, there was a borderline statistically significant difference in internal rotation stiffness between the constructs (P = 0.048). Specifically, construct C Was significantly stiffer than construct E (P = 0.04). Conclusions: All constructs showed no statistical differences when compared with one another, with the exception of construct E, which provided the least torsional stiffness. However, the Current in vitro model did not simulate fracture healing or support offered by soft tissues, both of which would affect the stiffness and load-to-failure levels reached.://000259104600003-346YD Times Cited:6 Cited References Count:41 0890-5339J Orthop TraumaISI:000259104600003Schetnitsch, E Univ Toronto, St Michaels Hosp, Div Orthopaed, Dept Surg,Martin Orthopaed Biomech Lab, Suite 800,55 Queen St E, Toronto, ON M5C 1R6, Canada Univ Toronto, St Michaels Hosp, Div Orthopaed, Dept Surg,Martin Orthopaed Biomech Lab, Suite 800,55 Queen St E, Toronto, ON M5C 1R6, Canada Univ Toronto, St Michaels Hosp, Div Orthopaed, Dept Surg,Martin Orthopaed Biomech Lab, Toronto, ON M5C 1R6, CanadaEnglish <7Beck, Z.2002ZBiomechanics of internal fixation of femoral neck fracture by spongious compressive screws297-304Periodicum Biologorum1043Pbiomechanics internal fixation femoral neck fracture spongious compressive screwSepPurpose: Osteosynthesis of femoral neck fracture with three spongious screws is incompletely investigated problem, especially from biomechanic aspect. It is this author's view that standard way of screw osteosynthesis with screws in triangle pattern with distally oriented triangle basis is less rigid than the opposit. The hypothesis was that stability of such osteosynthesis was dependent on screws position inside the femoral neck, and biomechanic model experiment was examined to confirm it. The purpose of work was to establish stability difference between osteosynthesis with screws in triangle pattern with basis oriented caudally and a triangle with basis oriented cranially. Material and Methods: Investigation was done in Laboratory for Biomechanics, Department of Anatomy, School of Medicine Faculty University of Zagreb, on seven macerated specimens of human femoral bone divided in subject and control group. Specimens were exposed to static bending and torsion force moments before and after osteotomy and osteosynthesis in increments which did not cause plastic deformation. The degree of elastic deformation was measured by laser beam deflection on millimeter paper. It was the basis for deflection in degrees and much greater thanrigiditymuch less than of every specimen counting. Results: All results were compared within and between groups and presented in tables and diagrams schematically. Before the experiment, all specimens were measured, geometrically defined and radiographed. Radiography was also done after osteotomies and osteosyntheses, Theoretical part of work was based on Pauwels' analyses and theorems of static and dynamic forces in fracture gap of femoral neck. In this regard, analysis of best screws position was done with the purpose of distraction and neutralization of shearing forces. Conclusion: Both parts of the study confirmed the hypothesis that osteosynthesis of femoral neck fracture with spongious screws in triangle pattern with proximally oriented basis was superior to osteosynthesis with screws in triangle pattern with distally oriented basis, probably because of better distraction and neutralization of shearing forces.://000179601800008-621QW Times Cited:0 Cited References Count:15 0031-5362 Period BiolISI:000179601800008Beck, Z Prim Dr M Horvat Hosp Orthoped & Rehabil, Brace Brajkov Bb, Rovinj 52210, Croatia Prim Dr M Horvat Hosp Orthoped & Rehabil, Brace Brajkov Bb, Rovinj 52210, Croatia Prim Dr M Horvat Hosp Orthoped & Rehabil, Rovinj 52210, CroatiaEnglish*<7Cunningham, J. L.2001%The biomechanics of fracture fixation457-464Current Orthopaedics156Iintramedullary nails pullout strength tibial fractures bone screws designDec://000176541800010-568KW Times Cited:5 Cited References Count:28 0268-0890Curr OrthopaedISI:000176541800010Cunningham, JL Univ Bath, Dept Engn Mech, Bath BA2 7AY, Avon, England Univ Bath, Dept Engn Mech, Bath BA2 7AY, Avon, England Univ Bath, Dept Engn Mech, Bath BA2 7AY, Avon, EnglandDOI 10.1054/cuor.2001.0211English <7<Johnson, A. L. Egger, E. L. Eurell, J. A. C. Losonsky, J. M.1998LBiomechanics and biology of fracture healing with external skeletal fixation487-+BCompendium on Continuing Education for the Practicing Veterinarian204AprThe morphology of fracture healing depends on the mechanical environment afforded by external fixation and ranges between the extremes of direct bone healing and spontaneous hone healing. The mechanical environment at a fracture is affected by the stiffness of the fixator and the degree of load sharing of the fixator with the bone. As the stability of the fracture increases because of increased fixator rigidity, anatomic fracture reduction, or a combination of these factors, callus formation decreases. However, optimal rigidity may consist of early rigid immobilization followed by destabilization of the fixator to allow controlled loading of the fracture site. The biological Environment at the fracture also affects fracture healing with external fixation. Surgical techniques and implants, which compromise the surrounding soft tissue and interfere with the vasculature to the injured bone, will delay bone union. Fixation techniques for severely comminuted fractures using closed reduction and external skeletal fixation allow presentation of soft tissue. These biologically oriented techniques have been termed biological fracture fixation and feature realignment of the limb (i.e., joint surfaces) rather than anatomic reconstruction of the fracture; minimal to no sort tissue dissection; and optimal stability, resulting in moderate strain levels and allowing the progression of bone formation. Fractures treated in this manner seem to heal with endosteal bone formation and bone bridging between fragments rather than with periosteal callus.://000073279600007-Zk047 Times Cited:21 Cited References Count:2 0193-1903Comp Cont Educ PractISI:000073279600007uJohnson, AL Univ Illinois, Coll Vet Med, Dept Vet Clin Med, Urbana, IL 61801 USA Univ Illinois, Coll Vet Med, Dept Vet Clin Med, Urbana, IL 61801 USA Univ Illinois, Coll Vet Med, Dept Vet Clin Med, Urbana, IL 61801 USA Univ Illinois, Coll Vet Med, Dept Vet Biosci, Urbana, IL 61801 USA Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Clin Sci, Ft Collins, CO 80523 USAEnglish<7Trostle, S. S. Markel, M. D.19965Fracture biology, biomechanics, and internal fixation19-&8Veterinary Clinics of North America-Food Animal Practice121Qlong-bone fractures holding power orthopedic screws large animals strength calvesMarThe success of orthopedic surgery in ruminants is directly related to the surgeon's knowledge and understanding of bone physiology and mechanics. The relationship of the macro and micro structure and function of bone as it relates to fracture physiology and repair is discussed. A basic review of the biomechanical principles of bone, bone fracture, and fracture repair are presented. The clinical and biomechanical principles of internal fixation are described for fracture repair in ruminants.://A1996UA66000003-Ua660 Times Cited:3 Cited References Count:52 0749-0720Vet Clin N Am-Food AISI:A1996UA66000003TUniv Wisconsin,Sch Vet Med,Dept Surg Sci,Comparat Orthopaed Res Lab,Madison,Wi 53706English<7Aro, H. T. Chao, E. Y. S.1993CBiomechanics and Biology of Fracture Repair under External Fixation531-542 Hand Clinics94Nov://A1993MW37700002-Mw377 Times Cited:22 Cited References Count:0 0749-0712 Hand ClinISI:A1993MW37700002Aro, Ht Johns Hopkins Univ,Dept Orthoped Surg,Ross Res Bldg,720 Rutland Ave,Room 225,Baltimore,Md 21205 Johns Hopkins Univ,Dept Orthoped Surg,Ross Res Bldg,720 Rutland Ave,Room 225,Baltimore,Md 21205English<79Sasso, R. Doherty, B. J. Crawford, M. J. Heggeness, M. H.1993^Biomechanics of Odontoid Fracture Fixation - Comparison of the One-Screw and 2-Screw Technique 1950-1953Spine18146odontoid fracture internal screw fixation biomechanicsOct 15Direct anterior screw fixation of odontoid fractures has become more prevalent clinically. No biomechanical study, however, has determined whether one or two screws should be used. This study measured the stability of the odontoid process after fracture and internal fixation with one or two screws. Internal fixation of Type II odontoid fractures did not restore the original stability of the intact specimen, direct internal fixation with one or two screws provided 50% of the stability of the unfractured odontoid, and no significant differences between the one- and two-screw technique was found under loading to failure, although the two-screw technique provided increased stiffness in extension loading.://A1993MD26400004-Md264 Times Cited:43 Cited References Count:0 0362-2436SpineISI:A1993MD26400004`Baylor Coll Med,Ctr Spinal Disorders,Dept Orthopaed Surg,6550 Fannin,Suite 2501,Houston,Tx 77030English<72Calhoun, J. H. Li, F. Ledbetter, B. R. Gill, C. A.1992:Biomechanics of the Ilizarov Fixator for Fracture Fixation15-22*Clinical Orthopaedics and Related Research280external fixation stiffnessJulCompression, distraction, and torsion stiffness of the Ilizarov external fixator was measured in two fracture models in autopsy specimens of tibia and fibula. A transverse model was tested in six frame constructions with the osteotomy site preloaded in four different positions. An oblique model was tested in four frame constructions also with four preloaded positions. Stiffness was more dependent on bone preload than wire number, wire type, or frame design. High stiffness was achieved by bone preloading, by compressing the rings together, by increasing the number of wires, and by using olive wires. The stiffness can be decreased (dynamization) by separating the rings and by removing wires. This data is helpful for frame design of the Ilizarov fixator.://A1992JC24600004.Jc246 Times Cited:43 Cited References Count:32 0009-921XClin Orthop Relat RISI:A1992JC24600004yCalhoun, Jh Univ Texas,Med Branch,Div Orthopaed,Galveston,Tx 77550 Univ Texas,Med Branch,Div Orthopaed,Galveston,Tx 77550English<7Hulse, D. Hyman, B.1991)Biomechanics of Fracture Fixation Failure647-6679Veterinary Clinics of North America-Small Animal Practice214Jul://A1991HP76300003-Hp763 Times Cited:10 Cited References Count:6 0195-5616Vet Clin N Am-SmallISI:A1991HP76300003Hulse, D Texas a&M Univ Syst,Coll Vet Med,Dept Small Anim Med & Surg,College Stn,Tx 77843 Texas a&M Univ Syst,Coll Vet Med,Dept Small Anim Med & Surg,College Stn,Tx 77843Englishs<7)Calhoun, J. Li, F. Ledbetter, B. Gill, C.1991CBiomechanics of the Ilizarov External Fixator for Fracture Fixation102-102ABulletin of the Hospital for Joint Diseases Orthopaedic Institute511Spr://A1991FV57800018,Fv578 Times Cited:0 Cited References Count:0 0883-9344B Hosp Joint Dis OrtISI:A1991FV57800018English<7Schwarz, P. D.1991/Biomechanics of Fractures and Fracture Fixation3-158Seminars in Veterinary Medicine and Surgery-Small Animal61Feb://A1991FB42300002-Fb423 Times Cited:10 Cited References Count:0 0882-0511Semin Vet Med SurgISI:A1991FB42300002wSchwarz, Pd Colorado State Univ,Dept Clin Sci,Ft Collins,Co 80523 Colorado State Univ,Dept Clin Sci,Ft Collins,Co 80523English{<7 Kyle, R. F.19850Biomechanics of Intramedullary Fracture Fixation 1356-1359 Orthopedics811://A1985AUY5400003-Auy54 Times Cited:36 Cited References Count:8 0147-7447 OrthopedicsISI:A1985AUY5400003xKyle, Rf Hennepin Cty Med Ctr,Dept Orthoped,Minneapolis,Mn 55404 Hennepin Cty Med Ctr,Dept Orthoped,Minneapolis,Mn 55404Englisha<7 +Brown, S. A. Gillett, N. A. Broaddus, T. W.1985HBiomechanics of Fracture Fixation by Plastic Rods with Transverse Screws545-545Journal of Biomechanics187://A1985ANY6300129,Any63 Times Cited:0 Cited References Count:0 0021-9290 J BiomechISI:A1985ANY6300129Univ Calif Davis,Davis,Ca 95616English<7 !Ritter, G. Weigand, H. Ahlers, J.1982UBiomechanics and Fracture-Healing Characteristics of External Fixation Osteosynthesis457-457 Langenbecks Archiv Fur Chirurgie358://A1982PR18400085,Pr184 Times Cited:0 Cited References Count:0 0023-8236Langenbeck Arch ChirISI:A1982PR18400085BUniv Mainz,Unfallchirurg Abt,Chirurg Klin,D-6500 Mainz,Fed Rep GerEnglish<7 Aro, H. T. Chao, E. Y. S.1993CBiomechanics and Biology of Fracture Repair under External Fixation531-542 Hand Clinics94Nov://A1993MW37700002-Mw377 Times Cited:22 Cited References Count:0 0749-0712 Hand ClinISI:A1993MW37700002Aro, Ht Johns Hopkins Univ,Dept Orthoped Surg,Ross Res Bldg,720 Rutland Ave,Room 225,Baltimore,Md 21205 Johns Hopkins Univ,Dept Orthoped Surg,Ross Res Bldg,720 Rutland Ave,Room 225,Baltimore,Md 21205English i||7 Aro, H. T. Chao, E. Y.1993CBiomechanics and biology of fracture repair under external fixation531-42 Hand Clinics94 1993/11/01,Animals Biomechanics Bone Nails Bone Plates Equipment Design *External Fixators Fracture Fixation/instrumentation/*methods Fracture Fixation, Internal/methods Fracture Healing/physiology Fractures, Bone/classification/physiopathology/*surgery Humans Models, Biological Osteotomy Pressure Time FactorsNovP The major factors determining the mechanical milieu of a healing fracture under external fixation, and thereby the mechanism of union, are the rigidity of the selected fixation device, the fracture configuration, the accuracy of fracture reduction, and the amount of physiologic stresses dictated by functional activity and loading. Bone healing problems encountered in fractures stabilized externally merely reflect the severity of the local soft-tissue and periosteal injury and should not be attributed to the inherent features of the fixation modality. Although some surgeons have had reservations concerning the use of external fixation for fracture treatment, based mainly on concerns of pin-tract infection and fracture nonunion, much of the clinical experience and basic science research results have proven the reverse. Many of the potential benefits of external fixation, such as the change of fixation stiffness, are not yet fully appreciated. Additional research and well-organized clinical trials must be performed. Pin-tract problems can be controlled, but the surgeon using such a device must be familiar with the techniques and follow the established regimens during postoperative care. One common mistake is to assume that external fixators, especially those of the simpler unilateral configuration, are easy to use and do not require learning or mastering the surgical techniques until the time of application. Periodic examination and radiographic evaluations are also essential to adjust conditions of the fracture site. The importance of balancing the biomechanical properties and the biologic consequences of different external fixation modalities has been demonstrated. Understanding this knowledge and the techniques of application associated with external fixation is the prerequisite to successful treatment. Some of the basic biomechanical information related to external fixation and bone fracture union is still unknown. This lack should provide the impetus for surgeons, bioengineers, and medical scientists to continue collaborative basic and applied research. Furthermore, by recognizing the proper cell mediators and the physical means to stimulate these cellular elements, the bone fracture healing process may be modulated, regardless of the fixation technique. The result of such effort should provide new modalities to improve fracture management.*http://www.ncbi.nlm.nih.gov/pubmed/8300724Aro, H T Chao, E Y Comparative Study Research Support, Non-U.S. Gov't Review United states Hand clinics Hand Clin. 1993 Nov;9(4):531-42.%0749-0712 (Print) 0749-0712 (Linking)8300724PDepartment of Orthopedic Surgery, Johns Hopkins University, Baltimore, Maryland.eng<7 Aro, H. T. Chao, E. Y. S.1993CBiomechanics and Biology of Fracture Repair under External Fixation531-542 Hand Clinics94Nov://A1993MW37700002-Mw377 Times Cited:22 Cited References Count:0 0749-0712 Hand ClinISI:A1993MW37700002Aro, Ht Johns Hopkins Univ,Dept Orthoped Surg,Ross Res Bldg,720 Rutland Ave,Room 225,Baltimore,Md 21205 Johns Hopkins Univ,Dept Orthoped Surg,Ross Res Bldg,720 Rutland Ave,Room 225,Baltimore,Md 21205Englishs<7Chao, E. Y. S.19967Orthopaedic biomechanics - The past, present and future239-243International Orthopaedics204Aug://A1996VC97100012,Vc971 Times Cited:3 Cited References Count:0 0341-2695 Int OrthopISI:A1996VC97100012UChao, EYS Johns Hopkins Univ,Baltimore,Md 21218 Johns Hopkins Univ,Baltimore,Md 21218Englishs<7Chao, E. Y. S.19967Orthopaedic biomechanics - The past, present and future239-243International Orthopaedics204Aug://A1996VC97100012,Vc971 Times Cited:3 Cited References Count:0 0341-2695 Int OrthopISI:A1996VC97100012UChao, EYS Johns Hopkins Univ,Baltimore,Md 21218 Johns Hopkins Univ,Baltimore,Md 21218English<7Buxton, G. A. Clarke, N.20068Computational phlebology: The simulation of a vein valve507-521Journal of Biological Physics326vein valves phlebology venous simulation lattice spring modei lattice boltzmann lattice boltzmann-equation mechanical-properties venous valves closure flow microcapsules dynamics modelWe present a three-dimensional computer simulation of the dynamics of a vein valve. In particular, we couple the solid mechanics of the vein wall and valve leaflets with the fluid dynamics of the blood flow in the valve. Our model captures the unidirectional nature of blood flow in vein valves; blood is allowed to flow proximally back to the heart, while retrograde blood flow is prohibited through the occlusion of the vein by the valve cusps. Furthermore, we investigate the dynamics of the valve opening area and the blood flow rate through the valve, gaining new insights into the physics of vein valve operation. It is anticipated that through computer simulations we can help raise our understanding of venous hemodynamics and various forms of venous dysfunction.://000247311900004-179TB Times Cited:4 Cited References Count:34 0092-0606 J Biol PhysISI:000247311900004Buxton, GA Univ Durham, Dept Chem, Durham DH1 3LE, England Univ Durham, Dept Chem, Durham DH1 3LE, England Univ Durham, Dept Chem, Durham DH1 3LE, EnglandDOI 10.1007/s10867-007-9033-4English||7Low, H. T. Chew, Y. T.1991[Pressure/flow relationships in collapsible tubes; effects of upstream pressure fluctuations217-21Med Biol Eng Comput292 1991/03/013Blood Vessels/*physiology Humans Pressure *RheologyMarAn experimental investigation has been made on the pressure/flow behaviour of a collapsible tube. Of particular interest are the effects of upstream pressure fluctuations on the mean pressure/flow relationships. These mean pressure/flow relationships were found to exhibit features generally similar to the steady-flow situation, including flow limitation where the flow rate becomes independent of the driving pressure during the tube-collapsed phase. However, the tube collapsed under a higher downstream pressure and the maximum flow rate was reduced, when either the frequency or amplitude of the upstream pressure fluctuations was increased.*http://www.ncbi.nlm.nih.gov/pubmed/1857129Low, H T Chew, Y T Research Support, Non-U.S. Gov't England Medical & biological engineering & computing Med Biol Eng Comput. 1991 Mar;29(2):217-21.%0140-0118 (Print) 0140-0118 (Linking)1857129TDepartment of Mechanical & Production Engineering, National University of Singapore.engp||7Koh, Y. G. Baines, A. D.1974NPressure-flow relationships in Henle's loops and long collapsible rubber tubes30-8 Kidney Int51 1974/01/01Animals *Diuresis Female Glycerol Hydrostatic Pressure *Intubation Kidney Tubules/*physiology Kidney Tubules, Distal/physiology Kidney Tubules, Proximal/physiology Loop of Henle/physiology Male Mannitol Perfusion *Pressure Punctures Rats *Rubber TransducersJan*http://www.ncbi.nlm.nih.gov/pubmed/4813588WKoh, Y G Baines, A D United states Kidney international Kidney Int. 1974 Jan;5(1):30-8.%0085-2538 (Print) 0085-2538 (Linking)4813588eng||7 Conrad, W. A.19691Pressure--flow relationships in collapsible tubes284-95IEEE Trans Biomed Eng164 1969/10/01R*Bionics Blood Circulation Blood Flow Velocity *Models, Biological Venous PressureOct*http://www.ncbi.nlm.nih.gov/pubmed/5354907tConrad, W A United states IEEE transactions on bio-medical engineering IEEE Trans Biomed Eng. 1969 Oct;16(4):284-95.%0018-9294 (Print) 0018-9294 (Linking)5354907eng<7cMcKee, M. D. Bowden, S. H. King, G. J. Patterson, S. D. Jupiter, J. B. Bamberger, H. B. Paksima, N.1998XManagement of recurrent, complex instability of the elbow with a hinged external fixator 1031-10360Journal of Bone and Joint Surgery-British Volume80B6NovWe have treated 16 patients with recurrent complex elbow instability using a hinged external fixator. All patients had instability, dislocation or subluxation of the ulnohumeral joint. The injuries were open in eight patients and were associated with 20 other fractures and five peripheral nerve injuries. Two patients had received initial treatment from us; 14 had previously had a mean of 2.1 unsuccessful surgical procedures (1 to 6). The fixator was applied at a mean of 4.8 weeks (0 to 9) after the injury and remained on the elbow for a mean of 8.5 weeks (6 to 11). After treatment we found the mean range of flexion-extension to be 105 degrees (65 to 140). At a final follow-up of 23 months (14 to 40), the mean Morrey score was 84 (49 to 96): this translated into one poor, three fair, ten good and two excellent results. Complications included one fractured humeral pin, one temporary palsy of the radial nerve, one recurrent instability, one wound infection, one severe pin-track infection and one patient with reflex sympathetic dystrophy. Although technically demanding, the use of the fixator is an important advance in the management of recurrent complex elbow instability after failure of conventional treatment.://000077211800018.142QL Times Cited:44 Cited References Count:19 0301-620XJ Bone Joint Surg BrISI:000077211800018+McKee, MD Suite 800,55 Queen St E, Toronto, ON M5C 1R6, Canada Suite 800,55 Queen St E, Toronto, ON M5C 1R6, Canada Univ Toronto, Toronto, ON M5B 1W8, Canada Univ Western Ontario, Hand & Upper Limb Ctr, London, ON N6A 4LS, Canada Ohio Univ, Dayton, OH 45405 USA Harvard Univ, Cambridge, MA 02138 USAEnglish<7&Chin, K. R. Pess, G. M. Jupiter, J. B.1998cChronic lymphocytic leukemia presenting as pyogenic arthritis of the proximal interphalangeal joint545-550'Journal of Hand Surgery-American Volume23A3MayA 66-year-old woman was seen and treated for a chronic lymphocystic leukemic infiltrate of a proximal interphalangeal joint, which presented with clinical and radiologic signs consistent with a pyogenic arthritis. Copyright (C) 1998 by the American Society for Surgery of the Hand.://000073670300025-Zn674 Times Cited:0 Cited References Count:12 0363-5023J Hand Surg-AmISI:000073670300025Jupiter, JB Massachusetts Gen Hosp, Acc 527,15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp, Acc 527,15 Parkman St, Boston, MA 02114 USA Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Orthopaed Surg,Hand Surg Serv, Boston, MA USAEnglishJ<7Faierman, E. Jupiter, J. B.1998XThe management of acute fractures involving the distal radio-ulnar joint and distal ulna213-+ Hand Clinics142`colles fracture wrist head replacement injuries forearm complications dislocation children elbowMaygThe acute management of fractures involving the distal radio-ulnar joint and distal ulna is controversial. The primary goal is recognition and differentiation between stable and unstable fracture patterns. Although an operative approach is adopted in the treatment of these injuries, the optimal management protocol awaits good prospective randomized studies.://000073670600007.Zn677 Times Cited:14 Cited References Count:92 0749-0712 Hand ClinISI:000073670600007@Jupiter, JB Massachusetts Gen Hosp, Orthopaed Hand Serv, Dept Orthopaed Surg, WACC 527,15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp, Orthopaed Hand Serv, Dept Orthopaed Surg, WACC 527,15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp, Orthopaed Hand Serv, Dept Orthopaed Surg, Boston, MA 02114 USAEnglish<7Ring, D. Jupiter, J. B.1998!Fracture-dislocation of the elbow566-5801Journal of Bone and Joint Surgery-American Volume80A4bradial head fractures internal-fixation replacement joint stability arthroplasty ligament excisionApr://000073137700014/Zh688 Times Cited:59 Cited References Count:124 0021-9355J Bone Joint Surg AmISI:000073137700014Ring, D Massachusetts Gen Hosp, Dept Orthopaed Surg, ACC 527,15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Orthopaed Surg, ACC 527,15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USAEnglish<7,McKee, M. D. Jupiter, J. B. Bamberger, P. B.1998Untitled - Reply604-6041Journal of Bone and Joint Surgery-American Volume80A4Apr://000073137700020,Zh688 Times Cited:0 Cited References Count:1 0021-9355J Bone Joint Surg AmISI:000073137700020McKee, MD St Michaels Hosp Orthopaed Associates, Upper Extrem Serv, 55 Queen St E,Suite 800, Toronto, ON M5C 1R6, Canada St Michaels Hosp Orthopaed Associates, Upper Extrem Serv, 55 Queen St E,Suite 800, Toronto, ON M5C 1R6, Canada St Michaels Hosp Orthopaed Associates, Upper Extrem Serv, Toronto, ON M5C 1R6, Canada Harvard Univ, Massachusetts Gen Hosp, Orthopaed Hand Serv, Boston, MA 02114 USA Orthopaed Associates SW Ohio, Dayton, OH 45405 USAEnglish<7Jupiter, J. B.1998Untitled - In reply353-353'Journal of Hand Surgery-American Volume23A2Mar://000072974400029,Zg173 Times Cited:0 Cited References Count:0 0363-5023J Hand Surg-AmISI:000072974400029 Jupiter, JB Harvard Univ, Sch Med, Orthopaed Hand Serv, WACC 527, 15 Parkman St, Boston, MA 02114 USA Harvard Univ, Sch Med, Orthopaed Hand Serv, WACC 527, 15 Parkman St, Boston, MA 02114 USA Harvard Univ, Sch Med, Orthopaed Hand Serv, WACC 527, Boston, MA 02114 USAEnglish<7Modabber, M. R. Jupiter, J. B.1998OOperative management of diaphyseal fractures of the humerus - Plate versus nail93-104*Clinical Orthopaedics and Related Research3474shaft fractures experience strength fixation systemsFebYAlthough nonoperative treatment is indicated and successful for the majority of diaphyseal humeral fractures, operative intervention is indicated in several situations, Either intramedullary nail or plate fixation commonly is used for the operative management of this problem, Familiarity with the surgical techniques and application of both types (and subtypes) of implants is necessary to allow optimal treatment for the widest range of fracture patterns, In most indications for operative management, internal fixation with plates is preferred, Stable fixation, sparing adjacent joints from iatrogenic injuries, and direct visualization and protection of the radial nerve are of critical importance in maximizing postoperative function and in most cases outweigh the potential advantages of a loadsharing implant inserted through a more limited incision.://000072402600013.Za795 Times Cited:29 Cited References Count:44 0009-921XClin Orthop Relat RISI:000072402600013Jupiter, JB Massachusetts Gen Hosp, Orthopaed Hand Surg Serv, 15 Parkman St,Suite 527, Boston, MA 02115 USA Massachusetts Gen Hosp, Orthopaed Hand Surg Serv, 15 Parkman St,Suite 527, Boston, MA 02115 USA Massachusetts Gen Hosp, Orthopaed Hand Surg Serv, Boston, MA 02115 USAEnglish )<7Jupiter, J. B. Ring, D.1998DOperative treatment of post-traumatic proximal radioulnar synostosis248-257!Journal of Bone and Joint Surgery80A2boneFebThe results of operative resection of a post-traumatic proximal radioulnar synostosis performed by one surgeon in eighteen limbs of seventeen consecutive patients during an eight-year period were reviewed retrospectively, The resection was performed an average of nineteen months after the injury; eight limbs had the resection less than twelve months after the injury, A free fat graft was used in the first eight patients, No adjuvant non-steroidal anti-inflammatory medication or low-dose radiation was used postoperatively as prophylaxis against heterotopic ossification, We classified the proximal radioulnar synostoses into three subgroups: A indicated a synostosis at or distal to the bicipital tuberosity (four limbs), B indicated a synostosis involving the radial head and the proximal radioulnar joint (seven limbs), and C indicated a synostosis that was contiguous with bone extending across the elbow to the distal aspect of the humerus (seven limbs), The patients were followed for an average of thirty-four months (range, twenty-four to sixty months), The synostosis recurred in one patient, the only patient in the series who had sustained a closed head injury at the time of the initial injury, Additional complications included a fracture of the ulna, a broken pin on a hinged elbow distracter, and dislodgment of a free nonvascularized fat graft in one patient each, The seventeen limbs that did not have a recurrence regained an average of 139 degrees of rotation of the forearm, With the number of patients available, we could not detect a significant relationship between subsequent rotation of the forearm and the size of the synostosis, the use of interpositional fat, or the concomitant use of a hinged elbow distracter, The eight limbs that had resection of the synostosis less than twelve months after the injury regained an average of 144 degrees of rotation compared with 134 degrees in the nine limbs that had resection at least twelve months after the injury, This difference could not be shown to be significant. In this series, operative resection of a post-traumatic proximal radioulnar synostosis led to good results despite the lack of adjuvant radiation therapy or antiinflammatory medication.://000072146400012.Yy436 Times Cited:44 Cited References Count:31 0021-9355J Bone Joint Surg AmISI:000072146400012"Jupiter, JB Massachusetts Gen Hosp, Orthopaed Hand Serv, Dept Orthopaed Surg, WAC-527, Boston, MA 02114 USA Massachusetts Gen Hosp, Orthopaed Hand Serv, Dept Orthopaed Surg, WAC-527, Boston, MA 02114 USA Massachusetts Gen Hosp, Orthopaed Hand Serv, Dept Orthopaed Surg, Boston, MA 02114 USAEnglish<71McKee, M. D. Jupiter, J. B. Bosse, G. Goodman, L.1998MOutcome of ulnar neurolysis during post-traumatic reconstruction of the elbow100-1050Journal of Bone and Joint Surgery-British Volume80B1+health-status transposition fractures nerveJanWe performed ulnar nerve neurolysis and transposition during reconstructive operations on 20 consecutive patients (21 elbows) with neuropathy after the failure of primary treatment of elbow fractures. There were 11 men and nine women with a mean age of 48.3 years. Preoperatively, four elbows were in McGowan stage I, seven in stage II and ten in stage III and the mean Gabel and Amadio ulnar nerve score was 3.2. At a mean follow-up of 32.1 months (24 to 67) eve performed comprehensive neurological, functional, electrophysiological and outcome assessments. Patient satisfaction was high with good pain relief and restoration of hand strength and dexterity. The mean Gabel and Amadio score had improved to 6.5, an improvement of 3.3. There were one excellent, 16 good, 2 fair and 2 poor results; both of the last were due to failure of the underlying elbow reconstruction. Even for advanced stage-II and stage-III lesions we achieved good function, return of intrinsic power, and a high rate of patient satisfaction.://000071622000021.Yt587 Times Cited:12 Cited References Count:28 0301-620XJ Bone Joint Surg BrISI:000071622000021 McKee, MD 55 Queen St E,Suite 800, Toronto, ON M5C 1R6, Canada 55 Queen St E,Suite 800, Toronto, ON M5C 1R6, Canada Univ Toronto, St Michaels Hosp, Dept Surg, Div Orthopaed,Upper Extrem Reconstruct Serv, Toronto, ON M5B 1W8, Canada Harvard Univ, Boston, MA 02115 USAEnglish<7Ring, D. Jupiter, J. B.1997AMini-symposium: Elbow problems (iii) Elbow fractures in the adult242-248Current Orthopaedics114distal humerus radiusOct://000071513200003-Yr617 Times Cited:1 Cited References Count:36 0268-0890Curr OrthopaedISI:000071513200003]Ring, D 11 Hancock St,Unit 4, Boston, MA 02114 USA 11 Hancock St,Unit 4, Boston, MA 02114 USAEnglish c<7bJupiter, J. B. Winters, S. Sigman, S. Lowe, C. Pappas, C. Ladd, A. L. Van Wagoner, M. Smith, S. T.1997kRepair of five distal radius fractures with an investigational cancellous bone cement: A preliminary report110-116Journal of Orthopaedic Trauma112cancellous calcium phosphate cement colles' fracture distal radius fracture hydroxyapatite norian srs colles fractures external fixation plasterFeb-MarObjective: The purpose of the study was to evaluate the feasibility of Norian SRS bone cement injected percutaneously into a distal radius following reduction in both preventing loss of reduction as well as safety. Design: The study was a prospective clinical study with an established protocol. Setting: The study was conducted al the Massachusetts General Hospital following approval of the institutions Investigational Review Board. All patients were required to read and approve an informed consent document. Patients: While twenty patients' radiographs fulfilled the requirement of a dorsally displaced extraarticular fracture to have occurred within 72 hours of presentation, only five consented to participate fully and one voluntarily withdrew after a six-month follow-up. Intervention: All fractures were reduced under regional or general anesthesia, and the Norian SRS was introduced via a catheter system into the metaphyseal defect of the fracture. A short arm cast was applied and remained in place for six weeks. Main Outcome Measurements: Radiographic parameters of fracture reduction were measured prospectively by an independent radiologist throughout the 12 months of the study. Clinical parameters of hand and wrist function were measured prospectively by an independent occupational therapist. Results: At 12-month follow-up, radial length was a mean 9.9 mm with an average loss of < 1mm; radial angle maintained at a mean 25.4 degrees; volar angle was within normal range (0-21 degrees) in 4; and 1 patient had a dorsal angle of 7 degrees. Wrist motion improved 50 percent between 6 weeks and 3 months and improved further by 12 months when grip strength reached a mean of 88 percent of the contralateral side. Dorsal and volar extrusion of injected Norian SRS in 4 patients resorbed over time. There were no clinically significant adverse effects or complications. Conclusions: Norian SRS proved to be clinically safe and effective as a cancellous bone cement to maintain fracture reduction of unstable extraarticular distal radius fractures.://000071405600008.Yq615 Times Cited:90 Cited References Count:34 0890-5339J Orthop TraumaISI:000071405600008 Jupiter, JB Norian Corp, 10260 Bubb Rd, Cupertino, CA 95014 USA Norian Corp, 10260 Bubb Rd, Cupertino, CA 95014 USA Norian Corp, Cupertino, CA 95014 USA Stanford Univ, Med Ctr, Stanford, CA 94305 USA Massachusetts Gen Hosp, Orthopaed Hand Serv, Boston, MA 02114 USAEnglish<76Cove, J. A. Lhowe, D. W. Jupiter, J. B. Siliski, J. M.1997.The management of femoral diaphyseal nonunions513-520Journal of Orthopaedic Trauma117zexternal fixation femur fracture infection plate fixation vascularized fibula transfer open fractures reconstruction femurOct1Objective: To assess the efficacy of treatment and develop an algorithm for management of nonunions of the femoral diaphysis. Study Design: Retrospective. Setting: University hospital. Methods: Forty-four patients treated at one institution for nonunion of the femoral diaphysis were studied. Thirteen of these patients had a history of infection. After debridement (where appropriate) and repair of the femoral: nonunion, followup averaged twenty-eight months (range, 24 to 108 months). All patients were examined at final follow-up. Results: Thirty-three patients achieved union after one procedure, and eight patients achieved union after additional procedures. One patient underwent above-knee amputation, and two patients remained ununited at the time of their final follow-up. Time to union averaged 11.8 months. Seventeen patients healed with more than two centimeters of shortening, and ten patients lost more than 30 degrees of knee flexion. Conclusion: Established femoral diaphyseal nonunions can be treated effectively, even in the presence of chronic sepsis: Selective use of a vascularized fibula transfer has proven beneficial in addressing intercalary defects. Plate fixation, with or without a vascularized fibula transfer, has been the predominant mode of skeletal stabilization in more complex reconstructions.://000071406100009.Yq620 Times Cited:21 Cited References Count:23 0890-5339J Orthop TraumaISI:000071406100009Lhowe, DW Massachusetts Gen Hosp, Dept Orthopaed Surg, ACC 525, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Orthopaed Surg, ACC 525, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USAEnglish <7 >Ring, D. Jupiter, J. B. Sanders, R. W. Mast, J. Simpson, N. S.19970Transolecranon fracture-dislocation of the elbow545-550Journal of Orthopaedic Trauma118<comminution dislocation elbow olecranon trochlear notch ulnaNovcObjective: To characterize the prevalence, morphology, and prognosis of anterior (transolecranon) fracture-dislocations of the elbow. Design: Retrospective case series. Setting: A consecutive series of thirteen patients from a single level-one trauma center, plus four patients from the practices of two of the senior authors. Patients: Three of seventeen patients had simple, oblique fractures of the olecranon, and fourteen had complex, comminuted fractures of the proximal ulna, including fragmentation of the olecranon in seven patients, large coronoid fragments in eight patients, and segmental fractures of the ulna in six patients. Fourteen patients were male and three were female, with an average age of thirty-eight years (range, 18 to 78 years). Intervention: All fractures were treated by open reduction and internal fixation. Two one-third tubular plates had to be revised to 3.5-millimeter dynamic compression plates within six weeks of the initial operation. Main Outcome Measure: Elbow performance rating of Broberg and Morrey. Results: At an average follow-up of twenty-five months, overall outcome was rated as excellent in seven patients, good in eight, and fair in two. Mild posttraumatic arthritis was noted in only two patients. Large coronoid fragments and extensive comminution of the trochlear notch did not preclude a good result provided that stable, anatomic fixation was achieved. Conclusions: Anterior elbow dislocations occur most often as a fracture-dislocation in which the distal humerus is driven through the olecranon, thereby causing a complex, comminuted fracture of the proximal ulna. This injury is frequently confused with anterior Monteggia lesions by virtue of the readily apparent radiocapitellar dislocation. Stable restoration of the appropriate contour and dimensions of the trochlear notch of the ulna will lead to a good result in most cases.://000071406200001.Yq621 Times Cited:45 Cited References Count:39 0890-5339J Orthop TraumaISI:000071406200001Jupiter, JB Massachusetts Gen Hosp, ACC 527,15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp, ACC 527,15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp, Boston, MA 02114 USA Tampa Gen Hosp, Tampa, FL 33606 USA Wayne State Univ, Sch Med, Detroit, MI USAEnglish <7!3Shea, K. Fernandez, D. L. Jupiter, J. B. Martin, C.1997_Corrective osteotomy for malunited, volarly displaced fractures of the distal end of the radius 1816-18261Journal of Bone and Joint Surgery-American Volume79A12DecTwenty-five patients who had had an opening-wedge osteotomy for the treatment of a malunited, volarly diplaced fracture of the distal end of the radius were studied retrospectively. The indications for the operation were pain and functional limitations rather than the degree of anatomical deformity. Fifteen patients were men and ten were women; their average age was forty-six years (range, twenty-one to eighty-four years). Preoperative radiographs revealed an average ulnar inclination of 14 degrees, an average ulnar variance of five millimeters, and an average volar inclination of 24 degrees. Extension of the wrist averaged 25 degrees; flexion of the wrist, 53 degrees; supination of the forearm, 41 degrees; and pronation of the forearm, 64 degrees. The average grip strength was a force of seventeen kilograms compared with a force of forty kilograms compared with a force of forty kilograms in the contralateral hand. At an average of sixty-one months (range, eighteen to 114 months) after the osteotomy, supination of the forearm had improved to an average of 69 degrees and pronation had improved to an average of 75 degrees (p < 0.05 for both), Extension of the wrist had improved to an average of 55 degrees, and grip strength had improved to a force of thirty kilograms (p < 0.05 for both), Volar inclination averaged 5 degrees; ulnar variance, zero millimeters; and ulnar inclination, 22 degrees, A reoperation was performed in eleven patients, Seven patients had removal of the hardware only two had a procedure involving the distal radioulnar Joint, one had a procedure because the site of the osteotomy had not healed, and one had a median-nerve release. The functional result was rated as very good in ten patients, good in eight, fair in three, and poor in four.://000071006800007.Yl909 Times Cited:31 Cited References Count:35 0021-9355J Bone Joint Surg AmISI:000071006800007mShea, K Univ Utah, Dept Orthopaed Surg, 50 N Med Dr, Salt Lake City, UT 84132 USA Univ Utah, Dept Orthopaed Surg, 50 N Med Dr, Salt Lake City, UT 84132 USA Univ Utah, Dept Orthopaed Surg, Salt Lake City, UT 84132 USA Orthopaed Chirurg FMH, CH-3012 Bern, Switzerland Massachusetts Gen Hosp, Orthopaed Hand Serv, Boston, MA 02114 USA Kantonsspital, Aarau, SwitzerlandEnglish`t, Orthopaed Hand Serv, Dept Orthopaed Surg, Boston, MA 02114 USAEnglishPK1=I/**refs.frm 0B< !// !HPRIMARYyearIndex 6ByP/) idreference_type text_stylesauthoryear title pages secondary_title volume numbernumber_of_volumessecondary_authorplace_published publishersubsidiary_authoredition keywords type_of_workdate2)  abstractlabelurltertiary_titletertiary_author notes isbn custom_1 custom_2 custom_3 custom_4alternate_titleaccession_number call_number short_title custom_5 custom_6sectionoriginal_publicationH) reprint_editionreviewed_itemauthor_addressimagecaption custom_7 electronic_resource_number link_to_pdf translated_author translated_titlename_of_databasedatabase_providerresearch_notes language access_datelast_modified_date !! 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